Zinlirvimab / 8g6u

A4DAB308_8g6u_M_N | Source PDB: 8g6u | Chains: M, N | Done
100
Yes
10 Å
Yes
Avg A4D Score
-0.6173
Max Score
2.3967
Min Score
-3.6314
Total Score
-145.07
Score CDR
-0.3657
Score non-CDR
-0.7075

Calculation Parameters

Chain Sequence(s) QVQLQESGPGLVKPSETLSVTCSVSGDSMNNYYWTWIRQSPGKGLEWIGYISDRESATYNPSLNSRVVISRDTSKNQLSLKLNSVTPADTAVYYCATARRGQRIYGVVSFGEFFYYYSMDVWGKGTTVTVSLSVALGETARISCGRQALGSRAVQWYQHRPGQAPILLIYNNQDRPSGIPERFSGTPDINFGTRATLTISGVEAGDEADYYCHMWDSRSGFSWSFGGATRLTVLG input.pdb
Selected Chain(s) M (Heavy), N (Light)
Distance of Aggregation 10 Å
FoldX Energy Minimization Yes
pH Calculations Yes
Downloads Download all data (.tar.gz)

Aggrescan4D Profile

Aggregation-prone (score > 0)
Soluble (score < 0)
Buried (score = 0)

Per-Residue A4D Scores

Download CSV
Minimum Score -3.6314
Maximum Score 2.3967
Average Score -0.6173
Total Score -145.0686

Residues with A4D score > 0.0 are highlighted as aggregation-prone.

