Diridavumab / 4evn

A4DAB087_4evn_I_J | Source PDB: 4evn | Chains: I, J | Done
96.55
Yes
10 Å
Yes
Avg A4D Score
-0.6426
Max Score
3.1495
Min Score
-3.142
Total Score
-278.91
Score CDR
-0.0367
Score non-CDR
-0.7269

Calculation Parameters

Chain Sequence(s) QVQLVESGAEVKKPGSSVKVSCKASGGPFRSYAISWVRQAPGQGPEWMGGIIPIFGTTKYAPKFQGRVTITADDFAGTVYMELSSLRSEDTAMYYCAKHMGYQVRETMDVWGKGTTVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPVLTQPPSVSAAPGQKVTISCSGSSSNIGNNYVSWYQQLPGTAPKLLIYDNNKRPSGIPDRFSGSKSGTSATLGITGLQTGDEADYYCGTWDSSLSAYVVFGGGTKLTVLGQPKANPTVTLFPPSSEELQANKATLVCLISDFYPGAVTVAWKADGSPVKAGVETTKPSKQSNNKYAASSYLSLTPEQWKSHRSYSCQVTHEGSTVEKTVAPTE input.pdb
Selected Chain(s) I (Heavy), J (Light)
Distance of Aggregation 10 Å
FoldX Energy Minimization Yes
pH Calculations Yes
Downloads Download all data (.tar.gz)

Aggrescan4D Profile

Aggregation-prone (score > 0)
Soluble (score < 0)
Buried (score = 0)

Per-Residue A4D Scores

Download CSV
Minimum Score -3.142
Maximum Score 3.1495
Average Score -0.6426
Total Score -278.9095

Residues with A4D score > 0.0 are highlighted as aggregation-prone.

