Regdanvimab / 7cm4

A4DAB221_7cm4_H_L | Source PDB: 7cm4 | Chains: H, L | Done
100
Yes
10 Å
Yes
Avg A4D Score
-0.7158
Max Score
1.2902
Min Score
-3.252
Total Score
-314.22
Score CDR
-0.6206
Score non-CDR
-0.7305

Calculation Parameters

Chain Sequence(s) QITLKESGPTLVKPTQTLTLTCSFSGFSLSTSGVGVGWIRQPPGKALEWLALIDWDDNKYHTTSLKTRLTISKDTSKNQVVLTMTNMDPVDTATYYCARIPGFLRYRNRYYYYGMDVWGQGTTVTVSSASTKGPSVFPLAPSSTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCELVLTQPPSVSAAPGQKVTISCSGSSSNIGNNYVSWYQQLPGTAPKLLIYDNNKRPSGIPDRFSGSKSGTSATLGITGLQTGDEADYYCGTWDSSLSAGVFGGGTELTVLGQPKAAPSVTLFPPSSEELQANKATLVCLISDFYPGAVTVAWKADGSPVKAGVETTKPSKQSNNKYAASSYLSLTPEQWKSHRSYSCQVTHEGSTVEKTVAPTE input.pdb
Selected Chain(s) H (Heavy), L (Light)
Distance of Aggregation 10 Å
FoldX Energy Minimization Yes
pH Calculations Yes
Downloads Download all data (.tar.gz)

Aggrescan4D Profile

Aggregation-prone (score > 0)
Soluble (score < 0)
Buried (score = 0)

Per-Residue A4D Scores

Download CSV
Minimum Score -3.252
Maximum Score 1.2902
Average Score -0.7158
Total Score -314.2211

Residues with A4D score > 0.0 are highlighted as aggregation-prone.