Index Residue Chain A4D Score Classification
1 Q M -1.6053 Soluble
2 V M -1.0041 Soluble
3 Q M -1.7730 Soluble
4 L M -1.3112 Soluble
5 Q M -1.9211 Soluble
6 E M -1.2437 Soluble
7 S M -0.7154 Soluble
8 G M -0.2840 Soluble
9 P M 0.0821 Aggregation-prone
11 G M 0.6086 Aggregation-prone
12 L M 1.1754 Aggregation-prone
13 V M -0.1934 Soluble
14 K M -1.7168 Soluble
15 P M -1.4498 Soluble
16 S M -1.6424 Soluble
17 E M -2.3364 Soluble
18 T M -1.7941 Soluble
19 L M 0.0000 Buried
20 S M -0.7974 Soluble
21 V M 0.0000 Buried
22 T M -0.7819 Soluble
23 C M 0.0000 Buried
24 S M -1.1642 Soluble
25 V M -1.2719 Soluble
26 S M -1.4924 Soluble
27 G M -1.4144 Soluble
28 D M -1.6163 Soluble
29 S M -0.9480 Soluble
30 M M -0.5463 Soluble
35 N M -1.8276 Soluble
36 N M -1.6881 Soluble
37 Y M 0.0000 Buried
38 Y M -1.1563 Soluble
39 W M -0.4374 Soluble
40 T M 0.0000 Buried
41 W M 0.0000 Buried
42 I M 0.0000 Buried
43 R M 0.0000 Buried
44 Q M -1.1934 Soluble
45 S M -0.8940 Soluble
46 P M -1.0546 Soluble
47 G M -1.5371 Soluble
48 K M -2.2796 Soluble
49 G M -1.5247 Soluble
50 L M -0.9281 Soluble
51 E M -1.0812 Soluble
52 W M 0.0000 Buried
53 I M 0.0000 Buried
54 G M 0.0000 Buried
55 Y M -0.2026 Soluble
56 I M 0.0000 Buried
57 S M -1.9123 Soluble
58 D M -2.6217 Soluble
59 R M -3.4205 Soluble
63 E M -3.6314 Soluble
64 S M -1.8533 Soluble
65 A M -0.3210 Soluble
66 T M -0.0177 Soluble
67 Y M 0.0568 Aggregation-prone
68 N M 0.0000 Buried
69 P M -0.7097 Soluble
70 S M -0.7067 Soluble
71 L M -0.8696 Soluble
72 N M -1.5934 Soluble
74 S M -0.8575 Soluble
75 R M -1.1194 Soluble
76 V M 0.0000 Buried
77 V M 0.7731 Aggregation-prone
78 I M 0.0000 Buried
79 S M 0.0000 Buried
80 R M -3.3463 Soluble
81 D M -3.0985 Soluble
82 T M -2.0405 Soluble
83 S M -1.9467 Soluble
84 K M -2.4505 Soluble
85 N M -2.1421 Soluble
86 Q M -1.9987 Soluble
87 L M 0.0000 Buried
88 S M -1.0994 Soluble
89 L M 0.0000 Buried
90 K M -1.1992 Soluble
91 L M 0.0000 Buried
92 N M -1.9485 Soluble
93 S M -1.5926 Soluble
94 V M 0.0000 Buried
95 T M -0.8046 Soluble
96 P M -0.5181 Soluble
97 A M -0.2031 Soluble
98 D M -0.2683 Soluble
99 T M -0.1815 Soluble
100 A M -0.1091 Soluble
101 V M -0.1240 Soluble
102 Y M 0.0000 Buried
103 Y M 0.0000 Buried
104 C M 0.0000 Buried
105 A M 0.0000 Buried
106 T M 0.0000 Buried
107 A M 0.0000 Buried
108 R M -2.1466 Soluble
109 R M -2.2952 Soluble
110 G M -1.4835 Soluble
111 Q M -0.8255 Soluble
111A R M 0.0987 Aggregation-prone
111B I M 1.6450 Aggregation-prone
111C Y M 1.5535 Aggregation-prone
111D G M 1.2575 Aggregation-prone
111E V M 2.2694 Aggregation-prone
111F V M 2.3967 Aggregation-prone
112G S M 1.4208 Aggregation-prone
112F F M 2.1087 Aggregation-prone
112E G M 0.7842 Aggregation-prone
112D E M 0.4973 Aggregation-prone
112C F M 1.3065 Aggregation-prone
112B F M 0.6756 Aggregation-prone
112A Y M 0.9215 Aggregation-prone
112 Y M 0.0000 Buried
113 Y M -0.9452 Soluble
114 S M -0.8491 Soluble
115 M M 0.0000 Buried
116 D M -0.0900 Soluble
117 V M 0.4623 Aggregation-prone
118 W M 0.0000 Buried
119 G M 0.0000 Buried
120 K M -2.5004 Soluble
121 G M 0.0000 Buried
122 T M -0.6599 Soluble
123 T M -0.0602 Soluble
124 V M 0.0000 Buried
125 T M 0.2783 Aggregation-prone
126 V M 0.0306 Aggregation-prone
127 S M -0.2911 Soluble
11 L N 1.1681 Aggregation-prone
12 S N 0.2589 Aggregation-prone
13 V N 0.2299 Aggregation-prone
14 A N 0.8680 Aggregation-prone
15 L N 1.1860 Aggregation-prone
16 G N -0.7889 Soluble
17 E N -1.4972 Soluble
18 T N -1.0478 Soluble
19 A N -1.1772 Soluble
20 R N -1.6861 Soluble
21 I N -0.6390 Soluble
22 S N -1.0793 Soluble
23 C N -1.1949 Soluble
24 G N -1.9195 Soluble
25 R N -2.8515 Soluble
26 Q N -2.4303 Soluble
27 A N -1.0578 Soluble
28 L N -0.3351 Soluble
29 G N -0.1043 Soluble
36 S N 0.0000 Buried
37 R N 0.0000 Buried
38 A N 0.0000 Buried
39 V N 0.0000 Buried
40 Q N 0.0000 Buried
41 W N 0.0000 Buried
42 Y N 0.0000 Buried
43 Q N 0.0000 Buried
44 H N 0.0000 Buried
45 R N -0.8782 Soluble
46 P N -1.0505 Soluble
47 G N -1.5402 Soluble
48 Q N -2.0094 Soluble
49 A N -0.9351 Soluble
50 P N 0.0000 Buried
51 I N 0.8041 Aggregation-prone
52 L N 0.0000 Buried
53 L N 0.0000 Buried
54 I N 0.0000 Buried
55 Y N -1.0742 Soluble
56 N N -1.7501 Soluble
57 N N 0.0000 Buried
65 Q N -2.3896 Soluble
66 D N -3.1320 Soluble
67 R N -3.0543 Soluble
68 P N -1.4569 Soluble
69 S N -1.0623 Soluble
70 G N -0.9663 Soluble
71 I N -1.0952 Soluble
72 P N -1.7870 Soluble
74 E N -2.9496 Soluble
75 R N -2.6668 Soluble
76 F N -1.6226 Soluble
77 S N -1.8052 Soluble
78 G N -1.1143 Soluble
79 T N -0.5172 Soluble
80 P N -0.2675 Soluble
81 D N 0.0444 Aggregation-prone
81A I N 1.5729 Aggregation-prone
82 N N 0.3448 Aggregation-prone
83 F N 1.2931 Aggregation-prone
84 G N -0.1477 Soluble
85 T N -0.7370 Soluble
86 R N -2.2538 Soluble
87 A N -1.5097 Soluble
88 T N -0.9209 Soluble
89 L N 0.0000 Buried
90 T N -1.2556 Soluble
91 I N 0.0000 Buried
92 S N -1.2768 Soluble
93 G N -1.1277 Soluble
94 V N -0.9349 Soluble
95 E N -1.9842 Soluble
96 A N -1.2453 Soluble
97 G N 0.0000 Buried
98 D N 0.0000 Buried
99 E N -1.6868 Soluble
100 A N 0.0000 Buried
101 D N 0.0000 Buried
102 Y N 0.0000 Buried
103 Y N 0.0000 Buried
104 C N 0.0000 Buried
105 H N 0.0000 Buried
106 M N 0.0000 Buried
107 W N 0.0000 Buried
108 D N 0.0000 Buried
109 S N -0.5410 Soluble
110 R N -1.8495 Soluble
112 S N -0.9591 Soluble
113 G N -0.4056 Soluble
114 F N 0.6739 Aggregation-prone
115 S N 0.1305 Aggregation-prone
116 W N 0.2714 Aggregation-prone
117 S N -0.1628 Soluble
118 F N 0.0000 Buried
119 G N -0.6996 Soluble
120 G N -1.1166 Soluble
121 A N -0.7260 Soluble
122 T N -0.6429 Soluble
123 R N -1.5505 Soluble
124 L N -0.3889 Soluble
125 T N 0.4908 Aggregation-prone
126 V N 1.2557 Aggregation-prone
127 L N 1.8980 Aggregation-prone
128 G N 0.7754 Aggregation-prone

