Ociperlimab / 8jen

A4DAB185_8jen_G_H | Source PDB: 8jen | Chains: G, H | Done
100
Yes
10 Å
Yes
Avg A4D Score
-0.7311
Max Score
1.9136
Min Score
-3.6673
Total Score
-315.1
Score CDR
-0.4416
Score non-CDR
-0.7657

Calculation Parameters

Chain Sequence(s) EVQLVESGGGLVQPGGSLRLSCAASGFTFSDYYMYWVRQAPGKGLEWVAYITKGGGSTYYPDSVKGRFTISRDNAKNTLYLQMNSLRAEDTAVYYCARQTNYDFTMDYWGQGTLVTVSSASTKGPSVFPLAPSSGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCEIVMTQSPATLSVSPGERATLSCKASQDVGTSVAWYQQKPGQAPRLLIYWASARHTGIPARFSGSGSGTEFTLTISSLQSEDFAVYYCQQYSSYPLTFGGGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC input.pdb
Selected Chain(s) G (Heavy), H (Light)
Distance of Aggregation 10 Å
FoldX Energy Minimization Yes
pH Calculations Yes
Downloads Download all data (.tar.gz)

Aggrescan4D Profile

Aggregation-prone (score > 0)
Soluble (score < 0)
Buried (score = 0)

Per-Residue A4D Scores

Download CSV
Minimum Score -3.6673
Maximum Score 1.9136
Average Score -0.7311
Total Score -315.1018

Residues with A4D score > 0.0 are highlighted as aggregation-prone.

