Zinlirvimab / 6v8z

A4DAB308_6v8z_J_K | Source PDB: 6v8z | Chains: J, K | Done
100
Yes
10 Å
Yes
Avg A4D Score
-0.6617
Max Score
2.7138
Min Score
-3.1236
Total Score
-289.82
Score CDR
-0.2813
Score non-CDR
-0.7244

Calculation Parameters

Chain Sequence(s) QVQLQESGPGLVKPSETLSVTCSVSGDSMNNYYWTWIRQSPGKGLEWIGYISDRESATYNPSLNSRVVISRDTSKNQLSLKLNSVTPADTAVYYCATARRGQRIYGVVSFGEFFYYYSMDVWGKGTTVTVSSASTKGPSVFPLAPSSKTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCLSVALGETARISCGRQALGSRAVQWYQHRPGQAPILLIYNNQDRPSGIPERFSGTPDINFGTRATLTISGVEAGDEADYYCHMWDSRSGFSWSFGGATRLTVLGQPKAAPSVTLFPPSSEELQANKATLVCLISDFYPGAVTVAWKADSSPVKAGVETTTPSKQSNNKYAASSYLSLTPEQWKSHRSYSCQVTHEGSTVEKTVAPTEC input.pdb
Selected Chain(s) J (Heavy), K (Light)
Distance of Aggregation 10 Å
FoldX Energy Minimization Yes
pH Calculations Yes
Downloads Download all data (.tar.gz)

Aggrescan4D Profile

Aggregation-prone (score > 0)
Soluble (score < 0)
Buried (score = 0)

Per-Residue A4D Scores

Download CSV
Minimum Score -3.1236
Maximum Score 2.7138
Average Score -0.6617
Total Score -289.8191

Residues with A4D score > 0.0 are highlighted as aggregation-prone.

