Tralokinumab / 5l6y

A4DAB276_5l6y_H_L | Source PDB: 5l6y | Chains: H, L | Done
100
Yes
10 Å
Yes
Avg A4D Score
-0.7229
Max Score
1.5885
Min Score
-3.2324
Total Score
-320.97
Score CDR
-0.3749
Score non-CDR
-0.7681

Calculation Parameters

Chain Sequence(s) VQLVQSGAEVKKPGASVKVSCKASGYTFTNYGLSWVRQAPGQGLEWMGWISANNGDTNYGQEFQGRVTMTTDTSTSTAYMELRSLRSDDTAVYYCARDSSSSWARWFFDLWGRGTLVTVSSASTKGPSVFPLAPISKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVGPSQTYICNVNHKPSNTKVDKRVESKYGPPSPSSPAPAKNYVLTQPPSVSVAPGKTARITCGGNIIGSKLVHWYQQKPGQAPVLVIYDDGDRPSGIPERFSGSNSGNTATLTISRVEAGDEADYYCQVWDTGSDPVVFGGGTKLTVLGQPKAAPSVTLFPPSSEELQANKATLVCLISDFYPGAVTVAWKADSSPVKAGVETTTPSKQSNNKYAASSYLSLTPEQWKSHRSYSCQVTHEGSTVEKTVAPTEC input.pdb
Selected Chain(s) H (Heavy), L (Light)
Distance of Aggregation 10 Å
FoldX Energy Minimization Yes
pH Calculations Yes
Downloads Download all data (.tar.gz)

Aggrescan4D Profile

Aggregation-prone (score > 0)
Soluble (score < 0)
Buried (score = 0)

Per-Residue A4D Scores

Download CSV
Minimum Score -3.2324
Maximum Score 1.5885
Average Score -0.7229
Total Score -320.9733

Residues with A4D score > 0.0 are highlighted as aggregation-prone.

