Diridavumab / 8dim

A4DAB087_8dim_H_I | Source PDB: 8dim | Chains: H, I | Done
100
Yes
10 Å
Yes
Avg A4D Score
-0.4766
Max Score
3.0143
Min Score
-3.119
Total Score
-108.19
Score CDR
-0.2274
Score non-CDR
-0.5525

Calculation Parameters

Chain Sequence(s) VQLVESGAEVKKPGSSVKVSCKASGGPFRSYAISWVRQAPGQGPEWMGGIIPIFGTTKYAPKFQGRVTITADDFAGTVYMELSSLRSEDTAMYYCAKHMGYQVRETMDVWGKGTTVTVVLTQPPSVSAAPGQKVTISCSGSSSNIGNDYVSWYQQLPGTAPKLLIYDNNKRPSGIPDRFSGSKSGTSATLGITGLQTGDEANYYCATWDRRPTAYVVFGGGTKLTVL input.pdb
Selected Chain(s) H (Heavy), I (Light)
Distance of Aggregation 10 Å
FoldX Energy Minimization Yes
pH Calculations Yes
Downloads Download all data (.tar.gz)

Aggrescan4D Profile

Aggregation-prone (score > 0)
Soluble (score < 0)
Buried (score = 0)

Per-Residue A4D Scores

Download CSV
Minimum Score -3.119
Maximum Score 3.0143
Average Score -0.4766
Total Score -108.1879

Residues with A4D score > 0.0 are highlighted as aggregation-prone.

