Casdozokitug / 7zxk

A4DAB059_7zxk_H_L | Source PDB: 7zxk | Chains: H, L | Done
100
Yes
10 Å
Yes
Avg A4D Score
-0.7121
Max Score
1.8967
Min Score
-3.6785
Total Score
-315.45
Score CDR
-0.3157
Score non-CDR
-0.773

Calculation Parameters

Chain Sequence(s) EVQLVESGGGLVKPGGSLRLSCAASGFTFRSYGMNWVRQAPGKGLEWVSGISSSGSYIYYADSVKGRFTISRDNAKNSLYLQMNSLRAEDTAVYYCARDGGRTSYTATAHNWFDPWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPDIVMTQSPDSLAVSLGERATINCKSSQSVLFSSNNKNYLAWYQQKPGQPPKLLIYWASTRESGVPDRFSGSGSGTDFTLTISSLQAEDVAVYYCQQHASAPPTFGGGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGE input.pdb
Selected Chain(s) H (Heavy), L (Light)
Distance of Aggregation 10 Å
FoldX Energy Minimization Yes
pH Calculations Yes
Downloads Download all data (.tar.gz)

Aggrescan4D Profile

Aggregation-prone (score > 0)
Soluble (score < 0)
Buried (score = 0)

Per-Residue A4D Scores

Download CSV
Minimum Score -3.6785
Maximum Score 1.8967
Average Score -0.7121
Total Score -315.446

Residues with A4D score > 0.0 are highlighted as aggregation-prone.

