Zinlirvimab / 7ucg

A4DAB308_7ucg_J_K | Source PDB: 7ucg | Chains: J, K | Done
100
Yes
10 Å
Yes
Avg A4D Score
-0.5479
Max Score
2.4841
Min Score
-3.4591
Total Score
-126.01
Score CDR
-0.3805
Score non-CDR
-0.6096

Calculation Parameters

Chain Sequence(s) VQLQESGPGLVKPSETLSVTCSVSGDSMNNYYWTWIRQSPGKGLEWIGYISDRESATYNPSLNSRVVISRDTSKNQLSLKLNSVTPADTAVYYCATARRGQRIYGVVSFGEFFYYYSMDVWGKGTTVTLSVALGETARISCGRQALGSRAVQWYQHRPGQAPILLIYNNQDRPSGIPERFSGTPDINFGTRATLTISGVEAGDEADYYCHMWDSRSGFSWSFGGATRLTV input.pdb
Selected Chain(s) J (Heavy), K (Light)
Distance of Aggregation 10 Å
FoldX Energy Minimization Yes
pH Calculations Yes
Downloads Download all data (.tar.gz)

Aggrescan4D Profile

Aggregation-prone (score > 0)
Soluble (score < 0)
Buried (score = 0)

Per-Residue A4D Scores

Download CSV
Minimum Score -3.4591
Maximum Score 2.4841
Average Score -0.5479
Total Score -126.0061

Residues with A4D score > 0.0 are highlighted as aggregation-prone.

