Paridiprubart / 4r7n

A4DAB203_4r7n_C_D | Source PDB: 4r7n | Chains: C, D | Done
96
Yes
10 Å
Yes
Avg A4D Score
-0.7134
Max Score
1.8
Min Score
-4.1273
Total Score
-306.04
Score CDR
-0.2683
Score non-CDR
-0.7655

Calculation Parameters

Chain Sequence(s) QVQLQESGPGLVKPSDTLSLTCAVSGYPIRFGYSWHWIRQPPGKGLEWMGYIHYSGYTDFNPSLKTRITISRDTSKNQFSLKLSSVTAVDTAVYYCARKDSGNYFPYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPEIVLTQSPDFQSVTPKEKVTITCRASQSISDHLHWYQQKPDQSPKLLIKYASHAISGVPSRFSGSGSGTDFTLTINSLEAEDAATYYCQQGYDFPLTFGGGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNR input.pdb
Selected Chain(s) C (Heavy), D (Light)
Distance of Aggregation 10 Å
FoldX Energy Minimization Yes
pH Calculations Yes
Downloads Download all data (.tar.gz)

Aggrescan4D Profile

Aggregation-prone (score > 0)
Soluble (score < 0)
Buried (score = 0)

Per-Residue A4D Scores

Download CSV
Minimum Score -4.1273
Maximum Score 1.8
Average Score -0.7134
Total Score -306.0368

Residues with A4D score > 0.0 are highlighted as aggregation-prone.

