Zinlirvimab / 5t3z

A4DAB308_5t3z_H_L | Source PDB: 5t3z | Chains: H, L | Done
100
Yes
10 Å
Yes
Avg A4D Score
-0.6131
Max Score
2.8055
Min Score
-3.9115
Total Score
-268.55
Score CDR
-0.3265
Score non-CDR
-0.6604

Calculation Parameters

Chain Sequence(s) QVQLQESGPGLVKPSETLSVTCSVSGDSMNNYYWTWIRQSPGKGLEWIGYISDRESATYNPSLNSRVVISRDTSKNQLSLKLNSVTPADTAVYYCATARRGQRIYGVVSFGEFFYYYSMDVWGKGTTVTVSSASTKGPSVFPLAPSSKTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCLSVALGETARISCGRQALGSRAVQWYQHRPGQAPILLIYNNQDRPSGIPERFSGTPDINFGTRATLTISGVEAGDEADYYCHMWDSRSGFSWSFGGATRLTVLGQPKAAPSVTLFPPSSEELQANKATLVCLISDFYPGAVTVAWKADSSPVKAGVETTTPSKQSNNKYAASSYLSLTPEQWKSHRSYSCQVTHEGSTVEKTVAPTEC input.pdb
Selected Chain(s) H (Heavy), L (Light)
Distance of Aggregation 10 Å
FoldX Energy Minimization Yes
pH Calculations Yes
Downloads Download all data (.tar.gz)

Aggrescan4D Profile

Aggregation-prone (score > 0)
Soluble (score < 0)
Buried (score = 0)

Per-Residue A4D Scores

Download CSV
Minimum Score -3.9115
Maximum Score 2.8055
Average Score -0.6131
Total Score -268.5503

Residues with A4D score > 0.0 are highlighted as aggregation-prone.

