Vixticibart / 8tga

A4DAB296_8tga_E_F | Source PDB: 8tga | Chains: E, F | Done
100
Yes
10 Å
Yes
Avg A4D Score
-0.6417
Max Score
1.4753
Min Score
-3.6742
Total Score
-274.01
Score CDR
-0.0841
Score non-CDR
-0.7157

Calculation Parameters

Chain Sequence(s) VQLVQSGAEVKKPGASVTVSCKASGYTFTDYYMHWVRQAPGQGLEWMGWIKPNSGGTNSAQRFQGRITMTWDTSISTAYMELSRLRSDDTAVYYCSRGGPVMNYYYYYGMDVWGQGTTVTVSSASTKGPSVFPLAPCTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTKTYTCNVDHKPSNTKVDKRVNIQMTQSPSSLSASVGDRVTITCRASQSIDSYLNWYQQKPGKAPKLLIYVASSLQSGVPSRFSGSGSGKDFTLTISSLQPEDFATYYCQQSYSIPTFGQGTRLEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC input.pdb
Selected Chain(s) E (Heavy), F (Light)
Distance of Aggregation 10 Å
FoldX Energy Minimization Yes
pH Calculations Yes
Downloads Download all data (.tar.gz)

Aggrescan4D Profile

Aggregation-prone (score > 0)
Soluble (score < 0)
Buried (score = 0)

Per-Residue A4D Scores

Download CSV
Minimum Score -3.6742
Maximum Score 1.4753
Average Score -0.6417
Total Score -274.0107

Residues with A4D score > 0.0 are highlighted as aggregation-prone.