Index Residue Chain A4D Score Classification
1 Q C -1.5420 Soluble
2 V C 0.0000 Buried
3 Q C -1.9068 Soluble
4 L C 0.0000 Buried
5 Q C -1.9223 Soluble
6 E C 0.0000 Buried
7 S C -0.8692 Soluble
8 G C -0.5931 Soluble
9 P C -0.5344 Soluble
11 G C -0.4468 Soluble
12 L C -0.2402 Soluble
13 V C 0.0000 Buried
14 K C -2.0061 Soluble
15 P C -1.1027 Soluble
16 S C -1.1092 Soluble
17 D C -1.3885 Soluble
18 T C -1.1098 Soluble
19 L C 0.0000 Buried
20 S C -0.8008 Soluble
21 L C 0.0000 Buried
22 T C -0.7592 Soluble
23 C C 0.0000 Buried
24 A C -1.1190 Soluble
25 V C 0.0000 Buried
26 S C -1.3668 Soluble
27 G C -1.1102 Soluble
28 Y C -0.3844 Soluble
29 P C -0.4248 Soluble
30 I C 0.0000 Buried
31 R C -0.9393 Soluble
35 F C 1.0979 Aggregation-prone
36 G C 0.5185 Aggregation-prone
37 Y C 0.3596 Aggregation-prone
38 S C 0.0000 Buried
39 W C 0.0000 Buried
40 H C 0.0000 Buried
41 W C 0.0000 Buried
42 I C 0.0000 Buried
43 R C 0.0000 Buried
44 Q C -0.9013 Soluble
45 P C -0.7112 Soluble
46 P C -1.1806 Soluble
47 G C -1.4859 Soluble
48 K C -2.3241 Soluble
49 G C -1.5302 Soluble
50 L C 0.0000 Buried
51 E C -1.3256 Soluble
52 W C 0.0000 Buried
53 M C 0.0000 Buried
54 G C 0.0000 Buried
55 Y C 0.0000 Buried
56 I C 0.0000 Buried
57 H C 0.1153 Aggregation-prone
58 Y C 0.2364 Aggregation-prone
59 S C 0.0886 Aggregation-prone
63 G C -0.1413 Soluble
64 Y C 0.9080 Aggregation-prone
65 T C 0.1284 Aggregation-prone
66 D C -0.6347 Soluble
67 F C -0.5211 Soluble
68 N C -0.9047 Soluble
69 P C -1.1463 Soluble
70 S C -0.8923 Soluble
71 L C 0.0000 Buried
72 K C -2.0093 Soluble
74 T C -1.1557 Soluble
75 R C -1.2054 Soluble
76 I C 0.0000 Buried
77 T C -0.9053 Soluble
78 I C 0.0000 Buried
79 S C -0.8191 Soluble
80 R C -1.1493 Soluble
81 D C -1.5890 Soluble
82 T C -1.5522 Soluble
83 S C -1.5735 Soluble
84 K C -2.1935 Soluble
85 N C -1.7415 Soluble
86 Q C -1.3839 Soluble
87 F C 0.0000 Buried
88 S C -0.7346 Soluble
89 L C 0.0000 Buried
90 K C -1.3614 Soluble
91 L C 0.0000 Buried
92 S C -0.8540 Soluble
93 S C -0.8712 Soluble
94 V C 0.0000 Buried
95 T C 0.0864 Aggregation-prone
96 A C 0.6766 Aggregation-prone
97 V C 1.8000 Aggregation-prone
98 D C 0.0000 Buried
99 T C 0.7029 Aggregation-prone
100 A C 0.0000 Buried
101 V C 0.0009 Aggregation-prone
102 Y C 0.0000 Buried
103 Y C 0.0000 Buried
104 C C 0.0000 Buried
105 A C 0.0000 Buried
106 R C 0.0000 Buried
107 K C -0.3894 Soluble
108 D C -0.3923 Soluble
109 S C -0.4418 Soluble
110 G C -0.2179 Soluble
113 N C -0.4066 Soluble
114 Y C 0.0000 Buried
115 F C 0.0000 Buried
116 P C -0.1713 Soluble
117 Y C -0.2232 Soluble
118 W C -0.6589 Soluble
119 G C 0.0000 Buried
120 Q C -2.0384 Soluble
121 G C -1.2025 Soluble
122 T C -0.4109 Soluble
123 L C 0.2135 Aggregation-prone
124 V C 0.0000 Buried
125 T C 0.1285 Aggregation-prone
126 V C -0.1306 Soluble
127 S C -0.5880 Soluble
128 S C -0.8195 Soluble
129 A C -0.6278 Soluble
130 S C -0.8258 Soluble
131 T C -1.0969 Soluble
132 K C -2.1062 Soluble
133 G C -2.1827 Soluble
134 P C 0.0000 Buried
135 S C -0.6686 Soluble
136 V C 0.0000 Buried
137 F C -0.7537 Soluble
138 P C -1.0656 Soluble
139 L C 0.0000 Buried
140 A C -0.5486 Soluble
141 P C 0.0000 Buried
142 S C -0.7865 Soluble
143 S C -1.2227 Soluble
144 K C -2.1310 Soluble
145 S C -1.4913 Soluble
146 T C -1.0481 Soluble
147 S C -1.2573 Soluble
148 G C -1.1804 Soluble
149 G C -1.0082 Soluble
150 T C -0.7144 Soluble
151 A C 0.0000 Buried
152 A C 0.0000 Buried
153 L C 0.0000 Buried
154 G C 0.0000 Buried
155 C C 0.0000 Buried
156 L C 0.0000 Buried
157 V C 0.0000 Buried
158 K C -0.4645 Soluble
159 D C -1.0530 Soluble
160 Y C 0.0000 Buried
161 F C 0.0000 Buried
162 P C 0.0000 Buried
163 E C -0.3553 Soluble
164 P C -0.6227 Soluble
165 V C -0.7339 Soluble
166 T C -0.6767 Soluble
167 V C -0.4123 Soluble
168 S C -0.4022 Soluble
169 W C 0.0000 Buried
170 N C -0.6409 Soluble
171 S C -0.5863 Soluble
172 G C -0.5923 Soluble
173 A C -0.2585 Soluble
174 L C -0.0593 Soluble
175 T C -0.2052 Soluble
176 S C -0.2232 Soluble
177 G C -0.2183 Soluble
178 V C 0.0886 Aggregation-prone
179 H C -0.2950 Soluble
180 T C 0.0126 Aggregation-prone
181 F C 0.0000 Buried
182 P C -0.4009 Soluble
183 A C 0.2178 Aggregation-prone
184 V C 0.4746 Aggregation-prone
185 L C 1.0948 Aggregation-prone
186 Q C 0.1079 Aggregation-prone
187 S C -0.1899 Soluble
188 S C -0.3152 Soluble
189 G C -0.0717 Soluble
190 L C -0.2708 Soluble
191 Y C 0.2098 Aggregation-prone
192 S C 0.0000 Buried
193 L C 0.0000 Buried
194 S C 0.0000 Buried
195 S C 0.0000 Buried
196 V C 0.0000 Buried
197 V C 0.0000 Buried
198 T C -0.1344 Soluble
199 V C 0.0000 Buried
200 P C -0.5437 Soluble
201 S C 0.0000 Buried
202 S C -0.7704 Soluble
203 S C -0.7051 Soluble
204 L C -0.9013 Soluble
205 G C -1.0725 Soluble
206 T C -0.8030 Soluble
207 Q C -1.1906 Soluble
208 T C -1.2249 Soluble
209 Y C 0.0000 Buried
210 I C -1.1143 Soluble
211 C C 0.0000 Buried
212 N C -1.3422 Soluble
213 V C 0.0000 Buried
214 N C -2.1213 Soluble
215 H C 0.0000 Buried
216 K C -2.6351 Soluble
217 P C -1.6978 Soluble
218 S C -2.0440 Soluble
219 N C -2.3745 Soluble
220 T C -2.2439 Soluble
221 K C -2.6519 Soluble