Index Residue Chain A4D Score Classification
1 Q H -1.7462 Soluble
2 V H -1.3442 Soluble
3 Q H -1.8908 Soluble
4 L H 0.0000 Buried
5 Q H -1.4238 Soluble
6 E H 0.0000 Buried
7 S H -0.6153 Soluble
8 G H -0.2578 Soluble
9 P H -0.2342 Soluble
11 G H 0.0000 Buried
12 L H -0.3423 Soluble
13 V H -0.9043 Soluble
14 K H -2.0193 Soluble
15 P H -1.4435 Soluble
16 S H -1.3500 Soluble
17 E H -1.6947 Soluble
18 T H -1.3691 Soluble
19 L H 0.0000 Buried
20 S H -0.5885 Soluble
21 V H 0.0000 Buried
22 T H -0.4478 Soluble
23 C H 0.0000 Buried
24 S H -1.0034 Soluble
25 V H 0.0000 Buried
26 S H -1.3904 Soluble
27 G H -1.7121 Soluble
28 D H -2.1470 Soluble
29 S H -1.4393 Soluble
30 M H 0.0000 Buried
35 N H -3.0630 Soluble
36 N H -2.3846 Soluble
37 Y H -1.5005 Soluble
38 Y H -1.4772 Soluble
39 W H 0.0000 Buried
40 T H 0.0000 Buried
41 W H 0.0000 Buried
42 I H 0.0000 Buried
43 R H -0.4663 Soluble
44 Q H -0.9593 Soluble
45 S H -1.0643 Soluble
46 P H -1.0800 Soluble
47 G H -1.5011 Soluble
48 K H -2.2193 Soluble
49 G H -1.4606 Soluble
50 L H -0.8143 Soluble
51 E H -1.1086 Soluble
52 W H 0.0000 Buried
53 I H 0.0000 Buried
54 G H 0.0000 Buried
55 Y H 0.0101 Aggregation-prone
56 I H 0.0000 Buried
57 S H -2.5445 Soluble
58 D H -3.9115 Soluble
59 R H -3.8316 Soluble
63 E H -3.5881 Soluble
64 S H -1.9254 Soluble
65 A H -0.7804 Soluble
66 T H 0.0144 Aggregation-prone
67 Y H 0.2309 Aggregation-prone
68 N H 0.0000 Buried
69 P H -0.6095 Soluble
70 S H -0.6355 Soluble
71 L H -0.7331 Soluble
72 N H -1.5177 Soluble
74 S H -0.9740 Soluble
75 R H -1.1458 Soluble
76 V H 0.0000 Buried
77 V H 0.3525 Aggregation-prone
78 I H 0.0000 Buried
79 S H -0.6139 Soluble
80 R H -1.2201 Soluble
81 D H -1.3902 Soluble
82 T H -1.3101 Soluble
83 S H -1.3517 Soluble
84 K H -2.2142 Soluble
85 N H -1.8503 Soluble
86 Q H -1.3943 Soluble
87 L H 0.0000 Buried
88 S H -0.4117 Soluble
89 L H 0.0000 Buried
90 K H -0.8957 Soluble
91 L H 0.0000 Buried
92 N H -1.4828 Soluble
93 S H -1.3091 Soluble
94 V H 0.0000 Buried
95 T H -0.8041 Soluble
96 P H -0.6382 Soluble
97 A H -0.2420 Soluble
98 D H -0.3830 Soluble
99 T H -0.1862 Soluble
100 A H 0.0000 Buried
101 V H -0.1233 Soluble
102 Y H 0.0000 Buried
103 Y H 0.0000 Buried
104 C H 0.0000 Buried
105 A H 0.0000 Buried
106 T H 0.0000 Buried
107 A H 0.0000 Buried
108 R H -1.5759 Soluble
109 R H -1.6080 Soluble
110 G H -0.9698 Soluble
111 Q H -0.5050 Soluble
111A R H -0.0065 Soluble
111B I H 1.5637 Aggregation-prone
111C Y H 1.6398 Aggregation-prone
111D G H 1.6654 Aggregation-prone
111E V H 2.6342 Aggregation-prone
111F V H 2.8055 Aggregation-prone
112G S H 1.6559 Aggregation-prone
112F F H 2.3399 Aggregation-prone
112E G H 1.3844 Aggregation-prone
112D E H 0.9881 Aggregation-prone
112C F H 1.3377 Aggregation-prone
112B F H 0.2256 Aggregation-prone
112A Y H 0.2679 Aggregation-prone
112 Y H 0.0000 Buried
113 Y H 0.0000 Buried
114 S H 0.0000 Buried
115 M H 0.0000 Buried
116 D H -0.4182 Soluble
117 V H 0.0596 Aggregation-prone
118 W H -0.2998 Soluble
119 G H 0.0000 Buried
120 K H -2.2285 Soluble
121 G H -1.2228 Soluble
122 T H -0.6884 Soluble
123 T H -0.2702 Soluble
124 V H 0.0000 Buried
125 T H -0.3157 Soluble
126 V H 0.0000 Buried
127 S H -0.7556 Soluble
128 S H -0.9227 Soluble
129 A H -0.5381 Soluble
130 S H -0.6161 Soluble
131 T H -0.5563 Soluble
132 K H -1.1929 Soluble
133 G H -1.3948 Soluble
134 P H -0.7254 Soluble
135 S H -0.3102 Soluble
136 V H -0.3268 Soluble
137 F H -0.4848 Soluble
138 P H -1.0994 Soluble
139 L H 0.0000 Buried
140 A H 0.0000 Buried
141 P H 0.0000 Buried
