Zinlirvimab / 8czz

A4DAB308_8czz_O_P | Source PDB: 8czz | Chains: O, P | Done
100
Yes
10 Å
Yes
Avg A4D Score
-0.4438
Max Score
3.1679
Min Score
-2.9353
Total Score
-104.29
Score CDR
-0.146
Score non-CDR
-0.5505

Calculation Parameters

Chain Sequence(s) QVQLQESGPGLVKPSETLSVTCSVSGDSMNNYYWTWIRQSPGKGLEWIGYISDRESATYNPSLNSRVVISRDTSKNQLSLKLNSVTPADTAVYYCATARRGQRIYGVVSFGEFFYYYSMDVWGKGTTVTVSLSVALGETARISCGRQALGSRAVQWYQHRPGQAPILLIYNNQDRPSGIPERFSGTPDINFGTRATLTISGVEAGDEADYYCHMWDSRSGFSWSFGGATRLTVLG input.pdb
Selected Chain(s) O (Heavy), P (Light)
Distance of Aggregation 10 Å
FoldX Energy Minimization Yes
pH Calculations Yes
Downloads Download all data (.tar.gz)

Aggrescan4D Profile

Aggregation-prone (score > 0)
Soluble (score < 0)
Buried (score = 0)

Per-Residue A4D Scores

Download CSV
Minimum Score -2.9353
Maximum Score 3.1679
Average Score -0.4438
Total Score -104.2895

Residues with A4D score > 0.0 are highlighted as aggregation-prone.

