Zinlirvimab / 7ugo

A4DAB308_7ugo_M_P | Source PDB: 7ugo | Chains: M, P | Done
100
Yes
10 Å
Yes
Avg A4D Score
-0.5631
Max Score
2.9677
Min Score
-3.6504
Total Score
-133.45
Score CDR
-0.2539
Score non-CDR
-0.6726

Calculation Parameters

Chain Sequence(s) QVQLQESGPGLVKPSETLSVTCSVSGDSMNNYYWTWIRQSPGKGLEWIGYISDRESATYNPSLNSRVVISRDTSKNQLSLKLNSVTPADTAVYYCATARRGQRIYGVVSFGEFFYYYSMDVWGKGTTVTVSSALSVALGETARISCGRQALGSRAVQWYQHRPGQAPILLIYNNQDRPSGIPERFSGTPDINFGTRATLTISGVEAGDEADYYCHMWDSRSGFSWSFGGATRLTVLG input.pdb
Selected Chain(s) M (Heavy), P (Light)
Distance of Aggregation 10 Å
FoldX Energy Minimization Yes
pH Calculations Yes
Downloads Download all data (.tar.gz)

Aggrescan4D Profile

Aggregation-prone (score > 0)
Soluble (score < 0)
Buried (score = 0)

Per-Residue A4D Scores

Download CSV
Minimum Score -3.6504
Maximum Score 2.9677
Average Score -0.5631
Total Score -133.4548

Residues with A4D score > 0.0 are highlighted as aggregation-prone.