Index Residue Chain A4D Score Classification
2 V E 1.0475 Aggregation-prone
3 Q E -0.3734 Soluble
4 L E 0.0000 Buried
5 V E -0.2091 Soluble
6 Q E 0.0000 Buried
7 S E -0.7859 Soluble
8 G E -1.0182 Soluble
9 A E -1.1218 Soluble
11 E E -1.7939 Soluble
12 V E -1.0113 Soluble
13 K E -1.5736 Soluble
14 K E -2.0405 Soluble
15 P E -1.9839 Soluble
16 G E -1.9461 Soluble
17 A E -1.4630 Soluble
18 S E -1.2705 Soluble
19 V E 0.0000 Buried
20 T E -0.7742 Soluble
21 V E 0.0000 Buried
22 S E -0.3443 Soluble
23 C E 0.0000 Buried
24 K E -0.8926 Soluble
25 A E 0.0000 Buried
26 S E -0.0915 Soluble
27 G E 0.0463 Aggregation-prone
28 Y E 0.1583 Aggregation-prone
29 T E -0.0802 Soluble
30 F E 0.0000 Buried
35 T E -0.8195 Soluble
36 D E -0.7182 Soluble
37 Y E 0.1339 Aggregation-prone
38 Y E 0.0000 Buried
39 M E 0.0000 Buried
40 H E 0.0000 Buried
41 W E 0.0000 Buried
42 V E 0.0000 Buried
43 R E 0.0000 Buried
44 Q E -0.6614 Soluble
45 A E -1.0218 Soluble
46 P E -0.8065 Soluble
47 G E -1.2268 Soluble
48 Q E -1.8720 Soluble
49 G E -1.3411 Soluble
50 L E 0.0000 Buried
51 E E -0.8568 Soluble
52 W E 0.0000 Buried
53 M E 0.0000 Buried
54 G E 0.0000 Buried
55 W E 0.0000 Buried
56 I E 0.0000 Buried
57 K E 0.0000 Buried
58 P E 0.0000 Buried
59 N E -1.5471 Soluble
62 S E -1.1106 Soluble
63 G E -1.0231 Soluble
64 G E -0.7876 Soluble
65 T E -0.5228 Soluble
66 N E -0.7636 Soluble
67 S E -1.0880 Soluble
68 A E 0.0000 Buried
69 Q E -2.5149 Soluble
70 R E -2.9087 Soluble
71 F E 0.0000 Buried
72 Q E -2.5184 Soluble
74 G E -1.6142 Soluble
75 R E -1.6367 Soluble
76 I E -0.9853 Soluble
77 T E -0.6245 Soluble
78 M E -0.1425 Soluble
79 T E -0.1631 Soluble
80 W E 0.0050 Aggregation-prone
81 D E -0.2272 Soluble
82 T E -0.0392 Soluble
83 S E 0.4048 Aggregation-prone
84 I E 1.1973 Aggregation-prone
85 S E 0.2118 Aggregation-prone
86 T E 0.0000 Buried
87 A E 0.0000 Buried
88 Y E -0.1367 Soluble
89 M E 0.0000 Buried
90 E E -1.2062 Soluble
91 L E 0.0000 Buried
92 S E -1.7226 Soluble
93 R E -2.6240 Soluble
94 L E 0.0000 Buried
95 R E -3.0009 Soluble
96 S E -1.9438 Soluble
97 D E -2.0155 Soluble
98 D E 0.0000 Buried
99 T E -0.7621 Soluble
100 A E 0.0000 Buried
101 V E 0.0161 Aggregation-prone
102 Y E 0.0000 Buried
103 Y E 0.0000 Buried
104 C E 0.0000 Buried
105 S E 0.0000 Buried
106 R E -0.1741 Soluble
107 G E 0.0000 Buried
108 G E 0.0000 Buried
109 P E 0.5266 Aggregation-prone
110 V E 0.0000 Buried
111 M E 0.6128 Aggregation-prone
111A N E 0.0359 Aggregation-prone
111B Y E 1.4250 Aggregation-prone
112B Y E 1.3680 Aggregation-prone
112A Y E 1.3456 Aggregation-prone
112 Y E 1.4753 Aggregation-prone
113 Y E 0.9755 Aggregation-prone
114 G E 0.0000 Buried
115 M E 0.0000 Buried
116 D E -1.3428 Soluble
117 V E -0.4402 Soluble
118 W E -0.8071 Soluble
119 G E 0.0000 Buried
120 Q E -1.3762 Soluble
121 G E -0.7771 Soluble
122 T E 0.0000 Buried
123 T E -0.4710 Soluble
124 V E 0.0000 Buried
125 T E -0.9718 Soluble
126 V E 0.0000 Buried
127 S E -1.1148 Soluble
128 S E -0.7255 Soluble
129 A E -0.6416 Soluble
130 S E -0.7120 Soluble
131 T E -1.1454 Soluble
132 K E -1.9953 Soluble
133 G E -2.0833 Soluble
134 P E -1.2961 Soluble
135 S E -0.5402 Soluble
136 V E 0.0000 Buried
137 F E -0.3066 Soluble
138 P E -0.0979 Soluble
139 L E 0.0000 Buried
140 A E 0.3798 Aggregation-prone
141 P E 0.3822 Aggregation-prone
142 C E 0.5474 Aggregation-prone
143 T E -0.1000 Soluble
144 A E 0.1078 Aggregation-prone
145 A E 0.0000 Buried
146 L E 0.0000 Buried