Index Residue Chain A4D Score Classification
1 Q O -1.6184 Soluble
2 V O -1.0815 Soluble
3 Q O -1.8516 Soluble
4 L O -1.3536 Soluble
5 Q O -2.0199 Soluble
6 E O -1.3503 Soluble
7 S O -0.7970 Soluble
8 G O -0.3135 Soluble
9 P O 0.0278 Aggregation-prone
11 G O 0.4844 Aggregation-prone
12 L O 1.0096 Aggregation-prone
13 V O 0.0000 Buried
14 K O -1.7353 Soluble
15 P O -1.2247 Soluble
16 S O -1.2123 Soluble
17 E O -1.6639 Soluble
18 T O -0.8636 Soluble
19 L O 0.0000 Buried
20 S O -0.3124 Soluble
21 V O 0.0000 Buried
22 T O -1.0253 Soluble
23 C O 0.0000 Buried
24 S O -1.3773 Soluble
25 V O 0.0000 Buried
26 S O -1.4882 Soluble
27 G O -1.2710 Soluble
28 D O -1.2179 Soluble
29 S O -0.9113 Soluble
30 M O -1.3170 Soluble
35 N O -1.7509 Soluble
36 N O -1.2929 Soluble
37 Y O -0.9263 Soluble
38 Y O -0.9813 Soluble
39 W O 0.0000 Buried
40 T O 0.0000 Buried
41 W O 0.0000 Buried
42 I O 0.0000 Buried
43 R O -0.5571 Soluble
44 Q O -0.8132 Soluble
45 S O -0.8112 Soluble
46 P O -0.9195 Soluble
47 G O -1.1081 Soluble
48 K O -1.2584 Soluble
49 G O -0.9937 Soluble
50 L O -0.5692 Soluble
51 E O -0.6577 Soluble
52 W O 0.0000 Buried
53 I O 0.0000 Buried
54 G O 0.0000 Buried
55 Y O 0.1613 Aggregation-prone
56 I O 0.0000 Buried
57 S O -1.3503 Soluble
58 D O 0.0000 Buried
59 R O -2.9353 Soluble
63 E O -2.9063 Soluble
64 S O -1.6915 Soluble
65 A O -0.4546 Soluble
66 T O -0.1927 Soluble
67 Y O -0.3585 Soluble
68 N O -0.8317 Soluble
69 P O -0.8196 Soluble
70 S O -1.0095 Soluble
71 L O 0.0000 Buried
72 N O -2.0789 Soluble
74 S O -1.3863 Soluble
75 R O -2.0401 Soluble
76 V O 0.0000 Buried
77 V O 1.0685 Aggregation-prone
78 I O 0.0000 Buried
79 S O -0.5368 Soluble
80 R O -1.4624 Soluble
81 D O -1.7929 Soluble
82 T O -1.5091 Soluble
83 S O -1.4783 Soluble
84 K O -2.3965 Soluble
85 N O -1.8593 Soluble
86 Q O -1.7986 Soluble
87 L O 0.0000 Buried
88 S O 0.0000 Buried
89 L O 0.0000 Buried
90 K O -0.1340 Soluble
91 L O 0.0000 Buried
92 N O -0.8265 Soluble
93 S O -1.0929 Soluble
94 V O -1.0244 Soluble
95 T O -0.5854 Soluble
96 P O -0.2894 Soluble
97 A O -0.1656 Soluble
98 D O -0.3222 Soluble
99 T O -0.2050 Soluble
100 A O 0.0000 Buried
101 V O -0.3485 Soluble
102 Y O 0.0000 Buried
103 Y O 0.0000 Buried
104 C O 0.0000 Buried
105 A O 0.0000 Buried
106 T O 0.0000 Buried
107 A O -0.7695 Soluble
108 R O -1.7323 Soluble
109 R O -1.7516 Soluble
110 G O -1.1731 Soluble
111 Q O -0.3402 Soluble
111A R O 0.2726 Aggregation-prone
111B I O 2.3155 Aggregation-prone
111C Y O 2.1731 Aggregation-prone
111D G O 2.0646 Aggregation-prone
111E V O 3.0105 Aggregation-prone
111F V O 3.1679 Aggregation-prone
112G S O 1.7732 Aggregation-prone
112F F O 2.4438 Aggregation-prone
112E G O 1.4454 Aggregation-prone
112D E O 1.2886 Aggregation-prone
112C F O 1.8393 Aggregation-prone
112B F O 0.4337 Aggregation-prone
112A Y O 0.1428 Aggregation-prone
112 Y O 0.0835 Aggregation-prone
113 Y O -0.2163 Soluble
114 S O -0.4750 Soluble
115 M O 0.0000 Buried
116 D O 0.1494 Aggregation-prone
117 V O 0.2726 Aggregation-prone
118 W O 0.0000 Buried
119 G O 0.0000 Buried
120 K O -2.3060 Soluble
121 G O 0.0000 Buried
122 T O -0.6722 Soluble
123 T O -0.0883 Soluble
124 V O 0.0000 Buried
125 T O 0.1533 Aggregation-prone
126 V O -0.1101 Soluble
127 S O -0.3796 Soluble
11 L P 1.0186 Aggregation-prone
12 S P 0.4475 Aggregation-prone
13 V P 1.1429 Aggregation-prone
14 A P 1.0734 Aggregation-prone
15 L P 1.3433 Aggregation-prone
16 G P -0.4537 Soluble
17 E P -1.5605 Soluble
18 T P -1.1207 Soluble
19 A P 0.0000 Buried
20 R P -1.7464 Soluble
21 I P -0.6105 Soluble
22 S P -0.9264 Soluble
23 C P 0.0000 Buried
24 G P -1.7232 Soluble
25 R P -2.6383 Soluble
26 Q P -2.0783 Soluble
27 A P -0.7390 Soluble
28 L P 0.1520 Aggregation-prone
29 G P 0.1984 Aggregation-prone
36 S P 0.7878 Aggregation-prone
37 R P 0.0000 Buried
38 A P 0.0000 Buried
39 V P 0.0000 Buried
40 Q P 0.0000 Buried
41 W P 0.0000 Buried
42 Y P 0.0000 Buried
43 Q P 0.1012 Aggregation-prone
44 H P 0.0000 Buried
45 R P -1.3008 Soluble
46 P P -1.3711 Soluble
47 G P -1.6896 Soluble
48 Q P -2.0717 Soluble
49 A P -0.8048 Soluble
50 P P 0.0000 Buried
51 I P 1.8772 Aggregation-prone
52 L P 1.1916 Aggregation-prone
53 L P 0.0000 Buried
54 I P -0.0291 Soluble
55 Y P -0.0808 Soluble
56 N P -0.8678 Soluble
57 N P -1.0815 Soluble
65 Q P -1.9917 Soluble
66 D P -1.6034 Soluble
67 R P -1.6308 Soluble
68 P P -0.7678 Soluble
69 S P -0.6377 Soluble
70 G P -0.7779 Soluble
71 I P -0.8230 Soluble
72 P P -1.4943 Soluble
74 E P -2.5049 Soluble
75 R P -2.0027 Soluble
76 F P -1.1591 Soluble
77 S P -1.2868 Soluble
78 G P -1.4997 Soluble
79 T P -0.5587 Soluble
80 P P -0.5477 Soluble
81 D P 0.1255 Aggregation-prone
81A I P 1.5589 Aggregation-prone
82 N P 0.3803 Aggregation-prone
83 F P 1.6305 Aggregation-prone
84 G P 0.2820 Aggregation-prone
85 T P -0.0586 Soluble
86 R P -0.7698 Soluble
87 A P 0.0000 Buried
88 T P -0.7314 Soluble
89 L P 0.0000 Buried
90 T P -1.1738 Soluble
91 I P 0.0000 Buried
92 S P -1.0168 Soluble
93 G P -0.6839 Soluble
94 V P -0.4815 Soluble
95 E P -1.7179 Soluble
96 A P -0.9580 Soluble
97 G P -1.1385 Soluble
98 D P 0.0000 Buried
99 E P -2.1773 Soluble
100 A P 0.0000 Buried
101 D P -1.7723 Soluble
102 Y P 0.0000 Buried
103 Y P -0.3321 Soluble
104 C P 0.0000 Buried
105 H P 0.0000 Buried
106 M P 0.0000 Buried
107 W P 0.0000 Buried
108 D P 0.0000 Buried
109 S P -0.4415 Soluble
110 R P -1.7084 Soluble
112 S P -0.9015 Soluble
113 G P -0.5384 Soluble
114 F P 0.4362 Aggregation-prone
115 S P 0.2547 Aggregation-prone
116 W P 0.1535 Aggregation-prone
117 S P -0.1785 Soluble
118 F P 0.0000 Buried
119 G P -0.5834 Soluble
120 G P -0.9925 Soluble
121 A P -0.6775 Soluble
122 T P -0.9425 Soluble
123 R P -1.9615 Soluble
124 L P 0.0000 Buried
125 T P 0.2891 Aggregation-prone
126 V P 1.3455 Aggregation-prone
127 L P 2.0745 Aggregation-prone
128 G P 0.7253 Aggregation-prone

