Zinlirvimab / 7ugp

A4DAB308_7ugp_O_R | Source PDB: 7ugp | Chains: O, R | Done
100
Yes
10 Å
Yes
Avg A4D Score
-0.5657
Max Score
2.9069
Min Score
-3.6112
Total Score
-134.08
Score CDR
-0.4196
Score non-CDR
-0.6175

Calculation Parameters

Chain Sequence(s) QVQLQESGPGLVKPSETLSVTCSVSGDSMNNYYWTWIRQSPGKGLEWIGYISDRESATYNPSLNSRVVISRDTSKNQLSLKLNSVTPADTAVYYCATARRGQRIYGVVSFGEFFYYYSMDVWGKGTTVTVSSALSVALGETARISCGRQALGSRAVQWYQHRPGQAPILLIYNNQDRPSGIPERFSGTPDINFGTRATLTISGVEAGDEADYYCHMWDSRSGFSWSFGGATRLTVLG input.pdb
Selected Chain(s) O (Heavy), R (Light)
Distance of Aggregation 10 Å
FoldX Energy Minimization Yes
pH Calculations Yes
Downloads Download all data (.tar.gz)

Aggrescan4D Profile

Aggregation-prone (score > 0)
Soluble (score < 0)
Buried (score = 0)

Per-Residue A4D Scores

Download CSV
Minimum Score -3.6112
Maximum Score 2.9069
Average Score -0.5657
Total Score -134.0804

Residues with A4D score > 0.0 are highlighted as aggregation-prone.