147 G E 0.0000 Buried
148 C E 0.0000 Buried
149 L E 0.0000 Buried
150 V E 0.0000 Buried
151 K E -0.6697 Soluble
152 D E -1.3818 Soluble
153 Y E 0.0000 Buried
154 F E 0.0000 Buried
155 P E -1.0828 Soluble
156 E E -1.1766 Soluble
157 P E -1.1253 Soluble
158 V E -0.7090 Soluble
159 T E -0.5739 Soluble
160 V E -0.2409 Soluble
161 S E -0.5213 Soluble
162 W E 0.0000 Buried
163 N E -1.0143 Soluble
164 S E -0.7841 Soluble
165 G E -0.5971 Soluble
166 A E -0.2737 Soluble
167 L E -0.0758 Soluble
168 T E -0.1961 Soluble
169 S E -0.1780 Soluble
170 G E -0.1431 Soluble
171 V E 0.1451 Aggregation-prone
172 H E -0.2117 Soluble
173 T E -0.0194 Soluble
174 F E 0.0000 Buried
175 P E -0.0512 Soluble
176 A E 0.3796 Aggregation-prone
177 V E 0.7280 Aggregation-prone
178 L E 1.4446 Aggregation-prone
179 Q E 0.1902 Aggregation-prone
180 S E -0.0540 Soluble
181 S E -0.3249 Soluble
182 G E -0.1806 Soluble
183 L E 0.0000 Buried
184 Y E 0.1199 Aggregation-prone
185 S E 0.0000 Buried
186 L E 0.2641 Aggregation-prone
187 S E 0.0117 Aggregation-prone
188 S E 0.0000 Buried
189 V E 0.0000 Buried
190 V E 0.0000 Buried
191 T E -0.1605 Soluble
192 V E 0.0000 Buried
193 P E -0.1288 Soluble
194 S E 0.0085 Aggregation-prone
195 S E -0.1149 Soluble
196 S E 0.0000 Buried
197 L E 0.8640 Aggregation-prone
198 G E -0.2078 Soluble
199 T E -0.5403 Soluble
200 K E -1.1340 Soluble
201 T E -0.7171 Soluble
202 Y E 0.0000 Buried
203 T E -1.2574 Soluble
204 C E 0.0000 Buried
205 N E -1.7959 Soluble
206 V E 0.0000 Buried
207 D E -2.2400 Soluble
208 H E 0.0000 Buried
209 K E -2.9204 Soluble
210 P E -1.8747 Soluble
211 S E -2.0628 Soluble
212 N E -2.7916 Soluble
213 T E -2.4782 Soluble
214 K E -2.7608 Soluble
215 V E -1.8420 Soluble
216 D E -2.7039 Soluble
217 K E -2.0499 Soluble
218 R E -1.9571 Soluble
219 V E -0.0846 Soluble
1 N F -1.5813 Soluble
2 I F 0.0000 Buried
3 Q F -1.9799 Soluble
4 M F 0.0000 Buried
5 T F -1.3184 Soluble
6 Q F 0.0000 Buried
7 S F -0.6482 Soluble
8 P F -0.5455 Soluble
9 S F -0.9271 Soluble
10 S F -0.9952 Soluble
11 L F -0.6636 Soluble
12 S F -0.9705 Soluble
13 A F 0.0000 Buried
14 S F -0.5305 Soluble
15 V F 0.5743 Aggregation-prone
16 G F -0.6802 Soluble
17 D F -1.5897 Soluble
18 R F -2.2541 Soluble
19 V F 0.0000 Buried
20 T F -0.4879 Soluble
21 I F 0.0000 Buried
22 T F -0.7611 Soluble
23 C F 0.0000 Buried
24 R F -2.8028 Soluble
25 A F 0.0000 Buried
26 S F -2.0720 Soluble
27 Q F -2.2356 Soluble
28 S F -1.8822 Soluble
29 I F 0.0000 Buried
36 D F -1.9304 Soluble
37 S F -0.8101 Soluble
38 Y F 0.2455 Aggregation-prone
39 L F 0.0000 Buried
40 N F 0.0000 Buried
41 W F 0.0000 Buried
42 Y F 0.0000 Buried
43 Q F 0.0000 Buried
44 Q F 0.0000 Buried
45 K F -1.6924 Soluble
46 P F -1.4255 Soluble
47 G F -1.6430 Soluble
48 K F -2.5050 Soluble
49 A F -1.5742 Soluble
50 P F 0.0000 Buried
51 K F -1.7841 Soluble
52 L F 0.0000 Buried
53 L F 0.0000 Buried
54 I F 0.0000 Buried
55 Y F 0.5563 Aggregation-prone
56 V F 0.5645 Aggregation-prone
57 A F 0.0000 Buried
65 S F -0.1236 Soluble
66 S F 0.1701 Aggregation-prone
67 L F 0.3583 Aggregation-prone
68 Q F -0.3274 Soluble
69 S F -0.4129 Soluble
70 G F -0.5062 Soluble
71 V F -0.1950 Soluble
72 P F -0.3564 Soluble
74 S F -0.4695 Soluble
75 R F -0.8812 Soluble
76 F F 0.0000 Buried
77 S F -0.3780 Soluble
78 G F -0.2246 Soluble
79 S F -0.6384 Soluble
80 G F -1.2689 Soluble
83 S F -1.8033 Soluble
84 G F -2.2563 Soluble
85 K F -3.0255 Soluble
86 D F -2.5081 Soluble
