Sonavibart / 5jw4

A4DAB244_5jw4_S_T | Source PDB: 5jw4 | Chains: S, T | Done
100
Yes
10 Å
Yes
Avg A4D Score
-0.656
Max Score
2.1562
Min Score
-3.634
Total Score
-281.42
Score CDR
-0.0888
Score non-CDR
-0.7325

Calculation Parameters

Chain Sequence(s) QVQLQQSGPGLVKPSQTLSLTCAISGDSVSSYNAVWNWIRQSPSRGLEWLGRTYYRSGWYNDYAESVKSRITINPDTSKNQFSLQLNSVTPEDTAVYYCARSGHITVFGVNVDAFDMWGQGTMVTVSSASTKGPSVFPLAPSSGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPMTQSPSSLSASVGDRVTITCRTSQSLSSYTHWYQQKPGKAPKLLIYAASSRGSGVPSRFSGSGSGTDFTLTISSLQPEDFATYYCQQSRTFGQGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGE input.pdb
Selected Chain(s) S (Heavy), T (Light)
Distance of Aggregation 10 Å
FoldX Energy Minimization Yes
pH Calculations Yes
Downloads Download all data (.tar.gz)

Aggrescan4D Profile

Aggregation-prone (score > 0)
Soluble (score < 0)
Buried (score = 0)

Per-Residue A4D Scores

Download CSV
Minimum Score -3.634
Maximum Score 2.1562
Average Score -0.656
Total Score -281.4193

Residues with A4D score > 0.0 are highlighted as aggregation-prone.

