Cosfroviximab / 5kem

A4DAB073_5kem_I_J | Source PDB: 5kem | Chains: I, J | Done
100
Yes
10 Å
Yes
Avg A4D Score
-0.6037
Max Score
1.1107
Min Score
-2.7931
Total Score
-137.65
Score CDR
-0.496
Score non-CDR
-0.6332

Calculation Parameters

Chain Sequence(s) DVKLLESGGGLVQPGGSLKLSCAASGFSLSTSGVGVGWFRQPSGKGLEWLALIWWDDDKYYNPSLKSQLSISKDFSRNQVFLKISNVDIADTATYYCARRDPFGYDNAMGYWGQGTSVTVSDIVMTQSPLSLSTSVGDRVSLTCKASQNVGTAVAWYQQKPGQSPKLLIYSASNRYTGVPDRFTGSGSGTDFTLTISNMQSEDLADYFCQQYSSYPLTFGAGTKLELR input.pdb
Selected Chain(s) I (Heavy), J (Light)
Distance of Aggregation 10 Å
FoldX Energy Minimization Yes
pH Calculations Yes
Downloads Download all data (.tar.gz)

Aggrescan4D Profile

Aggregation-prone (score > 0)
Soluble (score < 0)
Buried (score = 0)

Per-Residue A4D Scores

Download CSV
Minimum Score -2.7931
Maximum Score 1.1107
Average Score -0.6037
Total Score -137.648

Residues with A4D score > 0.0 are highlighted as aggregation-prone.