87 F F 0.0000 Buried
88 T F -0.7391 Soluble
89 L F 0.0000 Buried
90 T F -0.5970 Soluble
91 I F 0.0000 Buried
92 S F -1.2879 Soluble
93 S F -1.0233 Soluble
94 L F 0.0000 Buried
95 Q F -0.9664 Soluble
96 P F -1.0062 Soluble
97 E F -2.0661 Soluble
98 D F 0.0000 Buried
99 F F -0.7351 Soluble
100 A F 0.0000 Buried
101 T F 0.0000 Buried
102 Y F 0.0000 Buried
103 Y F 0.0000 Buried
104 C F 0.0000 Buried
105 Q F 0.0000 Buried
106 Q F 0.0000 Buried
107 S F 0.0000 Buried
108 Y F 0.9268 Aggregation-prone
114 S F 0.6979 Aggregation-prone
115 I F 0.6422 Aggregation-prone
116 P F 0.4575 Aggregation-prone
117 T F -0.2925 Soluble
118 F F -0.4733 Soluble
119 G F -1.0355 Soluble
120 Q F -1.4995 Soluble
121 G F -1.3174 Soluble
122 T F 0.0000 Buried
123 R F -2.0459 Soluble
124 L F 0.0000 Buried
125 E F -1.0204 Soluble
126 I F -0.5284 Soluble
127 K F -1.5180 Soluble
128 R F -1.1434 Soluble
129 T F -0.0442 Soluble
130 V F 0.6695 Aggregation-prone
131 A F 0.2349 Aggregation-prone
132 A F -0.0779 Soluble
133 P F -0.0883 Soluble
134 S F -0.1665 Soluble
135 V F 0.0000 Buried
136 F F 0.3024 Aggregation-prone
137 I F 0.3370 Aggregation-prone
138 F F 0.0000 Buried
139 P F -0.0569 Soluble
140 P F -0.4148 Soluble
141 S F -1.2365 Soluble
142 D F -2.5824 Soluble
143 E F -2.3205 Soluble
144 Q F 0.0000 Buried
145 L F -2.2043 Soluble
146 K F -2.7349 Soluble
147 S F -1.7189 Soluble
148 G F -1.3351 Soluble
149 T F -1.0754 Soluble
150 A F 0.0000 Buried
151 S F 0.0000 Buried
152 V F 0.0000 Buried
153 V F 0.0000 Buried
154 C F 0.0000 Buried
155 L F 0.0000 Buried
156 L F 0.0000 Buried
157 N F -0.4734 Soluble
158 N F -1.1234 Soluble
159 F F 0.0000 Buried
160 Y F 0.0000 Buried
161 P F -1.8186 Soluble
162 R F -3.2559 Soluble
163 E F -3.2275 Soluble
164 A F -2.2782 Soluble
165 K F -2.1946 Soluble
166 V F -0.8752 Soluble
167 Q F -0.4206 Soluble
168 W F 0.0000 Buried
169 K F -0.7194 Soluble
170 V F 0.0000 Buried
171 D F -1.8047 Soluble
172 N F -1.3720 Soluble
173 A F -0.3089 Soluble
174 L F 0.8315 Aggregation-prone
175 Q F -0.3402 Soluble
176 S F -0.7478 Soluble
177 G F -1.3751 Soluble
178 N F -1.7907 Soluble
179 S F -1.6659 Soluble
180 Q F -1.9217 Soluble
181 E F -1.7982 Soluble
182 S F -0.6453 Soluble
183 V F -0.5883 Soluble
184 T F -1.1812 Soluble
185 E F -2.4462 Soluble
186 Q F -2.4044 Soluble
187 D F -2.7104 Soluble
188 S F -2.1631 Soluble
189 K F -2.6418 Soluble
190 D F -2.4066 Soluble
191 S F 0.0000 Buried
192 T F 0.0000 Buried
193 Y F 0.0000 Buried
194 S F 0.0000 Buried
195 L F 0.0000 Buried
196 S F 0.0000 Buried
197 S F 0.0000 Buried
198 T F -0.8528 Soluble
199 L F 0.0000 Buried
200 T F -0.6598 Soluble
201 L F -0.6612 Soluble
202 S F -1.1513 Soluble
203 K F -2.3610 Soluble
204 A F -1.8817 Soluble
205 D F -2.4001 Soluble
206 Y F 0.0000 Buried
207 E F -3.6742 Soluble
208 K F -3.5644 Soluble
209 H F -2.8463 Soluble
210 K F -3.0416 Soluble
211 V F -1.5050 Soluble
212 Y F 0.0000 Buried
213 A F 0.0000 Buried
214 C F 0.0000 Buried
215 E F -0.6666 Soluble
216 V F 0.0000 Buried
217 T F -1.0983 Soluble
218 H F 0.0000 Buried
219 Q F -1.7608 Soluble
220 G F -0.3984 Soluble
221 L F -0.2280 Soluble
222 S F -0.4872 Soluble
223 S F -0.4529 Soluble
224 P F -0.5218 Soluble
225 V F -0.0032 Soluble
226 T F -0.4098 Soluble
227 K F -0.5656 Soluble
228 S F -0.5454 Soluble
229 F F 0.0000 Buried
230 N F -1.6861 Soluble
231 R F -2.2778 Soluble
232 G F -2.0512 Soluble
233 E F -2.0249 Soluble
234 C F -0.3891 Soluble