Index Residue Chain A4D Score Classification
2 V J 0.7007 Aggregation-prone
3 Q J -0.9155 Soluble
4 L J 0.0000 Buried
5 Q J -1.6960 Soluble
6 E J -1.1737 Soluble
7 S J -0.8073 Soluble
8 G J -0.4338 Soluble
9 P J 0.0129 Aggregation-prone
11 G J 0.4644 Aggregation-prone
12 L J 1.0516 Aggregation-prone
13 V J -0.1356 Soluble
14 K J -1.6970 Soluble
15 P J -1.4321 Soluble
16 S J -1.5365 Soluble
17 E J -1.9749 Soluble
18 T J -1.5731 Soluble
19 L J 0.0000 Buried
20 S J -0.9356 Soluble
21 V J 0.0000 Buried
22 T J -0.6811 Soluble
23 C J 0.0000 Buried
24 S J -1.1760 Soluble
25 V J -0.7486 Soluble
26 S J -0.9956 Soluble
27 G J -1.1068 Soluble
28 D J -2.1567 Soluble
29 S J -1.8702 Soluble
30 M J -1.5780 Soluble
35 N J -2.3837 Soluble
36 N J -2.1405 Soluble
37 Y J -1.1931 Soluble
38 Y J -0.5395 Soluble
39 W J 0.0000 Buried
40 T J 0.0000 Buried
41 W J 0.0000 Buried
42 I J 0.0000 Buried
43 R J 0.0000 Buried
44 Q J -0.7513 Soluble
45 S J -0.9574 Soluble
46 P J -1.0940 Soluble
47 G J -1.4873 Soluble
48 K J -2.2643 Soluble
49 G J -1.5371 Soluble
50 L J 0.0000 Buried
51 E J -0.9083 Soluble
52 W J 0.0000 Buried
53 I J 0.0000 Buried
54 G J 0.0000 Buried
55 Y J 0.3023 Aggregation-prone
56 I J 0.0000 Buried
57 S J -1.7541 Soluble
58 D J -2.9044 Soluble
59 R J -3.4591 Soluble
63 E J -3.2782 Soluble
64 S J -1.8833 Soluble
65 A J -0.7125 Soluble
66 T J 0.1163 Aggregation-prone
67 Y J 0.0805 Aggregation-prone
68 N J 0.0000 Buried
69 P J -0.7560 Soluble
70 S J -0.7368 Soluble
71 L J -0.7711 Soluble
72 N J -1.5065 Soluble
74 S J -0.8419 Soluble
75 R J -1.0009 Soluble
76 V J 0.0000 Buried
77 V J 0.0886 Aggregation-prone
78 I J 0.0000 Buried
79 S J -0.7717 Soluble
80 R J -1.7173 Soluble
81 D J -1.7792 Soluble
82 T J -1.6606 Soluble
83 S J -1.6712 Soluble
84 K J -2.6698 Soluble
85 N J -2.4229 Soluble
86 Q J -1.6292 Soluble
87 L J 0.0000 Buried
88 S J -0.7072 Soluble
89 L J 0.0000 Buried
90 K J -1.4328 Soluble
91 L J 0.0000 Buried
92 N J -1.7004 Soluble
93 S J -1.2191 Soluble
94 V J -0.9637 Soluble
95 T J -0.6680 Soluble
96 P J -0.4519 Soluble
97 A J -0.1003 Soluble
98 D J 0.0000 Buried
99 T J 0.0591 Aggregation-prone
100 A J 0.0000 Buried
101 V J -0.1566 Soluble
102 Y J 0.0000 Buried
103 Y J 0.0000 Buried
104 C J 0.0000 Buried
105 A J 0.0000 Buried
106 T J 0.0000 Buried
107 A J 0.0000 Buried
108 R J -1.4330 Soluble
109 R J -1.6611 Soluble
110 G J -1.1026 Soluble
111 Q J -0.5442 Soluble
111A R J 0.0000 Buried
111B I J 1.6560 Aggregation-prone
111C Y J 1.3347 Aggregation-prone
111D G J 1.3572 Aggregation-prone
111E V J 2.2563 Aggregation-prone
111F V J 2.4841 Aggregation-prone
112G S J 1.4872 Aggregation-prone
112F F J 2.2012 Aggregation-prone
112E G J 1.1605 Aggregation-prone
112D E J 0.9997 Aggregation-prone
112C F J 1.3331 Aggregation-prone
112B F J 0.3849 Aggregation-prone
112A Y J 0.2111 Aggregation-prone
112 Y J 0.0000 Buried
113 Y J -0.7589 Soluble
114 S J 0.0000 Buried
115 M J 0.0000 Buried
116 D J -0.2973 Soluble
117 V J 0.2858 Aggregation-prone
118 W J 0.0000 Buried
119 G J 0.0000 Buried
120 K J -2.2556 Soluble
121 G J -1.2252 Soluble
122 T J -0.6909 Soluble
123 T J 0.0634 Aggregation-prone
124 V J 0.0000 Buried
125 T J 0.2540 Aggregation-prone
11 L K 0.9168 Aggregation-prone
12 S K 0.6869 Aggregation-prone
13 V K 0.4567 Aggregation-prone
14 A K 0.3649 Aggregation-prone
15 L K 0.6884 Aggregation-prone
16 G K -0.8907 Soluble
17 E K -1.8833 Soluble
18 T K -1.3347 Soluble
19 A K 0.0000 Buried
20 R K -1.9069 Soluble
21 I K 0.0000 Buried
22 S K -1.1554 Soluble
23 C K -1.4785 Soluble
24 G K -1.5360 Soluble
25 R K -2.0223 Soluble
26 Q K -2.1078 Soluble
27 A K -0.9320 Soluble
28 L K -0.0693 Soluble
29 G K -0.1507 Soluble
36 S K 0.3259 Aggregation-prone
37 R K 0.0000 Buried
38 A K 0.0000 Buried
39 V K 0.0000 Buried
40 Q K 0.0000 Buried
41 W K 0.0000 Buried
42 Y K 0.0000 Buried
43 Q K -0.5327 Soluble
44 H K 0.0000 Buried
45 R K -1.8218 Soluble
46 P K -1.3114 Soluble
47 G K -1.4061 Soluble
48 Q K -1.5892 Soluble
49 A K -0.9359 Soluble
50 P K 0.0000 Buried
51 I K 0.5688 Aggregation-prone
52 L K 0.0000 Buried
53 L K 0.0000 Buried
54 I K 0.0000 Buried
55 Y K -0.9653 Soluble
56 N K -1.5325 Soluble
57 N K 0.0000 Buried
65 Q K -1.5817 Soluble
66 D K -1.9458 Soluble
67 R K -1.5601 Soluble
68 P K -0.7167 Soluble
69 S K -0.7960 Soluble
70 G K -0.6360 Soluble
71 I K -0.5145 Soluble
72 P K -1.2147 Soluble
74 E K -2.1658 Soluble
75 R K -1.5368 Soluble
76 F K 0.0000 Buried
77 S K -0.9944 Soluble
78 G K -0.8108 Soluble
79 T K -0.3601 Soluble
80 P K -0.5213 Soluble
81 D K 0.0656 Aggregation-prone
81A I K 1.5514 Aggregation-prone
82 N K 0.3965 Aggregation-prone
83 F K 1.2922 Aggregation-prone
84 G K -0.1067 Soluble
85 T K -0.6171 Soluble
86 R K -1.9218 Soluble
87 A K 0.0000 Buried
88 T K -1.0415 Soluble
89 L K 0.0000 Buried
90 T K -0.9885 Soluble
91 I K 0.0000 Buried
92 S K -1.4256 Soluble
93 G K -1.0817 Soluble
94 V K 0.0000 Buried
95 E K -1.5628 Soluble
96 A K -0.7172 Soluble
97 G K -1.2876 Soluble
98 D K 0.0000 Buried
99 E K -1.6254 Soluble
100 A K 0.0000 Buried
101 D K 0.0000 Buried
102 Y K 0.0000 Buried
103 Y K 0.0000 Buried
104 C K 0.0000 Buried
105 H K 0.0000 Buried
106 M K 0.0000 Buried
107 W K 0.0000 Buried
108 D K 0.0000 Buried
109 S K -0.6521 Soluble
110 R K -1.8765 Soluble
112 S K -1.0092 Soluble
113 G K -0.6425 Soluble
114 F K 0.3728 Aggregation-prone
115 S K 0.1463 Aggregation-prone
116 W K 0.0372 Aggregation-prone
117 S K -0.4192 Soluble
118 F K 0.0000 Buried
119 G K -1.1738 Soluble
120 G K -1.4653 Soluble
121 A K -1.1383 Soluble
122 T K -0.8492 Soluble
123 R K -1.7849 Soluble
124 L K 0.0000 Buried
125 T K 0.0708 Aggregation-prone
126 V K 1.1873 Aggregation-prone

