Beludavimab / 7tm0

A4DAB038_7tm0_N_O | Source PDB: 7tm0 | Chains: N, O | Done
99.57
Yes
10 Å
Yes
Avg A4D Score
-0.6792
Max Score
2.071
Min Score
-3.6507
Total Score
-156.88
Score CDR
-0.1786
Score non-CDR
-0.8319

Calculation Parameters

Chain Sequence(s) QVQLVQSGAEVKKPGASVKVSCKASGYPFTSYGISWVRQAPGQGLEWMGWISTYNGNTNYAQKFQGRVTMTTDTSTTTGYMELRRLRSDDTAVYYCARDYTRGAWFGESLIGGFDNWGQGTLVTVSSIVLTQSPGTLSLSPGERATLSCRASQTVSSTSLAWYQQKPGQAPRLLIYGASSRATGIPDRFSGSGSGTDFTLTISRLEPEDFAVYYCQQHDTSLTFGGGTKVE input.pdb
Selected Chain(s) N (Heavy), O (Light)
Distance of Aggregation 10 Å
FoldX Energy Minimization Yes
pH Calculations Yes
Downloads Download all data (.tar.gz)

Aggrescan4D Profile

Aggregation-prone (score > 0)
Soluble (score < 0)
Buried (score = 0)

Per-Residue A4D Scores

Download CSV
Minimum Score -3.6507
Maximum Score 2.071
Average Score -0.6792
Total Score -156.8847

Residues with A4D score > 0.0 are highlighted as aggregation-prone.