Index Residue Chain A4D Score Classification
1 Q H -1.1714 Soluble
2 I H -0.5286 Soluble
3 T H -0.8907 Soluble
4 L H 0.0000 Buried
5 K H -2.1591 Soluble
6 E H 0.0000 Buried
7 S H -0.8036 Soluble
8 G H -0.3321 Soluble
9 P H 0.0009 Aggregation-prone
11 T H 0.2943 Aggregation-prone
12 L H 0.5964 Aggregation-prone
13 V H 0.0000 Buried
14 K H -2.1462 Soluble
15 P H -1.6697 Soluble
16 T H -1.9725 Soluble
17 Q H -2.3224 Soluble
18 T H -1.4485 Soluble
19 L H 0.0000 Buried
20 T H -0.1952 Soluble
21 L H 0.0000 Buried
22 T H -0.3274 Soluble
23 C H 0.0000 Buried
24 S H -1.1625 Soluble
25 F H 0.0000 Buried
26 S H -1.0428 Soluble
27 G H -0.7641 Soluble
28 F H -0.3511 Soluble
29 S H -0.5119 Soluble
30 L H 0.0000 Buried
31 S H -0.8001 Soluble
34 T H -0.4444 Soluble
35 S H -0.5325 Soluble
36 G H 0.0000 Buried
37 V H 0.0000 Buried
38 G H 0.0000 Buried
39 V H 0.0000 Buried
40 G H 0.0000 Buried
41 W H 0.0000 Buried
42 I H 0.0000 Buried
43 R H 0.0000 Buried
44 Q H -0.9234 Soluble
45 P H -0.6971 Soluble
46 P H -0.8853 Soluble
47 G H -1.7601 Soluble
48 K H -2.1799 Soluble
49 A H -1.2075 Soluble
50 L H 0.0000 Buried
51 E H -0.7396 Soluble
52 W H 0.0000 Buried
53 L H 0.0000 Buried
54 A H 0.0000 Buried
55 L H 0.0000 Buried
56 I H 0.0000 Buried
57 D H 0.0000 Buried
58 W H -1.5746 Soluble
59 D H -2.8324 Soluble
63 D H -3.0209 Soluble
64 N H -2.7997 Soluble
65 K H -2.0230 Soluble
66 Y H 0.0000 Buried
67 H H -0.9147 Soluble
68 T H -0.6630 Soluble
69 T H -0.7033 Soluble
70 S H -0.7391 Soluble
71 L H 0.0000 Buried
72 K H -1.9741 Soluble
74 T H -1.1407 Soluble
75 R H -1.2680 Soluble
76 L H 0.0000 Buried
77 T H -0.5301 Soluble
78 I H 0.0000 Buried
79 S H -0.8123 Soluble
80 K H -1.1888 Soluble
81 D H -1.5191 Soluble
82 T H -1.2968 Soluble
83 S H -1.4684 Soluble
84 K H -2.3538 Soluble
85 N H -1.7264 Soluble
86 Q H -1.5344 Soluble
87 V H 0.0000 Buried
88 V H 0.2413 Aggregation-prone
89 L H 0.0000 Buried
90 T H -0.0170 Soluble
91 M H 0.0000 Buried
92 T H -1.2553 Soluble
93 N H -2.2358 Soluble
94 M H 0.0000 Buried
95 D H -1.3493 Soluble
96 P H -0.1352 Soluble
97 V H 1.2902 Aggregation-prone
98 D H 0.0000 Buried
99 T H 0.3555 Aggregation-prone
100 A H 0.0000 Buried
101 T H -0.3019 Soluble
102 Y H 0.0000 Buried
103 Y H 0.0000 Buried
104 C H 0.0000 Buried
105 A H 0.0000 Buried
106 R H -0.1877 Soluble
107 I H 0.0000 Buried
108 P H -0.1619 Soluble
109 G H 0.0027 Aggregation-prone
110 F H 0.0000 Buried
111 L H -0.5931 Soluble
111A R H -1.8909 Soluble
111B Y H -1.1242 Soluble
111C R H -2.7015 Soluble
112D N H -3.0247 Soluble
112C R H -2.9685 Soluble
112B Y H 0.0000 Buried
112A Y H -0.0645 Soluble
112 Y H 0.0000 Buried
113 Y H 0.3103 Aggregation-prone
114 G H 0.0000 Buried
115 M H 0.0000 Buried
116 D H -0.4612 Soluble
117 V H -0.3878 Soluble
118 W H -0.6523 Soluble
119 G H 0.0000 Buried
120 Q H -1.6557 Soluble
121 G H -1.0171 Soluble
122 T H -0.6896 Soluble
123 T H -0.1839 Soluble
124 V H 0.0000 Buried
125 T H 0.1454 Aggregation-prone
126 V H 0.0000 Buried
127 S H -0.5025 Soluble
128 S H -0.8356 Soluble
129 A H -0.5929 Soluble
130 S H -0.5175 Soluble
131 T H -0.8689 Soluble
132 K H -1.1948 Soluble
133 G H -1.3743 Soluble
134 P H 0.0000 Buried
135 S H -0.1807 Soluble
136 V H 0.0000 Buried
137 F H 0.0000 Buried
138 P H -1.0132 Soluble
139 L H 0.0000 Buried
140 A H -1.2199 Soluble
141 P H 0.0000 Buried
142 S H -0.5387 Soluble
143 S H -0.5575 Soluble
144 T H -0.2921 Soluble
145 A H 0.0000 Buried
146 A H -0.2163 Soluble
