Cosfroviximab / 5kel

A4DAB073_5kel_C_D | Source PDB: 5kel | Chains: C, D | Done
100
Yes
10 Å
Yes
Avg A4D Score
-0.6204
Max Score
1.3152
Min Score
-3.3531
Total Score
-141.46
Score CDR
-0.4941
Score non-CDR
-0.655

Calculation Parameters

Chain Sequence(s) DVKLLESGGGLVQPGGSLKLSCAASGFSLSTSGVGVGWFRQPSGKGLEWLALIWWDDDKYYNPSLKSQLSISKDFSRNQVFLKISNVDIADTATYYCARRDPFGYDNAMGYWGQGTSVTVSDIVMTQSPLSLSTSVGDRVSLTCKASQNVGTAVAWYQQKPGQSPKLLIYSASNRYTGVPDRFTGSGSGTDFTLTISNMQSEDLADYFCQQYSSYPLTFGAGTKLELR input.pdb
Selected Chain(s) C (Heavy), D (Light)
Distance of Aggregation 10 Å
FoldX Energy Minimization Yes
pH Calculations Yes
Downloads Download all data (.tar.gz)

Aggrescan4D Profile

Aggregation-prone (score > 0)
Soluble (score < 0)
Buried (score = 0)

Per-Residue A4D Scores

Download CSV
Minimum Score -3.3531
Maximum Score 1.3152
Average Score -0.6204
Total Score -141.4587

Residues with A4D score > 0.0 are highlighted as aggregation-prone.