Index Residue Chain A4D Score Classification
1 Q J -1.7130 Soluble
2 V J -1.4587 Soluble
3 Q J -1.9854 Soluble
4 L J 0.0000 Buried
5 Q J -1.4965 Soluble
6 E J 0.0000 Buried
7 S J -0.7848 Soluble
8 G J -0.4389 Soluble
9 P J -0.5088 Soluble
11 G J -0.5217 Soluble
12 L J -0.3958 Soluble
13 V J 0.0000 Buried
14 K J -1.9445 Soluble
15 P J -1.3918 Soluble
16 S J -1.4189 Soluble
17 E J -1.9420 Soluble
18 T J -1.4060 Soluble
19 L J 0.0000 Buried
20 S J -0.6262 Soluble
21 V J 0.0000 Buried
22 T J -0.4783 Soluble
23 C J 0.0000 Buried
24 S J -0.9690 Soluble
25 V J -1.2980 Soluble
26 S J -1.7669 Soluble
27 G J -1.9036 Soluble
28 D J -2.8555 Soluble
29 S J -1.8154 Soluble
30 M J 0.0000 Buried
35 N J -2.1057 Soluble
36 N J -1.9840 Soluble
37 Y J -1.1857 Soluble
38 Y J -1.1101 Soluble
39 W J 0.0000 Buried
40 T J 0.0000 Buried
41 W J 0.0000 Buried
42 I J 0.0000 Buried
43 R J -0.7233 Soluble
44 Q J -1.0764 Soluble
45 S J -1.0096 Soluble
46 P J -1.0877 Soluble
47 G J -1.5012 Soluble
48 K J -2.3521 Soluble
49 G J -1.6728 Soluble
50 L J 0.0000 Buried
51 E J -1.3450 Soluble
52 W J 0.0000 Buried
53 I J 0.0000 Buried
54 G J 0.0000 Buried
55 Y J 0.0000 Buried
56 I J 0.0000 Buried
57 S J 0.0000 Buried
58 D J -2.3077 Soluble
59 R J -3.0182 Soluble
63 E J -2.9154 Soluble
64 S J -1.6366 Soluble
65 A J -0.4555 Soluble
66 T J 0.2017 Aggregation-prone
67 Y J 0.5993 Aggregation-prone
68 N J 0.0000 Buried
69 P J -0.4065 Soluble
70 S J -0.5061 Soluble
71 L J -0.5386 Soluble
72 N J -1.4572 Soluble
74 S J -0.8273 Soluble
75 R J -0.9327 Soluble
76 V J 0.0000 Buried
77 V J 0.8535 Aggregation-prone
78 I J 0.3820 Aggregation-prone
79 S J -0.4853 Soluble
80 R J -1.2646 Soluble
81 D J -1.5508 Soluble
82 T J -1.6202 Soluble
83 S J -1.6339 Soluble
84 K J -2.4740 Soluble
85 N J -2.1414 Soluble
86 Q J -1.5589 Soluble
87 L J 0.0000 Buried
88 S J -0.3698 Soluble
89 L J 0.0000 Buried
90 K J -0.7422 Soluble
91 L J 0.0000 Buried
92 N J -1.4435 Soluble
93 S J -1.2103 Soluble
94 V J 0.0000 Buried
95 T J -0.7724 Soluble
96 P J -0.4912 Soluble
97 A J -0.1032 Soluble
98 D J 0.0000 Buried
99 T J -0.1548 Soluble
100 A J 0.0000 Buried
101 V J -0.0906 Soluble
102 Y J 0.0000 Buried
103 Y J 0.0000 Buried
104 C J 0.0000 Buried
105 A J 0.0000 Buried
106 T J 0.0000 Buried
107 A J 0.0000 Buried
108 R J -1.8414 Soluble
109 R J -2.0020 Soluble
110 G J -1.0560 Soluble
111 Q J -0.2620 Soluble
111A R J 0.2934 Aggregation-prone
111B I J 1.7389 Aggregation-prone
111C Y J 1.4971 Aggregation-prone
111D G J 1.6000 Aggregation-prone
111E V J 2.6879 Aggregation-prone
111F V J 2.7138 Aggregation-prone
112G S J 1.5329 Aggregation-prone
112F F J 2.3395 Aggregation-prone
112E G J 1.1881 Aggregation-prone
112D E J 1.1148 Aggregation-prone
112C F J 1.4603 Aggregation-prone
112B F J 0.9678 Aggregation-prone
112A Y J 0.8128 Aggregation-prone
112 Y J 0.0000 Buried
113 Y J -0.6800 Soluble
114 S J 0.0000 Buried
115 M J 0.0000 Buried
116 D J -0.4699 Soluble
117 V J -0.2173 Soluble
118 W J -0.4821 Soluble
119 G J -1.3420 Soluble
120 K J -2.2390 Soluble
121 G J -1.1968 Soluble
122 T J 0.0000 Buried
123 T J -0.1356 Soluble
124 V J 0.0000 Buried
125 T J -0.3271 Soluble
126 V J 0.0000 Buried
127 S J -0.7553 Soluble
128 S J -0.7914 Soluble
129 A J -0.5734 Soluble
130 S J -0.7560 Soluble
131 T J -0.9730 Soluble
132 K J -1.5739 Soluble
133 G J -1.4950 Soluble
134 P J -0.7979 Soluble
135 S J -0.4320 Soluble
136 V J 0.0000 Buried
137 F J -0.6476 Soluble
138 P J 0.0000 Buried
139 L J 0.0000 Buried
140 A J 0.0000 Buried
141 P J -0.7727 Soluble