Index Residue Chain A4D Score Classification
1 Q I -1.3955 Soluble
2 V I -0.8605 Soluble
3 Q I -1.2919 Soluble
4 L I 0.0000 Buried
5 V I 0.4892 Aggregation-prone
6 E I -0.1423 Soluble
7 S I -0.5009 Soluble
8 G I -0.4964 Soluble
9 A I -0.2974 Soluble
11 E I -0.5926 Soluble
12 V I 0.0879 Aggregation-prone
13 K I -1.2817 Soluble
14 K I -2.3293 Soluble
15 P I -2.3103 Soluble
16 G I -1.6758 Soluble
17 S I -1.3138 Soluble
18 S I -1.3119 Soluble
19 V I 0.0000 Buried
20 K I -2.1308 Soluble
21 V I 0.0000 Buried
22 S I -0.6564 Soluble
23 C I 0.0000 Buried
24 K I -0.9976 Soluble
25 A I 0.0000 Buried
26 S I -0.7588 Soluble
27 G I -0.8987 Soluble
28 G I -0.4695 Soluble
29 P I 0.3751 Aggregation-prone
30 F I 2.0100 Aggregation-prone
35 R I 0.0000 Buried
36 S I 0.8240 Aggregation-prone
37 Y I 0.0000 Buried
38 A I 0.0000 Buried
39 I I 0.0000 Buried
40 S I 0.0000 Buried
41 W I 0.0000 Buried
42 V I 0.0000 Buried
43 R I -0.3235 Soluble
44 Q I -0.5293 Soluble
45 A I -0.8729 Soluble
46 P I -0.7210 Soluble
47 G I -1.2618 Soluble
48 Q I -1.3160 Soluble
49 G I -0.9549 Soluble
50 P I 0.0000 Buried
51 E I -0.6002 Soluble
52 W I 0.0000 Buried
53 M I 0.0000 Buried
54 G I 0.0000 Buried
55 G I 0.0000 Buried
56 I I 0.0000 Buried
57 I I 0.0000 Buried
58 P I 0.0000 Buried
59 I I 3.1495 Aggregation-prone
62 F I 2.7535 Aggregation-prone
63 G I 1.1199 Aggregation-prone
64 T I 0.5266 Aggregation-prone
65 T I -0.2252 Soluble
66 K I -0.8806 Soluble
67 Y I -0.8712 Soluble
68 A I 0.0000 Buried
69 P I -1.3189 Soluble
70 K I -2.2579 Soluble
71 F I 0.0000 Buried
72 Q I -2.1834 Soluble
74 G I -1.5576 Soluble
75 R I -1.5483 Soluble
76 V I 0.0000 Buried
77 T I -0.9510 Soluble
78 I I 0.0000 Buried
79 T I -0.3409 Soluble
80 A I -0.0261 Soluble
81 D I -0.0316 Soluble
82 D I 0.8490 Aggregation-prone
83 F I 1.8969 Aggregation-prone
84 A I 0.6314 Aggregation-prone
85 G I 0.0000 Buried
86 T I -0.1094 Soluble
87 V I 0.0000 Buried
88 Y I -0.6987 Soluble
89 M I 0.0000 Buried
90 E I -1.5978 Soluble
91 L I 0.0000 Buried
92 S I -1.2956 Soluble
93 S I -1.2981 Soluble
94 L I 0.0000 Buried
95 R I -3.1093 Soluble
96 S I -2.3977 Soluble
97 E I -2.5338 Soluble
98 D I 0.0000 Buried
99 T I -0.9376 Soluble
100 A I 0.0000 Buried
101 M I 0.0226 Aggregation-prone
102 Y I 0.0000 Buried
103 Y I 0.0000 Buried
104 C I 0.0000 Buried
105 A I 0.0000 Buried
106 K I -0.0588 Soluble
107 H I 0.0000 Buried
108 M I 0.1832 Aggregation-prone
109 G I 0.1277 Aggregation-prone
110 Y I 0.9319 Aggregation-prone
111 Q I -0.5326 Soluble
112A V I 0.0000 Buried
112 R I -1.9223 Soluble
113 E I -1.4208 Soluble
114 T I -0.6873 Soluble
115 M I 0.0000 Buried
116 D I -0.3585 Soluble
117 V I -0.2171 Soluble
118 W I 0.0000 Buried
119 G I 0.0000 Buried
120 K I -1.4595 Soluble
121 G I 0.0000 Buried
122 T I 0.0000 Buried
123 T I -0.0202 Soluble
124 V I 0.0000 Buried
125 T I -0.6738 Soluble
126 V I 0.0000 Buried
127 S I -1.2161 Soluble
128 S I -1.2637 Soluble
129 A I -0.7235 Soluble
130 S I -0.7546 Soluble
131 T I -0.7616 Soluble
132 K I -1.5652 Soluble
133 G I -1.6345 Soluble
134 P I -0.7802 Soluble
135 S I -0.3597 Soluble
136 V I 0.0000 Buried
137 F I 0.0000 Buried
138 P I -1.1047 Soluble
139 L I 0.0000 Buried
140 A I -0.9266 Soluble
141 P I 0.0000 Buried
142 S I -0.6797 Soluble
143 S I -0.6340 Soluble
144 K I -0.8410 Soluble
145 S I 0.0000 Buried
146 T I -0.6480 Soluble
147 S I -0.7604 Soluble
148 G I -0.8247 Soluble
149 G I -0.8566 Soluble
150 T I -0.6020 Soluble
