Gedivumab / 4kvn

A4DAB127_4kvn_H_L | Source PDB: 4kvn | Chains: H, L | Done
98.71
Yes
10 Å
Yes
Avg A4D Score
-0.5783
Max Score
3.092
Min Score
-3.7178
Total Score
-248.08
Score CDR
—
Score non-CDR
—

Calculation Parameters

Chain Sequence(s) VQLVESGGGVVQPGKSPRLSCAASGSSYAVHWVRQAPGKGLEWVTLISYDGANQYYADSVKGRFTISRDNSKNTVYLQMNSLRPEDTAVYYCAVPGPVFGIFPPWSYFDNWGQGILVTVSSASTKGPSVFPLAPSSTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKIVLTQSPATLSVSPGERATLSCRASQVISHNLAWYQQKPGQAPRLLIYGASTRASGIPARFSGSGSGTDYTLTITSLQPEDFAVYYCQHYSNWPPRLTFGGGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRG input.pdb
Selected Chain(s) H (Heavy), L (Light)
Distance of Aggregation 10 Å
FoldX Energy Minimization Yes
pH Calculations Yes
Downloads Download all data (.tar.gz)

Aggrescan4D Profile

Aggregation-prone (score > 0)
Soluble (score < 0)
Buried (score = 0)

Per-Residue A4D Scores

Download CSV
Minimum Score -3.7178
Maximum Score 3.092
Average Score -0.5783
Total Score -248.0823

Residues with A4D score > 0.0 are highlighted as aggregation-prone.