Index Residue Chain A4D Score Classification
1 E G -1.9805 Soluble
2 V G -1.0511 Soluble
3 Q G -1.3676 Soluble
4 L G 0.0000 Buried
5 V G 0.0185 Aggregation-prone
6 E G 0.0000 Buried
7 S G -0.6105 Soluble
8 G G -0.9929 Soluble
9 G G -0.5555 Soluble
11 G G 0.0143 Aggregation-prone
12 L G 0.1193 Aggregation-prone
13 V G -0.5657 Soluble
14 Q G -1.5323 Soluble
15 P G -1.4575 Soluble
16 G G -1.4367 Soluble
17 G G -1.1254 Soluble
18 S G -1.3349 Soluble
19 L G -1.1325 Soluble
20 R G -2.0212 Soluble
21 L G 0.0000 Buried
22 S G -0.5467 Soluble
23 C G 0.0000 Buried
24 A G -0.4283 Soluble
25 A G 0.0000 Buried
26 S G -0.8714 Soluble
27 G G -1.1706 Soluble
28 F G -0.6613 Soluble
29 T G -0.6422 Soluble
30 F G 0.0000 Buried
35 S G -1.6910 Soluble
36 D G -2.3738 Soluble
37 Y G -1.3646 Soluble
38 Y G -0.5270 Soluble
39 M G 0.0000 Buried
40 Y G 0.0000 Buried
41 W G 0.0000 Buried
42 V G 0.0000 Buried
43 R G 0.0000 Buried
44 Q G -0.7836 Soluble
45 A G -1.1513 Soluble
46 P G -0.9595 Soluble
47 G G -1.4963 Soluble
48 K G -2.2932 Soluble
49 G G -1.5027 Soluble
50 L G 0.0000 Buried
51 E G -1.0651 Soluble
52 W G 0.0000 Buried
53 V G 0.0000 Buried
54 A G 0.0000 Buried
55 Y G 0.0000 Buried
56 I G 0.0000 Buried
57 T G -1.0497 Soluble
58 K G -2.0895 Soluble
59 G G -1.7094 Soluble
62 G G -1.1885 Soluble
63 G G -1.0022 Soluble
64 S G -0.5714 Soluble
65 T G 0.1097 Aggregation-prone
66 Y G 0.3997 Aggregation-prone
67 Y G -0.4725 Soluble
68 P G 0.0000 Buried
69 D G -2.2764 Soluble
70 S G -1.7905 Soluble
71 V G 0.0000 Buried
72 K G -2.5015 Soluble
74 G G -1.8305 Soluble
75 R G -1.5262 Soluble
76 F G 0.0000 Buried
77 T G -0.8152 Soluble
78 I G 0.0000 Buried
79 S G -0.4481 Soluble
80 R G -1.1324 Soluble
81 D G -1.4681 Soluble
82 N G -1.9014 Soluble
83 A G -1.2976 Soluble
84 K G -2.2021 Soluble
85 N G -1.6851 Soluble
86 T G -0.9762 Soluble
87 L G 0.0000 Buried
88 Y G -0.4954 Soluble
89 L G 0.0000 Buried
90 Q G -1.2053 Soluble
91 M G 0.0000 Buried
92 N G -1.5775 Soluble
93 S G -1.3799 Soluble
94 L G 0.0000 Buried
95 R G -2.3454 Soluble
96 A G -1.7385 Soluble
97 E G -2.2317 Soluble
98 D G 0.0000 Buried
99 T G -0.7298 Soluble
100 A G 0.0000 Buried
101 V G 0.1946 Aggregation-prone
102 Y G 0.0000 Buried
103 Y G 0.0000 Buried
104 C G 0.0000 Buried
105 A G 0.0000 Buried
106 R G 0.0000 Buried
107 Q G 0.0000 Buried
108 T G 0.0000 Buried
109 N G -0.9445 Soluble
110 Y G 0.3276 Aggregation-prone
112 D G 0.8816 Aggregation-prone
113 F G 1.9136 Aggregation-prone
114 T G 0.0000 Buried
115 M G 0.0000 Buried
116 D G 0.0000 Buried
117 Y G -0.2058 Soluble
118 W G 0.0000 Buried
119 G G 0.0000 Buried
120 Q G -1.4522 Soluble
121 G G -0.6040 Soluble
122 T G 0.0000 Buried
123 L G 0.2897 Aggregation-prone
124 V G 0.0000 Buried
125 T G 0.0000 Buried
126 V G 0.0000 Buried
127 S G -0.9430 Soluble
128 S G -0.6731 Soluble
129 A G -0.5690 Soluble
130 S G -0.7371 Soluble
131 T G -0.9425 Soluble
132 K G -1.9348 Soluble
133 G G -1.7754 Soluble
134 P G -0.8879 Soluble
135 S G -0.3441 Soluble
136 V G 0.0000 Buried
137 F G -0.6672 Soluble
138 P G -0.9779 Soluble
139 L G 0.0000 Buried
140 A G -1.0992 Soluble
141 P G 0.0000 Buried
142 S G -0.6097 Soluble
143 S G -0.1430 Soluble
144 G G -0.6307 Soluble
145 T G -0.5013 Soluble
146 A G 0.0000 Buried
147 A G 0.0000 Buried
148 L G 0.0000 Buried
149 G G 0.0000 Buried
150 C G 0.0000 Buried
151 L G 0.0000 Buried
152 V G 0.0000 Buried
153 K G 0.0000 Buried
154 D G -0.6633 Soluble
