Tixagevimab / 7b0b

A4DAB270_7b0b_H_L | Source PDB: 7b0b | Chains: H, L | Done
95.69
Yes
10 Å
Yes
Avg A4D Score
-0.7342
Max Score
1.78
Min Score
-3.923
Total Score
-317.89
Score CDR
-0.1972
Score non-CDR
-0.8058

Calculation Parameters

Chain Sequence(s) MQLVQSGPEVKKPGTSVKVSCKASGFTFTSSAVQWVRQARGQRLEWIGWIVVGSGNTNYAQKFQERVTITRDMSTSTAYMELSSLRSEDTAVYYCAAPHCSSTICYDGFDIWGQGTMVTVSSASTKGPSVFPLAPSSGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKEIVLTQSPGTLSLSPGERATLSCRASQSVSSSYLAWYQQKPGQAPRLLIYGASSRATGIPDRFSGSGSGTDFTLTISRVEPEDFAVYYCQQYGSSPWTFGQGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC input.pdb
Selected Chain(s) H (Heavy), L (Light)
Distance of Aggregation 10 Å
FoldX Energy Minimization Yes
pH Calculations Yes
Downloads Download all data (.tar.gz)

Aggrescan4D Profile

Aggregation-prone (score > 0)
Soluble (score < 0)
Buried (score = 0)

Per-Residue A4D Scores

Download CSV
Minimum Score -3.923
Maximum Score 1.78
Average Score -0.7342
Total Score -317.8891

Residues with A4D score > 0.0 are highlighted as aggregation-prone.