151 A I 0.0000 Buried
152 A I 0.0000 Buried
153 L I 0.0000 Buried
154 G I 0.0000 Buried
155 C I 0.0000 Buried
156 L I 0.0000 Buried
157 V I 0.0000 Buried
158 K I 0.0000 Buried
159 D I -0.6006 Soluble
160 Y I 0.0000 Buried
161 F I 0.0000 Buried
162 P I -0.7846 Soluble
163 E I -0.9742 Soluble
164 P I -0.9134 Soluble
165 V I -0.7291 Soluble
166 T I -0.6309 Soluble
167 V I -0.3402 Soluble
168 S I -0.3845 Soluble
169 W I 0.0000 Buried
170 N I -0.8410 Soluble
171 S I -0.7003 Soluble
172 G I -0.5311 Soluble
173 A I -0.2094 Soluble
174 L I 0.0867 Aggregation-prone
175 T I -0.1320 Soluble
176 S I -0.2505 Soluble
177 G I -0.3251 Soluble
178 V I 0.1502 Aggregation-prone
179 H I -0.2195 Soluble
180 T I -0.0625 Soluble
181 F I 0.0000 Buried
182 P I -0.2516 Soluble
183 A I 0.0418 Aggregation-prone
184 V I 0.0000 Buried
185 L I 1.1101 Aggregation-prone
186 Q I 0.1210 Aggregation-prone
187 S I -0.1827 Soluble
188 S I -0.2368 Soluble
189 G I -0.0515 Soluble
190 L I -0.0707 Soluble
191 Y I 0.2099 Aggregation-prone
192 S I 0.0000 Buried
193 L I 0.0000 Buried
194 S I 0.0000 Buried
195 S I 0.0000 Buried
196 V I 0.0000 Buried
197 V I 0.0000 Buried
198 T I -0.2433 Soluble
199 V I 0.0000 Buried
200 P I -0.6644 Soluble
201 S I -0.6460 Soluble
202 S I -0.5953 Soluble
203 S I -0.6602 Soluble
204 L I -0.8469 Soluble
205 G I -1.0991 Soluble
206 T I -0.7358 Soluble
207 Q I -1.3155 Soluble
208 T I -1.1696 Soluble
209 Y I 0.0000 Buried
210 I I -1.4052 Soluble
211 C I 0.0000 Buried
212 N I -1.5866 Soluble
213 V I 0.0000 Buried
214 N I -1.9258 Soluble
215 H I 0.0000 Buried
216 K I -2.7901 Soluble
217 P I -1.7544 Soluble
218 S I -1.9175 Soluble
219 N I -2.6185 Soluble
220 T I -2.1201 Soluble
221 K I -2.6900 Soluble
222 V I -1.5931 Soluble
223 D I -2.7099 Soluble
224 K I -2.3220 Soluble
225 R I -2.8250 Soluble
226 V I 0.0000 Buried
227 E I -2.5703 Soluble
228 P I -1.2262 Soluble
3 V J 1.6121 Aggregation-prone
4 L J 0.0000 Buried
5 T J 0.0570 Aggregation-prone
6 Q J 0.0000 Buried
7 P J -0.4891 Soluble
8 P J -0.7354 Soluble
9 S J -0.6767 Soluble
11 V J -0.2019 Soluble
12 S J -0.3162 Soluble
13 A J -0.6130 Soluble
14 A J -0.9842 Soluble
15 P J -1.5754 Soluble
16 G J -2.0326 Soluble
17 Q J -2.5979 Soluble
18 K J -2.5897 Soluble
19 V J 0.0000 Buried
20 T J -0.4639 Soluble
21 I J 0.0000 Buried
22 S J -0.2922 Soluble
23 C J 0.0000 Buried
24 S J -0.1678 Soluble
25 G J -0.0857 Soluble
26 S J -0.4084 Soluble
27 S J -0.8716 Soluble
28 S J -0.5147 Soluble
29 N J 0.0000 Buried
30 I J 0.0000 Buried
35 G J -1.0174 Soluble
36 N J -1.2549 Soluble
37 N J 0.0000 Buried
38 Y J 0.1021 Aggregation-prone
39 V J 0.0000 Buried
40 S J 0.0000 Buried
41 W J 0.0000 Buried
42 Y J 0.0000 Buried
43 Q J 0.0000 Buried
44 Q J 0.0000 Buried
45 L J -0.3213 Soluble
46 P J -0.5662 Soluble
47 G J -0.7649 Soluble
48 T J -0.8390 Soluble
49 A J -0.9489 Soluble
50 P J 0.0000 Buried
51 K J -0.9761 Soluble
52 L J 0.0000 Buried
53 L J 0.0000 Buried
54 I J 0.0000 Buried
55 Y J -1.2725 Soluble
56 D J -1.6283 Soluble
57 N J -1.5466 Soluble
65 N J -2.6087 Soluble
66 K J -2.9330 Soluble
67 R J -2.4273 Soluble
68 P J -1.1701 Soluble
69 S J -0.9593 Soluble
70 G J -0.8466 Soluble
71 I J -0.9247 Soluble
72 P J -1.3073 Soluble
74 D J -2.2243 Soluble
75 R J -1.5466 Soluble
76 F J 0.0000 Buried
77 S J -1.4974 Soluble
78 G J -1.4997 Soluble
79 S J -1.3852 Soluble
80 K J -1.1155 Soluble
83 S J -0.8199 Soluble
84 G J -1.0249 Soluble
85 T J -0.8774 Soluble