155 Y G 0.0000 Buried
156 F G 0.0000 Buried
157 P G 0.0000 Buried
158 E G -0.3971 Soluble
159 P G -0.7534 Soluble
160 V G -0.8389 Soluble
161 T G -0.7546 Soluble
162 V G -0.5195 Soluble
163 S G -0.3885 Soluble
164 W G 0.0000 Buried
165 N G -0.5862 Soluble
166 S G -0.5454 Soluble
167 G G -0.3883 Soluble
168 A G -0.1429 Soluble
169 L G 0.0580 Aggregation-prone
170 T G -0.1645 Soluble
171 S G -0.2594 Soluble
172 G G -0.4248 Soluble
173 V G 0.0916 Aggregation-prone
174 H G 0.0000 Buried
175 T G 0.0429 Aggregation-prone
176 F G 0.0000 Buried
177 P G -0.1853 Soluble
178 A G 0.3327 Aggregation-prone
179 V G 0.6238 Aggregation-prone
180 L G 1.3282 Aggregation-prone
181 Q G 0.2500 Aggregation-prone
182 S G -0.1510 Soluble
183 S G -0.1760 Soluble
184 G G 0.1048 Aggregation-prone
185 L G 0.0367 Aggregation-prone
186 Y G 0.3944 Aggregation-prone
187 S G 0.0000 Buried
188 L G 0.0000 Buried
189 S G 0.0000 Buried
190 S G 0.0000 Buried
191 V G 0.0000 Buried
192 V G 0.0000 Buried
193 T G -0.2375 Soluble
194 V G 0.0000 Buried
195 P G -0.5765 Soluble
196 S G -0.5537 Soluble
197 S G -0.5997 Soluble
198 S G -0.5867 Soluble
199 L G -0.7811 Soluble
200 G G -0.9410 Soluble
201 T G -0.6725 Soluble
202 Q G -1.1141 Soluble
203 T G -1.0007 Soluble
204 Y G 0.0000 Buried
205 I G -1.0559 Soluble
206 C G 0.0000 Buried
207 N G -1.5501 Soluble
208 V G 0.0000 Buried
209 N G -2.4028 Soluble
210 H G 0.0000 Buried
211 K G -2.8489 Soluble
212 P G -1.7186 Soluble
213 S G -2.0985 Soluble
214 N G -2.7011 Soluble
215 T G -2.2945 Soluble
216 K G -2.8974 Soluble
217 V G -1.6117 Soluble
218 D G -2.5445 Soluble
219 K G -1.8752 Soluble
220 K G -2.2899 Soluble
221 V G 0.0000 Buried
222 E G -2.6924 Soluble
223 P G -1.7175 Soluble
224 K G -1.6051 Soluble
225 S G -0.6295 Soluble
226 C G 0.2191 Aggregation-prone
1 E H -1.3735 Soluble
2 I H -0.5547 Soluble
3 V H 0.8708 Aggregation-prone
4 M H 0.0000 Buried
5 T H -0.4481 Soluble
6 Q H -0.5585 Soluble
7 S H -0.7115 Soluble
8 P H -0.4675 Soluble
9 A H -0.4642 Soluble
10 T H -0.4254 Soluble
11 L H -0.2570 Soluble
12 S H -0.7158 Soluble
13 V H 0.0000 Buried
14 S H -1.8509 Soluble
15 P H -1.9879 Soluble
16 G H -1.9413 Soluble
17 E H -2.7838 Soluble
18 R H -2.8964 Soluble
19 A H 0.0000 Buried
20 T H -0.4868 Soluble
21 L H 0.0000 Buried
22 S H -0.8587 Soluble
23 C H 0.0000 Buried
24 K H -2.1781 Soluble
25 A H 0.0000 Buried
26 S H -1.3046 Soluble
27 Q H -2.4415 Soluble
28 D H -2.9065 Soluble
29 V H 0.0000 Buried
36 G H -1.0900 Soluble
37 T H -0.3759 Soluble
38 S H 0.2913 Aggregation-prone
39 V H 0.0000 Buried
40 A H 0.0000 Buried
41 W H 0.0000 Buried
42 Y H 0.0000 Buried
43 Q H -1.2215 Soluble
44 Q H 0.0000 Buried
45 K H -2.9593 Soluble
46 P H -1.9133 Soluble
47 G H -1.7236 Soluble
48 Q H -2.4854 Soluble
49 A H -1.7234 Soluble
50 P H 0.0000 Buried
51 R H -1.9409 Soluble
52 L H 0.0000 Buried
53 L H 0.0000 Buried
54 I H 0.0000 Buried
55 Y H 0.6798 Aggregation-prone
56 W H 1.1642 Aggregation-prone
57 A H 0.0000 Buried
65 S H -0.2832 Soluble
66 A H -0.3150 Soluble
67 R H -1.1258 Soluble
68 H H 0.0000 Buried
69 T H -0.6031 Soluble
70 G H -0.6876 Soluble
71 I H 0.0000 Buried
72 P H -0.5237 Soluble
74 A H -0.5225 Soluble
75 R H -0.8808 Soluble
76 F H 0.0000 Buried
77 S H -0.6268 Soluble
78 G H -0.4470 Soluble
79 S H -0.5970 Soluble
80 G H -1.0308 Soluble
83 S H -1.2301 Soluble
84 G H -1.8439 Soluble
85 T H -2.4147 Soluble
86 E H -2.9126 Soluble