Index Residue Chain A4D Score Classification
1 Q N -1.4460 Soluble
2 V N -1.0726 Soluble
3 Q N -1.3368 Soluble
4 L N 0.0000 Buried
5 V N 0.1517 Aggregation-prone
6 Q N -0.2446 Soluble
7 S N -0.6420 Soluble
8 G N -0.5545 Soluble
9 A N 0.1576 Aggregation-prone
11 E N -0.1289 Soluble
12 V N 0.9000 Aggregation-prone
13 K N -0.9865 Soluble
14 K N -2.3481 Soluble
15 P N -2.6593 Soluble
16 G N -2.1790 Soluble
17 A N -1.6565 Soluble
18 S N -2.1535 Soluble
19 V N 0.0000 Buried
20 K N -2.0471 Soluble
21 V N 0.0000 Buried
22 S N -0.5252 Soluble
23 C N 0.0000 Buried
24 K N -0.7988 Soluble
25 A N 0.0000 Buried
26 S N -0.7812 Soluble
27 G N -0.9890 Soluble
28 Y N -0.4622 Soluble
29 P N -0.2621 Soluble
30 F N 0.0000 Buried
35 T N 0.2363 Aggregation-prone
36 S N 0.3939 Aggregation-prone
37 Y N 0.5715 Aggregation-prone
38 G N 0.0000 Buried
39 I N 0.0000 Buried
40 S N 0.0000 Buried
41 W N 0.0000 Buried
42 V N 0.0000 Buried
43 R N 0.0000 Buried
44 Q N -0.7228 Soluble
45 A N -1.0055 Soluble
46 P N -0.8597 Soluble
47 G N -1.2188 Soluble
48 Q N -1.8293 Soluble
49 G N -1.1999 Soluble
50 L N 0.0000 Buried
51 E N -1.3589 Soluble
52 W N 0.0000 Buried
53 M N 0.0000 Buried
54 G N 0.0000 Buried
55 W N 0.0000 Buried
56 I N 0.0000 Buried
57 S N 0.0000 Buried
58 T N 0.0000 Buried
59 Y N 0.3617 Aggregation-prone
62 N N -0.9980 Soluble
63 G N -1.4051 Soluble
64 N N -1.6562 Soluble
65 T N -1.3519 Soluble
66 N N -1.4427 Soluble
67 Y N -1.2768 Soluble
68 A N 0.0000 Buried
69 Q N -2.6975 Soluble
70 K N -2.9073 Soluble
71 F N -2.3329 Soluble
72 Q N -2.7690 Soluble
74 G N -2.4763 Soluble
75 R N -3.1597 Soluble
76 V N 0.0000 Buried
77 T N -0.9746 Soluble
78 M N 0.0000 Buried
79 T N -0.4652 Soluble
80 T N -0.5691 Soluble
81 D N -1.0574 Soluble
82 T N -0.5373 Soluble
83 S N -0.5712 Soluble
84 T N -0.6377 Soluble
85 T N -0.6919 Soluble
86 T N 0.0000 Buried
87 G N 0.0000 Buried
88 Y N -0.4810 Soluble
89 M N 0.0000 Buried
90 E N -1.5362 Soluble
91 L N 0.0000 Buried
92 R N -2.8215 Soluble
93 R N -3.3846 Soluble
94 L N 0.0000 Buried
95 R N -3.6507 Soluble
96 S N -2.5077 Soluble
97 D N -2.6838 Soluble
98 D N -2.0262 Soluble
99 T N -0.8202 Soluble
100 A N 0.0000 Buried
101 V N 0.4024 Aggregation-prone
102 Y N 0.0000 Buried
103 Y N 0.0000 Buried
104 C N 0.0000 Buried
105 A N 0.0000 Buried
106 R N -0.2508 Soluble
107 D N 0.0000 Buried
108 Y N 0.9421 Aggregation-prone
109 T N 0.0000 Buried
110 R N 0.0777 Aggregation-prone
111 G N 0.3985 Aggregation-prone
111A A N 0.0000 Buried
111B W N 1.4821 Aggregation-prone
111C F N 1.5184 Aggregation-prone
112D G N -0.5053 Soluble
112C E N -1.3233 Soluble
112B S N -0.5954 Soluble
112A L N 0.6921 Aggregation-prone
112 I N 2.0710 Aggregation-prone
113 G N 0.0000 Buried
114 G N 0.0000 Buried
115 F N 0.0000 Buried
116 D N -0.8439 Soluble
117 N N -0.9962 Soluble
118 W N -0.8541 Soluble
119 G N 0.0000 Buried
120 Q N -1.3313 Soluble
121 G N -0.4768 Soluble
122 T N 0.0000 Buried
123 L N 0.7644 Aggregation-prone
124 V N 0.0000 Buried
125 T N -0.2534 Soluble
126 V N 0.0000 Buried
127 S N -1.1988 Soluble
128 S N -0.7548 Soluble
2 I O 0.7788 Aggregation-prone
3 V O 1.3883 Aggregation-prone
4 L O 0.0000 Buried
5 T O -0.4950 Soluble
6 Q O -0.9404 Soluble
7 S O -0.9480 Soluble
8 P O -0.6673 Soluble
9 G O -0.9326 Soluble
10 T O -1.0383 Soluble
11 L O -0.6686 Soluble
12 S O -0.8026 Soluble
13 L O -1.0352 Soluble
14 S O -1.4151 Soluble
15 P O -1.9465 Soluble
16 G O -2.2746 Soluble
17 E O -3.3081 Soluble
18 R O -3.4890 Soluble
19 A O 0.0000 Buried
20 T O -0.5129 Soluble
21 L O 0.0000 Buried
22 S O -1.0365 Soluble
23 C O 0.0000 Buried
24 R O -2.6255 Soluble
25 A O 0.0000 Buried
26 S O -0.7659 Soluble
27 Q O -1.4990 Soluble
28 T O -1.4318 Soluble
29 V O 0.0000 Buried
30 S O -0.7617 Soluble
36 S O -0.2801 Soluble
37 T O 0.3270 Aggregation-prone
38 S O 0.0000 Buried
39 L O 0.0000 Buried
40 A O 0.0000 Buried
41 W O 0.0000 Buried
42 Y O 0.0000 Buried
43 Q O 0.0000 Buried
44 Q O 0.0000 Buried
45 K O -1.3788 Soluble
46 P O -0.9603 Soluble
47 G O -1.4956 Soluble
48 Q O -2.1195 Soluble
49 A O -1.4336 Soluble
50 P O 0.0000 Buried
51 R O -1.4872 Soluble
52 L O 0.0000 Buried
53 L O 0.0000 Buried
54 I O 0.0000 Buried
55 Y O 0.2428 Aggregation-prone
56 G O 0.2970 Aggregation-prone
57 A O 0.0000 Buried
65 S O -0.6448 Soluble
66 S O -0.5567 Soluble
67 R O -1.5838 Soluble
68 A O -0.8938 Soluble
69 T O -0.6340 Soluble
70 G O -0.8148 Soluble
71 I O -1.0148 Soluble
72 P O -1.3660 Soluble
74 D O -2.3174 Soluble
75 R O -2.0938 Soluble
76 F O 0.0000 Buried
77 S O -0.9704 Soluble
78 G O -0.4895 Soluble
79 S O -0.7044 Soluble
80 G O -1.3213 Soluble
83 S O -1.0839 Soluble
84 G O -1.3980 Soluble
85 T O -2.0881 Soluble
86 D O -2.8875 Soluble
87 F O 0.0000 Buried
88 T O -0.9414 Soluble
89 L O 0.0000 Buried
90 T O -0.8143 Soluble
91 I O 0.0000 Buried
92 S O -2.4398 Soluble
93 R O -3.4351 Soluble
94 L O 0.0000 Buried
95 E O -1.9220 Soluble
96 P O -1.2425 Soluble
97 E O -1.7502 Soluble
98 D O 0.0000 Buried
99 F O -0.0370 Soluble
100 A O 0.0000 Buried
101 V O -0.1521 Soluble
102 Y O 0.0000 Buried
103 Y O 0.0000 Buried
104 C O 0.0000 Buried
105 Q O 0.0000 Buried
106 Q O 0.0000 Buried
107 H O 0.0000 Buried
108 D O -1.3659 Soluble
114 T O -0.7566 Soluble
115 S O -0.6139 Soluble
116 L O -0.1736 Soluble
117 T O 0.1505 Aggregation-prone
118 F O 0.1740 Aggregation-prone
119 G O 0.0000 Buried
120 G O -0.7466 Soluble
121 G O -0.8197 Soluble
122 T O 0.0000 Buried
123 K O -1.1697 Soluble
124 V O 0.0000 Buried
125 E O -1.6288 Soluble