86 S J -0.6756 Soluble
87 A J 0.0000 Buried
88 T J -0.5564 Soluble
89 L J 0.0000 Buried
90 G J 0.0000 Buried
91 I J 0.0000 Buried
92 T J -1.9587 Soluble
93 G J -1.8949 Soluble
94 L J 0.0000 Buried
95 Q J -1.9064 Soluble
96 T J -1.0563 Soluble
97 G J -0.9239 Soluble
98 D J 0.0000 Buried
99 E J -0.7424 Soluble
100 A J 0.0000 Buried
101 D J -1.1311 Soluble
102 Y J 0.0000 Buried
103 Y J 0.0000 Buried
104 C J 0.0000 Buried
105 G J 0.0000 Buried
106 T J 0.0000 Buried
107 W J 0.0000 Buried
108 D J 0.0000 Buried
109 S J -0.3088 Soluble
110 S J 0.5522 Aggregation-prone
112 L J 1.4146 Aggregation-prone
113 S J 0.4155 Aggregation-prone
114 A J 0.1728 Aggregation-prone
115 Y J -0.0631 Soluble
116 V J 0.0000 Buried
117 V J 0.0000 Buried
118 F J 0.0000 Buried
119 G J 0.0000 Buried
120 G J -0.6033 Soluble
121 G J -0.9744 Soluble
122 T J 0.0000 Buried
123 K J -1.2131 Soluble
124 L J 0.0000 Buried
125 T J -0.4032 Soluble
126 V J 0.0000 Buried
127 L J -0.0991 Soluble
128 G J -0.8313 Soluble
129 Q J -1.0822 Soluble
130 P J -1.3684 Soluble
131 K J -2.5083 Soluble
132 A J -2.0189 Soluble
133 N J -2.1415 Soluble
134 P J 0.0000 Buried
135 T J -0.4675 Soluble
136 V J 0.0000 Buried
137 T J -0.3992 Soluble
138 L J 0.0000 Buried
139 F J 0.0000 Buried
140 P J -0.1779 Soluble
141 P J -0.5540 Soluble
142 S J -0.9853 Soluble
143 S J -1.6213 Soluble
144 E J -2.6256 Soluble
145 E J 0.0000 Buried
146 L J -2.1060 Soluble
147 Q J -2.4656 Soluble
148 A J -2.0004 Soluble
149 N J -2.6841 Soluble
150 K J -2.5268 Soluble
151 A J 0.0000 Buried
152 T J 0.0000 Buried
153 L J 0.0000 Buried
154 V J 0.0000 Buried
155 C J 0.0000 Buried
156 L J 0.0000 Buried
157 I J 0.0000 Buried
158 S J -0.7889 Soluble
159 D J -1.6403 Soluble
160 F J 0.0000 Buried
161 Y J 0.0000 Buried
162 P J -1.1827 Soluble
163 G J -1.1374 Soluble
164 A J -0.4606 Soluble
165 V J -0.3412 Soluble
166 T J -0.0756 Soluble
167 V J 0.0437 Aggregation-prone
168 A J -0.4416 Soluble
169 W J 0.0000 Buried
170 K J -1.0291 Soluble
171 A J -1.3275 Soluble
172 D J -1.6415 Soluble
173 G J -1.2036 Soluble
174 S J -0.7655 Soluble
175 P J -0.9342 Soluble
176 V J -0.8533 Soluble
177 K J -1.6909 Soluble
178 A J -0.8832 Soluble
179 G J -0.7736 Soluble
180 V J -0.6184 Soluble
181 E J -0.7096 Soluble
182 T J -0.5076 Soluble
183 T J -0.8350 Soluble
184 K J -1.7956 Soluble
185 P J -1.1707 Soluble
186 S J -1.2783 Soluble
187 K J -1.9561 Soluble
188 Q J -1.8102 Soluble
189 S J -1.6495 Soluble
190 N J -2.4326 Soluble
191 N J -2.6377 Soluble
192 K J -2.3463 Soluble
193 Y J 0.0000 Buried
194 A J 0.0000 Buried
195 A J 0.0000 Buried
196 S J 0.0000 Buried
197 S J 0.0000 Buried
198 Y J 0.0000 Buried
199 L J 0.0000 Buried
200 S J -0.6207 Soluble
201 L J -1.1353 Soluble
202 T J -1.8073 Soluble
203 P J -2.4547 Soluble
204 E J -3.1420 Soluble
205 Q J -2.4171 Soluble
206 W J 0.0000 Buried
207 K J -3.0620 Soluble
208 S J -2.5116 Soluble
209 H J -2.4412 Soluble
210 R J -2.8643 Soluble
211 S J 0.0000 Buried
212 Y J 0.0000 Buried
213 S J 0.0000 Buried
214 C J 0.0000 Buried
215 Q J -0.8672 Soluble
216 V J 0.0000 Buried
217 T J -0.8033 Soluble
218 H J 0.0000 Buried
219 E J -2.5056 Soluble
220 G J -1.3996 Soluble
221 S J -1.0564 Soluble
222 T J -0.8894 Soluble
223 V J -0.7076 Soluble
224 E J -1.6116 Soluble
225 K J -1.1844 Soluble
226 T J -0.8053 Soluble
227 V J 0.0000 Buried
228 A J -1.5519 Soluble
229 P J -1.6688 Soluble
230 T J -1.2146 Soluble
231 E J -2.1389 Soluble