Index Residue Chain A4D Score Classification
1 Q S -1.6034 Soluble
2 V S 0.0000 Buried
3 Q S -1.7918 Soluble
4 L S 0.0000 Buried
5 Q S -1.8439 Soluble
6 Q S -1.2711 Soluble
7 S S -0.8853 Soluble
8 G S -0.4510 Soluble
9 P S -0.5406 Soluble
11 G S -0.2569 Soluble
12 L S -0.2889 Soluble
13 V S 0.0000 Buried
14 K S -2.2493 Soluble
15 P S -1.5975 Soluble
16 S S -1.5870 Soluble
17 Q S -2.1605 Soluble
18 T S -1.5810 Soluble
19 L S 0.0000 Buried
20 S S -0.7398 Soluble
21 L S 0.0000 Buried
22 T S -0.7716 Soluble
23 C S 0.0000 Buried
24 A S -1.2180 Soluble
25 I S 0.0000 Buried
26 S S -1.3055 Soluble
27 G S -1.3100 Soluble
28 D S -1.2111 Soluble
29 S S -0.5399 Soluble
30 V S 0.0000 Buried
31 S S -0.0165 Soluble
34 S S 0.0627 Aggregation-prone
35 Y S 0.5753 Aggregation-prone
36 N S -0.8899 Soluble
37 A S 0.0000 Buried
38 V S 0.0000 Buried
39 W S 0.0000 Buried
40 N S 0.0000 Buried
41 W S 0.0000 Buried
42 I S 0.0000 Buried
43 R S 0.0000 Buried
44 Q S -0.5121 Soluble
45 S S -1.0250 Soluble
46 P S -0.8941 Soluble
47 S S -1.6287 Soluble
48 R S -2.5143 Soluble
49 G S -1.4861 Soluble
50 L S 0.0000 Buried
51 E S 0.0000 Buried
52 W S 0.0000 Buried
53 L S 0.0000 Buried
54 G S 0.0000 Buried
55 R S 0.0000 Buried
56 T S 0.0000 Buried
57 Y S 0.2888 Aggregation-prone
58 Y S 0.6392 Aggregation-prone
59 R S 0.1647 Aggregation-prone
60 S S 0.0325 Aggregation-prone
62 G S 0.1894 Aggregation-prone
63 W S 0.5202 Aggregation-prone
64 Y S 0.2944 Aggregation-prone
65 N S -0.9748 Soluble
66 D S -1.7146 Soluble
67 Y S -1.6200 Soluble
68 A S -1.8112 Soluble
69 E S -2.6143 Soluble
70 S S -1.6049 Soluble
71 V S 0.0000 Buried
72 K S -2.6951 Soluble
74 S S -1.6514 Soluble
75 R S -1.4648 Soluble
76 I S 0.0000 Buried
77 T S -1.2990 Soluble
78 I S 0.0000 Buried
79 N S -1.5120 Soluble
80 P S -1.1510 Soluble
81 D S -1.5859 Soluble
82 T S -1.2680 Soluble
83 S S -1.3633 Soluble
84 K S -2.1970 Soluble
85 N S -1.6213 Soluble
86 Q S -1.5409 Soluble
87 F S 0.0000 Buried
88 S S -0.8516 Soluble
89 L S 0.0000 Buried
90 Q S -1.1504 Soluble
91 L S 0.0000 Buried
92 N S -1.6652 Soluble
93 S S -1.4785 Soluble
94 V S 0.0000 Buried
95 T S -1.4282 Soluble
96 P S -1.4154 Soluble
97 E S -2.2236 Soluble
98 D S 0.0000 Buried
99 T S -0.5697 Soluble
100 A S 0.0000 Buried
101 V S 0.3515 Aggregation-prone
102 Y S 0.0000 Buried
103 Y S 0.0000 Buried
104 C S 0.0000 Buried
105 A S 0.0000 Buried
106 R S 0.0000 Buried
107 S S 0.0000 Buried
108 G S 0.0000 Buried
109 H S -0.9321 Soluble
110 I S -0.0866 Soluble
111 T S 0.4858 Aggregation-prone
111A V S 1.4617 Aggregation-prone
111B F S 2.1562 Aggregation-prone
112C G S 0.7770 Aggregation-prone
112B V S 1.1197 Aggregation-prone
112A N S -0.1551 Soluble
112 V S 0.0000 Buried
113 D S -0.4960 Soluble
114 A S 0.0000 Buried
115 F S 0.0000 Buried
116 D S -0.6596 Soluble
117 M S -0.7739 Soluble
118 W S 0.0000 Buried
119 G S 0.0000 Buried
120 Q S -1.9422 Soluble
121 G S -0.9691 Soluble
122 T S -0.2600 Soluble
123 M S 0.3121 Aggregation-prone
124 V S 0.0000 Buried
125 T S -0.4189 Soluble
126 V S 0.0000 Buried
127 S S -0.7962 Soluble
128 S S -0.8735 Soluble
129 A S -0.5863 Soluble
130 S S -0.7327 Soluble
131 T S -0.9331 Soluble
132 K S -1.5945 Soluble
133 G S -1.6006 Soluble
134 P S -0.7449 Soluble
135 S S -0.3900 Soluble
136 V S 0.0000 Buried
137 F S 0.0000 Buried
138 P S -1.0927 Soluble
139 L S 0.0000 Buried
140 A S -0.8372 Soluble
141 P S 0.0000 Buried
142 S S -0.5374 Soluble