3D Structure — colored by A4D score

Sequence - click residue to focus in viewer  |  colored by A4D score
Load structure to view sequence…
Downloads
Color Legend (B-factor = A4D Score)
Score > 1.5 — highly aggregation-prone
Score 0.5–1.5 — aggregation-prone
Score ≈ 0 — buried
Score −1 to −0.5 — soluble
Score < −2.5 — highly soluble
pH Structure
Load structure at specific pH condition
A4D Score Threshold
Highlight residues > threshold in the sequence panel
CDR Regions
HCDR1
HCDR2
HCDR3
LCDR1
LCDR2
LCDR3
Display Options

pH-Dependent Aggregation Profiles

A4D scores calculated across 11 pH conditions (4.0–9.0, step 0.5). Click a row to view the structure at that pH. The input structure is globular — max score is recommended for pH analysis.

pH Avg A4D Score Max A4D Score Downloads
4.0 -0.5975 5.2983 CSV PDB
4.5 -0.6399 5.1916 CSV PDB
5.0 -0.689 5.0856 CSV PDB
5.5 -0.7372 5.0184 CSV PDB
6.0 -0.7775 4.9587 CSV PDB
6.5 -0.8039 4.9168 CSV PDB
7.0 -0.8152 4.895 CSV PDB
7.5 -0.8156 4.8862 CSV PDB
8.0 -0.8087 4.8832 CSV PDB
8.5 -0.7953 4.8821 CSV PDB
9.0 -0.7754 4.8814 CSV PDB
Average A4D Score vs pH
Max A4D Score vs pH