Zinlirvimab / 7ugp

A4DAB308_7ugp_M_P | Source PDB: 7ugp | Chains: M, P | Done
100
Yes
10 Å
Yes
Avg A4D Score
-0.511
Max Score
3.0069
Min Score
-3.6453
Total Score
-121.1
Score CDR
-0.327
Score non-CDR
-0.5762

Calculation Parameters

Chain Sequence(s) QVQLQESGPGLVKPSETLSVTCSVSGDSMNNYYWTWIRQSPGKGLEWIGYISDRESATYNPSLNSRVVISRDTSKNQLSLKLNSVTPADTAVYYCATARRGQRIYGVVSFGEFFYYYSMDVWGKGTTVTVSSALSVALGETARISCGRQALGSRAVQWYQHRPGQAPILLIYNNQDRPSGIPERFSGTPDINFGTRATLTISGVEAGDEADYYCHMWDSRSGFSWSFGGATRLTVLG input.pdb
Selected Chain(s) M (Heavy), P (Light)
Distance of Aggregation 10 Å
FoldX Energy Minimization Yes
pH Calculations Yes
Downloads Download all data (.tar.gz)

Aggrescan4D Profile

Aggregation-prone (score > 0)
Soluble (score < 0)
Buried (score = 0)

Per-Residue A4D Scores

Download CSV
Minimum Score -3.6453
Maximum Score 3.0069
Average Score -0.511
Total Score -121.0987

Residues with A4D score > 0.0 are highlighted as aggregation-prone.

