Danvilostomig / 7elx

A4DAB080_7elx_H_L | Source PDB: 7elx | Chains: H, L | Done
100
Yes
10 Å
Yes
Avg A4D Score
-0.6754
Max Score
2.1656
Min Score
-3.9623
Total Score
-285.68
Score CDR
-0.1751
Score non-CDR
-0.7364

Calculation Parameters

Chain Sequence(s) QVQLVESGGGVVQPGRSLRLSCAASGFTFSSYTMHWVRQAPGKGLEWVTFISYDGNNKYYADSVKGRFTISRDNSKNTLYLQMNSLRAEDTAIYYCARTGWLGPFDYWGQGTLVTVSSASTKGPSVFPLAPSTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPEIVLTQSPGTLSLSPGERATLSCRASQSVGSSYLAWYQQKPGQAPRLLIYGAFSRATGIPDRFSGSGSGTDFTLTISRLEPEDFAVYYCQQYGSSPWTFGQGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNR input.pdb
Selected Chain(s) H (Heavy), L (Light)
Distance of Aggregation 10 Å
FoldX Energy Minimization Yes
pH Calculations Yes
Downloads Download all data (.tar.gz)

Aggrescan4D Profile

Aggregation-prone (score > 0)
Soluble (score < 0)
Buried (score = 0)

Per-Residue A4D Scores

Download CSV
Minimum Score -3.9623
Maximum Score 2.1656
Average Score -0.6754
Total Score -285.6804

Residues with A4D score > 0.0 are highlighted as aggregation-prone.