147 L H 0.0000 Buried
148 G H 0.0000 Buried
149 C H 0.0000 Buried
150 L H 0.0000 Buried
151 V H 0.0000 Buried
152 K H 0.0000 Buried
153 D H -0.2858 Soluble
154 Y H 0.0000 Buried
155 F H 0.0000 Buried
156 P H -0.9197 Soluble
157 E H -1.1248 Soluble
158 P H -1.0872 Soluble
159 V H -0.9530 Soluble
160 T H -0.7773 Soluble
161 V H -0.3523 Soluble
162 S H -0.4729 Soluble
163 W H 0.0000 Buried
164 N H -0.8245 Soluble
165 S H -0.6901 Soluble
166 G H -0.5473 Soluble
167 A H -0.2200 Soluble
168 L H -0.0337 Soluble
169 T H -0.2249 Soluble
170 S H -0.3243 Soluble
171 G H -0.6184 Soluble
172 V H -0.0441 Soluble
173 H H -0.4118 Soluble
174 T H -0.0442 Soluble
175 F H 0.0000 Buried
176 P H -0.4618 Soluble
177 A H -0.2007 Soluble
178 V H 0.0000 Buried
179 L H 0.6642 Aggregation-prone
180 Q H -0.0446 Soluble
181 S H -0.2781 Soluble
182 S H -0.2268 Soluble
183 G H -0.1035 Soluble
184 L H -0.0200 Soluble
185 Y H 0.1072 Aggregation-prone
186 S H 0.0000 Buried
187 L H 0.0000 Buried
188 S H 0.0000 Buried
189 S H 0.0000 Buried
190 V H 0.0000 Buried
191 V H 0.0000 Buried
192 T H -0.2591 Soluble
193 V H 0.0000 Buried
194 P H -0.5233 Soluble
195 S H -0.4752 Soluble
196 S H -0.6048 Soluble
197 S H -0.7361 Soluble
198 L H -0.9755 Soluble
199 G H -1.0982 Soluble
200 T H -0.8859 Soluble
201 Q H -1.5923 Soluble
202 T H -1.3746 Soluble
203 Y H 0.0000 Buried
204 I H -1.3555 Soluble
205 C H 0.0000 Buried
206 N H -1.5532 Soluble
207 V H 0.0000 Buried
208 N H -2.3061 Soluble
209 H H 0.0000 Buried
210 K H -2.8724 Soluble
211 P H -1.7578 Soluble
212 S H -1.8836 Soluble
213 N H -2.6285 Soluble
214 T H -2.1471 Soluble
215 K H -2.7542 Soluble
216 V H -1.4304 Soluble
217 D H -2.4554 Soluble
218 K H -2.0366 Soluble
219 R H -2.7473 Soluble
220 V H 0.0000 Buried
221 E H -2.8466 Soluble
222 P H -1.8225 Soluble
223 K H -1.6127 Soluble
224 S H -0.6811 Soluble
225 C H -0.0656 Soluble
1 E L -1.0450 Soluble
2 L L 0.6322 Aggregation-prone
3 V L 0.9252 Aggregation-prone
4 L L 0.0000 Buried
5 T L -0.0080 Soluble
6 Q L 0.0000 Buried
7 P L -0.5780 Soluble
8 P L -0.9303 Soluble
9 S L -1.0061 Soluble
11 V L -0.3711 Soluble
12 S L -0.6008 Soluble
13 A L -0.6807 Soluble
14 A L -1.0659 Soluble
15 P L -1.4487 Soluble
16 G L -1.8143 Soluble
17 Q L -2.4442 Soluble
18 K L -2.4993 Soluble
19 V L 0.0000 Buried
20 T L -0.4953 Soluble
21 I L 0.0000 Buried
22 S L -0.3315 Soluble
23 C L 0.0000 Buried
24 S L -0.3599 Soluble
25 G L -0.0643 Soluble
26 S L -0.4105 Soluble
27 S L -0.7768 Soluble
28 S L -0.3895 Soluble
29 N L 0.0000 Buried
30 I L 0.0000 Buried
35 G L -0.8823 Soluble
36 N L -1.1183 Soluble
37 N L 0.0000 Buried
38 Y L 0.3687 Aggregation-prone
39 V L 0.0000 Buried
40 S L 0.0000 Buried
41 W L 0.0000 Buried
42 Y L 0.0000 Buried
43 Q L 0.0000 Buried
44 Q L 0.0000 Buried
45 L L -0.5343 Soluble
46 P L -0.4712 Soluble
47 G L -0.5087 Soluble
48 T L -0.6342 Soluble
49 A L -0.6703 Soluble
50 P L 0.0000 Buried
51 K L -1.2766 Soluble
52 L L 0.0000 Buried
53 L L 0.0000 Buried
54 I L 0.0000 Buried
55 Y L -0.8141 Soluble
56 D L -0.7882 Soluble
57 N L -1.2711 Soluble
65 N L -2.3061 Soluble
66 K L -2.4219 Soluble
67 R L -2.3948 Soluble
68 P L -1.0559 Soluble
69 S L -0.8108 Soluble
70 G L -0.8900 Soluble
71 I L -1.0749 Soluble
72 P L -1.4042 Soluble
74 D L -2.2526 Soluble
75 R L -1.5250 Soluble
76 F L 0.0000 Buried
77 S L -1.5620 Soluble
78 G L -1.3778 Soluble
79 S L -1.1862 Soluble
80 K L -1.0001 Soluble
83 S L -0.7759 Soluble