Index Residue Chain A4D Score Classification
2 V H 1.3400 Aggregation-prone
3 Q H -0.0573 Soluble
4 L H 0.0000 Buried
5 V H -0.5391 Soluble
6 Q H -0.7854 Soluble
7 S H -0.8410 Soluble
8 G H -0.5474 Soluble
9 A H 0.0755 Aggregation-prone
11 E H -0.2131 Soluble
12 V H 0.8629 Aggregation-prone
13 K H -0.9331 Soluble
14 K H -2.1474 Soluble
15 P H -2.3196 Soluble
16 G H -1.7379 Soluble
17 A H -1.3890 Soluble
18 S H -1.5231 Soluble
19 V H 0.0000 Buried
20 K H -1.9750 Soluble
21 V H 0.0000 Buried
22 S H -0.6452 Soluble
23 C H 0.0000 Buried
24 K H -0.9989 Soluble
25 A H 0.0000 Buried
26 S H -0.0394 Soluble
27 G H 0.2126 Aggregation-prone
28 Y H 0.1661 Aggregation-prone
29 T H -0.2050 Soluble
30 F H 0.0000 Buried
35 T H -1.3451 Soluble
36 N H -1.5561 Soluble
37 Y H -0.5186 Soluble
38 G H 0.0000 Buried
39 L H 0.0000 Buried
40 S H 0.0000 Buried
41 W H 0.0000 Buried
42 V H 0.0000 Buried
43 R H -0.5691 Soluble
44 Q H -0.7819 Soluble
45 A H -1.0271 Soluble
46 P H -0.8607 Soluble
47 G H -1.2702 Soluble
48 Q H -1.8272 Soluble
49 G H -1.3694 Soluble
50 L H 0.0000 Buried
51 E H -1.4480 Soluble
52 W H 0.0000 Buried
53 M H 0.0000 Buried
54 G H 0.0000 Buried
55 W H 0.0000 Buried
56 I H 0.0000 Buried
57 S H 0.0000 Buried
58 A H 0.0000 Buried
59 N H -2.4614 Soluble
62 N H -2.5774 Soluble
63 G H -1.9678 Soluble
64 D H -2.2690 Soluble
65 T H -1.2355 Soluble
66 N H -1.2390 Soluble
67 Y H -1.3225 Soluble
68 G H 0.0000 Buried
69 Q H -2.8213 Soluble
70 E H -3.0404 Soluble
71 F H 0.0000 Buried
72 Q H -2.4813 Soluble
74 G H -1.7107 Soluble
75 R H -1.5622 Soluble
76 V H 0.0000 Buried
77 T H -0.7625 Soluble
78 M H 0.0000 Buried
79 T H -0.3609 Soluble
80 T H -0.9352 Soluble
81 D H -0.8290 Soluble
82 T H -0.8638 Soluble
83 S H -0.4791 Soluble
84 T H -0.5747 Soluble
85 S H -0.6239 Soluble
86 T H -0.6241 Soluble
87 A H 0.0000 Buried
88 Y H -0.4352 Soluble
89 M H 0.0000 Buried
90 E H -1.2282 Soluble
91 L H 0.0000 Buried
92 R H -1.5902 Soluble
93 S H -1.4692 Soluble
94 L H 0.0000 Buried
95 R H -3.1671 Soluble
96 S H -2.3986 Soluble
97 D H -2.5306 Soluble
98 D H 0.0000 Buried
99 T H -0.7393 Soluble
100 A H 0.0000 Buried
101 V H 0.1325 Aggregation-prone
102 Y H 0.0000 Buried
103 Y H 0.0000 Buried
104 C H 0.0000 Buried
105 A H 0.0000 Buried
106 R H -0.1809 Soluble
107 D H 0.0000 Buried
108 S H 0.0000 Buried
109 S H -0.6780 Soluble
110 S H -0.0288 Soluble
111 S H -0.0503 Soluble
111A W H 1.1466 Aggregation-prone
112A A H 0.0000 Buried
112 R H 0.0000 Buried
113 W H 1.3376 Aggregation-prone
114 F H 0.7016 Aggregation-prone
115 F H 0.0000 Buried
116 D H -0.5868 Soluble
117 L H -0.1611 Soluble
118 W H -0.4136 Soluble
119 G H 0.0000 Buried
120 R H -2.0529 Soluble
121 G H -1.0228 Soluble
122 T H 0.0000 Buried
123 L H 0.5881 Aggregation-prone
124 V H 0.0000 Buried
125 T H 0.0000 Buried
126 V H 0.0000 Buried
127 S H 0.0000 Buried
128 S H -1.0960 Soluble
129 A H -0.6531 Soluble
130 S H -0.8707 Soluble
131 T H -1.0312 Soluble
132 K H -1.8031 Soluble
133 G H -1.6675 Soluble
134 P H -0.7015 Soluble
135 S H -0.4501 Soluble
136 V H 0.0000 Buried
137 F H 0.0000 Buried
138 P H -0.9183 Soluble
139 L H 0.0000 Buried
140 A H -0.8289 Soluble
141 P H -0.6439 Soluble
142 I H 0.0000 Buried
143 S H -1.1326 Soluble
144 K H -0.9689 Soluble
145 S H -0.7579 Soluble
146 T H -0.6428 Soluble
147 S H -0.7605 Soluble
148 G H -0.7801 Soluble
149 G H -0.6283 Soluble
150 T H -0.4492 Soluble
151 A H -0.3545 Soluble
152 A H 0.0000 Buried
153 L H 0.0000 Buried
154 G H 0.0000 Buried
155 C H 0.0000 Buried