142 S J -0.7660 Soluble
143 S J -1.1873 Soluble
144 K J -1.8526 Soluble
145 T J -0.7906 Soluble
146 A J 0.0000 Buried
147 A J -0.4090 Soluble
148 L J 0.0000 Buried
149 G J 0.0000 Buried
150 C J 0.0000 Buried
151 L J 0.0000 Buried
152 V J 0.0000 Buried
153 K J -0.3585 Soluble
154 D J -0.8048 Soluble
155 Y J 0.0000 Buried
156 F J -0.5195 Soluble
157 P J 0.0000 Buried
158 E J -0.4520 Soluble
159 P J -0.4947 Soluble
160 V J -0.5513 Soluble
161 T J -0.7201 Soluble
162 V J 0.0000 Buried
163 S J -0.3445 Soluble
164 W J 0.0000 Buried
165 N J -0.8728 Soluble
166 S J -0.6673 Soluble
167 G J -0.3543 Soluble
168 A J -0.1662 Soluble
169 L J -0.0236 Soluble
170 T J -0.1227 Soluble
171 S J -0.2579 Soluble
172 G J -0.3074 Soluble
173 V J 0.1374 Aggregation-prone
174 H J -0.1544 Soluble
175 T J 0.0468 Aggregation-prone
176 F J -0.1084 Soluble
177 P J 0.0884 Aggregation-prone
178 A J 0.1401 Aggregation-prone
179 V J 0.0000 Buried
180 L J 0.7659 Aggregation-prone
181 Q J -0.0015 Soluble
182 S J -0.2789 Soluble
183 S J -0.3941 Soluble
184 G J -0.3238 Soluble
185 L J -0.1651 Soluble
186 Y J 0.1738 Aggregation-prone
187 S J 0.0000 Buried
188 L J 0.0000 Buried
189 S J 0.0000 Buried
190 S J 0.0000 Buried
191 V J 0.2301 Aggregation-prone
192 V J 0.0000 Buried
193 T J -0.3768 Soluble
194 V J 0.0000 Buried
195 P J -0.7740 Soluble
196 S J -0.9035 Soluble
197 S J -0.4795 Soluble
198 S J -0.7050 Soluble
199 L J 0.0000 Buried
200 G J -1.0840 Soluble
201 T J -0.9639 Soluble
202 Q J -1.3866 Soluble
203 T J -1.1719 Soluble
204 Y J 0.0000 Buried
205 I J -1.5850 Soluble
206 C J 0.0000 Buried
207 N J -1.7086 Soluble
208 V J 0.0000 Buried
209 N J -2.6355 Soluble
210 H J 0.0000 Buried
211 K J -2.8305 Soluble
212 P J -1.7698 Soluble
213 S J -1.9801 Soluble
214 N J -2.6942 Soluble
215 T J -2.3128 Soluble
216 K J -3.0205 Soluble
217 V J -1.9805 Soluble
218 D J -2.9435 Soluble
219 K J -2.3584 Soluble
220 R J -2.7014 Soluble
221 V J 0.0000 Buried
222 E J -1.8868 Soluble
223 P J -1.2851 Soluble
224 K J -0.9955 Soluble
225 S J -0.7930 Soluble
226 C J -0.8649 Soluble
11 L K 0.2193 Aggregation-prone
12 S K 0.3298 Aggregation-prone
13 V K 0.0530 Aggregation-prone
14 A K 0.0218 Aggregation-prone
15 L K -0.3927 Soluble
16 G K -1.3857 Soluble
17 E K -1.8793 Soluble
18 T K -1.4569 Soluble
19 A K 0.0000 Buried
20 R K -1.9311 Soluble
21 I K 0.0000 Buried
22 S K -1.1101 Soluble
23 C K -1.2432 Soluble
24 G K -1.5588 Soluble
25 R K -1.9092 Soluble
26 Q K -1.8519 Soluble
27 A K -1.3829 Soluble
28 L K -0.4606 Soluble
29 G K -0.3555 Soluble
36 S K 0.1755 Aggregation-prone
37 R K -0.1229 Soluble
38 A K 0.0000 Buried
39 V K 0.0000 Buried
40 Q K 0.0000 Buried
41 W K 0.0000 Buried
42 Y K 0.0000 Buried
43 Q K 0.0000 Buried
44 H K 0.0000 Buried
45 R K -1.2528 Soluble
46 P K -1.3011 Soluble
47 G K -1.4940 Soluble
48 Q K -1.8360 Soluble
49 A K -0.9534 Soluble
50 P K 0.0000 Buried
51 I K 0.3799 Aggregation-prone
52 L K 0.0000 Buried
53 L K 0.0000 Buried
54 I K 0.0000 Buried
55 Y K -0.8767 Soluble
56 N K -1.0792 Soluble
57 N K -1.2760 Soluble
65 Q K -1.9287 Soluble
66 D K -1.7569 Soluble
67 R K -2.0116 Soluble
68 P K -1.2654 Soluble
69 S K -0.9174 Soluble
70 G K -0.7696 Soluble
71 I K -0.7878 Soluble
72 P K -1.3508 Soluble
74 E K -2.3676 Soluble
75 R K -1.7283 Soluble
76 F K 0.0000 Buried
77 S K -1.1519 Soluble
78 G K 0.0000 Buried
79 T K -1.2850 Soluble
80 P K -1.6130 Soluble
81 D K -2.0890 Soluble
81A I K -0.9678 Soluble
82 N K -0.8554 Soluble
83 F K 0.9233 Aggregation-prone
84 G K -0.2034 Soluble