3D Structure — colored by A4D score

Sequence - click residue to focus in viewer  |  colored by A4D score
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Color Legend (B-factor = A4D Score)
Score > 1.5 — highly aggregation-prone
Score 0.5–1.5 — aggregation-prone
Score ≈ 0 — buried
Score −1 to −0.5 — soluble
Score < −2.5 — highly soluble
pH Structure
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A4D Score Threshold
Highlight residues > threshold in the sequence panel
CDR Regions
HCDR1
HCDR2
HCDR3
LCDR1
LCDR2
LCDR3
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pH-Dependent Aggregation Profiles

A4D scores calculated across 11 pH conditions (4.0–9.0, step 0.5). Click a row to view the structure at that pH. The input structure is globular — max score is recommended for pH analysis.

pH Avg A4D Score Max A4D Score Downloads
4.0 -0.589 6.2399 CSV PDB
4.5 -0.6207 6.1834 CSV PDB
5.0 -0.6569 6.1211 CSV PDB
5.5 -0.6883 6.0567 CSV PDB
6.0 -0.7044 5.9915 CSV PDB
6.5 -0.6969 5.9263 CSV PDB
7.0 -0.6668 5.8614 CSV PDB
7.5 -0.623 5.7981 CSV PDB
8.0 -0.5725 5.7391 CSV PDB
8.5 -0.5181 5.69 CSV PDB
9.0 -0.4604 5.6568 CSV PDB
Average A4D Score vs pH
Max A4D Score vs pH