Index Residue Chain A4D Score Classification
2 M H 0.5790 Aggregation-prone
3 Q H -0.3219 Soluble
4 L H 0.0000 Buried
5 V H -0.2295 Soluble
6 Q H -0.4633 Soluble
7 S H -0.8023 Soluble
8 G H -0.6861 Soluble
9 P H -0.5250 Soluble
11 E H -0.7278 Soluble
12 V H -0.3693 Soluble
13 K H -1.5942 Soluble
14 K H -2.4282 Soluble
15 P H -2.1554 Soluble
16 G H -1.6586 Soluble
17 T H -1.2573 Soluble
18 S H -1.3712 Soluble
19 V H 0.0000 Buried
20 K H -1.9228 Soluble
21 V H 0.0000 Buried
22 S H -0.6792 Soluble
23 C H 0.0000 Buried
24 K H -0.9935 Soluble
25 A H -0.4161 Soluble
26 S H -0.2926 Soluble
27 G H -0.1898 Soluble
28 F H -0.0559 Soluble
29 T H -0.0355 Soluble
30 F H 0.0000 Buried
35 T H -0.2380 Soluble
36 S H -0.0334 Soluble
37 S H 0.0000 Buried
38 A H 0.0732 Aggregation-prone
39 V H 0.0000 Buried
40 Q H 0.0000 Buried
41 W H 0.0000 Buried
42 V H 0.0000 Buried
43 R H 0.0000 Buried
44 Q H 0.0000 Buried
45 A H -1.9253 Soluble
46 R H -2.6336 Soluble
47 G H -2.2985 Soluble
48 Q H -2.7964 Soluble
49 R H -2.5510 Soluble
50 L H 0.0000 Buried
51 E H -0.8078 Soluble
52 W H 0.0000 Buried
53 I H 0.0000 Buried
54 G H 0.0000 Buried
55 W H -0.0546 Soluble
56 I H 0.0000 Buried
57 V H -0.2330 Soluble
58 V H 0.0000 Buried
59 G H -0.7251 Soluble
62 S H -0.8401 Soluble
63 G H -1.1116 Soluble
64 N H -1.4537 Soluble
65 T H -0.8303 Soluble
66 N H -1.0809 Soluble
67 Y H -1.3531 Soluble
68 A H 0.0000 Buried
69 Q H -3.0321 Soluble
70 K H -2.9048 Soluble
71 F H 0.0000 Buried
72 Q H -3.1143 Soluble
74 E H -3.0090 Soluble
75 R H -2.0305 Soluble
76 V H 0.0000 Buried
77 T H -0.9714 Soluble
78 I H 0.0000 Buried
79 T H -0.6017 Soluble
80 R H -1.0431 Soluble
81 D H -1.2999 Soluble
82 M H -0.6937 Soluble
83 S H -0.5229 Soluble
84 T H -0.6223 Soluble
85 S H -0.6986 Soluble
86 T H 0.0000 Buried
87 A H 0.0000 Buried
88 Y H -0.7460 Soluble
89 M H 0.0000 Buried
90 E H -1.3745 Soluble
91 L H 0.0000 Buried
92 S H -1.2792 Soluble
93 S H -1.4335 Soluble
94 L H 0.0000 Buried
95 R H -3.0474 Soluble
96 S H -2.4657 Soluble
97 E H -2.5398 Soluble
98 D H 0.0000 Buried
99 T H -1.1915 Soluble
100 A H 0.0000 Buried
101 V H -0.3256 Soluble
102 Y H 0.0000 Buried
103 Y H 0.0000 Buried
104 C H 0.0000 Buried
105 A H 0.0000 Buried
106 A H 0.0000 Buried
107 P H -0.3784 Soluble
108 H H -0.1666 Soluble
109 C H 0.0000 Buried
110 S H 0.3558 Aggregation-prone
111 S H 0.2427 Aggregation-prone
111A T H 0.7868 Aggregation-prone
112B I H 1.7800 Aggregation-prone
112A C H 0.7071 Aggregation-prone
112 Y H -0.1700 Soluble
113 D H -1.3064 Soluble
114 G H 0.0000 Buried
115 F H 0.0000 Buried
116 D H 0.0000 Buried
117 I H 0.0076 Aggregation-prone
118 W H -0.1786 Soluble
119 G H 0.0000 Buried
120 Q H -1.2603 Soluble
121 G H -0.7334 Soluble
122 T H 0.0000 Buried
123 M H -0.3023 Soluble
124 V H 0.0000 Buried
125 T H 0.0000 Buried
126 V H 0.0000 Buried
127 S H -1.3603 Soluble
128 S H -1.0269 Soluble
129 A H -0.7074 Soluble
130 S H -0.7991 Soluble
131 T H -0.7142 Soluble
132 K H -1.5039 Soluble
133 G H -1.4390 Soluble
134 P H 0.0000 Buried
135 S H -0.3281 Soluble
136 V H 0.0000 Buried
137 F H 0.0000 Buried
138 P H -1.2599 Soluble
139 L H 0.0000 Buried
140 A H -1.3032 Soluble
141 P H 0.0000 Buried
142 S H -0.4952 Soluble
143 S H -0.5558 Soluble
144 G H -0.6101 Soluble
145 T H -0.4421 Soluble
146 A H -0.2374 Soluble
147 A H 0.0000 Buried
148 L H 0.0000 Buried
149 G H 0.0000 Buried
150 C H 0.0000 Buried