Index Residue Chain A4D Score Classification
1 Q M -1.8537 Soluble
2 V M -1.5037 Soluble
3 Q M -1.8740 Soluble
4 L M -1.4434 Soluble
5 Q M -1.7262 Soluble
6 E M -1.2423 Soluble
7 S M -0.7043 Soluble
8 G M -0.3896 Soluble
9 P M 0.0498 Aggregation-prone
11 G M 0.5148 Aggregation-prone
12 L M 1.2452 Aggregation-prone
13 V M 0.0000 Buried
14 K M -0.8789 Soluble
15 P M -1.2082 Soluble
16 S M -1.2854 Soluble
17 E M -1.8104 Soluble
18 T M -1.2637 Soluble
19 L M 0.0000 Buried
20 S M -0.6909 Soluble
21 V M 0.0000 Buried
22 T M -0.6222 Soluble
23 C M 0.0000 Buried
24 S M -1.2701 Soluble
25 V M 0.0000 Buried
26 S M -1.4038 Soluble
27 G M -1.7552 Soluble
28 D M -2.2469 Soluble
29 S M -1.2676 Soluble
30 M M -0.5434 Soluble
35 N M -1.8402 Soluble
36 N M -2.1485 Soluble
37 Y M -1.0332 Soluble
38 Y M -0.8427 Soluble
39 W M 0.0000 Buried
40 T M 0.0000 Buried
41 W M 0.0000 Buried
42 I M 0.0000 Buried
43 R M 0.0000 Buried
44 Q M -0.7381 Soluble
45 S M 0.0000 Buried
46 P M -1.0077 Soluble
47 G M -1.4254 Soluble
48 K M -1.9830 Soluble
49 G M -1.4121 Soluble
50 L M 0.0000 Buried
51 E M 0.0000 Buried
52 W M 0.0000 Buried
53 I M 0.0000 Buried
54 G M 0.0000 Buried
55 Y M 0.0763 Aggregation-prone
56 I M 0.0000 Buried
57 S M -2.3400 Soluble
58 D M -3.6453 Soluble
59 R M -3.6230 Soluble
63 E M -3.3966 Soluble
64 S M -1.8141 Soluble
65 A M -0.6016 Soluble
66 T M -0.1442 Soluble
67 Y M 0.2387 Aggregation-prone
68 N M 0.0000 Buried
69 P M -0.7530 Soluble
70 S M -0.7936 Soluble
71 L M 0.0000 Buried
72 N M -1.6294 Soluble
74 S M -0.9248 Soluble
75 R M -1.1277 Soluble
76 V M 0.0000 Buried
77 V M 1.3176 Aggregation-prone
78 I M 0.7933 Aggregation-prone
79 S M -0.4391 Soluble
80 R M -1.8384 Soluble
81 D M -2.1310 Soluble
82 T M -1.6607 Soluble
83 S M -1.8224 Soluble
84 K M -2.7545 Soluble
85 N M -2.5696 Soluble
86 Q M -1.8158 Soluble
87 L M 0.0000 Buried
88 S M -0.3425 Soluble
89 L M 0.0000 Buried
90 K M -0.7804 Soluble
91 L M 0.0000 Buried
92 N M -1.7916 Soluble
93 S M -1.2919 Soluble
94 V M -0.8897 Soluble
95 T M -0.4294 Soluble
96 P M -0.3751 Soluble
97 A M -0.3386 Soluble
98 D M 0.0000 Buried
99 T M 0.0659 Aggregation-prone
100 A M 0.0000 Buried
101 V M -0.1123 Soluble
102 Y M 0.0000 Buried
103 Y M 0.0000 Buried
104 C M 0.0000 Buried
105 A M 0.0000 Buried
106 T M 0.0000 Buried
107 A M 0.0000 Buried
108 R M -1.9589 Soluble
109 R M -1.6374 Soluble
110 G M -1.0748 Soluble
111 Q M -0.5201 Soluble
111A R M 0.4240 Aggregation-prone
111B I M 2.2326 Aggregation-prone
111C Y M 1.7228 Aggregation-prone
111D G M 1.6591 Aggregation-prone
111E V M 2.6231 Aggregation-prone
111F V M 3.0069 Aggregation-prone
112G S M 1.7070 Aggregation-prone
112F F M 2.3730 Aggregation-prone
112E G M 1.4047 Aggregation-prone
112D E M 1.4423 Aggregation-prone
112C F M 1.7653 Aggregation-prone
112B F M 0.5945 Aggregation-prone
112A Y M 0.1151 Aggregation-prone
112 Y M 0.0000 Buried
113 Y M 0.0000 Buried
114 S M 0.0000 Buried
115 M M 0.0000 Buried
116 D M -0.6124 Soluble
117 V M -0.1339 Soluble
118 W M -0.2232 Soluble
119 G M -1.2587 Soluble
120 K M -2.3168 Soluble
121 G M 0.0000 Buried
122 T M -0.6247 Soluble
123 T M -0.0317 Soluble
124 V M 0.0000 Buried
125 T M 0.2628 Aggregation-prone
126 V M 0.0000 Buried
127 S M -0.0445 Soluble
128 S M -0.3320 Soluble
129 A M -0.2362 Soluble
11 L P 0.7020 Aggregation-prone
12 S P 0.6527 Aggregation-prone
13 V P 0.2837 Aggregation-prone
14 A P 0.3737 Aggregation-prone
15 L P 0.6066 Aggregation-prone
16 G P -0.9868 Soluble
17 E P -1.8879 Soluble
18 T P -1.4907 Soluble
19 A P 0.0000 Buried
20 R P -1.9597 Soluble
21 I P 0.0000 Buried
22 S P -0.7435 Soluble
23 C P -1.0984 Soluble
24 G P -1.2263 Soluble
25 R P -1.4976 Soluble
26 Q P -1.8191 Soluble
27 A P -1.1747 Soluble
28 L P -0.5364 Soluble
29 G P -0.3372 Soluble
36 S P 0.5166 Aggregation-prone
37 R P 0.0000 Buried
38 A P 0.0000 Buried
39 V P 0.0000 Buried
40 Q P 0.0000 Buried
41 W P 0.0000 Buried
42 Y P 0.0000 Buried
43 Q P 0.0000 Buried
44 H P 0.0000 Buried
45 R P -1.5762 Soluble
46 P P -1.3539 Soluble
47 G P -1.5597 Soluble
48 Q P -2.0579 Soluble
49 A P -1.1485 Soluble
50 P P 0.0000 Buried
51 I P 0.3267 Aggregation-prone
52 L P 0.0000 Buried
53 L P 0.0000 Buried
54 I P 0.0000 Buried
55 Y P -0.8422 Soluble
56 N P -1.2368 Soluble
57 N P 0.0000 Buried
65 Q P -2.0214 Soluble
66 D P -2.0290 Soluble
67 R P -1.6376 Soluble
68 P P -0.6975 Soluble
69 S P -0.5872 Soluble
70 G P -0.4676 Soluble
71 I P -0.5830 Soluble
72 P P -1.2629 Soluble
74 E P -2.1269 Soluble
75 R P -1.4142 Soluble
76 F P 0.0000 Buried
77 S P -1.3715 Soluble
78 G P -1.0390 Soluble
79 T P -0.5403 Soluble
80 P P -0.4174 Soluble
81 D P 0.2779 Aggregation-prone
81A I P 1.7067 Aggregation-prone
82 N P 0.3220 Aggregation-prone
83 F P 1.1081 Aggregation-prone
84 G P -0.1304 Soluble
85 T P -0.6169 Soluble
86 R P -1.9602 Soluble
87 A P 0.0000 Buried
88 T P 0.0000 Buried
89 L P 0.0000 Buried
90 T P -1.2025 Soluble
91 I P 0.0000 Buried
92 S P -1.5272 Soluble
93 G P -1.1575 Soluble
94 V P 0.0000 Buried
95 E P -1.5189 Soluble
96 A P -0.7499 Soluble
97 G P -1.0910 Soluble
98 D P -1.3315 Soluble
99 E P -1.6116 Soluble
100 A P 0.0000 Buried
101 D P 0.0000 Buried
102 Y P 0.0000 Buried
103 Y P 0.0000 Buried
104 C P 0.0000 Buried
105 H P 0.0000 Buried
106 M P 0.0000 Buried
107 W P 0.0000 Buried
108 D P 0.0000 Buried
109 S P -0.7478 Soluble
110 R P -1.8850 Soluble
112 S P -0.9589 Soluble
113 G P -0.4845 Soluble
114 F P 0.6251 Aggregation-prone
115 S P 0.0000 Buried
116 W P 0.2076 Aggregation-prone
117 S P -0.2733 Soluble
118 F P 0.0000 Buried
119 G P -1.0001 Soluble
120 G P -1.1519 Soluble
121 A P -1.0237 Soluble
122 T P -0.8114 Soluble
123 R P -1.6473 Soluble
124 L P 0.0000 Buried
125 T P -0.0398 Soluble
126 V P 0.0000 Buried
127 L P 1.3862 Aggregation-prone
128 G P 0.4176 Aggregation-prone