3D Structure — colored by A4D score

Sequence - click residue to focus in viewer  |  colored by A4D score
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Color Legend (B-factor = A4D Score)
Score > 1.5 — highly aggregation-prone
Score 0.5–1.5 — aggregation-prone
Score ≈ 0 — buried
Score −1 to −0.5 — soluble
Score < −2.5 — highly soluble
pH Structure
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A4D Score Threshold
Highlight residues > threshold in the sequence panel
CDR Regions
HCDR1
HCDR2
HCDR3
LCDR1
LCDR2
LCDR3
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pH-Dependent Aggregation Profiles

A4D scores calculated across 11 pH conditions (4.0–9.0, step 0.5). Click a row to view the structure at that pH. The input structure is globular — max score is recommended for pH analysis.

pH Avg A4D Score Max A4D Score Downloads
4.0 -0.6355 2.8871 CSV PDB
4.5 -0.679 2.8482 CSV PDB
5.0 -0.7291 2.7909 CSV PDB
5.5 -0.7767 2.768 CSV PDB
6.0 -0.8121 2.768 CSV PDB
6.5 -0.827 2.768 CSV PDB
7.0 -0.8215 2.768 CSV PDB
7.5 -0.8028 2.768 CSV PDB
8.0 -0.7766 2.768 CSV PDB
8.5 -0.7444 2.768 CSV PDB
9.0 -0.7054 2.768 CSV PDB
Average A4D Score vs pH
Max A4D Score vs pH