151 L H 0.0000 Buried
152 V H 0.0000 Buried
153 K H 0.0000 Buried
154 D H -0.4373 Soluble
155 Y H 0.0000 Buried
156 F H 0.0000 Buried
157 P H 0.0000 Buried
158 E H -0.6159 Soluble
159 P H -0.7966 Soluble
160 V H -0.7202 Soluble
161 T H -0.6502 Soluble
162 V H -0.2149 Soluble
163 S H -0.2490 Soluble
164 W H 0.0000 Buried
165 N H -0.6904 Soluble
166 S H -0.5188 Soluble
167 G H -0.4889 Soluble
168 A H -0.2442 Soluble
169 L H -0.0069 Soluble
170 T H -0.1978 Soluble
171 S H -0.2486 Soluble
172 G H -0.3355 Soluble
173 V H 0.0693 Aggregation-prone
174 H H -0.4032 Soluble
175 T H -0.0180 Soluble
176 F H 0.0000 Buried
177 P H -0.3397 Soluble
178 A H 0.1043 Aggregation-prone
179 V H 0.3302 Aggregation-prone
180 L H 1.0047 Aggregation-prone
181 Q H -0.0242 Soluble
182 S H -0.2326 Soluble
183 S H -0.2195 Soluble
184 G H -0.0017 Soluble
185 L H -0.0651 Soluble
186 Y H 0.0000 Buried
187 S H 0.1813 Aggregation-prone
188 L H 0.0000 Buried
189 S H 0.0000 Buried
190 S H 0.0000 Buried
191 V H 0.0000 Buried
192 V H 0.0000 Buried
193 T H -0.1621 Soluble
194 V H 0.0000 Buried
195 P H -0.4047 Soluble
196 S H -0.5173 Soluble
197 S H -0.5765 Soluble
198 S H -0.5677 Soluble
199 L H -0.7227 Soluble
200 G H -0.9964 Soluble
201 T H -0.7613 Soluble
202 Q H -1.1449 Soluble
203 T H -1.2195 Soluble
204 Y H 0.0000 Buried
205 I H -0.9970 Soluble
206 C H 0.0000 Buried
207 N H 0.0000 Buried
208 V H 0.0000 Buried
209 N H -2.1370 Soluble
210 H H 0.0000 Buried
211 K H -2.7929 Soluble
212 P H -1.7122 Soluble
213 S H -1.8978 Soluble
214 N H -2.6178 Soluble
215 T H -2.2624 Soluble
216 K H -2.5519 Soluble
217 V H -1.2524 Soluble
218 D H -1.6325 Soluble
219 K H -1.7095 Soluble
220 R H -2.5365 Soluble
221 V H 0.0000 Buried
222 E H -2.7934 Soluble
223 P H -2.1634 Soluble
224 K H -2.1309 Soluble
1 E L -1.6830 Soluble
2 I L 0.0000 Buried
3 V L 0.6557 Aggregation-prone
4 L L 0.0000 Buried
5 T L -0.7334 Soluble
6 Q L 0.0000 Buried
7 S L -0.9032 Soluble
8 P L -0.5480 Soluble
9 G L -0.8912 Soluble
10 T L -0.5137 Soluble
11 L L -0.2953 Soluble
12 S L -0.7046 Soluble
13 L L 0.0000 Buried
14 S L -1.7455 Soluble
15 P L -2.0336 Soluble
16 G L -2.3602 Soluble
17 E L -3.1244 Soluble
18 R L -3.1710 Soluble
19 A L 0.0000 Buried
20 T L -0.5427 Soluble
21 L L 0.0000 Buried
22 S L -0.9307 Soluble
23 C L 0.0000 Buried
24 R L -2.3472 Soluble
25 A L 0.0000 Buried
26 S L -1.0437 Soluble
27 Q L -1.7304 Soluble
28 S L -1.3824 Soluble
29 V L 0.0000 Buried
30 S L -0.2021 Soluble
36 S L -0.3336 Soluble
37 S L -0.2400 Soluble
38 Y L 0.3720 Aggregation-prone
39 L L 0.0000 Buried
40 A L 0.0000 Buried
41 W L 0.0000 Buried
42 Y L 0.0000 Buried
43 Q L -0.7410 Soluble
44 Q L 0.0000 Buried
45 K L -1.8966 Soluble
46 P L -1.8289 Soluble
47 G L -1.7962 Soluble
48 Q L -2.1562 Soluble
49 A L -1.4041 Soluble
50 P L 0.0000 Buried
51 R L -1.0461 Soluble
52 L L 0.0000 Buried
53 L L 0.0000 Buried
54 I L 0.0000 Buried
55 Y L -0.4171 Soluble
56 G L -0.4666 Soluble
57 A L 0.0000 Buried
65 S L -0.6816 Soluble
66 S L -0.9032 Soluble
67 R L -1.3096 Soluble
68 A L 0.0000 Buried
69 T L -0.4818 Soluble
70 G L -0.7888 Soluble
71 I L -0.8550 Soluble
72 P L -1.2208 Soluble
74 D L -2.1298 Soluble
75 R L -1.7645 Soluble
76 F L 0.0000 Buried
77 S L -0.8621 Soluble
78 G L 0.0000 Buried
79 S L -0.6882 Soluble
80 G L -1.1216 Soluble
83 S L -1.1413 Soluble
84 G L -1.2389 Soluble
85 T L -1.8012 Soluble
86 D L -2.1797 Soluble