Index Residue Chain A4D Score Classification
1 D I -2.0856 Soluble
2 V I -1.3754 Soluble
3 K I -1.8433 Soluble
4 L I 0.0000 Buried
5 L I -0.4211 Soluble
6 E I 0.0000 Buried
7 S I -0.7185 Soluble
8 G I -0.8377 Soluble
9 G I -0.6111 Soluble
11 G I 0.3347 Aggregation-prone
12 L I 1.1107 Aggregation-prone
13 V I 0.0000 Buried
14 Q I -1.0598 Soluble
15 P I -0.8206 Soluble
16 G I -1.5207 Soluble
17 G I -1.4590 Soluble
18 S I -1.4634 Soluble
19 L I -1.3080 Soluble
20 K I -2.1678 Soluble
21 L I 0.0000 Buried
22 S I -0.7343 Soluble
23 C I 0.0000 Buried
24 A I -0.8407 Soluble
25 A I 0.0000 Buried
26 S I -1.2083 Soluble
27 G I -1.0337 Soluble
28 F I -0.6659 Soluble
29 S I -0.2236 Soluble
30 L I -0.1496 Soluble
31 S I 0.1543 Aggregation-prone
34 T I -0.1687 Soluble
35 S I -0.3759 Soluble
36 G I -0.5845 Soluble
37 V I -0.1472 Soluble
38 G I -0.5546 Soluble
39 V I 0.0000 Buried
40 G I 0.0000 Buried
41 W I 0.0000 Buried
42 F I 0.0000 Buried
43 R I 0.0000 Buried
44 Q I 0.0000 Buried
45 P I -0.6803 Soluble
46 S I -0.9210 Soluble
47 G I -1.6878 Soluble
48 K I -2.1574 Soluble
49 G I -1.2688 Soluble
50 L I -0.3722 Soluble
51 E I -0.7756 Soluble
52 W I 0.0000 Buried
53 L I 0.0000 Buried
54 A I 0.0000 Buried
55 L I -0.3374 Soluble
56 I I 0.0000 Buried
57 W I -1.0479 Soluble
58 W I -0.8844 Soluble
59 D I -2.5278 Soluble
63 D I -2.7931 Soluble
64 D I -2.0611 Soluble
65 K I -1.6918 Soluble
66 Y I -0.7427 Soluble
67 Y I 0.0000 Buried
68 N I -0.7106 Soluble
69 P I -0.7778 Soluble
70 S I -0.6233 Soluble
71 L I -0.4816 Soluble
72 K I -1.3246 Soluble
74 S I -1.0213 Soluble
75 Q I -1.5637 Soluble
76 L I 0.0000 Buried
77 S I -1.1534 Soluble
78 I I 0.0000 Buried
79 S I -0.9457 Soluble
80 K I -0.7263 Soluble
81 D I -0.8945 Soluble
82 F I -0.2204 Soluble
83 S I -0.9395 Soluble
84 R I -2.0175 Soluble
85 N I -1.2710 Soluble
86 Q I -1.1115 Soluble
87 V I 0.0000 Buried
88 F I -0.7634 Soluble
89 L I 0.0000 Buried
90 K I -1.8745 Soluble
91 I I 0.0000 Buried
92 S I -1.8514 Soluble
93 N I -1.9269 Soluble
94 V I -1.2869 Soluble
95 D I -1.0886 Soluble
96 I I 0.8717 Aggregation-prone
97 A I 0.4000 Aggregation-prone
98 D I -0.1718 Soluble
99 T I 0.2854 Aggregation-prone
100 A I 0.0000 Buried
101 T I -0.4410 Soluble
102 Y I 0.0000 Buried
103 Y I 0.0340 Aggregation-prone
104 C I 0.0000 Buried
105 A I 0.0000 Buried
106 R I -0.7451 Soluble
107 R I -1.1457 Soluble
108 D I -1.7331 Soluble
109 P I -0.6601 Soluble
110 F I 0.1497 Aggregation-prone
111 G I 0.0898 Aggregation-prone
112A Y I 1.0445 Aggregation-prone
112 D I 0.2060 Aggregation-prone
113 N I -0.2045 Soluble
114 A I 0.0000 Buried
115 M I -0.3674 Soluble
116 G I 0.0000 Buried
117 Y I -0.4432 Soluble
118 W I -0.4526 Soluble
119 G I -0.4469 Soluble
120 Q I -0.9762 Soluble
121 G I -0.8166 Soluble
122 T I -0.5831 Soluble
123 S I -0.2380 Soluble
124 V I 0.0000 Buried
125 T I 0.6211 Aggregation-prone
126 V I 0.4866 Aggregation-prone
127 S I 0.0620 Aggregation-prone
1 D J -1.2990 Soluble
2 I J 0.0000 Buried
3 V J 1.0731 Aggregation-prone
4 M J 0.3541 Aggregation-prone
5 T J -0.2642 Soluble
6 Q J -0.3611 Soluble
7 S J -0.1063 Soluble
8 P J 0.3659 Aggregation-prone
9 L J 1.0021 Aggregation-prone
10 S J 0.2247 Aggregation-prone
11 L J -0.0506 Soluble
12 S J -0.8976 Soluble
13 T J 0.0000 Buried
14 S J -0.4333 Soluble
15 V J 0.3844 Aggregation-prone
16 G J -0.8786 Soluble
17 D J -1.7457 Soluble
18 R J -2.6250 Soluble
19 V J -1.3585 Soluble
20 S J -0.7110 Soluble
21 L J 0.0000 Buried
22 T J -0.6743 Soluble
23 C J 0.0000 Buried
24 K J -1.7026 Soluble
25 A J -0.8324 Soluble
26 S J -0.8121 Soluble
27 Q J -1.5478 Soluble
28 N J -2.0336 Soluble
29 V J 0.0000 Buried
36 G J -1.0003 Soluble
37 T J -0.4909 Soluble
38 A J -0.2670 Soluble
39 V J 0.0000 Buried
40 A J 0.0000 Buried
41 W J 0.0000 Buried
42 Y J 0.0000 Buried
43 Q J -0.8780 Soluble
44 Q J -1.4837 Soluble
45 K J -1.9074 Soluble
46 P J -1.3323 Soluble
47 G J -1.4001 Soluble
48 Q J -2.0627 Soluble
49 S J -1.3837 Soluble
50 P J -1.2168 Soluble
51 K J -1.4390 Soluble
52 L J 0.0000 Buried
53 L J 0.0000 Buried
54 I J 0.0000 Buried
55 Y J -0.5739 Soluble
56 S J -0.5002 Soluble
57 A J 0.0000 Buried
65 S J -1.0360 Soluble
66 N J -1.7046 Soluble
67 R J -1.7590 Soluble
68 Y J 0.0000 Buried
69 T J -0.5700 Soluble
70 G J -0.9076 Soluble
71 V J -0.9699 Soluble
72 P J -1.3291 Soluble
74 D J -2.2287 Soluble
75 R J -1.8803 Soluble
76 F J 0.0000 Buried
77 T J -1.0381 Soluble
78 G J 0.0000 Buried
79 S J -0.7242 Soluble
80 G J -0.9399 Soluble
83 S J -1.2592 Soluble
84 G J 0.0000 Buried
85 T J -1.6149 Soluble
86 D J -2.0401 Soluble
87 F J 0.0000 Buried
88 T J -0.6876 Soluble
89 L J 0.0000 Buried
90 T J -0.6285 Soluble
91 I J 0.0000 Buried
92 S J -2.0617 Soluble
93 N J -2.1664 Soluble
94 M J 0.0000 Buried
95 Q J -1.1324 Soluble
96 S J -0.8447 Soluble
97 E J -1.9983 Soluble
98 D J -1.3269 Soluble
99 L J -1.0592 Soluble
100 A J 0.0000 Buried
101 D J -0.4912 Soluble
102 Y J 0.0000 Buried
103 F J 0.0800 Aggregation-prone
104 C J 0.0000 Buried
105 Q J 0.0000 Buried
106 Q J 0.0000 Buried
107 Y J 0.2195 Aggregation-prone
108 S J -0.3365 Soluble
109 S J 0.1430 Aggregation-prone
114 Y J 0.3895 Aggregation-prone
115 P J 0.2380 Aggregation-prone
116 L J 0.0000 Buried
117 T J 0.4827 Aggregation-prone
118 F J 0.5331 Aggregation-prone
119 G J 0.0000 Buried
120 A J 0.0743 Aggregation-prone
121 G J -0.0778 Soluble
122 T J 0.0000 Buried
123 K J -0.4518 Soluble
124 L J 0.0000 Buried
125 E J -1.2502 Soluble
126 L J -0.3742 Soluble
127 R J -1.5762 Soluble