Index Residue Chain A4D Score Classification
1 E H -1.9614 Soluble
2 V H -0.9223 Soluble
3 Q H -1.1849 Soluble
4 L H 0.0000 Buried
5 V H 1.0976 Aggregation-prone
6 E H 0.0934 Aggregation-prone
7 S H -0.3639 Soluble
8 G H -0.9458 Soluble
9 G H -0.5920 Soluble
11 G H -0.3402 Soluble
12 L H -0.2468 Soluble
13 V H 0.0000 Buried
14 K H -2.1149 Soluble
15 P H -1.8505 Soluble
16 G H -1.5112 Soluble
17 G H -1.2523 Soluble
18 S H -1.2321 Soluble
19 L H -1.2052 Soluble
20 R H -2.0967 Soluble
21 L H 0.0000 Buried
22 S H -0.5213 Soluble
23 C H 0.0000 Buried
24 A H -0.1295 Soluble
25 A H 0.0000 Buried
26 S H -0.7772 Soluble
27 G H -0.9567 Soluble
28 F H -0.5733 Soluble
29 T H -0.6804 Soluble
30 F H 0.0000 Buried
35 R H -2.2818 Soluble
36 S H -1.5302 Soluble
37 Y H 0.0000 Buried
38 G H -0.4794 Soluble
39 M H 0.0000 Buried
40 N H 0.0000 Buried
41 W H 0.0000 Buried
42 V H 0.0000 Buried
43 R H 0.0000 Buried
44 Q H -0.8759 Soluble
45 A H -1.2422 Soluble
46 P H -0.9793 Soluble
47 G H -1.4700 Soluble
48 K H -2.3035 Soluble
49 G H -1.4641 Soluble
50 L H 0.0000 Buried
51 E H -1.1148 Soluble
52 W H 0.0000 Buried
53 V H 0.0000 Buried
54 S H 0.0000 Buried
55 G H 0.0000 Buried
56 I H 0.0000 Buried
57 S H 0.0000 Buried
58 S H -0.9606 Soluble
59 S H -0.6103 Soluble
62 G H -0.0865 Soluble
63 S H 0.5657 Aggregation-prone
64 Y H 1.7797 Aggregation-prone
65 I H 1.8967 Aggregation-prone
66 Y H 1.0487 Aggregation-prone
67 Y H -0.3606 Soluble
68 A H -1.2656 Soluble
69 D H -2.3920 Soluble
70 S H -1.8150 Soluble
71 V H 0.0000 Buried
72 K H -2.5233 Soluble
74 G H -1.7480 Soluble
75 R H -1.3791 Soluble
76 F H 0.0000 Buried
77 T H -0.7616 Soluble
78 I H 0.0000 Buried
79 S H -0.3825 Soluble
80 R H -1.2921 Soluble
81 D H -1.9123 Soluble
82 N H -2.2134 Soluble
83 A H -1.6515 Soluble
84 K H -2.2895 Soluble
85 N H -1.9343 Soluble
86 S H 0.0000 Buried
87 L H 0.0000 Buried
88 Y H 0.0000 Buried
89 L H 0.0000 Buried
90 Q H -1.4966 Soluble
91 M H 0.0000 Buried
92 N H -1.3383 Soluble
93 S H -1.2144 Soluble
94 L H 0.0000 Buried
95 R H -2.1715 Soluble
96 A H -1.7089 Soluble
97 E H -2.1871 Soluble
98 D H 0.0000 Buried
99 T H -0.7269 Soluble
100 A H 0.0000 Buried
101 V H 0.1355 Aggregation-prone
102 Y H 0.0000 Buried
103 Y H 0.0000 Buried
104 C H 0.0000 Buried
105 A H 0.0000 Buried
106 R H 0.0000 Buried
107 D H 0.0000 Buried
108 G H -0.6204 Soluble
109 G H -0.9489 Soluble
110 R H -1.8620 Soluble
111 T H -0.8209 Soluble
111A S H -0.2372 Soluble
111B Y H 0.3585 Aggregation-prone
111C T H 0.0000 Buried
112C A H -0.1098 Soluble
112B T H 0.0000 Buried
112A A H 0.0000 Buried
112 H H -0.1566 Soluble
113 N H 0.0000 Buried
114 W H 0.0000 Buried
115 F H 0.0000 Buried
116 D H -0.5585 Soluble
117 P H -0.7135 Soluble
118 W H 0.0000 Buried
119 G H 0.0000 Buried
120 Q H -1.2363 Soluble
121 G H -0.5185 Soluble
122 T H -0.1509 Soluble
123 L H -0.0767 Soluble
124 V H 0.0000 Buried
125 T H -0.5648 Soluble
126 V H 0.0000 Buried
127 S H -0.9356 Soluble
128 S H -0.9302 Soluble
129 A H -0.5584 Soluble
130 S H -0.6314 Soluble
131 T H -0.6360 Soluble
132 K H -1.2362 Soluble
133 G H -1.3497 Soluble
134 P H -0.5360 Soluble
135 S H -0.4448 Soluble
136 V H 0.0000 Buried
137 F H 0.0000 Buried
138 P H -1.1231 Soluble
139 L H 0.0000 Buried
140 A H -0.7701 Soluble
141 P H 0.0000 Buried
142 S H -1.0462 Soluble
143 S H -1.2028 Soluble
144 K H -1.8785 Soluble
145 S H -1.0843 Soluble
146 T H -0.9629 Soluble
147 S H 0.0000 Buried
148 G H -0.7579 Soluble
149 G H -0.8473 Soluble
150 T H -0.6117 Soluble
151 A H 0.0000 Buried