Index Residue Chain A4D Score Classification
2 V H 1.0457 Aggregation-prone
3 Q H -0.6034 Soluble
4 L H 0.0000 Buried
5 V H -0.5988 Soluble
6 E H -0.6472 Soluble
7 S H -0.7085 Soluble
8 G H -0.5800 Soluble
9 A H -0.0019 Soluble
11 E H 0.0914 Aggregation-prone
12 V H 1.0916 Aggregation-prone
13 K H -0.8920 Soluble
14 K H -2.0042 Soluble
15 P H -2.0931 Soluble
16 G H -1.6082 Soluble
17 S H -1.3147 Soluble
18 S H -1.4777 Soluble
19 V H 0.0000 Buried
20 K H -2.0529 Soluble
21 V H 0.0000 Buried
22 S H -0.6747 Soluble
23 C H 0.0000 Buried
24 K H -1.2851 Soluble
25 A H -0.5144 Soluble
26 S H -0.5884 Soluble
27 G H -0.4871 Soluble
28 G H 0.0012 Aggregation-prone
29 P H 0.3813 Aggregation-prone
30 F H 1.7344 Aggregation-prone
35 R H 0.6167 Aggregation-prone
36 S H 0.7753 Aggregation-prone
37 Y H 0.8422 Aggregation-prone
38 A H 0.0000 Buried
39 I H 0.0000 Buried
40 S H 0.0000 Buried
41 W H 0.0000 Buried
42 V H 0.0000 Buried
43 R H -0.4667 Soluble
44 Q H -0.7229 Soluble
45 A H -1.0500 Soluble
46 P H -0.8702 Soluble
47 G H -1.2322 Soluble
48 Q H -1.7629 Soluble
49 G H -1.2291 Soluble
50 P H 0.0000 Buried
51 E H -0.7851 Soluble
52 W H 0.0000 Buried
53 M H 0.0000 Buried
54 G H 0.0000 Buried
55 G H 0.0000 Buried
56 I H 0.0000 Buried
57 I H 0.0000 Buried
58 P H 0.0000 Buried
59 I H 3.0143 Aggregation-prone
62 F H 2.8479 Aggregation-prone
63 G H 1.0956 Aggregation-prone
64 T H 0.3484 Aggregation-prone
65 T H -0.2286 Soluble
66 K H -0.8313 Soluble
67 Y H -0.8331 Soluble
68 A H 0.0000 Buried
69 P H -1.6220 Soluble
70 K H -2.2724 Soluble
71 F H 0.0000 Buried
72 Q H -2.1336 Soluble
74 G H -1.4499 Soluble
75 R H -1.2032 Soluble
76 V H 0.0000 Buried
77 T H -0.8085 Soluble
78 I H 0.0000 Buried
79 T H -0.3262 Soluble
80 A H -0.2860 Soluble
81 D H -0.3121 Soluble
82 D H 0.0983 Aggregation-prone
83 F H 1.5022 Aggregation-prone
84 A H 0.4089 Aggregation-prone
85 G H -0.1590 Soluble
86 T H 0.0000 Buried
87 V H 0.0000 Buried
88 Y H -0.4601 Soluble
89 M H 0.0000 Buried
90 E H -1.5004 Soluble
91 L H 0.0000 Buried
92 S H -1.0740 Soluble
93 S H -0.9701 Soluble
94 L H 0.0000 Buried
95 R H -2.6062 Soluble
96 S H -1.9222 Soluble
97 E H -2.2594 Soluble
98 D H 0.0000 Buried
99 T H -0.5832 Soluble
100 A H 0.0000 Buried
101 M H -0.0864 Soluble
102 Y H 0.0000 Buried
103 Y H 0.0000 Buried
104 C H 0.0000 Buried
105 A H 0.0000 Buried
106 K H 0.2469 Aggregation-prone
107 H H 0.0000 Buried
108 M H 0.5430 Aggregation-prone
109 G H 0.3995 Aggregation-prone
110 Y H 1.2254 Aggregation-prone
111 Q H -0.3889 Soluble
112A V H 0.0000 Buried
112 R H -0.3589 Soluble
113 E H 0.0000 Buried
114 T H -0.1163 Soluble
115 M H 0.0000 Buried
116 D H -0.4191 Soluble
117 V H 0.1630 Aggregation-prone
118 W H -0.3495 Soluble
119 G H 0.0000 Buried
120 K H -1.7612 Soluble
121 G H -0.8523 Soluble
122 T H 0.0000 Buried
123 T H 0.1137 Aggregation-prone
124 V H 0.0000 Buried
125 T H 0.1088 Aggregation-prone
126 V H -0.2734 Soluble
3 V I 1.5452 Aggregation-prone
4 L I 0.0000 Buried
5 T I 0.0059 Aggregation-prone
6 Q I 0.0000 Buried
7 P I -0.4465 Soluble
8 P I -0.6173 Soluble
9 S I -0.6034 Soluble
11 V I -0.1038 Soluble
12 S I 0.0462 Aggregation-prone
13 A I -0.1728 Soluble
14 A I -0.3154 Soluble
15 P I -1.0291 Soluble
16 G I -1.7911 Soluble
17 Q I -2.3523 Soluble
18 K I -2.4549 Soluble
19 V I 0.0000 Buried
20 T I -0.4659 Soluble
21 I I 0.0000 Buried
22 S I -0.3461 Soluble
23 C I 0.0000 Buried
24 S I -0.2273 Soluble
25 G I -0.0198 Soluble
26 S I -0.3739 Soluble
27 S I -0.9021 Soluble
28 S I -1.3197 Soluble
29 N I 0.0000 Buried
30 I I 0.0000 Buried
35 G I -1.1897 Soluble
36 N I -1.7100 Soluble
37 D I -0.9390 Soluble
38 Y I -0.0160 Soluble
39 V I 0.0000 Buried
40 S I 0.0000 Buried
41 W I 0.0000 Buried
42 Y I 0.0000 Buried
43 Q I 0.0000 Buried
44 Q I 0.0000 Buried
45 L I -0.3144 Soluble
46 P I -0.4408 Soluble
47 G I -0.7092 Soluble
48 T I -0.7329 Soluble
49 A I -0.6925 Soluble
50 P I 0.0000 Buried
51 K I -1.1325 Soluble
52 L I 0.0000 Buried
53 L I 0.0000 Buried
54 I I 0.0000 Buried
55 Y I -1.1214 Soluble
56 D I -1.5930 Soluble
57 N I -1.4229 Soluble
65 N I -2.1168 Soluble
66 K I -2.5267 Soluble
67 R I -2.3426 Soluble
68 P I -1.0374 Soluble
69 S I -0.7821 Soluble
70 G I -0.8733 Soluble
71 I I -0.9768 Soluble
72 P I -1.3259 Soluble
74 D I -2.2016 Soluble
75 R I -1.4994 Soluble
76 F I 0.0000 Buried
77 S I -1.2274 Soluble
78 G I -1.1603 Soluble
79 S I -1.2104 Soluble
80 K I -1.1310 Soluble
83 S I -0.8258 Soluble
84 G I -1.0512 Soluble
85 T I -0.9291 Soluble
86 S I -0.6925 Soluble
87 A I 0.0000 Buried
88 T I -0.5382 Soluble
89 L I 0.0000 Buried
90 G I -0.5991 Soluble
91 I I 0.0000 Buried
92 T I -1.8061 Soluble
93 G I -1.5974 Soluble
94 L I 0.0000 Buried
95 Q I -1.6604 Soluble
96 T I -0.8473 Soluble
97 G I -1.0299 Soluble
98 D I 0.0000 Buried
99 E I -1.0531 Soluble
100 A I 0.0000 Buried
101 N I -0.8657 Soluble
102 Y I 0.0000 Buried
103 Y I 0.0000 Buried
104 C I 0.0000 Buried
105 A I 0.0000 Buried
106 T I 0.0000 Buried
107 W I 0.0000 Buried
108 D I -1.5593 Soluble
109 R I -3.1190 Soluble
110 R I -2.9413 Soluble
112 P I -1.6655 Soluble
113 T I -1.3710 Soluble
114 A I -1.6327 Soluble
115 Y I -0.7883 Soluble
116 V I 0.0000 Buried
117 V I 0.0000 Buried
118 F I 0.0000 Buried
119 G I -0.0395 Soluble
120 G I -0.5153 Soluble
121 G I -0.9316 Soluble
122 T I 0.0000 Buried
123 K I -1.1370 Soluble
124 L I 0.0000 Buried
125 T I -0.1015 Soluble
126 V I 0.1476 Aggregation-prone
127 L I 1.3356 Aggregation-prone