3D Structure — colored by A4D score

Sequence - click residue to focus in viewer  |  colored by A4D score
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Color Legend (B-factor = A4D Score)
Score > 1.5 — highly aggregation-prone
Score 0.5–1.5 — aggregation-prone
Score ≈ 0 — buried
Score −1 to −0.5 — soluble
Score < −2.5 — highly soluble
pH Structure
Load structure at specific pH condition
A4D Score Threshold
Highlight residues > threshold in the sequence panel
CDR Regions
HCDR1
HCDR2
HCDR3
LCDR1
LCDR2
LCDR3
Display Options

pH-Dependent Aggregation Profiles

A4D scores calculated across 11 pH conditions (4.0–9.0, step 0.5). Click a row to view the structure at that pH. The input structure is globular — max score is recommended for pH analysis.

pH Avg A4D Score Max A4D Score Downloads
4.0 -0.4958 3.075 CSV PDB
4.5 -0.5465 2.8929 CSV PDB
5.0 -0.6028 2.6959 CSV PDB
5.5 -0.6564 2.4936 CSV PDB
6.0 -0.6991 2.3334 CSV PDB
6.5 -0.7261 2.3478 CSV PDB
7.0 -0.7391 2.3686 CSV PDB
7.5 -0.743 2.3929 CSV PDB
8.0 -0.7403 2.4185 CSV PDB
8.5 -0.7291 2.4446 CSV PDB
9.0 -0.7062 2.4707 CSV PDB
Average A4D Score vs pH
Max A4D Score vs pH