222 V C -1.2854 Soluble
223 D C -1.8936 Soluble
224 K C -1.8065 Soluble
225 R C -2.5851 Soluble
226 V C 0.0000 Buried
227 E C -2.4256 Soluble
228 P C -1.2452 Soluble
1 E D -1.6166 Soluble
2 I D 0.0000 Buried
3 V D 0.8145 Aggregation-prone
4 L D 0.0000 Buried
5 T D -0.6995 Soluble
6 Q D 0.0000 Buried
7 S D -1.0945 Soluble
8 P D -0.9306 Soluble
9 D D -1.6675 Soluble
10 F D -0.1859 Soluble
11 Q D -0.3935 Soluble
12 S D -0.3638 Soluble
13 V D -1.2100 Soluble
14 T D -1.8852 Soluble
15 P D -2.5476 Soluble
16 K D -3.5886 Soluble
17 E D -3.8410 Soluble
18 K D -3.3521 Soluble
19 V D 0.0000 Buried
20 T D -0.6915 Soluble
21 I D 0.0000 Buried
22 T D -0.8400 Soluble
23 C D 0.0000 Buried
24 R D -2.1738 Soluble
25 A D 0.0000 Buried
26 S D -0.7368 Soluble
27 Q D -0.9656 Soluble
28 S D -1.1402 Soluble
29 I D 0.0000 Buried
36 S D -1.2399 Soluble
37 D D -1.8514 Soluble
38 H D -0.9922 Soluble
39 L D 0.0000 Buried
40 H D 0.0000 Buried
41 W D 0.0000 Buried
42 Y D 0.0000 Buried
43 Q D 0.0000 Buried
44 Q D 0.0000 Buried
45 K D -1.7234 Soluble
46 P D -1.7245 Soluble
47 D D -2.6385 Soluble
48 Q D -2.3165 Soluble
49 S D -1.4838 Soluble
50 P D 0.0000 Buried
51 K D -1.5484 Soluble
52 L D 0.0000 Buried
53 L D 0.0000 Buried
54 I D 0.0000 Buried
55 K D -0.6795 Soluble
56 Y D -0.6190 Soluble
57 A D 0.0000 Buried
65 S D -1.0442 Soluble
66 H D -1.0106 Soluble
67 A D -0.4367 Soluble
68 I D -0.0962 Soluble
69 S D -0.3165 Soluble
70 G D -0.4117 Soluble
71 V D -0.2984 Soluble
72 P D -0.3666 Soluble
74 S D -0.6286 Soluble
75 R D -1.3151 Soluble
76 F D 0.0000 Buried
77 S D -0.7166 Soluble
78 G D -0.6353 Soluble
79 S D -0.7260 Soluble
80 G D -1.1035 Soluble
83 S D -1.3074 Soluble
84 G D -1.4427 Soluble
85 T D -1.4840 Soluble
86 D D -2.0102 Soluble
87 F D 0.0000 Buried
88 T D -0.7646 Soluble
89 L D 0.0000 Buried
90 T D -0.8695 Soluble
91 I D 0.0000 Buried
92 N D -2.8946 Soluble
93 S D -3.0209 Soluble
94 L D 0.0000 Buried
95 E D -3.3901 Soluble
96 A D -2.9439 Soluble
97 E D -3.0513 Soluble
98 D D 0.0000 Buried
99 A D 0.0000 Buried
100 A D 0.0000 Buried
101 T D -0.4999 Soluble
102 Y D 0.0000 Buried
103 Y D 0.0000 Buried
104 C D 0.0000 Buried
105 Q D 0.0000 Buried
106 Q D 0.0000 Buried
107 G D 0.0000 Buried
108 Y D -0.0454 Soluble
109 D D -0.9864 Soluble
114 F D -0.4674 Soluble
115 P D -0.6866 Soluble
116 L D 0.0000 Buried
117 T D -0.2469 Soluble
118 F D 0.0000 Buried
119 G D 0.0000 Buried
120 G D -1.0767 Soluble
121 G D -1.0759 Soluble
122 T D 0.0000 Buried
123 K D -0.9316 Soluble
124 V D 0.0000 Buried
125 E D 0.0000 Buried
126 I D 0.0000 Buried
127 K D -1.0847 Soluble
128 R D -0.7464 Soluble
129 T D 0.2598 Aggregation-prone
130 V D 1.1943 Aggregation-prone
131 A D 0.4617 Aggregation-prone
132 A D 0.0334 Aggregation-prone
133 P D 0.0000 Buried
134 S D -0.1241 Soluble
135 V D 0.0000 Buried
136 F D 0.1633 Aggregation-prone
137 I D 0.1812 Aggregation-prone
138 F D 0.0000 Buried
139 P D -0.6296 Soluble
140 P D -0.5780 Soluble
141 S D -1.4347 Soluble
142 D D -2.6686 Soluble
143 E D -2.5017 Soluble
144 Q D 0.0000 Buried
145 L D -2.1780 Soluble
146 K D -2.6365 Soluble
147 S D -1.6654 Soluble
148 G D -1.4425 Soluble
149 T D -0.9591 Soluble
150 A D 0.0000 Buried
151 S D 0.0000 Buried
152 V D 0.0000 Buried
153 V D 0.0000 Buried
154 C D 0.0000 Buried
155 L D 0.0000 Buried
156 L D 0.0000 Buried
157 N D 0.0000 Buried
158 N D -0.6917 Soluble
159 F D 0.0000 Buried
160 Y D 0.0000 Buried
161 P D -1.0984 Soluble
162 R D -2.0639 Soluble
163 E D -2.7279 Soluble
164 A D -2.0582 Soluble
165 K D -2.4043 Soluble
166 V D -1.2809 Soluble
167 Q D -0.5713 Soluble
168 W D 0.0000 Buried
169 K D -0.5374 Soluble
170 V D 0.0000 Buried
171 D D -2.1398 Soluble
172 N D -1.5694 Soluble
173 A D -0.2962 Soluble
174 L D 0.7851 Aggregation-prone
175 Q D -0.1553 Soluble
176 S D -0.6285 Soluble
177 G D -1.1298 Soluble
178 N D -1.2785 Soluble
179 S D -1.4308 Soluble
180 Q D -1.7432 Soluble
181 E D -2.1131 Soluble
182 S D -0.7220 Soluble
183 V D -0.2462 Soluble
184 T D -0.6693 Soluble
185 E D -1.8360 Soluble
186 Q D -1.7206 Soluble
187 D D -2.0879 Soluble
188 S D -2.5367 Soluble
189 K D -3.0114 Soluble
190 D D -2.2782 Soluble
191 S D 0.0000 Buried
192 T D 0.0000 Buried
193 Y D 0.0000 Buried
194 S D 0.0000 Buried
195 L D 0.0000 Buried
196 S D 0.0000 Buried
197 S D 0.0000 Buried
198 T D -0.8622 Soluble
199 L D 0.0000 Buried
200 T D -0.4842 Soluble
201 L D -0.8727 Soluble
202 S D -1.4409 Soluble
203 K D -2.4502 Soluble
204 A D -2.0769 Soluble
205 D D -3.0438 Soluble
206 Y D 0.0000 Buried
207 E D -4.1273 Soluble
208 K D -4.0962 Soluble
209 H D -3.6058 Soluble
210 K D -3.8140 Soluble
211 V D -2.0106 Soluble
212 Y D 0.0000 Buried
213 A D 0.0000 Buried
214 C D 0.0000 Buried
215 E D -0.9759 Soluble
216 V D 0.0000 Buried
217 T D -1.1804 Soluble
218 H D 0.0000 Buried
219 Q D -1.3296 Soluble
220 G D -0.3012 Soluble
221 L D -0.2141 Soluble
222 S D -0.4871 Soluble
223 S D -0.4390 Soluble
224 P D -0.5760 Soluble
225 V D -0.0624 Soluble
226 T D -0.4691 Soluble
227 K D -0.6356 Soluble
228 S D -0.5887 Soluble
229 F D -1.0777 Soluble
230 N D -2.6161 Soluble
231 R D -3.4991 Soluble