Index Residue Chain A4D Score Classification
1 Q O -1.8032 Soluble
2 V O -1.4887 Soluble
3 Q O -2.0189 Soluble
4 L O 0.0000 Buried
5 Q O -2.0090 Soluble
6 E O -1.4935 Soluble
7 S O -0.7679 Soluble
8 G O -0.3717 Soluble
9 P O 0.0284 Aggregation-prone
11 G O 0.5274 Aggregation-prone
12 L O 1.1306 Aggregation-prone
13 V O 0.0000 Buried
14 K O -1.5108 Soluble
15 P O -1.2996 Soluble
16 S O -1.1947 Soluble
17 E O -1.5031 Soluble
18 T O -1.0548 Soluble
19 L O 0.0000 Buried
20 S O -0.6187 Soluble
21 V O 0.0000 Buried
22 T O -0.6820 Soluble
23 C O 0.0000 Buried
24 S O -1.3023 Soluble
25 V O 0.0000 Buried
26 S O -1.3423 Soluble
27 G O -1.6991 Soluble
28 D O -2.2575 Soluble
29 S O -1.1740 Soluble
30 M O -0.5949 Soluble
35 N O -1.9042 Soluble
36 N O -2.3444 Soluble
37 Y O -1.2861 Soluble
38 Y O -0.9284 Soluble
39 W O 0.0000 Buried
40 T O 0.0000 Buried
41 W O 0.0000 Buried
42 I O 0.0000 Buried
43 R O 0.0000 Buried
44 Q O -0.6224 Soluble
45 S O 0.0000 Buried
46 P O -0.9142 Soluble
47 G O -1.2603 Soluble
48 K O -1.6795 Soluble
49 G O -1.1940 Soluble
50 L O 0.0000 Buried
51 E O 0.0000 Buried
52 W O 0.0000 Buried
53 I O 0.0000 Buried
54 G O 0.0000 Buried
55 Y O 0.2866 Aggregation-prone
56 I O 0.0000 Buried
57 S O -2.2944 Soluble
58 D O -3.5756 Soluble
59 R O -3.6112 Soluble
63 E O -3.4360 Soluble
64 S O -1.9093 Soluble
65 A O -0.6890 Soluble
66 T O 0.0424 Aggregation-prone
67 Y O 0.1140 Aggregation-prone
68 N O 0.0000 Buried
69 P O -0.8107 Soluble
70 S O -0.8058 Soluble
71 L O -0.9969 Soluble
72 N O -1.8439 Soluble
74 S O -1.3453 Soluble
75 R O -1.9880 Soluble
76 V O 0.0000 Buried
77 V O 1.1558 Aggregation-prone
78 I O 0.8420 Aggregation-prone
79 S O -0.4050 Soluble
80 R O -1.8825 Soluble
81 D O -2.0822 Soluble
82 T O -1.5414 Soluble
83 S O -1.7582 Soluble
84 K O -2.6402 Soluble
85 N O -2.3352 Soluble
86 Q O -1.7352 Soluble
87 L O 0.0000 Buried
88 S O -0.3411 Soluble
89 L O 0.0000 Buried
90 K O -0.7411 Soluble
91 L O 0.0000 Buried
92 N O -1.9804 Soluble
93 S O -1.2955 Soluble
94 V O -0.9523 Soluble
95 T O -0.4980 Soluble
96 P O -0.4551 Soluble
97 A O -0.3590 Soluble
98 D O -0.3419 Soluble
99 T O 0.0247 Aggregation-prone
100 A O 0.0000 Buried
101 V O -0.0741 Soluble
102 Y O 0.0000 Buried
103 Y O 0.0000 Buried
104 C O 0.0000 Buried
105 A O 0.0000 Buried
106 T O 0.0000 Buried
107 A O 0.0000 Buried
108 R O -2.2640 Soluble
109 R O -2.0327 Soluble
110 G O -1.4491 Soluble
111 Q O -1.0913 Soluble
111A R O -0.1187 Soluble
111B I O 1.5298 Aggregation-prone
111C Y O 1.3486 Aggregation-prone
111D G O 1.4412 Aggregation-prone
111E V O 2.5665 Aggregation-prone
111F V O 2.9069 Aggregation-prone
112G S O 1.7282 Aggregation-prone
112F F O 2.3294 Aggregation-prone
112E G O 1.2956 Aggregation-prone
112D E O 1.1912 Aggregation-prone
112C F O 1.3403 Aggregation-prone
112B F O 0.4053 Aggregation-prone
112A Y O -0.1381 Soluble
112 Y O 0.0000 Buried
113 Y O 0.0000 Buried
114 S O 0.0000 Buried
115 M O 0.0000 Buried
116 D O -0.3995 Soluble
117 V O -0.0593 Soluble
118 W O -0.1884 Soluble
119 G O -1.3529 Soluble
120 K O -2.3788 Soluble
121 G O 0.0000 Buried
122 T O -0.6344 Soluble
123 T O 0.1602 Aggregation-prone
124 V O 0.0000 Buried
125 T O 0.2842 Aggregation-prone
126 V O 0.0432 Aggregation-prone
127 S O -0.2418 Soluble
128 S O -0.5275 Soluble
129 A O -0.4444 Soluble
11 L R 0.6432 Aggregation-prone
12 S R 0.6287 Aggregation-prone
13 V R 0.3046 Aggregation-prone
14 A R 0.3539 Aggregation-prone
15 L R 0.5624 Aggregation-prone
16 G R -1.0341 Soluble
17 E R -1.8946 Soluble
18 T R -1.4932 Soluble
19 A R 0.0000 Buried
20 R R -1.9811 Soluble
21 I R 0.0000 Buried
22 S R -0.7239 Soluble
23 C R -1.0569 Soluble
24 G R -1.1674 Soluble
25 R R -1.4538 Soluble
26 Q R -1.7860 Soluble
27 A R -1.1045 Soluble
28 L R -0.4352 Soluble
29 G R -0.3057 Soluble
36 S R 0.3838 Aggregation-prone
37 R R 0.0000 Buried
38 A R 0.0000 Buried
39 V R 0.0000 Buried
40 Q R 0.0000 Buried
41 W R 0.0000 Buried
42 Y R 0.0000 Buried
43 Q R 0.0000 Buried
44 H R 0.0000 Buried
45 R R -1.2097 Soluble
46 P R -1.1936 Soluble
47 G R -1.4336 Soluble
48 Q R -1.8871 Soluble
49 A R -0.9992 Soluble
50 P R 0.0000 Buried
51 I R 0.4649 Aggregation-prone
52 L R 0.0000 Buried
53 L R 0.0000 Buried
54 I R 0.0000 Buried
55 Y R -1.4287 Soluble
56 N R -1.6354 Soluble
57 N R 0.0000 Buried
65 Q R -2.3708 Soluble
66 D R -2.6141 Soluble
67 R R -3.0221 Soluble
68 P R -1.4174 Soluble
69 S R -0.9945 Soluble
70 G R -0.6767 Soluble
71 I R -0.9496 Soluble
72 P R -1.4751 Soluble
74 E R -2.3187 Soluble
75 R R -1.4011 Soluble
76 F R 0.0000 Buried
77 S R -1.5575 Soluble
78 G R -1.1475 Soluble
79 T R -0.4966 Soluble
80 P R -0.4412 Soluble
81 D R 0.2127 Aggregation-prone
81A I R 1.6114 Aggregation-prone
82 N R 0.2343 Aggregation-prone
83 F R 0.9584 Aggregation-prone
84 G R -0.1991 Soluble
85 T R -0.7025 Soluble
86 R R -2.0037 Soluble
87 A R 0.0000 Buried
88 T R 0.0000 Buried
89 L R 0.0000 Buried
90 T R -1.2224 Soluble
91 I R 0.0000 Buried
92 S R -1.5580 Soluble
93 G R -1.1939 Soluble
94 V R 0.0000 Buried
95 E R -1.8630 Soluble
96 A R -0.8436 Soluble
97 G R -1.1365 Soluble
98 D R -1.3232 Soluble
99 E R -1.5398 Soluble
100 A R 0.0000 Buried
101 D R -1.2552 Soluble
102 Y R 0.0000 Buried
103 Y R 0.0000 Buried
104 C R 0.0000 Buried
105 H R 0.0000 Buried
106 M R 0.0000 Buried
107 W R 0.0000 Buried
108 D R 0.0000 Buried
109 S R -0.7760 Soluble
110 R R -1.8623 Soluble
112 S R -0.9584 Soluble
113 G R -0.5313 Soluble
114 F R 0.5093 Aggregation-prone
115 S R 0.2719 Aggregation-prone
116 W R 0.2150 Aggregation-prone
117 S R -0.2427 Soluble
118 F R 0.0000 Buried
119 G R -0.8997 Soluble
120 G R -1.0879 Soluble
121 A R -0.8584 Soluble
122 T R -0.8370 Soluble
123 R R -1.7129 Soluble
124 L R 0.0000 Buried
125 T R -0.0320 Soluble
126 V R 0.0000 Buried
127 L R 1.5495 Aggregation-prone
128 G R 0.4048 Aggregation-prone