Index Residue Chain A4D Score Classification
1 Q H -1.4977 Soluble
2 V H -0.9047 Soluble
3 Q H -0.8702 Soluble
4 L H 0.0000 Buried
5 V H 1.1356 Aggregation-prone
6 E H 0.1567 Aggregation-prone
7 S H -0.2740 Soluble
8 G H -0.7834 Soluble
9 G H -0.3701 Soluble
11 G H 0.0485 Aggregation-prone
12 V H 0.3158 Aggregation-prone
13 V H 0.0000 Buried
14 Q H -1.5473 Soluble
15 P H -1.9625 Soluble
16 G H -2.1257 Soluble
17 R H -2.6829 Soluble
18 S H -1.8380 Soluble
19 L H -1.3138 Soluble
20 R H -1.8071 Soluble
21 L H 0.0000 Buried
22 S H -0.3815 Soluble
23 C H 0.0000 Buried
24 A H -0.0641 Soluble
25 A H 0.0000 Buried
26 S H -0.7049 Soluble
27 G H -1.0543 Soluble
28 F H -0.4251 Soluble
29 T H -0.2017 Soluble
30 F H 0.0000 Buried
35 S H -0.5558 Soluble
36 S H 0.0571 Aggregation-prone
37 Y H 0.3501 Aggregation-prone
38 T H 0.0000 Buried
39 M H 0.0000 Buried
40 H H 0.0000 Buried
41 W H 0.0000 Buried
42 V H 0.0000 Buried
43 R H 0.0000 Buried
44 Q H -0.7164 Soluble
45 A H -1.0819 Soluble
46 P H -0.9009 Soluble
47 G H -1.5151 Soluble
48 K H -2.4017 Soluble
49 G H -1.6299 Soluble
50 L H 0.0000 Buried
51 E H -1.1716 Soluble
52 W H 0.0000 Buried
53 V H 0.0000 Buried
54 T H 0.0000 Buried
55 F H 0.1354 Aggregation-prone
56 I H 0.0000 Buried
57 S H -0.9234 Soluble
58 Y H -0.5317 Soluble
59 D H -2.1818 Soluble
62 G H -2.0101 Soluble
63 N H -2.4795 Soluble
64 N H -2.1772 Soluble
65 K H -1.0549 Soluble
66 Y H 0.0158 Aggregation-prone
67 Y H -0.5173 Soluble
68 A H 0.0000 Buried
69 D H -2.3601 Soluble
70 S H -1.7594 Soluble
71 V H 0.0000 Buried
72 K H -2.3988 Soluble
74 G H -1.6069 Soluble
75 R H 0.0000 Buried
76 F H 0.0000 Buried
77 T H -0.7069 Soluble
78 I H 0.0000 Buried
79 S H -0.9107 Soluble
80 R H -1.0565 Soluble
81 D H -1.6472 Soluble
82 N H -1.7162 Soluble
83 S H -1.5235 Soluble
84 K H -2.3075 Soluble
85 N H -1.7098 Soluble
86 T H 0.0000 Buried
87 L H 0.0000 Buried
88 Y H -0.5403 Soluble
89 L H 0.0000 Buried
90 Q H -1.2156 Soluble
91 M H 0.0000 Buried
92 N H -1.6863 Soluble
93 S H -1.6386 Soluble
94 L H 0.0000 Buried
95 R H -2.4548 Soluble
96 A H -1.6698 Soluble
97 E H -2.2363 Soluble
98 D H 0.0000 Buried
99 T H -0.6344 Soluble
100 A H 0.0000 Buried
101 I H 0.4983 Aggregation-prone
102 Y H 0.0000 Buried
103 Y H 0.0000 Buried
104 C H 0.0000 Buried
105 A H 0.0000 Buried
106 R H 0.0000 Buried
107 T H 0.5955 Aggregation-prone
108 G H 1.0716 Aggregation-prone
109 W H 1.8639 Aggregation-prone
110 L H 2.1656 Aggregation-prone
113 G H 1.1165 Aggregation-prone
114 P H 0.0000 Buried
115 F H 0.0000 Buried
116 D H 0.0188 Aggregation-prone
117 Y H -0.0355 Soluble
118 W H -0.1579 Soluble
119 G H 0.0000 Buried
120 Q H -1.1489 Soluble
121 G H -0.4072 Soluble
122 T H 0.0967 Aggregation-prone
123 L H 0.5361 Aggregation-prone
124 V H 0.0000 Buried
125 T H 0.0000 Buried
126 V H 0.0000 Buried
127 S H -0.7468 Soluble
128 S H -0.5171 Soluble
129 A H -0.4510 Soluble
130 S H -0.6419 Soluble
131 T H -0.9108 Soluble
132 K H -1.6368 Soluble
133 G H -1.6359 Soluble
134 P H 0.0000 Buried
135 S H -0.3405 Soluble
136 V H -0.4171 Soluble
137 F H -0.4496 Soluble
138 P H -0.9063 Soluble
139 L H 0.0000 Buried
140 A H -0.8452 Soluble
141 P H 0.0000 Buried
142 S H -0.4018 Soluble
143 T H -0.2592 Soluble
144 A H -0.1471 Soluble
145 A H 0.0000 Buried
146 L H 0.0000 Buried
147 G H 0.0000 Buried
148 C H 0.0000 Buried
149 L H 0.0000 Buried
150 V H 0.0000 Buried
151 K H 0.0000 Buried
152 D H -0.6715 Soluble
153 Y H 0.0000 Buried
154 F H 0.0000 Buried
155 P H 0.0000 Buried
156 E H -0.4865 Soluble
157 P H -0.8100 Soluble
158 V H -0.8168 Soluble
159 T H -0.6602 Soluble
160 V H -0.2087 Soluble
161 S H -0.4141 Soluble
162 W H 0.0000 Buried
163 N H -0.7196 Soluble
164 S H -0.6601 Soluble
165 G H -0.5283 Soluble
166 A H -0.2558 Soluble
167 L H -0.0315 Soluble
168 T H -0.1856 Soluble
169 S H -0.1895 Soluble
170 G H -0.2451 Soluble
171 V H 0.2038 Aggregation-prone
172 H H 0.0000 Buried
173 T H 0.0701 Aggregation-prone
174 F H 0.0000 Buried
175 P H -0.3888 Soluble
176 A H 0.0922 Aggregation-prone
177 V H 0.4584 Aggregation-prone
178 L H 1.1213 Aggregation-prone
179 Q H 0.2330 Aggregation-prone
180 S H -0.0599 Soluble
181 S H -0.2366 Soluble
182 G H -0.0375 Soluble
183 L H -0.1032 Soluble
184 Y H 0.0000 Buried
185 S H 0.0000 Buried
186 L H 0.0000 Buried
187 S H 0.0000 Buried
188 S H 0.0000 Buried
189 V H 0.0000 Buried
190 V H 0.0000 Buried
191 T H -0.1386 Soluble
192 V H 0.0000 Buried
193 P H -0.4854 Soluble
194 S H -0.4634 Soluble
195 S H -0.5167 Soluble
196 S H -0.5458 Soluble
197 L H -0.7192 Soluble
198 G H -0.9896 Soluble
199 T H -0.6604 Soluble
200 Q H -1.0951 Soluble
201 T H -1.0500 Soluble
202 Y H 0.0000 Buried
203 I H -1.1905 Soluble
204 C H 0.0000 Buried
205 N H -1.4865 Soluble
206 V H 0.0000 Buried
207 N H -2.1279 Soluble
208 H H 0.0000 Buried
209 K H -2.8133 Soluble
210 P H -1.6645 Soluble
211 S H -1.9752 Soluble
212 N H -2.6721 Soluble
213 T H -2.1729 Soluble
214 K H -2.7159 Soluble
215 V H -1.4354 Soluble
216 D H -2.4838 Soluble
217 K H -1.8784 Soluble
218 R H -2.3645 Soluble
219 V H 0.0000 Buried
220 E H -2.4294 Soluble