Index Residue Chain A4D Score Classification
1 Q M -1.7937 Soluble
2 V M -1.4366 Soluble
3 Q M -1.9470 Soluble
4 L M 0.0000 Buried
5 Q M -2.0558 Soluble
6 E M -1.3855 Soluble
7 S M -0.8560 Soluble
8 G M -0.4159 Soluble
9 P M 0.0110 Aggregation-prone
11 G M 0.4908 Aggregation-prone
12 L M 1.1250 Aggregation-prone
13 V M -0.2834 Soluble
14 K M -1.8018 Soluble
15 P M -1.6200 Soluble
16 S M -1.8717 Soluble
17 E M -2.6522 Soluble
18 T M -1.7764 Soluble
19 L M 0.0000 Buried
20 S M -0.8976 Soluble
21 V M 0.0000 Buried
22 T M -0.7716 Soluble
23 C M 0.0000 Buried
24 S M -1.1726 Soluble
25 V M -1.1829 Soluble
26 S M -1.4494 Soluble
27 G M -1.8896 Soluble
28 D M -2.5495 Soluble
29 S M -1.5093 Soluble
30 M M -1.1522 Soluble
35 N M -2.1052 Soluble
36 N M -2.0439 Soluble
37 Y M -0.9276 Soluble
38 Y M -0.6389 Soluble
39 W M 0.0000 Buried
40 T M 0.0000 Buried
41 W M 0.0000 Buried
42 I M 0.0000 Buried
43 R M -0.7244 Soluble
44 Q M -1.0853 Soluble
45 S M -1.2159 Soluble
46 P M -1.1438 Soluble
47 G M -1.5564 Soluble
48 K M -2.4132 Soluble
49 G M -1.8016 Soluble
50 L M 0.0000 Buried
51 E M -0.9868 Soluble
52 W M 0.0000 Buried
53 I M 0.0000 Buried
54 G M 0.0000 Buried
55 Y M 0.2038 Aggregation-prone
56 I M 0.0000 Buried
57 S M -2.0903 Soluble
58 D M -3.6075 Soluble
59 R M -3.6504 Soluble
63 E M -3.4111 Soluble
64 S M -1.9566 Soluble
65 A M -0.4971 Soluble
66 T M -0.0793 Soluble
67 Y M -0.0170 Soluble
68 N M -0.4260 Soluble
69 P M -0.5975 Soluble
70 S M -0.6097 Soluble
71 L M -0.6664 Soluble
72 N M -1.5665 Soluble
74 S M -1.0011 Soluble
75 R M -1.3709 Soluble
76 V M 0.0000 Buried
77 V M 0.3278 Aggregation-prone
78 I M 0.0000 Buried
79 S M -0.7063 Soluble
80 R M -1.8277 Soluble
81 D M -2.0008 Soluble
82 T M -1.5859 Soluble
83 S M -1.6582 Soluble
84 K M -2.5287 Soluble
85 N M -2.0615 Soluble
86 Q M -1.6656 Soluble
87 L M 0.0000 Buried
88 S M -0.5868 Soluble
89 L M 0.0000 Buried
90 K M -1.2394 Soluble
91 L M 0.0000 Buried
92 N M -2.1919 Soluble
93 S M -1.4435 Soluble
94 V M 0.0000 Buried
95 T M -0.9102 Soluble
96 P M -0.6706 Soluble
97 A M -0.3019 Soluble
98 D M -0.6063 Soluble
99 T M -0.2166 Soluble
100 A M 0.0000 Buried
101 V M -0.2980 Soluble
102 Y M 0.0000 Buried
103 Y M 0.0000 Buried
104 C M 0.0000 Buried
105 A M 0.0000 Buried
106 T M 0.0000 Buried
107 A M 0.0000 Buried
108 R M -1.2206 Soluble
109 R M -1.2589 Soluble
110 G M -1.0894 Soluble
111 Q M -0.5477 Soluble
111A R M 0.0873 Aggregation-prone
111B I M 1.8167 Aggregation-prone
111C Y M 1.7247 Aggregation-prone
111D G M 1.5454 Aggregation-prone
111E V M 2.5514 Aggregation-prone
111F V M 2.9677 Aggregation-prone
112G S M 1.7787 Aggregation-prone
112F F M 2.4473 Aggregation-prone
112E G M 1.6610 Aggregation-prone
112D E M 1.3042 Aggregation-prone
112C F M 1.8087 Aggregation-prone
112B F M 0.9590 Aggregation-prone
112A Y M 0.8500 Aggregation-prone
112 Y M 0.0000 Buried
113 Y M 0.0000 Buried
114 S M 0.0000 Buried
115 M M 0.0000 Buried
116 D M 0.0391 Aggregation-prone
117 V M 0.2186 Aggregation-prone
118 W M 0.0000 Buried
119 G M 0.0000 Buried
120 K M -2.4579 Soluble
121 G M -1.4648 Soluble
122 T M -0.7110 Soluble
123 T M -0.0080 Soluble
124 V M 0.0000 Buried
125 T M 0.1410 Aggregation-prone
126 V M 0.0000 Buried
127 S M -0.4887 Soluble
128 S M -0.6743 Soluble
129 A M -0.2414 Soluble
11 L P 0.8521 Aggregation-prone
12 S P 0.8045 Aggregation-prone
13 V P 0.4413 Aggregation-prone
14 A P 0.7042 Aggregation-prone
15 L P 0.1706 Aggregation-prone
16 G P -0.9976 Soluble
17 E P -1.5884 Soluble
18 T P -1.2753 Soluble
19 A P 0.0000 Buried
20 R P -1.8657 Soluble
21 I P 0.0000 Buried
22 S P -1.1903 Soluble
23 C P 0.0000 Buried
24 G P -1.8591 Soluble
25 R P -2.6303 Soluble
26 Q P -2.0845 Soluble
27 A P -0.8393 Soluble
28 L P 0.6628 Aggregation-prone
29 G P 0.3893 Aggregation-prone
36 S P 0.8013 Aggregation-prone
37 R P 0.0000 Buried
38 A P 0.0000 Buried
39 V P 0.0000 Buried
40 Q P 0.0000 Buried
41 W P 0.0000 Buried
42 Y P 0.0000 Buried
43 Q P -0.3913 Soluble
44 H P 0.0000 Buried
45 R P -1.6626 Soluble
46 P P -1.3120 Soluble
47 G P -1.5913 Soluble
48 Q P -1.8822 Soluble
49 A P -0.9403 Soluble
50 P P 0.0000 Buried
51 I P 1.3296 Aggregation-prone
52 L P 0.0000 Buried
53 L P 0.0000 Buried
54 I P 0.0000 Buried
55 Y P -1.0723 Soluble
56 N P -1.8568 Soluble
57 N P 0.0000 Buried
65 Q P -2.2575 Soluble
66 D P -2.2093 Soluble
67 R P -1.6944 Soluble
68 P P -0.8121 Soluble
69 S P -0.5733 Soluble
70 G P -0.6283 Soluble
71 I P -0.4677 Soluble
72 P P -1.1187 Soluble
74 E P -2.1655 Soluble
75 R P -1.5204 Soluble
76 F P 0.0000 Buried
77 S P -1.1326 Soluble
78 G P -1.0300 Soluble
79 T P -0.5718 Soluble
80 P P -0.4422 Soluble
81 D P 0.2644 Aggregation-prone
81A I P 1.6989 Aggregation-prone
82 N P 0.3737 Aggregation-prone
83 F P 1.4451 Aggregation-prone
84 G P 0.2560 Aggregation-prone
85 T P -0.2550 Soluble
86 R P -1.2265 Soluble
87 A P 0.0000 Buried
88 T P -0.8346 Soluble
89 L P 0.0000 Buried
90 T P -1.0666 Soluble
91 I P 0.0000 Buried
92 S P -1.5095 Soluble
93 G P -1.3454 Soluble
94 V P 0.0000 Buried
95 E P -2.1051 Soluble
96 A P -1.1228 Soluble
97 G P -1.3324 Soluble
98 D P -1.6361 Soluble
99 E P -2.1706 Soluble
100 A P 0.0000 Buried
101 D P -1.5040 Soluble
102 Y P 0.0000 Buried
103 Y P 0.0000 Buried
104 C P -0.3836 Soluble
105 H P 0.0000 Buried
106 M P -0.2975 Soluble
107 W P 0.0000 Buried
108 D P 0.0000 Buried
109 S P -0.3506 Soluble
110 R P -1.6113 Soluble
112 S P -0.8097 Soluble
113 G P -0.3140 Soluble
114 F P 0.9505 Aggregation-prone
115 S P 0.3957 Aggregation-prone
116 W P 0.1450 Aggregation-prone
117 S P -0.3660 Soluble
118 F P 0.0000 Buried
119 G P -1.2079 Soluble
120 G P -1.3246 Soluble
121 A P -1.0767 Soluble
122 T P -0.8379 Soluble
123 R P -1.7822 Soluble
124 L P 0.0000 Buried
125 T P 0.0774 Aggregation-prone
126 V P 0.5269 Aggregation-prone
127 L P 1.2171 Aggregation-prone
128 G P 0.4370 Aggregation-prone