87 F H 0.0000 Buried
88 T H -0.8685 Soluble
89 L H 0.0000 Buried
90 T H -0.6185 Soluble
91 I H 0.0000 Buried
92 S H -1.5321 Soluble
93 S H -1.8532 Soluble
94 L H 0.0000 Buried
95 Q H -2.0605 Soluble
96 S H -1.7719 Soluble
97 E H -2.4208 Soluble
98 D H 0.0000 Buried
99 F H 0.0000 Buried
100 A H 0.0000 Buried
101 V H -0.8678 Soluble
102 Y H 0.0000 Buried
103 Y H 0.0000 Buried
104 C H 0.0000 Buried
105 Q H 0.0000 Buried
106 Q H 0.0000 Buried
107 Y H 0.0000 Buried
108 S H -0.0848 Soluble
109 S H -0.2020 Soluble
114 Y H 0.0779 Aggregation-prone
115 P H -0.4366 Soluble
116 L H 0.0000 Buried
117 T H -0.0679 Soluble
118 F H 0.0000 Buried
119 G H 0.0000 Buried
120 G H -0.8131 Soluble
121 G H -0.8952 Soluble
122 T H 0.0000 Buried
123 K H -1.3808 Soluble
124 V H 0.0000 Buried
125 E H 0.0000 Buried
126 I H -1.1009 Soluble
127 K H -1.7630 Soluble
128 R H -1.2213 Soluble
129 T H -0.1292 Soluble
130 V H 0.3330 Aggregation-prone
131 A H 0.1534 Aggregation-prone
132 A H -0.0809 Soluble
133 P H 0.0000 Buried
134 S H -0.1124 Soluble
135 V H 0.0000 Buried
136 F H 0.2496 Aggregation-prone
137 I H 0.2330 Aggregation-prone
138 F H 0.0000 Buried
139 P H -0.4605 Soluble
140 P H -0.8498 Soluble
141 S H -1.7411 Soluble
142 D H -2.9876 Soluble
143 E H -3.0076 Soluble
144 Q H 0.0000 Buried
145 L H -2.3149 Soluble
146 K H -2.8591 Soluble
147 S H -1.7505 Soluble
148 G H -1.2948 Soluble
149 T H -0.9771 Soluble
150 A H 0.0000 Buried
151 S H 0.0000 Buried
152 V H 0.0000 Buried
153 V H 0.0000 Buried
154 C H 0.0000 Buried
155 L H 0.0000 Buried
156 L H 0.0000 Buried
157 N H -0.3304 Soluble
158 N H -1.0009 Soluble
159 F H 0.0000 Buried
160 Y H 0.0000 Buried
161 P H -1.8283 Soluble
162 R H -3.1032 Soluble
163 E H -3.2534 Soluble
164 A H -2.2980 Soluble
165 K H -2.3760 Soluble
166 V H -0.9936 Soluble
167 Q H -0.4837 Soluble
168 W H 0.0000 Buried
169 K H -0.5133 Soluble
170 V H 0.0000 Buried
171 D H -1.9838 Soluble
172 N H -1.5165 Soluble
173 A H -0.2914 Soluble
174 L H 0.6886 Aggregation-prone
175 Q H -0.4106 Soluble
176 S H -0.7589 Soluble
177 G H -1.3714 Soluble
178 N H -1.7570 Soluble
179 S H -1.5746 Soluble
180 Q H -1.6029 Soluble
181 E H -1.5596 Soluble
182 S H -0.7267 Soluble
183 V H -0.6964 Soluble
184 T H 0.0000 Buried
185 E H -2.4304 Soluble
186 Q H -1.9955 Soluble
187 D H -2.0402 Soluble
188 S H -2.0862 Soluble
189 K H -2.4630 Soluble
190 D H -2.1200 Soluble
191 S H -1.9251 Soluble
192 T H 0.0000 Buried
193 Y H 0.0000 Buried
194 S H 0.0000 Buried
195 L H 0.0000 Buried
196 S H 0.0000 Buried
197 S H 0.0000 Buried
198 T H -0.7448 Soluble
199 L H 0.0000 Buried
200 T H -0.6883 Soluble
201 L H -0.8100 Soluble
202 S H -1.2375 Soluble
203 K H -2.0793 Soluble
204 A H -1.8007 Soluble
205 D H -2.2514 Soluble
206 Y H 0.0000 Buried
207 E H -3.6673 Soluble
208 K H -3.6515 Soluble
209 H H -3.0627 Soluble
210 K H -3.3608 Soluble
211 V H -1.6659 Soluble
212 Y H 0.0000 Buried
213 A H 0.0000 Buried
214 C H 0.0000 Buried
215 E H -0.6052 Soluble
216 V H 0.0000 Buried
217 T H -1.1308 Soluble
218 H H 0.0000 Buried
219 Q H -1.5857 Soluble
220 G H -0.4129 Soluble
221 L H -0.2376 Soluble
222 S H -0.4356 Soluble
223 S H -0.3707 Soluble
224 P H -0.4220 Soluble
225 V H 0.2489 Aggregation-prone
226 T H -0.2294 Soluble
227 K H -0.3649 Soluble
228 S H -0.3686 Soluble
229 F H -0.7169 Soluble
230 N H -1.7692 Soluble
231 R H -2.5530 Soluble
232 G H -2.1144 Soluble
233 E H -2.0333 Soluble
234 C H -0.4572 Soluble