143 S S -0.3636 Soluble
144 G S -0.6449 Soluble
145 T S -0.4778 Soluble
146 A S 0.0000 Buried
147 A S 0.0000 Buried
148 L S 0.0000 Buried
149 G S 0.0000 Buried
150 C S 0.0000 Buried
151 L S 0.0000 Buried
152 V S 0.0000 Buried
153 K S 0.0000 Buried
154 D S -0.5513 Soluble
155 Y S 0.0000 Buried
156 F S 0.0000 Buried
157 P S 0.0000 Buried
158 E S -0.2523 Soluble
159 P S -0.5257 Soluble
160 V S -0.6254 Soluble
161 T S -0.5786 Soluble
162 V S -0.4169 Soluble
163 S S -0.4434 Soluble
164 W S 0.0000 Buried
165 N S -0.7691 Soluble
166 S S -0.6864 Soluble
167 G S -0.5709 Soluble
168 A S -0.2364 Soluble
169 L S 0.0045 Aggregation-prone
170 T S -0.1700 Soluble
171 S S -0.1803 Soluble
172 G S -0.2072 Soluble
173 V S 0.1562 Aggregation-prone
174 H S -0.2941 Soluble
175 T S -0.0030 Soluble
176 F S 0.0000 Buried
177 P S -0.2267 Soluble
178 A S 0.3455 Aggregation-prone
179 V S 0.7899 Aggregation-prone
180 L S 1.4809 Aggregation-prone
181 Q S 0.4488 Aggregation-prone
182 S S -0.0244 Soluble
183 S S -0.2129 Soluble
184 G S 0.0512 Aggregation-prone
185 L S 0.1543 Aggregation-prone
186 Y S 0.5232 Aggregation-prone
187 S S 0.0000 Buried
188 L S 0.0000 Buried
189 S S 0.0000 Buried
190 S S 0.0000 Buried
191 V S 0.0000 Buried
192 V S 0.0000 Buried
193 T S -0.1306 Soluble
194 V S 0.0000 Buried
195 P S -0.4909 Soluble
196 S S -0.5477 Soluble
197 S S -0.6110 Soluble
198 S S -0.6247 Soluble
199 L S -0.7889 Soluble
200 G S -0.9251 Soluble
201 T S -0.6823 Soluble
202 Q S -1.1210 Soluble
203 T S -1.0680 Soluble
204 Y S 0.0000 Buried
205 I S -1.3335 Soluble
206 C S 0.0000 Buried
207 N S -1.5557 Soluble
208 V S 0.0000 Buried
209 N S -2.0294 Soluble
210 H S 0.0000 Buried
211 K S -2.8026 Soluble
212 P S -1.6844 Soluble
213 S S -1.9755 Soluble
214 N S -2.6370 Soluble
215 T S -2.1984 Soluble
216 K S -2.7374 Soluble
217 V S -1.6629 Soluble
218 D S -2.5671 Soluble
219 K S -2.0164 Soluble
220 K S -2.5778 Soluble
221 V S 0.0000 Buried
222 E S -2.4717 Soluble
223 P S -1.2264 Soluble
4 M T -0.7725 Soluble
5 T T -1.0064 Soluble
6 Q T 0.0000 Buried
7 S T -0.7673 Soluble
8 P T -0.4162 Soluble
9 S T -0.7121 Soluble
10 S T -0.5971 Soluble
11 L T -0.4877 Soluble
12 S T -0.8931 Soluble
13 A T -1.0249 Soluble
14 S T -0.8006 Soluble
15 V T 0.2505 Aggregation-prone
16 G T -0.6720 Soluble
17 D T -1.5881 Soluble
18 R T -2.2489 Soluble
19 V T 0.0000 Buried
20 T T -0.6136 Soluble
21 I T 0.0000 Buried
22 T T -0.7644 Soluble
23 C T 0.0000 Buried
24 R T -2.3392 Soluble
25 T T 0.0000 Buried
26 S T -1.1286 Soluble
27 Q T -1.3472 Soluble
28 S T -0.9584 Soluble
29 L T 0.0314 Aggregation-prone
36 S T -0.2427 Soluble
37 S T 0.2830 Aggregation-prone
38 Y T 0.2600 Aggregation-prone
39 T T 0.0000 Buried
40 H T 0.0000 Buried
41 W T 0.0000 Buried
42 Y T 0.0000 Buried
43 Q T 0.0000 Buried
44 Q T -1.2765 Soluble
45 K T -1.7289 Soluble
46 P T -1.4463 Soluble
47 G T -1.6416 Soluble
48 K T -2.5733 Soluble
49 A T -1.6516 Soluble
50 P T 0.0000 Buried
51 K T -1.6320 Soluble
52 L T 0.0000 Buried
53 L T 0.0000 Buried
54 I T 0.0000 Buried
55 Y T -0.0916 Soluble
56 A T 0.0176 Aggregation-prone
57 A T 0.0000 Buried
65 S T -0.6862 Soluble
66 S T -0.7878 Soluble
67 R T -1.5476 Soluble
68 G T 0.0000 Buried
69 S T -0.9354 Soluble
70 G T -0.9480 Soluble
71 V T 0.0000 Buried
72 P T -0.7014 Soluble
74 S T -0.7571 Soluble
75 R T -0.9740 Soluble
76 F T 0.0000 Buried
77 S T -0.7356 Soluble
78 G T -0.5584 Soluble
79 S T -0.6069 Soluble