85 T K -1.0324 Soluble
86 R K -2.1369 Soluble
87 A K 0.0000 Buried
88 T K -1.0413 Soluble
89 L K 0.0000 Buried
90 T K -0.8645 Soluble
91 I K 0.0000 Buried
92 S K -1.5907 Soluble
93 G K -1.4256 Soluble
94 V K 0.0000 Buried
95 E K -1.9921 Soluble
96 A K -1.0877 Soluble
97 G K -1.0530 Soluble
98 D K 0.0000 Buried
99 E K -1.0481 Soluble
100 A K 0.0000 Buried
101 D K -1.1133 Soluble
102 Y K 0.0000 Buried
103 Y K 0.0000 Buried
104 C K 0.0000 Buried
105 H K 0.0000 Buried
106 M K 0.0000 Buried
107 W K 0.0000 Buried
108 D K 0.0000 Buried
109 S K -0.6898 Soluble
110 R K -1.8091 Soluble
112 S K -0.7893 Soluble
113 G K 0.0024 Aggregation-prone
114 F K 1.5642 Aggregation-prone
115 S K 0.7476 Aggregation-prone
116 W K 0.1617 Aggregation-prone
117 S K -0.3215 Soluble
118 F K 0.0000 Buried
119 G K -1.0779 Soluble
120 G K -1.2650 Soluble
121 A K -0.8348 Soluble
122 T K -0.8027 Soluble
123 R K -1.6852 Soluble
124 L K 0.0000 Buried
125 T K 0.0465 Aggregation-prone
126 V K 0.0000 Buried
127 L K 1.0583 Aggregation-prone
128 G K 0.0413 Aggregation-prone
129 Q K -0.6628 Soluble
130 P K -1.3340 Soluble
131 K K -2.1168 Soluble
132 A K -1.4060 Soluble
133 A K -0.7768 Soluble
134 P K -0.5429 Soluble
135 S K -0.3182 Soluble
136 V K 0.0000 Buried
137 T K -0.2094 Soluble
138 L K -0.0576 Soluble
139 F K 0.0000 Buried
140 P K 0.0000 Buried
141 P K 0.0000 Buried
142 S K 0.0000 Buried
143 S K -1.1573 Soluble
144 E K -1.8184 Soluble
145 E K 0.0000 Buried
146 L K -1.1874 Soluble
147 Q K -1.8244 Soluble
148 A K -1.4169 Soluble
149 N K -2.2134 Soluble
150 K K -1.7934 Soluble
151 A K 0.0000 Buried
152 T K 0.0000 Buried
153 L K 0.0000 Buried
154 V K 0.0000 Buried
155 C K 0.0000 Buried
156 L K 0.0000 Buried
157 I K 0.0000 Buried
158 S K -0.6540 Soluble
159 D K -1.5278 Soluble
160 F K 0.0000 Buried
161 Y K -1.1829 Soluble
162 P K -0.8995 Soluble
163 G K 0.0000 Buried
164 A K -0.1825 Soluble
165 V K -0.1364 Soluble
166 T K -0.1191 Soluble
167 V K 0.3343 Aggregation-prone
168 A K -0.4028 Soluble
169 W K 0.0000 Buried
170 K K -1.0504 Soluble
171 A K 0.0000 Buried
172 D K -1.3950 Soluble
173 S K -0.7337 Soluble
174 S K -0.6210 Soluble
175 P K -0.7908 Soluble
176 V K -0.5406 Soluble
177 K K -1.5300 Soluble
178 A K -0.7098 Soluble
179 G K -0.5397 Soluble
180 V K -0.3718 Soluble
181 E K -0.3235 Soluble
182 T K 0.0664 Aggregation-prone
183 T K 0.0398 Aggregation-prone
184 T K -0.1645 Soluble
185 P K -0.4227 Soluble
186 S K -0.8106 Soluble
187 K K -1.7754 Soluble
188 Q K -1.4896 Soluble
189 S K -1.1765 Soluble
190 N K -1.4391 Soluble
191 N K -1.3935 Soluble
192 K K -1.7870 Soluble
193 Y K -1.0737 Soluble
194 A K 0.0000 Buried
195 A K -0.2071 Soluble
196 S K 0.0000 Buried
197 S K 0.0000 Buried
198 Y K 0.0000 Buried
199 L K 0.0000 Buried
200 S K -0.3845 Soluble
201 L K 0.0000 Buried
202 T K -1.6509 Soluble
203 P K -2.1413 Soluble
204 E K -2.9749 Soluble
205 Q K -2.1602 Soluble
206 W K 0.0000 Buried
207 K K -3.1236 Soluble
208 S K -2.2775 Soluble
209 H K -2.4637 Soluble
210 R K -2.6925 Soluble
211 S K -1.8671 Soluble
212 Y K 0.0000 Buried
213 S K 0.0000 Buried
214 C K 0.0000 Buried
215 Q K -0.8232 Soluble
216 V K 0.0000 Buried
217 T K -0.8052 Soluble
218 H K -1.1470 Soluble
219 E K -2.1979 Soluble
220 G K -1.5132 Soluble
221 S K -1.1669 Soluble
222 T K -0.9378 Soluble
223 V K -0.7998 Soluble
224 E K -2.0563 Soluble
225 K K -1.5241 Soluble
226 T K -1.1855 Soluble
227 V K 0.0000 Buried
228 A K -1.4666 Soluble
229 P K -1.3096 Soluble
230 T K -1.2165 Soluble
231 E K -1.8488 Soluble
232 C K -0.8665 Soluble