3D Structure — colored by A4D score

Sequence - click residue to focus in viewer  |  colored by A4D score
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Downloads
Color Legend (B-factor = A4D Score)
Score > 1.5 — highly aggregation-prone
Score 0.5–1.5 — aggregation-prone
Score ≈ 0 — buried
Score −1 to −0.5 — soluble
Score < −2.5 — highly soluble
pH Structure
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A4D Score Threshold
Highlight residues > threshold in the sequence panel
CDR Regions
HCDR1
HCDR2
HCDR3
LCDR1
LCDR2
LCDR3
Display Options

pH-Dependent Aggregation Profiles

A4D scores calculated across 11 pH conditions (4.0–9.0, step 0.5). Click a row to view the structure at that pH. The input structure is globular — max score is recommended for pH analysis.

pH Avg A4D Score Max A4D Score Downloads
4.0 -0.334 4.5897 CSV PDB
4.5 -0.3697 4.5608 CSV PDB
5.0 -0.414 4.5195 CSV PDB
5.5 -0.4598 4.4727 CSV PDB
6.0 -0.4995 4.4277 CSV PDB
6.5 -0.5275 4.3919 CSV PDB
7.0 -0.5425 4.3703 CSV PDB
7.5 -0.5477 4.3607 CSV PDB
8.0 -0.5465 4.3571 CSV PDB
8.5 -0.5405 4.356 CSV PDB
9.0 -0.5298 4.3556 CSV PDB
Average A4D Score vs pH
Max A4D Score vs pH