80 G T -0.9693 Soluble
83 S T -0.9754 Soluble
84 G T -1.1837 Soluble
85 T T -1.4450 Soluble
86 D T -1.6687 Soluble
87 F T 0.0000 Buried
88 T T -0.6565 Soluble
89 L T 0.0000 Buried
90 T T -0.6098 Soluble
91 I T 0.0000 Buried
92 S T -1.3425 Soluble
93 S T -1.1328 Soluble
94 L T 0.0000 Buried
95 Q T -0.7867 Soluble
96 P T -1.4327 Soluble
97 E T -1.5013 Soluble
98 D T 0.0000 Buried
99 F T 0.0000 Buried
100 A T 0.0000 Buried
101 T T -0.7137 Soluble
102 Y T 0.0000 Buried
103 Y T 0.0000 Buried
104 C T 0.0000 Buried
105 Q T 0.0000 Buried
106 Q T 0.0000 Buried
107 S T -0.6201 Soluble
116 R T -1.2924 Soluble
117 T T -0.6963 Soluble
118 F T -0.4055 Soluble
119 G T 0.0000 Buried
120 Q T -1.5821 Soluble
121 G T 0.0000 Buried
122 T T 0.0000 Buried
123 K T -0.9981 Soluble
124 V T 0.0000 Buried
125 E T -1.4375 Soluble
126 I T 0.0000 Buried
127 K T -1.5534 Soluble
128 R T -1.0746 Soluble
129 T T -0.1060 Soluble
130 V T 0.6296 Aggregation-prone
131 A T 0.2673 Aggregation-prone
132 A T -0.0349 Soluble
133 P T 0.0000 Buried
134 S T -0.1600 Soluble
135 V T 0.0000 Buried
136 F T 0.1246 Aggregation-prone
137 I T 0.1085 Aggregation-prone
138 F T 0.0000 Buried
139 P T -0.4635 Soluble
140 P T -0.7496 Soluble
141 S T -1.4760 Soluble
142 D T -2.7062 Soluble
143 E T -2.5492 Soluble
144 Q T 0.0000 Buried
145 L T -2.0912 Soluble
146 K T -2.6561 Soluble
147 S T -1.6578 Soluble
148 G T -1.3611 Soluble
149 T T -0.9944 Soluble
150 A T 0.0000 Buried
151 S T 0.0000 Buried
152 V T 0.0000 Buried
153 V T 0.0000 Buried
154 C T 0.0000 Buried
155 L T 0.0000 Buried
156 L T 0.0000 Buried
157 N T 0.0000 Buried
158 N T -0.8319 Soluble
159 F T 0.0000 Buried
160 Y T 0.0000 Buried
161 P T -1.3680 Soluble
162 R T -2.3878 Soluble
163 E T -2.9450 Soluble
164 A T -2.2034 Soluble
165 K T -2.4472 Soluble
166 V T -1.1910 Soluble
167 Q T -0.7647 Soluble
168 W T 0.0000 Buried
169 K T -0.6228 Soluble
170 V T 0.0000 Buried
171 D T -1.8435 Soluble
172 N T -1.5520 Soluble
173 A T -0.2851 Soluble
174 L T 0.7006 Aggregation-prone
175 Q T -0.1498 Soluble
176 S T -0.4315 Soluble
177 G T -0.8518 Soluble
178 N T -0.7397 Soluble
179 S T -0.9311 Soluble
180 Q T -0.8831 Soluble
181 E T -1.4997 Soluble
182 S T -0.6371 Soluble
183 V T -0.6418 Soluble
184 T T -0.9843 Soluble
185 E T -1.9712 Soluble
186 Q T 0.0000 Buried
187 D T -2.0461 Soluble
188 S T -2.1425 Soluble
189 K T -2.5920 Soluble
190 D T -2.0414 Soluble
191 S T 0.0000 Buried
192 T T 0.0000 Buried
193 Y T 0.0000 Buried
194 S T 0.0000 Buried
195 L T 0.0000 Buried
196 S T 0.0000 Buried
197 S T 0.0000 Buried
198 T T 0.0000 Buried
199 L T 0.0000 Buried
200 T T -0.3838 Soluble
201 L T -0.7102 Soluble
202 S T -1.2862 Soluble
203 K T -2.1213 Soluble
204 A T -2.0485 Soluble
205 D T -2.8286 Soluble
206 Y T 0.0000 Buried
207 E T -3.4870 Soluble
208 K T -3.6340 Soluble
209 H T -2.9073 Soluble
210 K T -2.5656 Soluble
211 V T -0.9883 Soluble
212 Y T 0.0000 Buried
213 A T 0.0000 Buried
214 C T 0.0000 Buried
215 E T -1.0043 Soluble
216 V T 0.0000 Buried
217 T T -1.3041 Soluble
218 H T 0.0000 Buried
219 Q T -1.6475 Soluble
220 G T -0.3430 Soluble
221 L T -0.1787 Soluble
222 S T -0.4420 Soluble
223 S T -0.4736 Soluble
224 P T -0.6248 Soluble
225 V T -0.1167 Soluble
226 T T -0.5409 Soluble
227 K T -0.6661 Soluble
228 S T -0.4772 Soluble
229 F T -0.7773 Soluble
230 N T -1.5934 Soluble
231 R T -2.1989 Soluble
232 G T -2.0182 Soluble
233 E T -2.3966 Soluble