84 G L -0.9458 Soluble
85 T L -0.7999 Soluble
86 S L -0.6542 Soluble
87 A L 0.0000 Buried
88 T L -0.5743 Soluble
89 L L 0.0000 Buried
90 G L -0.6302 Soluble
91 I L 0.0000 Buried
92 T L -1.8613 Soluble
93 G L -1.5977 Soluble
94 L L 0.0000 Buried
95 Q L -1.8182 Soluble
96 T L -1.1330 Soluble
97 G L -1.0004 Soluble
98 D L 0.0000 Buried
99 E L -1.2606 Soluble
100 A L 0.0000 Buried
101 D L -1.4825 Soluble
102 Y L 0.0000 Buried
103 Y L 0.0000 Buried
104 C L 0.0000 Buried
105 G L 0.0000 Buried
106 T L 0.0000 Buried
107 W L 0.0000 Buried
108 D L 0.0000 Buried
109 S L -0.8133 Soluble
110 S L -0.2459 Soluble
113 L L 0.2484 Aggregation-prone
114 S L -0.1813 Soluble
115 A L 0.0000 Buried
116 G L 0.0000 Buried
117 V L 0.4503 Aggregation-prone
118 F L 0.0000 Buried
119 G L 0.0000 Buried
120 G L -0.7918 Soluble
121 G L -1.1248 Soluble
122 T L 0.0000 Buried
123 E L -2.2465 Soluble
124 L L 0.0000 Buried
125 T L -0.6755 Soluble
126 V L 0.0000 Buried
127 L L -0.5597 Soluble
128 G L -1.0472 Soluble
129 Q L -1.5557 Soluble
130 P L -1.4545 Soluble
131 K L -2.2739 Soluble
132 A L -1.3228 Soluble
133 A L -0.7007 Soluble
134 P L -0.3259 Soluble
135 S L -0.2236 Soluble
136 V L 0.0000 Buried
137 T L -0.4986 Soluble
138 L L 0.0000 Buried
139 F L 0.0000 Buried
140 P L -0.2816 Soluble
141 P L 0.0000 Buried
142 S L -0.8447 Soluble
143 S L -1.2490 Soluble
144 E L -2.0121 Soluble
145 E L 0.0000 Buried
146 L L -1.3512 Soluble
147 Q L -2.0784 Soluble
148 A L -1.6488 Soluble
149 N L -2.2721 Soluble
150 K L -1.8805 Soluble
151 A L 0.0000 Buried
152 T L 0.0000 Buried
153 L L 0.0000 Buried
154 V L 0.0000 Buried
155 C L 0.0000 Buried
156 L L 0.0000 Buried
157 I L 0.0000 Buried
158 S L -0.5445 Soluble
159 D L -1.1650 Soluble
160 F L 0.0000 Buried
161 Y L 0.0000 Buried
162 P L 0.0000 Buried
163 G L -0.8175 Soluble
164 A L -0.4319 Soluble
165 V L -0.2548 Soluble
166 T L -0.0712 Soluble
167 V L 0.1154 Aggregation-prone
168 A L -0.4412 Soluble
169 W L 0.0000 Buried
170 K L -1.1194 Soluble
171 A L 0.0000 Buried
172 D L -1.6213 Soluble
173 G L -1.2633 Soluble
174 S L -0.9744 Soluble
175 P L -0.9593 Soluble
176 V L -0.9350 Soluble
177 K L -1.7328 Soluble
178 A L -0.8087 Soluble
179 G L -0.6664 Soluble
180 V L -0.7194 Soluble
181 E L -0.8439 Soluble
182 T L -0.6420 Soluble
183 T L 0.0000 Buried
184 K L -1.8070 Soluble
185 P L -1.2738 Soluble
186 S L -1.6226 Soluble
187 K L -2.5781 Soluble
188 Q L -2.1339 Soluble
189 S L -1.8716 Soluble
190 N L -2.5175 Soluble
191 N L -2.7904 Soluble
192 K L -2.3264 Soluble
193 Y L -1.6021 Soluble
194 A L 0.0000 Buried
195 A L 0.0000 Buried
196 S L 0.0000 Buried
197 S L 0.0000 Buried
198 Y L 0.0000 Buried
199 L L 0.0000 Buried
200 S L -0.4473 Soluble
201 L L -1.0003 Soluble
202 T L -1.6418 Soluble
203 P L -2.2840 Soluble
204 E L -3.2307 Soluble
205 Q L -2.7301 Soluble
206 W L 0.0000 Buried
207 K L -3.2520 Soluble
208 S L -2.6328 Soluble
209 H L -2.5996 Soluble
210 R L -2.7614 Soluble
211 S L -1.8392 Soluble
212 Y L 0.0000 Buried
213 S L -1.0034 Soluble
214 C L 0.0000 Buried
215 Q L -0.8394 Soluble
216 V L 0.0000 Buried
217 T L -0.5589 Soluble
218 H L 0.0000 Buried
219 E L -2.2817 Soluble
220 G L -1.3600 Soluble
221 S L -0.8178 Soluble
222 T L -0.5013 Soluble
223 V L -0.3008 Soluble
224 E L -1.5893 Soluble
225 K L -1.4804 Soluble
226 T L -0.8550 Soluble
227 V L -0.6804 Soluble
228 A L -1.3662 Soluble
229 P L -1.5902 Soluble
230 T L -1.5383 Soluble
231 E L -1.7154 Soluble