3D Structure — colored by A4D score

Sequence - click residue to focus in viewer  |  colored by A4D score
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Downloads
Color Legend (B-factor = A4D Score)
Score > 1.5 — highly aggregation-prone
Score 0.5–1.5 — aggregation-prone
Score ≈ 0 — buried
Score −1 to −0.5 — soluble
Score < −2.5 — highly soluble
pH Structure
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A4D Score Threshold
Highlight residues > threshold in the sequence panel
CDR Regions
HCDR1
HCDR2
HCDR3
LCDR1
LCDR2
LCDR3
Display Options

pH-Dependent Aggregation Profiles

A4D scores calculated across 11 pH conditions (4.0–9.0, step 0.5). Click a row to view the structure at that pH. The input structure is globular — max score is recommended for pH analysis.

pH Avg A4D Score Max A4D Score Downloads
4.0 -0.4501 4.5387 CSV PDB
4.5 -0.4849 4.508 CSV PDB
5.0 -0.5276 4.4655 CSV PDB
5.5 -0.5706 4.4184 CSV PDB
6.0 -0.6065 4.374 CSV PDB
6.5 -0.6301 4.3397 CSV PDB
7.0 -0.641 4.3198 CSV PDB
7.5 -0.6428 4.3111 CSV PDB
8.0 -0.6392 4.308 CSV PDB
8.5 -0.6313 4.307 CSV PDB
9.0 -0.6191 4.3066 CSV PDB
Average A4D Score vs pH
Max A4D Score vs pH