Index Residue Chain A4D Score Classification
1 D C -2.1511 Soluble
2 V C -1.5780 Soluble
3 K C -2.1736 Soluble
4 L C -1.0898 Soluble
5 L C -0.4702 Soluble
6 E C -0.7171 Soluble
7 S C -0.7988 Soluble
8 G C -1.0385 Soluble
9 G C -0.8244 Soluble
11 G C -0.0718 Soluble
12 L C 1.0312 Aggregation-prone
13 V C 0.1990 Aggregation-prone
14 Q C -1.0312 Soluble
15 P C -0.7950 Soluble
16 G C -1.3366 Soluble
17 G C -1.0147 Soluble
18 S C -1.6055 Soluble
19 L C 0.0000 Buried
20 K C -2.0802 Soluble
21 L C 0.0000 Buried
22 S C -0.7427 Soluble
23 C C 0.0000 Buried
24 A C -0.6907 Soluble
25 A C 0.0000 Buried
26 S C -1.2527 Soluble
27 G C -1.3344 Soluble
28 F C -0.5598 Soluble
29 S C -0.3270 Soluble
30 L C -0.0904 Soluble
31 S C -0.2210 Soluble
34 T C -0.2696 Soluble
35 S C -0.9031 Soluble
36 G C -0.9372 Soluble
37 V C 0.0000 Buried
38 G C 0.0000 Buried
39 V C 0.1715 Aggregation-prone
40 G C 0.0000 Buried
41 W C 0.0000 Buried
42 F C 0.0000 Buried
43 R C 0.0000 Buried
44 Q C 0.0000 Buried
45 P C -0.9467 Soluble
46 S C -1.0182 Soluble
47 G C -1.4499 Soluble
48 K C -2.1214 Soluble
49 G C -1.1486 Soluble
50 L C 0.0000 Buried
51 E C -0.7369 Soluble
52 W C 0.0000 Buried
53 L C 0.0000 Buried
54 A C 0.0000 Buried
55 L C 0.0000 Buried
56 I C 0.0000 Buried
57 W C -1.6046 Soluble
58 W C -1.4485 Soluble
59 D C -2.9382 Soluble
63 D C -3.3531 Soluble
64 D C -2.7919 Soluble
65 K C -1.9655 Soluble
66 Y C -0.4146 Soluble
67 Y C -0.3684 Soluble
68 N C -0.6784 Soluble
69 P C -1.0345 Soluble
70 S C -1.0005 Soluble
71 L C -0.8959 Soluble
72 K C -1.7690 Soluble
74 S C -1.2843 Soluble
75 Q C -1.4093 Soluble
76 L C 0.0000 Buried
77 S C -1.0424 Soluble
78 I C 0.0000 Buried
79 S C -0.6024 Soluble
80 K C -1.0163 Soluble
81 D C -0.9284 Soluble
82 F C -0.4059 Soluble
83 S C -1.0299 Soluble
84 R C -2.0793 Soluble
85 N C -1.2353 Soluble
86 Q C -0.9603 Soluble
87 V C 0.0000 Buried
88 F C -0.6676 Soluble
89 L C 0.0000 Buried
90 K C -1.7747 Soluble
91 I C 0.0000 Buried
92 S C -1.6865 Soluble
93 N C -1.9072 Soluble
94 V C 0.0000 Buried
95 D C -0.5264 Soluble
96 I C 1.3152 Aggregation-prone
97 A C 0.8003 Aggregation-prone
98 D C 0.0000 Buried
99 T C 0.5910 Aggregation-prone
100 A C 0.0000 Buried
101 T C -0.5123 Soluble
102 Y C 0.0000 Buried
103 Y C 0.0000 Buried
104 C C 0.0000 Buried
105 A C 0.0000 Buried
106 R C 0.0386 Aggregation-prone
107 R C 0.0000 Buried
108 D C -0.1396 Soluble
109 P C 0.2522 Aggregation-prone
110 F C 0.5166 Aggregation-prone
111 G C 0.2397 Aggregation-prone
112A Y C 0.9433 Aggregation-prone
112 D C 0.0823 Aggregation-prone
113 N C -0.0380 Soluble
114 A C 0.0000 Buried
115 M C 0.0000 Buried
116 G C 0.0000 Buried
117 Y C -0.2343 Soluble
118 W C -0.6096 Soluble
119 G C 0.0000 Buried
120 Q C -1.6659 Soluble
121 G C -1.0491 Soluble
122 T C -0.5975 Soluble
123 S C -0.3190 Soluble
124 V C 0.0000 Buried
125 T C 0.4671 Aggregation-prone
126 V C 0.4293 Aggregation-prone
127 S C -0.0648 Soluble
1 D D -1.0651 Soluble
2 I D 0.2390 Aggregation-prone
3 V D 1.1112 Aggregation-prone
4 M D 0.3937 Aggregation-prone
5 T D 0.2751 Aggregation-prone
6 Q D 0.0000 Buried
7 S D 0.0281 Aggregation-prone
8 P D 0.3092 Aggregation-prone
9 L D 1.0064 Aggregation-prone
10 S D -0.3510 Soluble
11 L D -0.4463 Soluble
12 S D -1.3004 Soluble
13 T D 0.0000 Buried
14 S D -0.5834 Soluble
15 V D 0.2790 Aggregation-prone
16 G D -1.1201 Soluble
17 D D -1.8116 Soluble
18 R D -2.6003 Soluble
19 V D 0.0000 Buried
20 S D -0.7780 Soluble
21 L D 0.0000 Buried
22 T D -0.5884 Soluble
23 C D 0.0000 Buried
24 K D -1.6348 Soluble
25 A D 0.0000 Buried
26 S D -0.8881 Soluble
27 Q D -1.7797 Soluble
28 N D -2.4531 Soluble
29 V D 0.0000 Buried
36 G D -1.3891 Soluble
37 T D -0.9002 Soluble
38 A D -0.3541 Soluble
39 V D 0.0000 Buried
40 A D 0.0000 Buried
41 W D 0.0000 Buried
42 Y D 0.0000 Buried
43 Q D 0.0000 Buried
44 Q D -1.4199 Soluble
45 K D -1.5504 Soluble
46 P D -1.2317 Soluble
47 G D -1.4347 Soluble
48 Q D -2.0521 Soluble
49 S D -1.5267 Soluble
50 P D 0.0000 Buried
51 K D -1.6551 Soluble
52 L D 0.0000 Buried
53 L D 0.0000 Buried
54 I D 0.0000 Buried
55 Y D -0.5960 Soluble
56 S D -0.4803 Soluble
57 A D 0.0000 Buried
65 S D -1.1427 Soluble
66 N D -1.7395 Soluble
67 R D -1.8854 Soluble
68 Y D -1.0639 Soluble
69 T D -0.7719 Soluble
70 G D -0.8350 Soluble
71 V D 0.0000 Buried
72 P D -1.3590 Soluble
74 D D -2.3630 Soluble
75 R D -1.9722 Soluble
76 F D 0.0000 Buried
77 T D -1.1460 Soluble
78 G D -0.7207 Soluble
79 S D -0.8527 Soluble
80 G D -1.1135 Soluble
83 S D -1.2952 Soluble
84 G D -1.8391 Soluble
85 T D -2.1542 Soluble
86 D D -2.4591 Soluble
87 F D 0.0000 Buried
88 T D -0.7774 Soluble
89 L D 0.0000 Buried
90 T D -0.8796 Soluble
91 I D 0.0000 Buried
92 S D -2.1861 Soluble
93 N D -2.2755 Soluble
94 M D 0.0000 Buried
95 Q D -1.1333 Soluble
96 S D -1.2740 Soluble
97 E D -1.6688 Soluble
98 D D 0.0000 Buried
99 L D -1.0845 Soluble
100 A D 0.0000 Buried
101 D D -1.1213 Soluble
102 Y D 0.0000 Buried
103 F D 0.0000 Buried
104 C D 0.0000 Buried
105 Q D 0.0000 Buried
106 Q D 0.0000 Buried
107 Y D 0.1495 Aggregation-prone
108 S D -0.3768 Soluble
109 S D 0.0313 Aggregation-prone
114 Y D 0.9025 Aggregation-prone
115 P D 0.3106 Aggregation-prone
116 L D 0.3557 Aggregation-prone
117 T D 0.0000 Buried
118 F D 0.5498 Aggregation-prone
119 G D 0.0000 Buried
120 A D 0.2180 Aggregation-prone
121 G D -0.3660 Soluble
122 T D 0.0000 Buried
123 K D -1.8661 Soluble
124 L D 0.0000 Buried
125 E D -2.3604 Soluble
126 L D -1.1639 Soluble
127 R D -1.8815 Soluble

