Diridavumab / 8dis

A4DAB087_8dis_B_G | Source PDB: 8dis | Chains: B, G | Done
100
Yes
10 Å
Yes
Avg A4D Score
-0.491
Max Score
2.924
Min Score
-2.8853
Total Score
-111.94
Score CDR
-0.1981
Score non-CDR
-0.5797

Calculation Parameters

Chain Sequence(s) VQLVESGAEVKKPGSSVKVSCKASGGPFRSYAISWVRQAPGQGPEWMGGIIPIFGTTKYAPKFQGRVTITADDFAGTVYMELSSLRSEDTAMYYCAKHMGYQVRETMDVWGKGTTVTVSVLTQPPSVSAAPGQKVTISCSGSSSNIGNDYVSWYQQLPGTAPKLLIYDNNKRPSGIPDRFSGSKSGTSATLGITGLQTGDEANYYCATWDRRPTAYVVFGGGTKLTVL input.pdb
Selected Chain(s) B (Heavy), G (Light)
Distance of Aggregation 10 Å
FoldX Energy Minimization Yes
pH Calculations Yes
Downloads Download all data (.tar.gz)

Aggrescan4D Profile

Aggregation-prone (score > 0)
Soluble (score < 0)
Buried (score = 0)

Per-Residue A4D Scores

Download CSV
Minimum Score -2.8853
Maximum Score 2.924
Average Score -0.491
Total Score -111.9404

Residues with A4D score > 0.0 are highlighted as aggregation-prone.