3D Structure — colored by A4D score

Sequence - click residue to focus in viewer  |  colored by A4D score
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Color Legend (B-factor = A4D Score)
Score > 1.5 — highly aggregation-prone
Score 0.5–1.5 — aggregation-prone
Score ≈ 0 — buried
Score −1 to −0.5 — soluble
Score < −2.5 — highly soluble
pH Structure
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A4D Score Threshold
Highlight residues > threshold in the sequence panel
CDR Regions
HCDR1
HCDR2
HCDR3
LCDR1
LCDR2
LCDR3
Display Options

pH-Dependent Aggregation Profiles

A4D scores calculated across 11 pH conditions (4.0–9.0, step 0.5). Click a row to view the structure at that pH. The input structure is globular — max score is recommended for pH analysis.

pH Avg A4D Score Max A4D Score Downloads
4.0 -0.756 2.5772 CSV PDB
4.5 -0.8016 2.5807 CSV PDB
5.0 -0.8538 2.587 CSV PDB
5.5 -0.9012 2.5944 CSV PDB
6.0 -0.9308 2.6 CSV PDB
6.5 -0.9344 2.6028 CSV PDB
7.0 -0.9145 2.6039 CSV PDB
7.5 -0.8798 2.6043 CSV PDB
8.0 -0.8368 2.6043 CSV PDB
8.5 -0.7873 2.6041 CSV PDB
9.0 -0.731 2.6035 CSV PDB
Average A4D Score vs pH
Max A4D Score vs pH