Index Residue Chain A4D Score Classification
2 V H 1.0808 Aggregation-prone
3 Q H -0.1754 Soluble
4 L H 0.5319 Aggregation-prone
5 V H 1.1446 Aggregation-prone
6 E H 0.0000 Buried
7 S H -0.2565 Soluble
8 G H -0.7605 Soluble
9 G H -0.2431 Soluble
11 G H 0.0208 Aggregation-prone
12 V H 0.4071 Aggregation-prone
13 V H 0.0000 Buried
14 Q H -1.9648 Soluble
15 P H -2.0375 Soluble
16 G H -2.0289 Soluble
17 K H -2.6232 Soluble
18 S H -2.0909 Soluble
19 P H 0.0000 Buried
20 R H -2.4606 Soluble
21 L H 0.0000 Buried
22 S H -0.4105 Soluble
23 C H 0.0000 Buried
24 A H -0.0896 Soluble
25 A H -0.0154 Soluble
26 S H -0.0700 Soluble
27 G H -0.7166 Soluble
28 S H -0.2938 Soluble
29 S H -0.0187 Soluble
37 Y H 1.3343 Aggregation-prone
38 A H 0.0000 Buried
39 V H 0.0000 Buried
40 H H 0.0000 Buried
41 W H 0.0000 Buried
42 V H 0.0000 Buried
43 R H 0.0000 Buried
44 Q H -0.7404 Soluble
45 A H -1.1796 Soluble
46 P H -0.9326 Soluble
47 G H -1.4664 Soluble
48 K H -2.2836 Soluble
49 G H -1.4220 Soluble
50 L H 0.0000 Buried
51 E H -1.0450 Soluble
52 W H -0.2953 Soluble
53 V H 0.0000 Buried
54 T H 0.0000 Buried
55 L H 0.0000 Buried
56 I H 0.0000 Buried
57 S H 0.0000 Buried
58 Y H 0.5746 Aggregation-prone
59 D H -1.4795 Soluble
62 G H -1.2768 Soluble
63 A H -0.9469 Soluble
64 N H -1.3647 Soluble
65 Q H -0.8828 Soluble
66 Y H -0.4037 Soluble
67 Y H -0.6694 Soluble
68 A H -1.3210 Soluble
69 D H -2.4295 Soluble
70 S H -1.8124 Soluble
71 V H 0.0000 Buried
72 K H -2.5200 Soluble
74 G H -1.7358 Soluble
75 R H -1.7083 Soluble
76 F H 0.0000 Buried
77 T H -0.8972 Soluble
78 I H 0.0000 Buried
79 S H -0.6013 Soluble
80 R H -1.2740 Soluble
81 D H -2.0920 Soluble
82 N H -2.5231 Soluble
83 S H -1.9321 Soluble
84 K H -2.6054 Soluble
85 N H -2.0990 Soluble
86 T H -1.0921 Soluble
87 V H 0.0000 Buried
88 Y H -0.7134 Soluble
89 L H 0.0000 Buried
90 Q H -1.4834 Soluble
91 M H 0.0000 Buried
92 N H -1.8905 Soluble
93 S H -1.4278 Soluble
94 L H 0.0000 Buried
95 R H -2.8539 Soluble
96 P H -2.1706 Soluble
97 E H -2.5685 Soluble
98 D H 0.0000 Buried
99 T H -0.6688 Soluble
100 A H 0.0000 Buried
101 V H 0.4902 Aggregation-prone
102 Y H 0.0000 Buried
103 Y H 0.0000 Buried
104 C H 0.0000 Buried
105 A H 0.0000 Buried
106 V H 0.1813 Aggregation-prone
107 P H 0.0000 Buried
108 G H 0.0000 Buried
109 P H 1.3787 Aggregation-prone
110 V H 1.9758 Aggregation-prone
111 F H 2.5936 Aggregation-prone
111A G H 1.7920 Aggregation-prone
111B I H 3.0920 Aggregation-prone
112C F H 2.9215 Aggregation-prone
112B P H 1.2779 Aggregation-prone
112A P H 0.6159 Aggregation-prone
112 W H 0.0000 Buried
113 S H 0.0000 Buried
114 Y H 0.0000 Buried
115 F H 0.0000 Buried
116 D H -2.0953 Soluble
117 N H -1.1464 Soluble
118 W H -0.6933 Soluble
119 G H 0.0000 Buried
120 Q H -0.9063 Soluble
121 G H -0.1449 Soluble
122 I H 0.5894 Aggregation-prone
123 L H 1.0071 Aggregation-prone
124 V H 0.0000 Buried
125 T H 0.0000 Buried
126 V H 0.0000 Buried
127 S H -0.9074 Soluble
128 S H -0.9627 Soluble
129 A H -0.4754 Soluble
130 S H -0.6526 Soluble
131 T H -0.6814 Soluble
132 K H -1.0890 Soluble
133 G H -1.2010 Soluble
134 P H 0.0000 Buried
135 S H -0.2719 Soluble
136 V H 0.0000 Buried
137 F H 0.0000 Buried
138 P H -1.0066 Soluble
139 L H 0.0000 Buried
140 A H -1.2095 Soluble
141 P H 0.0000 Buried
142 S H -0.9183 Soluble
143 S H -0.7107 Soluble
144 T H -0.1475 Soluble
145 A H -0.0618 Soluble
146 A H 0.0000 Buried
147 L H 0.0000 Buried
148 G H 0.0000 Buried
149 C H 0.0000 Buried