142 S H -0.9287 Soluble
143 S H -1.1188 Soluble
144 K H -1.7882 Soluble
145 T H -0.2671 Soluble
146 A H -0.4099 Soluble
147 A H -0.0595 Soluble
148 L H 0.0000 Buried
149 G H 0.0000 Buried
150 C H 0.0000 Buried
151 L H 0.0000 Buried
152 V H 0.0000 Buried
153 K H -0.4697 Soluble
154 D H -0.6625 Soluble
155 Y H 0.0000 Buried
156 F H -0.4935 Soluble
157 P H 0.0000 Buried
158 E H -0.6386 Soluble
159 P H -0.5458 Soluble
160 V H -0.5285 Soluble
161 T H -0.4863 Soluble
162 V H -0.2785 Soluble
163 S H -0.3531 Soluble
164 W H 0.0000 Buried
165 N H -0.7960 Soluble
166 S H -0.6895 Soluble
167 G H -0.5193 Soluble
168 A H -0.2123 Soluble
169 L H 0.0568 Aggregation-prone
170 T H -0.1007 Soluble
171 S H -0.1230 Soluble
172 G H -0.0099 Soluble
173 V H 0.3299 Aggregation-prone
174 H H -0.2867 Soluble
175 T H -0.1344 Soluble
176 F H 0.0000 Buried
177 P H 0.0658 Aggregation-prone
178 A H 0.2160 Aggregation-prone
179 V H 0.0000 Buried
180 L H 1.2997 Aggregation-prone
181 Q H 0.2850 Aggregation-prone
182 S H -0.1264 Soluble
183 S H -0.2161 Soluble
184 G H 0.0784 Aggregation-prone
185 L H 0.0150 Aggregation-prone
186 Y H 0.3124 Aggregation-prone
187 S H 0.0000 Buried
188 L H 0.0000 Buried
189 S H 0.0000 Buried
190 S H 0.0000 Buried
191 V H 0.1643 Aggregation-prone
192 V H 0.0000 Buried
193 T H -0.0858 Soluble
194 V H 0.0000 Buried
195 P H -0.3440 Soluble
196 S H -0.5136 Soluble
197 S H -0.3815 Soluble
198 S H -0.3377 Soluble
199 L H -0.2744 Soluble
200 G H -0.8615 Soluble
201 T H -0.5598 Soluble
202 Q H -1.0796 Soluble
203 T H -1.0642 Soluble
204 Y H 0.0000 Buried
205 I H -1.3113 Soluble
206 C H 0.0000 Buried
207 N H 0.0000 Buried
208 V H 0.0000 Buried
209 N H -1.9860 Soluble
210 H H 0.0000 Buried
211 K H -2.0602 Soluble
212 P H -1.1485 Soluble
213 S H -1.5497 Soluble
214 N H -2.2538 Soluble
215 T H -2.1802 Soluble
216 K H -2.7578 Soluble
217 V H -1.8882 Soluble
218 D H -2.6284 Soluble
219 K H -2.2778 Soluble
220 R H -2.6262 Soluble
221 V H 0.0000 Buried
222 E H -2.5065 Soluble
223 P H -1.1559 Soluble
224 K H -0.7409 Soluble
225 S H -0.2798 Soluble
226 C H 0.3710 Aggregation-prone
11 L L 0.9975 Aggregation-prone
12 S L 0.6769 Aggregation-prone
13 V L -0.0575 Soluble
14 A L -0.2214 Soluble
15 L L -0.5839 Soluble
16 G L -1.5650 Soluble
17 E L -2.1668 Soluble
18 T L -1.5958 Soluble
19 A L 0.0000 Buried
20 R L -2.0709 Soluble
21 I L 0.0000 Buried
22 S L -1.2921 Soluble
23 C L 0.0000 Buried
24 G L -1.4404 Soluble
25 R L -1.6234 Soluble
26 Q L -1.6270 Soluble
27 A L 0.0000 Buried
28 L L 0.5258 Aggregation-prone
29 G L -0.0103 Soluble
36 S L 0.4780 Aggregation-prone
37 R L 0.0000 Buried
38 A L 0.0000 Buried
39 V L 0.0000 Buried
40 Q L 0.0000 Buried
41 W L 0.0000 Buried
42 Y L 0.0000 Buried
43 Q L 0.0000 Buried
44 H L 0.0000 Buried
45 R L -1.6253 Soluble
46 P L -1.3275 Soluble
47 G L -1.4780 Soluble
48 Q L -1.8497 Soluble
49 A L -1.0795 Soluble
50 P L 0.0000 Buried
51 I L 0.3503 Aggregation-prone
52 L L 0.0000 Buried
53 L L 0.0000 Buried
54 I L 0.0000 Buried
55 Y L -0.3250 Soluble
56 N L -0.8628 Soluble
57 N L 0.0000 Buried
65 Q L -1.6237 Soluble
66 D L -1.2752 Soluble
67 R L -1.4994 Soluble
68 P L -0.9528 Soluble
69 S L -0.5996 Soluble
70 G L -0.8049 Soluble
71 I L -0.7010 Soluble
72 P L -1.3288 Soluble
74 E L -2.2641 Soluble
75 R L -1.4691 Soluble
76 F L 0.0000 Buried
77 S L -1.4181 Soluble
78 G L -1.2165 Soluble
79 T L -0.8160 Soluble
80 P L -0.6604 Soluble
81 D L -0.3382 Soluble
81A I L 1.3143 Aggregation-prone
82 N L 0.1208 Aggregation-prone
83 F L 0.5573 Aggregation-prone