152 A H 0.0000 Buried
153 L H 0.0000 Buried
154 G H 0.0000 Buried
155 C H 0.0000 Buried
156 L H 0.0000 Buried
157 V H 0.0000 Buried
158 K H 0.0000 Buried
159 D H -0.2863 Soluble
160 Y H 0.0000 Buried
161 F H 0.0000 Buried
162 P H 0.0000 Buried
163 E H -0.5842 Soluble
164 P H -0.6707 Soluble
165 V H -0.5731 Soluble
166 T H -0.4998 Soluble
167 V H -0.1514 Soluble
168 S H -0.4100 Soluble
169 W H 0.0000 Buried
170 N H -0.9623 Soluble
171 S H -0.7174 Soluble
172 G H -0.5566 Soluble
173 A H -0.2746 Soluble
174 L H 0.0144 Aggregation-prone
175 T H -0.1713 Soluble
176 S H -0.1701 Soluble
177 G H -0.2241 Soluble
178 V H 0.1479 Aggregation-prone
179 H H -0.3131 Soluble
180 T H 0.0313 Aggregation-prone
181 F H 0.0000 Buried
182 P H -0.3149 Soluble
183 A H 0.2933 Aggregation-prone
184 V H 0.6369 Aggregation-prone
185 L H 1.5450 Aggregation-prone
186 Q H 0.4675 Aggregation-prone
187 S H -0.0911 Soluble
188 S H -0.1590 Soluble
189 G H 0.0996 Aggregation-prone
190 L H 0.2188 Aggregation-prone
191 Y H 0.5925 Aggregation-prone
192 S H 0.0000 Buried
193 L H 0.2368 Aggregation-prone
195 S H 0.0000 Buried
196 V H 0.0000 Buried
197 V H 0.0000 Buried
198 T H -0.1496 Soluble
199 V H 0.0000 Buried
200 P H -0.5326 Soluble
201 S H -0.7666 Soluble
202 S H -0.4469 Soluble
204 L H -0.7060 Soluble
205 G H -1.1649 Soluble
206 T H -0.8338 Soluble
207 Q H -1.3073 Soluble
208 T H -1.2239 Soluble
209 Y H -1.1326 Soluble
210 I H -1.2766 Soluble
211 C H 0.0000 Buried
212 N H -1.4308 Soluble
213 V H 0.0000 Buried
214 N H -1.7455 Soluble
215 H H 0.0000 Buried
216 K H -2.7169 Soluble
217 P H -1.5807 Soluble
218 S H -1.8241 Soluble
219 N H -2.5545 Soluble
220 T H -2.0280 Soluble
221 K H -2.6428 Soluble
222 V H -1.6559 Soluble
223 D H -2.4789 Soluble
224 K H -2.1049 Soluble
225 K H -2.4336 Soluble
226 V H 0.0000 Buried
227 E H -2.3458 Soluble
228 P H -1.2221 Soluble
1 D L -1.5321 Soluble
2 I L 0.0000 Buried
3 V L 0.8417 Aggregation-prone
4 M L 0.0000 Buried
5 T L -0.3935 Soluble
6 Q L 0.0000 Buried
7 S L -1.1734 Soluble
8 P L -1.4176 Soluble
9 D L -2.3643 Soluble
10 S L -1.5821 Soluble
11 L L -0.8811 Soluble
12 A L -0.8544 Soluble
13 V L -0.8857 Soluble
14 S L -0.8522 Soluble
15 L L 0.0990 Aggregation-prone
16 G L -0.7603 Soluble
17 E L -2.1710 Soluble
18 R L -2.4983 Soluble
19 A L 0.0000 Buried
20 T L -0.6147 Soluble
21 I L 0.0000 Buried
22 N L -1.4151 Soluble
23 C L 0.0000 Buried
24 K L -1.7177 Soluble
25 S L 0.0000 Buried
26 S L -0.8913 Soluble
27 Q L -1.3929 Soluble
28 S L -0.9754 Soluble
29 V L 0.0000 Buried
30 L L 0.0575 Aggregation-prone
31 F L 0.3254 Aggregation-prone
32 S L -0.4267 Soluble
33 S L -0.4094 Soluble
34 N L -0.7150 Soluble
35 N L -1.4114 Soluble
36 K L -0.8042 Soluble
37 N L -0.3899 Soluble
38 Y L 0.0000 Buried
39 L L 0.0000 Buried
40 A L 0.0000 Buried
41 W L 0.0000 Buried
42 Y L 0.0000 Buried
43 Q L 0.0000 Buried
44 Q L 0.0000 Buried
45 K L -1.8735 Soluble
46 P L -1.3736 Soluble
47 G L -1.3127 Soluble
48 Q L -1.7988 Soluble
49 P L -1.3589 Soluble
50 P L 0.0000 Buried
51 K L -1.5055 Soluble
52 L L 0.0000 Buried
53 L L 0.0000 Buried
54 I L 0.0000 Buried
55 Y L -0.1956 Soluble
56 W L -0.2439 Soluble
57 A L 0.0000 Buried
65 S L -0.7042 Soluble
66 T L -0.7160 Soluble
67 R L -1.7642 Soluble
68 E L -1.4978 Soluble
69 S L -1.1196 Soluble
70 G L -1.1033 Soluble
71 V L 0.0000 Buried
72 P L -1.4476 Soluble
74 D L -2.3451 Soluble
75 R L -1.5283 Soluble
76 F L 0.0000 Buried
77 S L -1.0366 Soluble
78 G L -0.5778 Soluble
79 S L -0.8239 Soluble