3D Structure — colored by A4D score

Sequence - click residue to focus in viewer  |  colored by A4D score
Load structure to view sequence…
Downloads
Color Legend (B-factor = A4D Score)
Score > 1.5 — highly aggregation-prone
Score 0.5–1.5 — aggregation-prone
Score ≈ 0 — buried
Score −1 to −0.5 — soluble
Score < −2.5 — highly soluble
pH Structure
Load structure at specific pH condition
A4D Score Threshold
Highlight residues > threshold in the sequence panel
CDR Regions
HCDR1
HCDR2
HCDR3
LCDR1
LCDR2
LCDR3
Display Options

pH-Dependent Aggregation Profiles

A4D scores calculated across 11 pH conditions (4.0–9.0, step 0.5). Click a row to view the structure at that pH. The input structure is globular — max score is recommended for pH analysis.

pH Avg A4D Score Max A4D Score Downloads
4.0 -0.5513 4.4123 CSV PDB
4.5 -0.591 4.3571 CSV PDB
5.0 -0.6394 4.2844 CSV PDB
5.5 -0.688 4.2063 CSV PDB
6.0 -0.7279 4.1348 CSV PDB
6.5 -0.7524 4.082 CSV PDB
7.0 -0.7607 4.053 CSV PDB
7.5 -0.7571 4.0409 CSV PDB
8.0 -0.7466 4.0367 CSV PDB
8.5 -0.7312 4.0353 CSV PDB
9.0 -0.7111 4.0348 CSV PDB
Average A4D Score vs pH
Max A4D Score vs pH