156 L H 0.0000 Buried
157 V H 0.0000 Buried
158 K H 0.0000 Buried
159 D H -0.5334 Soluble
160 Y H 0.0000 Buried
161 F H 0.0000 Buried
162 P H -0.8081 Soluble
163 E H -1.2002 Soluble
164 P H -1.0620 Soluble
165 V H -0.5583 Soluble
166 T H -0.5377 Soluble
167 V H -0.0521 Soluble
168 S H -0.3233 Soluble
169 W H 0.0000 Buried
170 N H -0.7800 Soluble
171 S H -0.6327 Soluble
172 G H -0.4487 Soluble
173 A H -0.2140 Soluble
174 L H 0.0200 Aggregation-prone
175 T H -0.1497 Soluble
176 S H -0.1858 Soluble
177 G H -0.3382 Soluble
178 V H 0.1978 Aggregation-prone
179 H H -0.2958 Soluble
180 T H -0.0184 Soluble
181 F H 0.0000 Buried
182 P H -0.1515 Soluble
183 A H -0.1789 Soluble
184 V H 0.0000 Buried
185 L H 0.0178 Aggregation-prone
186 Q H -0.3387 Soluble
187 S H -0.6430 Soluble
188 S H -0.3375 Soluble
189 G H 0.0000 Buried
190 L H -0.2881 Soluble
191 Y H -0.1800 Soluble
192 S H 0.0000 Buried
193 L H 0.0000 Buried
194 S H 0.0000 Buried
195 S H 0.0000 Buried
196 V H 0.0000 Buried
197 V H 0.0000 Buried
198 T H -0.0732 Soluble
199 V H -0.1245 Soluble
200 G H -0.6393 Soluble
201 P H -0.6812 Soluble
202 S H -0.9177 Soluble
203 Q H -1.4745 Soluble
204 T H -1.3213 Soluble
205 Y H 0.0000 Buried
206 I H -1.3339 Soluble
207 C H 0.0000 Buried
208 N H -1.4457 Soluble
209 V H 0.0000 Buried
210 N H -1.6314 Soluble
211 H H 0.0000 Buried
212 K H -2.7816 Soluble
213 P H -1.8450 Soluble
214 S H -2.0160 Soluble
215 N H -2.6476 Soluble
216 T H -2.1060 Soluble
217 K H -2.6066 Soluble
218 V H -1.6158 Soluble
219 D H -2.5752 Soluble
220 K H -2.1374 Soluble
221 R H -2.7099 Soluble
222 V H 0.0000 Buried
223 E H -2.8214 Soluble
224 S H -1.8047 Soluble
225 K H -2.0463 Soluble
226 Y H -0.8841 Soluble
227 G H -0.9489 Soluble
228 P H -0.7479 Soluble
229 P H -0.5520 Soluble
230 S H -0.4567 Soluble
231 P H -0.5698 Soluble
232 S H -0.4585 Soluble
233 S H -0.3497 Soluble
234 P H -0.3520 Soluble
235 A H -0.8877 Soluble
236 P H -1.0341 Soluble
237 A H -1.0682 Soluble
238 K H -1.9972 Soluble
239 N H -1.6675 Soluble
2 Y L 0.7680 Aggregation-prone
3 V L 1.5885 Aggregation-prone
4 L L 0.0000 Buried
5 T L 0.0244 Aggregation-prone
6 Q L 0.0000 Buried
7 P L -0.4222 Soluble
8 P L -0.6988 Soluble
9 S L -0.6059 Soluble
11 V L -0.5115 Soluble
12 S L -0.4151 Soluble
13 V L 0.0000 Buried
14 A L -1.2660 Soluble
15 P L -1.9893 Soluble
16 G L -2.6913 Soluble
17 K L -3.0790 Soluble
18 T L -2.2407 Soluble
19 A L 0.0000 Buried
20 R L -2.0418 Soluble
21 I L 0.0000 Buried
22 T L -0.5781 Soluble
23 C L 0.0000 Buried
24 G L -0.3990 Soluble
25 G L -0.2182 Soluble
26 N L -0.5953 Soluble
27 I L 0.4868 Aggregation-prone
28 I L 0.0000 Buried
29 G L -0.4431 Soluble
36 S L -0.0262 Soluble
37 K L 0.2259 Aggregation-prone
38 L L 0.8200 Aggregation-prone
39 V L 0.0000 Buried
40 H L 0.0000 Buried
41 W L 0.0000 Buried
42 Y L 0.0000 Buried
43 Q L -0.2824 Soluble
44 Q L 0.0000 Buried
45 K L -1.5008 Soluble
46 P L -1.4242 Soluble
47 G L -1.5648 Soluble
48 Q L -1.9489 Soluble
49 A L -1.0713 Soluble
50 P L 0.0000 Buried
51 V L 0.8291 Aggregation-prone
52 L L 0.0000 Buried
53 V L 0.0000 Buried
54 I L 0.0000 Buried
55 Y L -0.7753 Soluble
56 D L -0.9395 Soluble
57 D L -1.1908 Soluble
65 G L -1.5658 Soluble
66 D L -2.4389 Soluble
67 R L -2.0497 Soluble
68 P L -0.9093 Soluble
69 S L -0.9109 Soluble
70 G L -0.8066 Soluble
71 I L -0.7454 Soluble
72 P L -1.2432 Soluble
74 E L -2.3354 Soluble
75 R L -1.7258 Soluble
76 F L 0.0000 Buried
77 S L -1.3780 Soluble
78 G L -1.2271 Soluble
79 S L -0.9074 Soluble