3D Structure — colored by A4D score

Sequence - click residue to focus in viewer  |  colored by A4D score
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Downloads
Color Legend (B-factor = A4D Score)
Score > 1.5 — highly aggregation-prone
Score 0.5–1.5 — aggregation-prone
Score ≈ 0 — buried
Score −1 to −0.5 — soluble
Score < −2.5 — highly soluble
pH Structure
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A4D Score Threshold
Highlight residues > threshold in the sequence panel
CDR Regions
HCDR1
HCDR2
HCDR3
LCDR1
LCDR2
LCDR3
Display Options

pH-Dependent Aggregation Profiles

A4D scores calculated across 11 pH conditions (4.0–9.0, step 0.5). Click a row to view the structure at that pH. The input structure is globular — max score is recommended for pH analysis.

pH Avg A4D Score Max A4D Score Downloads
4.0 -0.4099 4.415 CSV PDB
4.5 -0.4466 4.3856 CSV PDB
5.0 -0.4922 4.3405 CSV PDB
5.5 -0.5385 4.287 CSV PDB
6.0 -0.5772 4.2335 CSV PDB
6.5 -0.6016 4.1886 CSV PDB
7.0 -0.6107 4.1595 CSV PDB
7.5 -0.6089 4.1456 CSV PDB
8.0 -0.601 4.1403 CSV PDB
8.5 -0.5886 4.1386 CSV PDB
9.0 -0.5717 4.138 CSV PDB
Average A4D Score vs pH
Max A4D Score vs pH