3D Structure — colored by A4D score

Sequence - click residue to focus in viewer  |  colored by A4D score
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Downloads
Color Legend (B-factor = A4D Score)
Score > 1.5 — highly aggregation-prone
Score 0.5–1.5 — aggregation-prone
Score ≈ 0 — buried
Score −1 to −0.5 — soluble
Score < −2.5 — highly soluble
pH Structure
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A4D Score Threshold
Highlight residues > threshold in the sequence panel
CDR Regions
HCDR1
HCDR2
HCDR3
LCDR1
LCDR2
LCDR3
Display Options

pH-Dependent Aggregation Profiles

A4D scores calculated across 11 pH conditions (4.0–9.0, step 0.5). Click a row to view the structure at that pH. The input structure is globular — max score is recommended for pH analysis.

pH Avg A4D Score Max A4D Score Downloads
4.0 -0.7577 2.3941 CSV PDB
4.5 -0.7916 2.3207 CSV PDB
5.0 -0.8295 2.2401 CSV PDB
5.5 -0.8623 2.157 CSV PDB
6.0 -0.8798 2.073 CSV PDB
6.5 -0.8745 1.989 CSV PDB
7.0 -0.8476 1.9054 CSV PDB
7.5 -0.8068 1.8236 CSV PDB
8.0 -0.7591 1.765 CSV PDB
8.5 -0.7065 1.7432 CSV PDB
9.0 -0.6498 1.808 CSV PDB
Average A4D Score vs pH
Max A4D Score vs pH