150 L H 0.0000 Buried
151 V H 0.0000 Buried
152 K H 0.0000 Buried
153 D H -0.3083 Soluble
154 Y H 0.0000 Buried
155 F H 0.0000 Buried
156 P H 0.0000 Buried
157 E H -0.9377 Soluble
158 P H -0.9448 Soluble
159 V H -0.7149 Soluble
160 T H -0.6112 Soluble
161 V H -0.4095 Soluble
162 S H -0.2174 Soluble
163 W H 0.0000 Buried
164 N H -0.7115 Soluble
165 S H -0.6578 Soluble
166 G H -0.5312 Soluble
167 A H -0.2082 Soluble
168 L H 0.0516 Aggregation-prone
169 T H -0.0762 Soluble
170 S H -0.0659 Soluble
171 G H -0.0522 Soluble
172 V H 0.2842 Aggregation-prone
173 H H -0.2478 Soluble
174 T H 0.0979 Aggregation-prone
175 F H 0.0000 Buried
176 P H -0.1197 Soluble
177 A H 0.3045 Aggregation-prone
178 V H 0.2376 Aggregation-prone
179 L H 0.9256 Aggregation-prone
180 Q H 0.0633 Aggregation-prone
181 S H -0.1831 Soluble
182 S H -0.2445 Soluble
183 G H -0.0718 Soluble
184 L H -0.0370 Soluble
185 Y H 0.0000 Buried
186 S H 0.0000 Buried
187 L H 0.3014 Aggregation-prone
188 S H 0.0000 Buried
189 S H 0.0000 Buried
190 V H 0.0000 Buried
191 V H 0.0000 Buried
192 T H 0.1393 Aggregation-prone
193 V H 0.1936 Aggregation-prone
194 P H -0.1384 Soluble
195 S H -0.4187 Soluble
196 S H -0.5229 Soluble
197 S H -0.5270 Soluble
198 L H -0.7628 Soluble
199 G H -1.0484 Soluble
200 T H -0.7596 Soluble
201 Q H -1.0530 Soluble
202 T H -1.1387 Soluble
203 Y H 0.0000 Buried
204 I H -1.0779 Soluble
205 C H 0.0000 Buried
206 N H -1.4673 Soluble
207 V H 0.0000 Buried
208 N H -1.7839 Soluble
209 H H 0.0000 Buried
210 K H -2.6092 Soluble
211 P H -1.6022 Soluble
212 S H -1.4517 Soluble
213 N H -2.3857 Soluble
214 T H -1.9763 Soluble
215 K H -2.5252 Soluble
216 V H -1.5259 Soluble
217 D H -2.5504 Soluble
218 K H -1.9320 Soluble
219 K H -2.6050 Soluble
220 V H 0.0000 Buried
221 E H -2.7806 Soluble
222 P H -2.0319 Soluble
223 K H -2.3196 Soluble
2 I L 1.3018 Aggregation-prone
3 V L 1.5327 Aggregation-prone
4 L L 0.0000 Buried
5 T L -0.6034 Soluble
6 Q L -0.8255 Soluble
7 S L -0.6545 Soluble
8 P L -0.2996 Soluble
9 A L -0.2000 Soluble
10 T L -0.1505 Soluble
11 L L 0.0695 Aggregation-prone
12 S L -0.2934 Soluble
13 V L 0.0000 Buried
14 S L -1.2003 Soluble
15 P L -1.4796 Soluble
16 G L -1.6249 Soluble
17 E L -2.2045 Soluble
18 R L -2.5818 Soluble
19 A L 0.0000 Buried
20 T L -0.5308 Soluble
21 L L 0.0000 Buried
22 S L -0.8708 Soluble
23 C L 0.0000 Buried
24 R L -1.8682 Soluble
25 A L 0.0000 Buried
26 S L -0.1623 Soluble
27 Q L -0.4470 Soluble
28 V L 0.5918 Aggregation-prone
29 I L 0.0000 Buried
36 S L -0.3295 Soluble
37 H L -0.8502 Soluble
38 N L -0.5316 Soluble
39 L L 0.0000 Buried
40 A L 0.0000 Buried
41 W L 0.0000 Buried
42 Y L 0.0000 Buried
43 Q L 0.0000 Buried
44 Q L 0.0000 Buried
45 K L -1.4100 Soluble
46 P L -1.2344 Soluble
47 G L -1.4101 Soluble
48 Q L -2.0409 Soluble
49 A L -1.3676 Soluble
50 P L 0.0000 Buried
51 R L -1.7990 Soluble
52 L L 0.0000 Buried
53 L L 0.0000 Buried
54 I L 0.0000 Buried
55 Y L -0.4813 Soluble
56 G L -0.3979 Soluble
57 A L 0.0000 Buried
65 S L -0.7698 Soluble
66 T L -0.7109 Soluble
67 R L -1.3175 Soluble
68 A L 0.0000 Buried
69 S L -0.9215 Soluble
70 G L -0.7436 Soluble
71 I L 0.0000 Buried
72 P L -0.4585 Soluble
74 A L -0.4192 Soluble
75 R L -0.7762 Soluble
76 F L 0.0000 Buried
77 S L -0.5498 Soluble
78 G L 0.0000 Buried
79 S L -0.6861 Soluble
80 G L -1.0952 Soluble
83 S L -0.7348 Soluble
84 G L -0.6312 Soluble
85 T L -1.1291 Soluble
86 D L -2.0165 Soluble
87 Y L 0.0000 Buried