221 P H -1.2032 Soluble
1 E L -1.4635 Soluble
2 I L -0.2392 Soluble
3 V L 0.8178 Aggregation-prone
4 L L 0.0000 Buried
5 T L -0.5858 Soluble
6 Q L 0.0000 Buried
7 S L -0.8188 Soluble
8 P L -0.5101 Soluble
9 G L -0.8515 Soluble
10 T L -0.4017 Soluble
11 L L -0.1660 Soluble
12 S L -0.4389 Soluble
13 L L -0.9460 Soluble
14 S L -1.5364 Soluble
15 P L -1.9939 Soluble
16 G L -2.4486 Soluble
17 E L -3.0419 Soluble
18 R L -3.3312 Soluble
19 A L 0.0000 Buried
20 T L -0.5456 Soluble
21 L L 0.0000 Buried
22 S L -0.7994 Soluble
23 C L 0.0000 Buried
24 R L -1.8632 Soluble
25 A L 0.0000 Buried
26 S L -0.9057 Soluble
27 Q L -1.6395 Soluble
28 S L -1.3092 Soluble
29 V L 0.0000 Buried
30 G L -0.4087 Soluble
36 S L 0.0050 Aggregation-prone
37 S L 0.5831 Aggregation-prone
38 Y L 0.7557 Aggregation-prone
39 L L 0.0000 Buried
40 A L 0.0000 Buried
41 W L 0.0000 Buried
42 Y L 0.0000 Buried
43 Q L 0.0000 Buried
44 Q L 0.0000 Buried
45 K L -1.4664 Soluble
46 P L -1.3646 Soluble
47 G L -1.4603 Soluble
48 Q L -2.1412 Soluble
49 A L -1.4163 Soluble
50 P L 0.0000 Buried
51 R L -1.5793 Soluble
52 L L 0.0000 Buried
53 L L 0.0000 Buried
54 I L 0.0000 Buried
55 Y L 0.8312 Aggregation-prone
56 G L 0.8853 Aggregation-prone
57 A L 0.0000 Buried
65 F L 1.5668 Aggregation-prone
66 S L 0.4276 Aggregation-prone
67 R L -0.7947 Soluble
68 A L -0.5449 Soluble
69 T L -0.5595 Soluble
70 G L -0.8826 Soluble
71 I L 0.0000 Buried
72 P L -1.3316 Soluble
74 D L -2.2109 Soluble
75 R L -1.9610 Soluble
76 F L 0.0000 Buried
77 S L -0.4206 Soluble
78 G L 0.4267 Aggregation-prone
79 S L 0.0545 Aggregation-prone
80 G L -0.5705 Soluble
83 S L -0.7455 Soluble
84 G L -1.2153 Soluble
85 T L -1.6816 Soluble
86 D L -2.0854 Soluble
87 F L 0.0000 Buried
88 T L -0.4462 Soluble
89 L L 0.0000 Buried
90 T L -0.8201 Soluble
91 I L 0.0000 Buried
92 S L -2.4159 Soluble
93 R L -3.4560 Soluble
94 L L 0.0000 Buried
95 E L -2.3738 Soluble
96 P L -1.6682 Soluble
97 E L -2.1790 Soluble
98 D L 0.0000 Buried
99 F L -0.5657 Soluble
100 A L 0.0000 Buried
101 V L -0.1410 Soluble
102 Y L 0.0000 Buried
103 Y L 0.0000 Buried
104 C L 0.0000 Buried
105 Q L 0.0000 Buried
106 Q L 0.0000 Buried
107 Y L 0.0000 Buried
108 G L -0.2269 Soluble
109 S L -0.5338 Soluble
114 S L -0.4109 Soluble
115 P L -0.7229 Soluble
116 W L -0.0741 Soluble
117 T L -0.1348 Soluble
118 F L 0.0561 Aggregation-prone
119 G L 0.0000 Buried
120 Q L -1.4907 Soluble
121 G L -1.0336 Soluble
122 T L 0.0000 Buried
123 K L -0.6313 Soluble
124 V L 0.0000 Buried
125 E L 0.0000 Buried
126 I L -0.6133 Soluble
127 K L -1.3000 Soluble
128 R L -0.9286 Soluble
129 T L -0.0301 Soluble
130 V L 0.4816 Aggregation-prone
131 A L 0.0489 Aggregation-prone
132 A L -0.0702 Soluble
133 P L 0.0000 Buried
134 S L -0.0788 Soluble
135 V L 0.0000 Buried
136 F L 0.2591 Aggregation-prone
137 I L 0.2165 Aggregation-prone
138 F L 0.0000 Buried
139 P L -0.7584 Soluble
140 P L -0.8393 Soluble
141 S L -1.3795 Soluble
142 D L -2.6410 Soluble
143 E L -2.3346 Soluble
144 Q L 0.0000 Buried
145 L L -1.9811 Soluble
146 K L -2.6408 Soluble
147 S L -1.6267 Soluble
148 G L -1.1173 Soluble
149 T L -0.9933 Soluble
150 A L 0.0000 Buried
151 S L 0.0000 Buried
152 V L 0.0000 Buried
153 V L 0.0000 Buried
154 C L 0.0000 Buried
155 L L 0.0000 Buried
156 L L 0.0000 Buried
157 N L 0.0000 Buried
158 N L -0.7857 Soluble
159 F L 0.0000 Buried
160 Y L 0.0000 Buried
161 P L -1.7502 Soluble
162 R L -3.0795 Soluble
163 E L -3.1838 Soluble
164 A L -2.2032 Soluble
165 K L -1.9869 Soluble
166 V L 0.0000 Buried
167 Q L -0.7285 Soluble
168 W L 0.0000 Buried
169 K L -0.6828 Soluble
170 V L 0.0000 Buried
171 D L -2.1795 Soluble
172 N L -1.6706 Soluble
173 A L -0.3793 Soluble
174 L L 0.4256 Aggregation-prone
175 Q L -0.4364 Soluble
176 S L -0.7292 Soluble
177 G L -1.2922 Soluble
178 N L -1.6084 Soluble
179 S L -1.4522 Soluble
180 Q L -1.3426 Soluble
181 E L -1.5493 Soluble
182 S L -0.6607 Soluble
183 V L -0.7564 Soluble
184 T L -1.1596 Soluble
185 E L -2.2294 Soluble
186 Q L -1.7827 Soluble
187 D L -1.8047 Soluble
188 S L -1.6324 Soluble
189 K L -2.1779 Soluble
190 D L -1.5809 Soluble
191 S L -1.5871 Soluble
192 T L 0.0000 Buried
193 Y L 0.0000 Buried
194 S L 0.0000 Buried
195 L L 0.0000 Buried
196 S L 0.0000 Buried
197 S L 0.0000 Buried
198 T L -0.6400 Soluble
199 L L 0.0000 Buried
200 T L -0.7250 Soluble
201 L L -0.9741 Soluble
202 S L -1.1795 Soluble
203 K L -2.1059 Soluble
204 A L -2.1130 Soluble
205 D L -3.1355 Soluble
206 Y L 0.0000 Buried
207 E L -3.7802 Soluble
208 K L -3.9623 Soluble
209 H L -3.7002 Soluble
210 K L -3.7528 Soluble
211 V L -2.0742 Soluble
212 Y L 0.0000 Buried
213 A L 0.0000 Buried
214 C L 0.0000 Buried
215 E L -0.7971 Soluble
216 V L 0.0000 Buried
217 T L -1.1317 Soluble
218 H L 0.0000 Buried
219 Q L -1.5713 Soluble
220 G L -0.3752 Soluble
221 L L -0.1956 Soluble
222 S L -0.4469 Soluble
223 S L -0.4226 Soluble
224 P L -0.5229 Soluble
225 V L -0.0978 Soluble
226 T L -0.5038 Soluble
227 K L -0.6175 Soluble
228 S L -0.5467 Soluble
229 F L -1.1512 Soluble
230 N L -2.7053 Soluble
231 R L -3.4220 Soluble