80 N L -0.7452 Soluble
83 S L -0.7955 Soluble
84 G L -0.9584 Soluble
85 N L -1.4067 Soluble
86 T L -0.9199 Soluble
87 A L 0.0000 Buried
88 T L -0.7875 Soluble
89 L L 0.0000 Buried
90 T L -0.9597 Soluble
91 I L 0.0000 Buried
92 S L -2.3995 Soluble
93 R L -3.2324 Soluble
94 V L 0.0000 Buried
95 E L -2.8418 Soluble
96 A L -1.2299 Soluble
97 G L -1.0932 Soluble
98 D L 0.0000 Buried
99 E L -1.2132 Soluble
100 A L 0.0000 Buried
101 D L -1.3388 Soluble
102 Y L 0.0000 Buried
103 Y L 0.0000 Buried
104 C L 0.0000 Buried
105 Q L 0.0000 Buried
106 V L 0.0000 Buried
107 W L 0.4677 Aggregation-prone
108 D L -0.1790 Soluble
109 T L -0.3442 Soluble
110 G L -0.8546 Soluble
113 S L -1.1486 Soluble
114 D L -1.4163 Soluble
115 P L -0.7525 Soluble
116 V L 0.0000 Buried
117 V L 0.0000 Buried
118 F L 0.0954 Aggregation-prone
119 G L 0.0000 Buried
120 G L -0.7964 Soluble
121 G L -0.9262 Soluble
122 T L 0.0000 Buried
123 K L -1.2564 Soluble
124 L L 0.0000 Buried
125 T L -0.4275 Soluble
126 V L 0.0000 Buried
127 L L -0.6971 Soluble
128 G L -1.0159 Soluble
129 Q L -1.2457 Soluble
130 P L -1.2895 Soluble
131 K L -2.2162 Soluble
132 A L -1.3397 Soluble
133 A L -0.7886 Soluble
134 P L 0.0000 Buried
135 S L -0.5131 Soluble
136 V L -0.4781 Soluble
137 T L -0.3668 Soluble
138 L L 0.0000 Buried
139 F L 0.0000 Buried
140 P L -0.2437 Soluble
141 P L 0.0000 Buried
142 S L -0.7355 Soluble
143 S L -1.2408 Soluble
144 E L -1.9166 Soluble
145 E L 0.0000 Buried
146 L L -1.7912 Soluble
147 Q L -2.1584 Soluble
148 A L -1.7834 Soluble
149 N L -2.5598 Soluble
150 K L -2.4169 Soluble
151 A L 0.0000 Buried
152 T L 0.0000 Buried
153 L L 0.0000 Buried
154 V L 0.0000 Buried
155 C L 0.0000 Buried
156 L L 0.0000 Buried
157 I L 0.0000 Buried
158 S L -0.6459 Soluble
159 D L -1.4268 Soluble
160 F L 0.0000 Buried
161 Y L 0.0000 Buried
162 P L 0.0000 Buried
163 G L -0.8003 Soluble
164 A L -0.1783 Soluble
165 V L -0.0777 Soluble
166 T L -0.0864 Soluble
167 V L 0.0280 Aggregation-prone
168 A L -0.5143 Soluble
169 W L 0.0000 Buried
170 K L -0.9976 Soluble
171 A L 0.0000 Buried
172 D L -1.3249 Soluble
173 S L -0.8905 Soluble
174 S L -0.8182 Soluble
175 P L -0.9131 Soluble
176 V L -0.8798 Soluble
177 K L -1.7669 Soluble
178 A L -0.9700 Soluble
179 G L -0.9165 Soluble
180 V L -0.7389 Soluble
181 E L -0.8836 Soluble
182 T L -0.2420 Soluble
183 T L 0.0000 Buried
184 T L -0.3523 Soluble
185 P L -0.4671 Soluble
186 S L -1.1010 Soluble
187 K L -2.4800 Soluble
188 Q L -2.0828 Soluble
189 S L -1.7548 Soluble
190 N L -2.5324 Soluble
191 N L -2.7532 Soluble
192 K L -2.3734 Soluble
193 Y L -1.5096 Soluble
194 A L 0.0000 Buried
195 A L 0.0000 Buried
196 S L 0.0000 Buried
197 S L 0.0000 Buried
198 Y L 0.0000 Buried
199 L L 0.0000 Buried
200 S L -0.6528 Soluble
201 L L 0.0000 Buried
202 T L -1.7650 Soluble
203 P L -2.4468 Soluble
204 E L -3.1638 Soluble
205 Q L -2.3034 Soluble
206 W L 0.0000 Buried
207 K L -3.0958 Soluble
208 S L -2.4150 Soluble
209 H L -2.3369 Soluble
210 R L -2.7008 Soluble
211 S L -1.7499 Soluble
212 Y L 0.0000 Buried
213 S L -1.0375 Soluble
214 C L 0.0000 Buried
215 Q L -1.0790 Soluble
216 V L 0.0000 Buried
217 T L -0.7173 Soluble
218 H L 0.0000 Buried
219 E L -2.2930 Soluble
220 G L -1.4176 Soluble
221 S L -0.8675 Soluble
222 T L -0.7886 Soluble
223 V L -0.7796 Soluble
224 E L -2.0825 Soluble
225 K L -1.8754 Soluble
226 T L -1.2621 Soluble
227 V L 0.0000 Buried
228 A L -1.5162 Soluble
229 P L 0.0000 Buried
230 T L -1.6073 Soluble
231 E L -2.0312 Soluble
232 C L -0.9882 Soluble