3D Structure — colored by A4D score

Sequence - click residue to focus in viewer  |  colored by A4D score
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Color Legend (B-factor = A4D Score)
Score > 1.5 — highly aggregation-prone
Score 0.5–1.5 — aggregation-prone
Score ≈ 0 — buried
Score −1 to −0.5 — soluble
Score < −2.5 — highly soluble
pH Structure
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A4D Score Threshold
Highlight residues > threshold in the sequence panel
CDR Regions
HCDR1
HCDR2
HCDR3
LCDR1
LCDR2
LCDR3
Display Options

pH-Dependent Aggregation Profiles

A4D scores calculated across 11 pH conditions (4.0–9.0, step 0.5). Click a row to view the structure at that pH. The input structure is globular — max score is recommended for pH analysis.

pH Avg A4D Score Max A4D Score Downloads
4.0 -0.5805 4.5094 CSV PDB
4.5 -0.6162 4.4742 CSV PDB
5.0 -0.6594 4.4269 CSV PDB
5.5 -0.7008 4.3753 CSV PDB
6.0 -0.7301 4.3275 CSV PDB
6.5 -0.7397 4.2914 CSV PDB
7.0 -0.7288 4.2711 CSV PDB
7.5 -0.7037 4.2625 CSV PDB
8.0 -0.6709 4.2594 CSV PDB
8.5 -0.6333 4.2584 CSV PDB
9.0 -0.5914 4.2581 CSV PDB
Average A4D Score vs pH
Max A4D Score vs pH