80 G L -1.2631 Soluble
83 S L -1.0885 Soluble
84 G L -1.0702 Soluble
85 T L -1.6631 Soluble
86 D L -2.4699 Soluble
87 F L 0.0000 Buried
88 T L -0.9967 Soluble
89 L L 0.0000 Buried
90 T L -0.6623 Soluble
91 I L 0.0000 Buried
92 S L -1.6574 Soluble
93 S L -1.4300 Soluble
94 L L 0.0000 Buried
95 Q L -1.3981 Soluble
96 A L -1.8165 Soluble
97 E L -2.7570 Soluble
98 D L 0.0000 Buried
99 V L 0.0000 Buried
100 A L 0.0000 Buried
101 V L -0.8698 Soluble
102 Y L 0.0000 Buried
103 Y L 0.0000 Buried
104 C L 0.0000 Buried
105 Q L 0.0000 Buried
106 Q L 0.0000 Buried
107 H L 0.0000 Buried
108 A L -0.0265 Soluble
109 S L -0.6831 Soluble
114 A L -0.3900 Soluble
115 P L -0.7143 Soluble
116 P L 0.0000 Buried
117 T L -0.1344 Soluble
118 F L 0.1389 Aggregation-prone
119 G L 0.0000 Buried
120 G L -1.0177 Soluble
121 G L -1.2123 Soluble
122 T L 0.0000 Buried
123 K L -1.8254 Soluble
124 V L 0.0000 Buried
125 E L -1.5890 Soluble
126 I L 0.0000 Buried
127 K L -1.2100 Soluble
128 R L -0.7680 Soluble
129 T L 0.0797 Aggregation-prone
130 V L 0.7603 Aggregation-prone
131 A L 0.3445 Aggregation-prone
132 A L -0.0510 Soluble
133 P L 0.0000 Buried
134 S L -0.2892 Soluble
135 V L 0.0000 Buried
136 F L 0.0000 Buried
137 I L 0.0245 Aggregation-prone
138 F L 0.0000 Buried
139 P L -0.5390 Soluble
140 P L -0.8671 Soluble
141 S L -1.7319 Soluble
142 D L -3.0905 Soluble
143 E L -3.2579 Soluble
144 Q L 0.0000 Buried
145 L L -2.3641 Soluble
146 K L -2.9195 Soluble
147 S L -1.8180 Soluble
148 G L -1.2905 Soluble
149 T L -1.0747 Soluble
150 A L 0.0000 Buried
151 S L 0.0000 Buried
152 V L 0.0000 Buried
153 V L 0.0000 Buried
154 C L 0.0000 Buried
155 L L 0.0000 Buried
156 L L 0.0000 Buried
157 N L 0.0000 Buried
158 N L -0.8904 Soluble
159 F L 0.0000 Buried
160 Y L 0.0000 Buried
161 P L -1.6826 Soluble
162 R L -3.1177 Soluble
163 E L -3.2814 Soluble
164 A L -2.3904 Soluble
165 K L -2.4313 Soluble
166 V L -1.0858 Soluble
167 Q L -0.5802 Soluble
168 W L 0.0000 Buried
169 K L -0.6139 Soluble
170 V L 0.0000 Buried
171 D L -2.0309 Soluble
172 N L -1.5801 Soluble
173 A L -0.3079 Soluble
174 L L 0.6903 Aggregation-prone
175 Q L -0.2944 Soluble
176 S L -0.6393 Soluble
177 G L -1.1717 Soluble
178 N L -1.4058 Soluble
179 S L -1.3482 Soluble
180 Q L -1.2645 Soluble
181 E L -1.8682 Soluble
182 S L -1.0099 Soluble
183 V L -0.9267 Soluble
184 T L -1.2086 Soluble
185 E L -2.3569 Soluble
186 Q L 0.0000 Buried
187 D L -2.1643 Soluble
188 S L -2.5917 Soluble
189 K L -2.7396 Soluble
190 D L -2.0436 Soluble
191 S L 0.0000 Buried
192 T L 0.0000 Buried
193 Y L 0.0000 Buried
194 S L 0.0000 Buried
195 L L 0.0000 Buried
196 S L -0.5752 Soluble
197 S L 0.0000 Buried
198 T L -0.6645 Soluble
199 L L 0.0000 Buried
200 T L -0.5834 Soluble
201 L L -0.8081 Soluble
202 S L -1.3029 Soluble
203 K L -2.1358 Soluble
204 A L -2.0001 Soluble
205 D L -2.7241 Soluble
206 Y L 0.0000 Buried
207 E L -3.4729 Soluble
208 K L -3.6785 Soluble
209 H L -3.1127 Soluble
210 K L -3.3695 Soluble
211 V L -1.5901 Soluble
212 Y L 0.0000 Buried
213 A L 0.0000 Buried
214 C L 0.0000 Buried
215 E L -0.5151 Soluble
216 V L 0.0000 Buried
217 T L -1.1631 Soluble
218 H L 0.0000 Buried
219 Q L -1.6806 Soluble
220 G L -0.2951 Soluble
221 L L -0.1733 Soluble
222 S L -0.4372 Soluble
223 S L -0.3763 Soluble
224 P L -0.4720 Soluble
225 V L 0.1961 Aggregation-prone
226 T L -0.2810 Soluble
227 K L -0.4372 Soluble
228 S L -0.5249 Soluble
229 F L -1.0682 Soluble
230 N L -2.2204 Soluble
231 R L -2.6991 Soluble
232 G L -2.2246 Soluble
233 E L -2.6134 Soluble