3D Structure — colored by A4D score

Sequence - click residue to focus in viewer  |  colored by A4D score
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Downloads
Color Legend (B-factor = A4D Score)
Score > 1.5 — highly aggregation-prone
Score 0.5–1.5 — aggregation-prone
Score ≈ 0 — buried
Score −1 to −0.5 — soluble
Score < −2.5 — highly soluble
pH Structure
Load structure at specific pH condition
A4D Score Threshold
Highlight residues > threshold in the sequence panel
CDR Regions
HCDR1
HCDR2
HCDR3
LCDR1
LCDR2
LCDR3
Display Options

pH-Dependent Aggregation Profiles

A4D scores calculated across 11 pH conditions (4.0–9.0, step 0.5). Click a row to view the structure at that pH. The input structure is globular — max score is recommended for pH analysis.

pH Avg A4D Score Max A4D Score Downloads
4.0 -0.6167 4.131 CSV PDB
4.5 -0.6533 4.0752 CSV PDB
5.0 -0.6976 4.0143 CSV PDB
5.5 -0.7406 3.9515 CSV PDB
6.0 -0.7715 3.8881 CSV PDB
6.5 -0.7818 3.8246 CSV PDB
7.0 -0.7705 3.7617 CSV PDB
7.5 -0.7438 3.7005 CSV PDB
8.0 -0.7082 3.6441 CSV PDB
8.5 -0.6667 3.5982 CSV PDB
9.0 -0.6201 3.5679 CSV PDB
Average A4D Score vs pH
Max A4D Score vs pH