Index Residue Chain A4D Score Classification
2 V B 1.0780 Aggregation-prone
3 Q B -0.4359 Soluble
4 L B 0.0000 Buried
5 V B 0.3208 Aggregation-prone
6 E B -0.2919 Soluble
7 S B -0.7182 Soluble
8 G B -0.6545 Soluble
9 A B -0.3611 Soluble
11 E B -0.5770 Soluble
12 V B 0.6231 Aggregation-prone
13 K B -0.9083 Soluble
14 K B -2.1381 Soluble
15 P B -2.1648 Soluble
16 G B -1.5358 Soluble
17 S B -1.1821 Soluble
18 S B -1.2781 Soluble
19 V B 0.0000 Buried
20 K B -1.9979 Soluble
21 V B 0.0000 Buried
22 S B -0.6608 Soluble
23 C B 0.0000 Buried
24 K B -1.3924 Soluble
25 A B -0.4934 Soluble
26 S B -0.5154 Soluble
27 G B -0.5331 Soluble
28 G B -0.2085 Soluble
29 P B 0.1632 Aggregation-prone
30 F B 1.5118 Aggregation-prone
35 R B 0.4511 Aggregation-prone
36 S B 0.6881 Aggregation-prone
37 Y B 0.7153 Aggregation-prone
38 A B 0.0000 Buried
39 I B 0.0000 Buried
40 S B 0.0000 Buried
41 W B 0.0000 Buried
42 V B 0.0000 Buried
43 R B -0.3926 Soluble
44 Q B 0.0000 Buried
45 A B -0.9359 Soluble
46 P B -0.8175 Soluble
47 G B -1.1985 Soluble
48 Q B -1.7083 Soluble
49 G B -1.1234 Soluble
50 P B 0.0000 Buried
51 E B -0.5146 Soluble
52 W B 0.0000 Buried
53 M B 0.0000 Buried
54 G B 0.0000 Buried
55 G B 0.0000 Buried
56 I B 0.0000 Buried
57 I B 0.0000 Buried
58 P B 1.4243 Aggregation-prone
59 I B 2.9240 Aggregation-prone
62 F B 2.7802 Aggregation-prone
63 G B 1.0962 Aggregation-prone
64 T B 0.3687 Aggregation-prone
65 T B -0.2103 Soluble
66 K B -0.6777 Soluble
67 Y B -0.7253 Soluble
68 A B 0.0000 Buried
69 P B -1.3546 Soluble
70 K B -2.1795 Soluble
71 F B 0.0000 Buried
72 Q B -2.0976 Soluble
74 G B -1.5206 Soluble
75 R B -1.3293 Soluble
76 V B 0.0000 Buried
77 T B -0.7613 Soluble
78 I B 0.0000 Buried
79 T B -0.4980 Soluble
80 A B -0.7566 Soluble
81 D B -1.0696 Soluble
82 D B -0.5571 Soluble
83 F B 1.1395 Aggregation-prone
84 A B 0.0276 Aggregation-prone
85 G B -0.6420 Soluble
86 T B 0.0000 Buried
87 V B 0.0000 Buried
88 Y B -0.6439 Soluble
89 M B 0.0000 Buried
90 E B -1.2278 Soluble
91 L B 0.0000 Buried
92 S B -1.0636 Soluble
93 S B -0.9868 Soluble
94 L B 0.0000 Buried
95 R B -2.7341 Soluble
96 S B -2.2233 Soluble
97 E B -2.4378 Soluble
98 D B 0.0000 Buried
99 T B -0.7782 Soluble
100 A B 0.0000 Buried
101 M B -0.0928 Soluble
102 Y B 0.0000 Buried
103 Y B 0.0000 Buried
104 C B 0.0000 Buried
105 A B 0.0000 Buried
106 K B 0.0516 Aggregation-prone
107 H B 0.0000 Buried
108 M B 0.3686 Aggregation-prone
109 G B 0.1913 Aggregation-prone
110 Y B 0.9734 Aggregation-prone
111 Q B -0.4869 Soluble
112A V B 0.0000 Buried
112 R B -0.5331 Soluble
113 E B 0.0000 Buried
114 T B 0.0000 Buried
115 M B 0.0000 Buried
116 D B -0.7028 Soluble
117 V B -0.0722 Soluble
118 W B 0.0000 Buried
119 G B 0.0000 Buried
120 K B -1.5319 Soluble
121 G B -0.7877 Soluble
122 T B 0.0000 Buried
123 T B -0.0448 Soluble
124 V B 0.0000 Buried
125 T B -0.4349 Soluble
126 V B 0.0000 Buried
127 S B -1.0777 Soluble
3 V G 1.6726 Aggregation-prone
4 L G 0.0000 Buried
5 T G 0.0560 Aggregation-prone
6 Q G 0.0000 Buried
7 P G -0.5127 Soluble
8 P G -0.7497 Soluble
9 S G -0.7302 Soluble
11 V G -0.3841 Soluble
12 S G -0.0426 Soluble
13 A G -0.2238 Soluble
14 A G -0.4282 Soluble
15 P G -0.9963 Soluble
16 G G -1.8221 Soluble
17 Q G -2.4410 Soluble
18 K G -2.4595 Soluble
19 V G -1.0541 Soluble
20 T G -0.4192 Soluble
21 I G 0.0000 Buried
22 S G -0.3708 Soluble
23 C G 0.0000 Buried
24 S G -0.2084 Soluble
25 G G 0.0262 Aggregation-prone
26 S G -0.2689 Soluble
27 S G -0.7730 Soluble
28 S G -1.0778 Soluble
29 N G 0.0000 Buried
30 I G 0.0000 Buried
35 G G -1.0928 Soluble
36 N G -1.6648 Soluble
37 D G -0.9362 Soluble
38 Y G -0.2119 Soluble
39 V G 0.0000 Buried
40 S G 0.0000 Buried
41 W G 0.0000 Buried
42 Y G 0.0000 Buried
43 Q G 0.0000 Buried
44 Q G -0.5284 Soluble
45 L G -0.2198 Soluble
46 P G -0.4116 Soluble
47 G G -0.4962 Soluble
48 T G -0.7181 Soluble
49 A G -0.7341 Soluble
50 P G 0.0000 Buried
51 K G -1.1777 Soluble
52 L G 0.0000 Buried
53 L G 0.0000 Buried
54 I G 0.0000 Buried
55 Y G -1.3579 Soluble
56 D G -1.7144 Soluble
57 N G -1.6569 Soluble
65 N G -2.5597 Soluble
66 K G -2.7506 Soluble
67 R G -2.4557 Soluble
68 P G -1.0781 Soluble
69 S G -0.6570 Soluble
70 G G -0.8641 Soluble
71 I G -0.9068 Soluble
72 P G -1.3573 Soluble
74 D G -2.2799 Soluble
75 R G -1.6361 Soluble
76 F G 0.0000 Buried
77 S G -1.4724 Soluble
78 G G -1.2941 Soluble
79 S G -1.2401 Soluble
80 K G -1.0159 Soluble
83 S G -0.7919 Soluble
84 G G -0.9755 Soluble
85 T G -0.8600 Soluble
86 S G -0.6608 Soluble
87 A G 0.0000 Buried
88 T G -0.5807 Soluble
89 L G 0.0000 Buried
90 G G -0.6032 Soluble
91 I G 0.0000 Buried
92 T G -1.8338 Soluble
93 G G -1.7369 Soluble
94 L G 0.0000 Buried
95 Q G -1.6290 Soluble
96 T G -0.8398 Soluble
97 G G -0.9543 Soluble
98 D G 0.0000 Buried
99 E G -1.0159 Soluble
100 A G 0.0000 Buried
101 N G -0.9112 Soluble
102 Y G 0.0000 Buried
103 Y G 0.0000 Buried
104 C G 0.0000 Buried
105 A G 0.0000 Buried
106 T G 0.0000 Buried
107 W G 0.0000 Buried
108 D G 0.0000 Buried
109 R G -2.8853 Soluble
110 R G -2.7581 Soluble
112 P G -1.5425 Soluble
113 T G -1.1988 Soluble
114 A G -1.3217 Soluble
115 Y G -0.5159 Soluble
116 V G 0.0000 Buried
117 V G 0.4518 Aggregation-prone
118 F G 0.3610 Aggregation-prone
119 G G 0.0740 Aggregation-prone
120 G G -0.5543 Soluble
121 G G -0.9410 Soluble
122 T G 0.0000 Buried
123 K G -1.3489 Soluble
124 L G 0.0000 Buried
125 T G -0.1643 Soluble
126 V G 0.1967 Aggregation-prone
127 L G 1.3772 Aggregation-prone