87 F L 0.0000 Buried
88 T L -0.7822 Soluble
89 L L 0.0000 Buried
90 T L -0.7670 Soluble
91 I L 0.0000 Buried
92 S L -2.3847 Soluble
93 R L -3.3742 Soluble
94 V L 0.0000 Buried
95 E L -2.5708 Soluble
96 P L -1.8728 Soluble
97 E L -2.3831 Soluble
98 D L 0.0000 Buried
99 F L -0.8646 Soluble
100 A L 0.0000 Buried
101 V L -0.5107 Soluble
102 Y L 0.0000 Buried
103 Y L 0.0000 Buried
104 C L 0.0000 Buried
105 Q L 0.0000 Buried
106 Q L 0.0000 Buried
107 Y L 0.0000 Buried
108 G L -0.1106 Soluble
109 S L -0.4937 Soluble
114 S L -0.7711 Soluble
115 P L 0.0000 Buried
116 W L -0.0698 Soluble
117 T L -0.1324 Soluble
118 F L 0.0000 Buried
119 G L 0.0000 Buried
120 Q L -1.5496 Soluble
121 G L -1.2406 Soluble
122 T L 0.0000 Buried
123 K L -0.9203 Soluble
124 V L 0.0000 Buried
125 E L 0.0000 Buried
126 I L -0.9315 Soluble
127 K L -1.5946 Soluble
128 R L -1.7945 Soluble
129 T L -0.4915 Soluble
130 V L 0.2471 Aggregation-prone
131 A L 0.0030 Aggregation-prone
132 A L -0.0967 Soluble
133 P L -0.0882 Soluble
134 S L -0.0399 Soluble
135 V L 0.0000 Buried
136 F L 0.1431 Aggregation-prone
137 I L 0.0000 Buried
138 F L 0.0000 Buried
139 P L -0.5762 Soluble
140 P L -0.7823 Soluble
141 S L 0.0000 Buried
142 D L -2.7671 Soluble
143 E L -2.8093 Soluble
144 Q L 0.0000 Buried
145 L L -1.8633 Soluble
146 K L -2.6920 Soluble
147 S L -1.7068 Soluble
148 G L -1.1097 Soluble
149 T L -1.0011 Soluble
150 A L 0.0000 Buried
151 S L 0.0000 Buried
152 V L 0.0000 Buried
153 V L 0.0000 Buried
154 C L 0.0000 Buried
155 L L 0.0000 Buried
156 L L 0.0000 Buried
157 N L 0.0000 Buried
158 N L -0.8119 Soluble
159 F L 0.0000 Buried
160 Y L 0.0000 Buried
161 P L -1.3881 Soluble
162 R L -2.0082 Soluble
163 E L -2.7346 Soluble
164 A L -2.0826 Soluble
165 K L -2.3133 Soluble
166 V L -1.0028 Soluble
167 Q L -0.4523 Soluble
168 W L 0.0000 Buried
169 K L -0.5360 Soluble
170 V L 0.0000 Buried
171 D L -2.0839 Soluble
172 N L -1.6464 Soluble
173 A L -0.1922 Soluble
174 L L 0.8754 Aggregation-prone
175 Q L -0.1784 Soluble
176 S L -0.7043 Soluble
177 G L -1.3244 Soluble
178 N L -1.7712 Soluble
179 S L -1.6419 Soluble
180 Q L -1.8551 Soluble
181 E L -1.8394 Soluble
182 S L -0.7685 Soluble
183 V L -0.6427 Soluble
184 T L -1.0863 Soluble
185 E L -2.1761 Soluble
186 Q L -1.8658 Soluble
187 D L -2.0908 Soluble
188 S L -2.0414 Soluble
189 K L -2.4765 Soluble
190 D L -2.2623 Soluble
191 S L 0.0000 Buried
192 T L 0.0000 Buried
193 Y L 0.0000 Buried
194 S L 0.0000 Buried
195 L L 0.0000 Buried
196 S L 0.0000 Buried
197 S L 0.0000 Buried
198 T L -0.8847 Soluble
199 L L 0.0000 Buried
200 T L -0.8230 Soluble
201 L L -1.0711 Soluble
202 S L -1.2623 Soluble
203 K L -2.2140 Soluble
204 A L -2.1728 Soluble
205 D L -3.1719 Soluble
206 Y L 0.0000 Buried
207 E L -3.9230 Soluble
208 K L -3.8566 Soluble
209 H L -3.3767 Soluble
210 K L -3.2950 Soluble
211 V L -1.8355 Soluble
212 Y L 0.0000 Buried
213 A L 0.0000 Buried
214 C L 0.0000 Buried
215 E L -0.9195 Soluble
216 V L 0.0000 Buried
217 T L -1.2232 Soluble
218 H L 0.0000 Buried
219 Q L -1.5655 Soluble
220 G L -0.4241 Soluble
221 L L -0.2328 Soluble
222 S L -0.4314 Soluble
223 S L -0.3940 Soluble
224 P L -0.6356 Soluble
225 V L -0.0175 Soluble
226 T L -0.5315 Soluble
227 K L -0.8284 Soluble
228 S L -0.9710 Soluble
229 F L -1.1253 Soluble
230 N L -2.0242 Soluble
231 R L -2.4760 Soluble
232 G L -2.0389 Soluble
233 E L -1.9944 Soluble
234 C L -0.8385 Soluble