88 T L -0.7551 Soluble
89 L L 0.0000 Buried
90 T L -0.6082 Soluble
91 I L 0.0000 Buried
92 T L -1.2574 Soluble
93 S L -1.4378 Soluble
94 L L 0.0000 Buried
95 Q L -1.7353 Soluble
96 P L -1.3470 Soluble
97 E L -2.1219 Soluble
98 D L 0.0000 Buried
99 F L -0.4479 Soluble
100 A L 0.0000 Buried
101 V L 0.1307 Aggregation-prone
102 Y L 0.0000 Buried
103 Y L 0.0000 Buried
104 C L 0.0000 Buried
105 Q L 0.0000 Buried
106 H L 0.0000 Buried
107 Y L 0.0000 Buried
108 S L -0.3664 Soluble
109 N L -0.2303 Soluble
110 W L 0.7249 Aggregation-prone
113 P L 0.0733 Aggregation-prone
114 P L -0.3100 Soluble
115 R L -0.4619 Soluble
116 L L 0.0000 Buried
117 T L 0.2117 Aggregation-prone
118 F L 0.0000 Buried
119 G L 0.0000 Buried
120 G L -0.7164 Soluble
121 G L -0.5863 Soluble
122 T L 0.0000 Buried
123 K L -0.1246 Soluble
124 V L 0.0000 Buried
125 E L 0.0000 Buried
126 I L -0.3075 Soluble
127 K L -0.7534 Soluble
128 R L -0.6236 Soluble
129 T L 0.2944 Aggregation-prone
130 V L 1.0834 Aggregation-prone
131 A L 0.3532 Aggregation-prone
132 A L -0.0433 Soluble
133 P L 0.0000 Buried
134 S L -0.2476 Soluble
135 V L 0.0000 Buried
136 F L 0.0943 Aggregation-prone
137 I L 0.0656 Aggregation-prone
138 F L 0.0000 Buried
139 P L -0.5196 Soluble
140 P L -0.5370 Soluble
141 S L -1.2495 Soluble
142 D L -2.4385 Soluble
143 E L -1.9918 Soluble
144 Q L 0.0000 Buried
145 L L -2.0957 Soluble
146 K L -2.6367 Soluble
147 S L -1.6757 Soluble
148 G L -1.3633 Soluble
149 T L -1.1202 Soluble
150 A L 0.0000 Buried
151 S L 0.0000 Buried
152 V L 0.0000 Buried
153 V L 0.0000 Buried
154 C L 0.0000 Buried
155 L L 0.0000 Buried
156 L L 0.0000 Buried
157 N L 0.0000 Buried
158 N L -1.1163 Soluble
159 F L 0.0000 Buried
160 Y L 0.0000 Buried
161 P L -0.9410 Soluble
162 R L -1.7451 Soluble
163 E L -2.5248 Soluble
164 A L -1.6554 Soluble
165 K L -1.5255 Soluble
166 V L -0.6569 Soluble
167 Q L -0.4124 Soluble
168 W L 0.0000 Buried
169 K L -0.6369 Soluble
170 V L 0.0000 Buried
171 D L -1.5365 Soluble
172 N L -1.2989 Soluble
173 A L -0.3823 Soluble
174 L L 0.4686 Aggregation-prone
175 Q L -0.2379 Soluble
176 S L -0.4482 Soluble
177 G L -0.9200 Soluble
178 N L -0.8405 Soluble
179 S L -1.2826 Soluble
180 Q L -1.7587 Soluble
181 E L -2.0137 Soluble
182 S L -0.7214 Soluble
183 V L -0.2904 Soluble
184 T L 0.0000 Buried
185 E L -2.0549 Soluble
186 Q L -1.7750 Soluble
187 D L -2.1749 Soluble
188 S L -1.8782 Soluble
189 K L -2.5076 Soluble
190 D L -2.2444 Soluble
191 S L -1.8719 Soluble
192 T L 0.0000 Buried
193 Y L 0.0000 Buried
194 S L 0.0000 Buried
195 L L -0.3535 Soluble
196 S L 0.0000 Buried
197 S L 0.0000 Buried
198 T L -0.7904 Soluble
199 L L 0.0000 Buried
200 T L -0.4624 Soluble
201 L L -0.7202 Soluble
202 S L -1.5013 Soluble
203 K L -2.9098 Soluble
204 A L -2.1540 Soluble
205 D L -2.3970 Soluble
206 Y L 0.0000 Buried
207 E L -3.7178 Soluble
208 K L -3.5771 Soluble
209 H L -2.8447 Soluble
210 K L -2.9683 Soluble
211 V L -1.5134 Soluble
212 Y L 0.0000 Buried
213 A L 0.0000 Buried
214 C L 0.0000 Buried
215 E L 0.0000 Buried
216 V L 0.0000 Buried
217 T L -0.8732 Soluble
218 H L 0.0000 Buried
219 Q L -1.4255 Soluble
220 G L -0.1839 Soluble
221 L L -0.1166 Soluble
222 S L -0.4426 Soluble
223 S L -0.4010 Soluble
224 P L -0.3615 Soluble
225 V L 0.1568 Aggregation-prone
226 T L -0.3912 Soluble
227 K L -0.7510 Soluble
228 S L -0.7479 Soluble
229 F L -0.9902 Soluble
230 N L -1.9816 Soluble
231 R L -1.9343 Soluble
232 G L -1.2696 Soluble