84 G L -0.2782 Soluble
85 T L -0.8371 Soluble
86 R L -2.2427 Soluble
87 A L 0.0000 Buried
88 T L -1.2512 Soluble
89 L L 0.0000 Buried
90 T L -1.2317 Soluble
91 I L 0.0000 Buried
92 S L -1.7125 Soluble
93 G L -1.4502 Soluble
94 V L 0.0000 Buried
95 E L -2.0566 Soluble
96 A L -0.9702 Soluble
97 G L -1.1829 Soluble
98 D L 0.0000 Buried
99 E L -1.0233 Soluble
100 A L 0.0000 Buried
101 D L 0.0000 Buried
102 Y L 0.0000 Buried
103 Y L 0.0000 Buried
104 C L 0.0000 Buried
105 H L 0.0000 Buried
106 M L 0.0000 Buried
107 W L 0.0000 Buried
108 D L 0.0000 Buried
109 S L -0.3799 Soluble
110 R L -1.5331 Soluble
112 S L -0.8368 Soluble
113 G L -0.1607 Soluble
114 F L 0.7390 Aggregation-prone
115 S L 0.3774 Aggregation-prone
116 W L 0.1244 Aggregation-prone
117 S L -0.2573 Soluble
118 F L 0.0000 Buried
119 G L -0.6711 Soluble
120 G L -0.9847 Soluble
121 A L -0.9878 Soluble
122 T L -0.7515 Soluble
123 R L -1.6872 Soluble
124 L L 0.0000 Buried
125 T L 0.0662 Aggregation-prone
126 V L 0.0000 Buried
127 L L 0.8416 Aggregation-prone
128 G L -0.2384 Soluble
129 Q L -0.6863 Soluble
130 P L -1.1179 Soluble
131 K L -2.3274 Soluble
132 A L -1.2089 Soluble
133 A L -0.8280 Soluble
134 P L 0.0000 Buried
135 S L -0.5064 Soluble
136 V L 0.0000 Buried
137 T L -0.2412 Soluble
138 L L -0.1926 Soluble
139 F L 0.0000 Buried
140 P L 0.0176 Aggregation-prone
141 P L 0.0000 Buried
142 S L 0.0000 Buried
143 S L -1.1995 Soluble
144 E L -2.0909 Soluble
145 E L 0.0000 Buried
146 L L -1.9159 Soluble
147 Q L -2.2760 Soluble
148 A L -1.8832 Soluble
149 N L -2.7076 Soluble
150 K L -2.8196 Soluble
151 A L 0.0000 Buried
152 T L -0.3791 Soluble
153 L L 0.0000 Buried
154 V L 0.0000 Buried
155 C L 0.0000 Buried
156 L L 0.0000 Buried
157 I L 0.0000 Buried
158 S L -0.8207 Soluble
159 D L -1.5407 Soluble
160 F L 0.0000 Buried
161 Y L 0.0000 Buried
162 P L -0.8930 Soluble
163 G L -0.6265 Soluble
164 A L -0.2062 Soluble
165 V L -0.1002 Soluble
166 T L -0.0949 Soluble
167 V L 0.0938 Aggregation-prone
168 A L -0.2948 Soluble
169 W L 0.0000 Buried
170 K L -0.8454 Soluble
171 A L -1.0036 Soluble
172 D L -1.3668 Soluble
173 S L -0.8583 Soluble
174 S L -0.5837 Soluble
175 P L -0.8208 Soluble
176 V L -0.7042 Soluble
177 K L -1.5041 Soluble
178 A L -0.6665 Soluble
179 G L -0.4590 Soluble
180 V L -0.1037 Soluble
181 E L -0.0455 Soluble
182 T L 0.1533 Aggregation-prone
183 T L 0.0000 Buried
184 T L -0.1546 Soluble
185 P L -0.2349 Soluble
186 S L -0.5604 Soluble
187 K L -1.1150 Soluble
188 Q L -1.1209 Soluble
189 S L -0.9139 Soluble
190 N L -1.2287 Soluble
191 N L -1.2122 Soluble
192 K L -1.3572 Soluble
193 Y L -0.6857 Soluble
194 A L 0.0000 Buried
195 A L 0.0000 Buried
196 S L 0.0000 Buried
197 S L 0.0000 Buried
198 Y L 0.0000 Buried
199 L L 0.0000 Buried
200 S L -0.3342 Soluble
201 L L -0.9087 Soluble
202 T L -1.9565 Soluble
203 P L -2.5921 Soluble
204 E L -3.3045 Soluble
205 Q L -2.6815 Soluble
206 W L 0.0000 Buried
207 K L -3.1862 Soluble
208 S L -2.5077 Soluble
209 H L -2.4986 Soluble
210 R L -2.5704 Soluble
211 S L -1.7096 Soluble
212 Y L 0.0000 Buried
213 S L 0.0000 Buried
214 C L 0.0000 Buried
215 Q L -0.7002 Soluble
216 V L 0.0000 Buried
217 T L -0.6542 Soluble
218 H L 0.0000 Buried
219 E L -2.3142 Soluble
220 G L -1.4001 Soluble
221 S L -1.0224 Soluble
222 T L -0.6718 Soluble
223 V L -0.3319 Soluble
224 E L -1.0494 Soluble
225 K L -1.0321 Soluble
226 T L -0.6017 Soluble
227 V L -0.4738 Soluble
228 A L -1.2738 Soluble
229 P L -1.4277 Soluble
230 T L -1.4454 Soluble
231 E L -1.5122 Soluble
232 C L -0.5864 Soluble