3D Structure — colored by A4D score

Sequence - click residue to focus in viewer  |  colored by A4D score
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Color Legend (B-factor = A4D Score)
Score > 1.5 — highly aggregation-prone
Score 0.5–1.5 — aggregation-prone
Score ≈ 0 — buried
Score −1 to −0.5 — soluble
Score < −2.5 — highly soluble
pH Structure
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A4D Score Threshold
Highlight residues > threshold in the sequence panel
CDR Regions
HCDR1
HCDR2
HCDR3
LCDR1
LCDR2
LCDR3
Display Options

pH-Dependent Aggregation Profiles

A4D scores calculated across 11 pH conditions (4.0–9.0, step 0.5). Click a row to view the structure at that pH. The input structure is globular — max score is recommended for pH analysis.

pH Avg A4D Score Max A4D Score Downloads
4.0 -0.3834 4.6424 CSV PDB
4.5 -0.4145 4.6005 CSV PDB
5.0 -0.454 4.5736 CSV PDB
5.5 -0.4947 4.5477 CSV PDB
6.0 -0.5289 4.5216 CSV PDB
6.5 -0.5508 4.4956 CSV PDB
7.0 -0.558 4.47 CSV PDB
7.5 -0.5536 4.4455 CSV PDB
8.0 -0.5423 4.424 CSV PDB
8.5 -0.5269 4.4083 CSV PDB
9.0 -0.5085 4.3997 CSV PDB
Average A4D Score vs pH
Max A4D Score vs pH