3D Structure — colored by A4D score

Sequence - click residue to focus in viewer  |  colored by A4D score
Load structure to view sequence…
Downloads
Color Legend (B-factor = A4D Score)
Score > 1.5 — highly aggregation-prone
Score 0.5–1.5 — aggregation-prone
Score ≈ 0 — buried
Score −1 to −0.5 — soluble
Score < −2.5 — highly soluble
pH Structure
Load structure at specific pH condition
A4D Score Threshold
Highlight residues > threshold in the sequence panel
CDR Regions
HCDR1
HCDR2
HCDR3
LCDR1
LCDR2
LCDR3
Display Options

pH-Dependent Aggregation Profiles

A4D scores calculated across 11 pH conditions (4.0–9.0, step 0.5). Click a row to view the structure at that pH. The input structure is globular — max score is recommended for pH analysis.

pH Avg A4D Score Max A4D Score Downloads
4.0 -0.5344 6.0713 CSV PDB
4.5 -0.5697 6.0713 CSV PDB
5.0 -0.6104 6.0713 CSV PDB
5.5 -0.6475 6.0713 CSV PDB
6.0 -0.6713 6.0713 CSV PDB
6.5 -0.6755 6.0713 CSV PDB
7.0 -0.6609 6.0713 CSV PDB
7.5 -0.6343 6.0712 CSV PDB
8.0 -0.6009 6.0711 CSV PDB
8.5 -0.5626 6.0707 CSV PDB
9.0 -0.5192 6.0694 CSV PDB
Average A4D Score vs pH
Max A4D Score vs pH