3D Structure — colored by A4D score

Sequence - click residue to focus in viewer  |  colored by A4D score
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Downloads
Color Legend (B-factor = A4D Score)
Score > 1.5 — highly aggregation-prone
Score 0.5–1.5 — aggregation-prone
Score ≈ 0 — buried
Score −1 to −0.5 — soluble
Score < −2.5 — highly soluble
pH Structure
Load structure at specific pH condition
A4D Score Threshold
Highlight residues > threshold in the sequence panel
CDR Regions
HCDR1
HCDR2
HCDR3
LCDR1
LCDR2
LCDR3
Display Options

pH-Dependent Aggregation Profiles

A4D scores calculated across 11 pH conditions (4.0–9.0, step 0.5). Click a row to view the structure at that pH. The input structure is globular — max score is recommended for pH analysis.

pH Avg A4D Score Max A4D Score Downloads
4.0 -0.8152 2.6165 CSV PDB
4.5 -0.8579 2.5884 CSV PDB
5.0 -0.9086 2.5496 CSV PDB
5.5 -0.957 2.5069 CSV PDB
6.0 -0.992 2.4666 CSV PDB
6.5 -1.0044 2.4297 CSV PDB
7.0 -0.9936 2.392 CSV PDB
7.5 -0.9673 2.3495 CSV PDB
8.0 -0.9327 2.3034 CSV PDB
8.5 -0.8923 2.2571 CSV PDB
9.0 -0.8469 2.215 CSV PDB
Average A4D Score vs pH
Max A4D Score vs pH