3D Structure — colored by A4D score

Sequence - click residue to focus in viewer  |  colored by A4D score
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Color Legend (B-factor = A4D Score)
Score > 1.5 — highly aggregation-prone
Score 0.5–1.5 — aggregation-prone
Score ≈ 0 — buried
Score −1 to −0.5 — soluble
Score < −2.5 — highly soluble
pH Structure
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A4D Score Threshold
Highlight residues > threshold in the sequence panel
CDR Regions
HCDR1
HCDR2
HCDR3
LCDR1
LCDR2
LCDR3
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pH-Dependent Aggregation Profiles

A4D scores calculated across 11 pH conditions (4.0–9.0, step 0.5). Click a row to view the structure at that pH. The input structure is globular — max score is recommended for pH analysis.

pH Avg A4D Score Max A4D Score Downloads
4.0 -0.7621 4.6381 CSV PDB
4.5 -0.7979 4.6381 CSV PDB
5.0 -0.8391 4.6381 CSV PDB
5.5 -0.8768 4.6381 CSV PDB
6.0 -0.9013 4.6381 CSV PDB
6.5 -0.905 4.6381 CSV PDB
7.0 -0.8877 4.6381 CSV PDB
7.5 -0.8566 4.6381 CSV PDB
8.0 -0.8181 4.6381 CSV PDB
8.5 -0.7742 4.6381 CSV PDB
9.0 -0.7251 4.6381 CSV PDB
Average A4D Score vs pH
Max A4D Score vs pH