3D Structure — colored by A4D score

Sequence - click residue to focus in viewer  |  colored by A4D score
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Downloads
Color Legend (B-factor = A4D Score)
Score > 1.5 — highly aggregation-prone
Score 0.5–1.5 — aggregation-prone
Score ≈ 0 — buried
Score −1 to −0.5 — soluble
Score < −2.5 — highly soluble
pH Structure
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A4D Score Threshold
Highlight residues > threshold in the sequence panel
CDR Regions
HCDR1
HCDR2
HCDR3
LCDR1
LCDR2
LCDR3
Display Options

pH-Dependent Aggregation Profiles

A4D scores calculated across 11 pH conditions (4.0–9.0, step 0.5). Click a row to view the structure at that pH. The input structure is globular — max score is recommended for pH analysis.

pH Avg A4D Score Max A4D Score Downloads
4.0 -0.3544 5.8867 CSV PDB
4.5 -0.3755 5.7946 CSV PDB
5.0 -0.4002 5.7861 CSV PDB
5.5 -0.4226 5.7861 CSV PDB
6.0 -0.4355 5.7861 CSV PDB
6.5 -0.4324 5.7861 CSV PDB
7.0 -0.4125 5.7861 CSV PDB
7.5 -0.3815 5.7861 CSV PDB
8.0 -0.3446 5.786 CSV PDB
8.5 -0.3037 5.7859 CSV PDB
9.0 -0.259 5.7856 CSV PDB
Average A4D Score vs pH
Max A4D Score vs pH