3D Structure — colored by A4D score

Sequence - click residue to focus in viewer  |  colored by A4D score
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Color Legend (B-factor = A4D Score)
Score > 1.5 — highly aggregation-prone
Score 0.5–1.5 — aggregation-prone
Score ≈ 0 — buried
Score −1 to −0.5 — soluble
Score < −2.5 — highly soluble
pH Structure
Load structure at specific pH condition
A4D Score Threshold
Highlight residues > threshold in the sequence panel
CDR Regions
HCDR1
HCDR2
HCDR3
LCDR1
LCDR2
LCDR3
Display Options

pH-Dependent Aggregation Profiles

A4D scores calculated across 11 pH conditions (4.0–9.0, step 0.5). Click a row to view the structure at that pH. The input structure is globular — max score is recommended for pH analysis.

pH Avg A4D Score Max A4D Score Downloads
4.0 -0.5904 4.5246 CSV PDB
4.5 -0.6276 4.476 CSV PDB
5.0 -0.672 4.4049 CSV PDB
5.5 -0.7147 4.3232 CSV PDB
6.0 -0.7465 4.2436 CSV PDB
6.5 -0.7591 4.1791 CSV PDB
7.0 -0.7509 4.1392 CSV PDB
7.5 -0.728 4.121 CSV PDB
8.0 -0.6968 4.1143 CSV PDB
8.5 -0.6601 4.112 CSV PDB
9.0 -0.619 4.1113 CSV PDB
Average A4D Score vs pH
Max A4D Score vs pH