3D Structure — colored by A4D score

Sequence - click residue to focus in viewer  |  colored by A4D score
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Color Legend (B-factor = A4D Score)
Score > 1.5 — highly aggregation-prone
Score 0.5–1.5 — aggregation-prone
Score ≈ 0 — buried
Score −1 to −0.5 — soluble
Score < −2.5 — highly soluble
pH Structure
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A4D Score Threshold
Highlight residues > threshold in the sequence panel
CDR Regions
HCDR1
HCDR2
HCDR3
LCDR1
LCDR2
LCDR3
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pH-Dependent Aggregation Profiles

A4D scores calculated across 11 pH conditions (4.0–9.0, step 0.5). Click a row to view the structure at that pH. The input structure is globular — max score is recommended for pH analysis.

pH Avg A4D Score Max A4D Score Downloads
4.0 -0.6555 4.3362 CSV PDB
4.5 -0.6986 4.3255 CSV PDB
5.0 -0.7496 4.3146 CSV PDB
5.5 -0.8 4.3036 CSV PDB
6.0 -0.8401 4.2926 CSV PDB
6.5 -0.8614 4.2818 CSV PDB
7.0 -0.8624 4.2712 CSV PDB
7.5 -0.849 4.2617 CSV PDB
8.0 -0.8276 4.2542 CSV PDB
8.5 -0.7999 4.2497 CSV PDB
9.0 -0.7653 4.2477 CSV PDB
Average A4D Score vs pH
Max A4D Score vs pH