3D Structure — colored by A4D score

Sequence - click residue to focus in viewer  |  colored by A4D score
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Color Legend (B-factor = A4D Score)
Score > 1.5 — highly aggregation-prone
Score 0.5–1.5 — aggregation-prone
Score ≈ 0 — buried
Score −1 to −0.5 — soluble
Score < −2.5 — highly soluble
pH Structure
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A4D Score Threshold
Highlight residues > threshold in the sequence panel
CDR Regions
HCDR1
HCDR2
HCDR3
LCDR1
LCDR2
LCDR3
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pH-Dependent Aggregation Profiles

A4D scores calculated across 11 pH conditions (4.0–9.0, step 0.5). Click a row to view the structure at that pH. The input structure is globular — max score is recommended for pH analysis.

pH Avg A4D Score Max A4D Score Downloads
4.0 -0.707 4.5348 CSV PDB
4.5 -0.7536 4.511 CSV PDB
5.0 -0.8078 4.4861 CSV PDB
5.5 -0.859 4.4609 CSV PDB
6.0 -0.8951 4.4356 CSV PDB
6.5 -0.9057 4.4104 CSV PDB
7.0 -0.8902 4.3856 CSV PDB
7.5 -0.8575 4.3619 CSV PDB
8.0 -0.8159 4.3411 CSV PDB
8.5 -0.768 4.326 CSV PDB
9.0 -0.7141 4.3175 CSV PDB
Average A4D Score vs pH
Max A4D Score vs pH