3D Structure — colored by A4D score

Sequence - click residue to focus in viewer  |  colored by A4D score
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Downloads
Color Legend (B-factor = A4D Score)
Score > 1.5 — highly aggregation-prone
Score 0.5–1.5 — aggregation-prone
Score ≈ 0 — buried
Score −1 to −0.5 — soluble
Score < −2.5 — highly soluble
pH Structure
Load structure at specific pH condition
A4D Score Threshold
Highlight residues > threshold in the sequence panel
CDR Regions
HCDR1
HCDR2
HCDR3
LCDR1
LCDR2
LCDR3
Display Options

pH-Dependent Aggregation Profiles

A4D scores calculated across 11 pH conditions (4.0–9.0, step 0.5). Click a row to view the structure at that pH. The input structure is globular — max score is recommended for pH analysis.

pH Avg A4D Score Max A4D Score Downloads
4.0 -0.4035 5.8625 CSV PDB
4.5 -0.4281 5.8109 CSV PDB
5.0 -0.4564 5.8109 CSV PDB
5.5 -0.4824 5.8109 CSV PDB
6.0 -0.4986 5.8109 CSV PDB
6.5 -0.4983 5.8109 CSV PDB
7.0 -0.4809 5.8109 CSV PDB
7.5 -0.452 5.8108 CSV PDB
8.0 -0.4168 5.8108 CSV PDB
8.5 -0.3768 5.8108 CSV PDB
9.0 -0.3321 5.8106 CSV PDB
Average A4D Score vs pH
Max A4D Score vs pH