3D Structure — colored by A4D score

Sequence - click residue to focus in viewer  |  colored by A4D score
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Color Legend (B-factor = A4D Score)
Score > 1.5 — highly aggregation-prone
Score 0.5–1.5 — aggregation-prone
Score ≈ 0 — buried
Score −1 to −0.5 — soluble
Score < −2.5 — highly soluble
pH Structure
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A4D Score Threshold
Highlight residues > threshold in the sequence panel
CDR Regions
HCDR1
HCDR2
HCDR3
LCDR1
LCDR2
LCDR3
Display Options

pH-Dependent Aggregation Profiles

A4D scores calculated across 11 pH conditions (4.0–9.0, step 0.5). Click a row to view the structure at that pH. The input structure is globular — max score is recommended for pH analysis.

pH Avg A4D Score Max A4D Score Downloads
4.0 -0.4041 4.6055 CSV PDB
4.5 -0.4445 4.5706 CSV PDB
5.0 -0.4944 4.5247 CSV PDB
5.5 -0.5454 4.4753 CSV PDB
6.0 -0.5891 4.4302 CSV PDB
6.5 -0.6186 4.3968 CSV PDB
7.0 -0.6322 4.3784 CSV PDB
7.5 -0.6339 4.3708 CSV PDB
8.0 -0.6287 4.3681 CSV PDB
8.5 -0.6185 4.3672 CSV PDB
9.0 -0.6032 4.367 CSV PDB
Average A4D Score vs pH
Max A4D Score vs pH