3D Structure — colored by A4D score

Sequence - click residue to focus in viewer  |  colored by A4D score
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Downloads
Color Legend (B-factor = A4D Score)
Score > 1.5 — highly aggregation-prone
Score 0.5–1.5 — aggregation-prone
Score ≈ 0 — buried
Score −1 to −0.5 — soluble
Score < −2.5 — highly soluble
pH Structure
Load structure at specific pH condition
A4D Score Threshold
Highlight residues > threshold in the sequence panel
CDR Regions
HCDR1
HCDR2
HCDR3
LCDR1
LCDR2
LCDR3
Display Options

pH-Dependent Aggregation Profiles

A4D scores calculated across 11 pH conditions (4.0–9.0, step 0.5). Click a row to view the structure at that pH. The input structure is globular — max score is recommended for pH analysis.

pH Avg A4D Score Max A4D Score Downloads
4.0 -0.7422 2.088 CSV PDB
4.5 -0.7907 2.088 CSV PDB
5.0 -0.8467 2.088 CSV PDB
5.5 -0.8999 2.088 CSV PDB
6.0 -0.9382 2.088 CSV PDB
6.5 -0.9521 2.088 CSV PDB
7.0 -0.9414 2.088 CSV PDB
7.5 -0.9147 2.0879 CSV PDB
8.0 -0.879 2.0876 CSV PDB
8.5 -0.8363 2.0866 CSV PDB
9.0 -0.7864 2.0837 CSV PDB
Average A4D Score vs pH
Max A4D Score vs pH