3D Structure — colored by A4D score

Sequence - click residue to focus in viewer  |  colored by A4D score
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Downloads
Color Legend (B-factor = A4D Score)
Score > 1.5 — highly aggregation-prone
Score 0.5–1.5 — aggregation-prone
Score ≈ 0 — buried
Score −1 to −0.5 — soluble
Score < −2.5 — highly soluble
pH Structure
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A4D Score Threshold
Highlight residues > threshold in the sequence panel
CDR Regions
HCDR1
HCDR2
HCDR3
LCDR1
LCDR2
LCDR3
Display Options

pH-Dependent Aggregation Profiles

A4D scores calculated across 11 pH conditions (4.0–9.0, step 0.5). Click a row to view the structure at that pH. The input structure is globular — max score is recommended for pH analysis.

pH Avg A4D Score Max A4D Score Downloads
4.0 -0.5956 3.2538 CSV PDB
4.5 -0.6434 3.1835 CSV PDB
5.0 -0.6964 3.1052 CSV PDB
5.5 -0.747 3.0238 CSV PDB
6.0 -0.787 2.9414 CSV PDB
6.5 -0.8096 2.8589 CSV PDB
7.0 -0.8153 2.7767 CSV PDB
7.5 -0.8098 2.696 CSV PDB
8.0 -0.7966 2.6194 CSV PDB
8.5 -0.7751 2.5536 CSV PDB
9.0 -0.743 2.5075 CSV PDB
Average A4D Score vs pH
Max A4D Score vs pH