Zinlirvimab / 6ccb

A4DAB308_6ccb_H_L | Source PDB: 6ccb | Chains: H, L | Done
100
Yes
10 Å
Yes
Avg A4D Score
-0.605
Max Score
2.8553
Min Score
-3.1789
Total Score
-264.99
Score CDR
-0.2327
Score non-CDR
-0.6664

Calculation Parameters

Chain Sequence(s) QVQLQESGPGLVKPSETLSVTCSVSGDSMNNYYWTWIRQSPGKGLEWIGYISDRESATYNPSLNSRVVISRDTSKNQLSLKLNSVTPADTAVYYCATARRGQRIYGVVSFGEFFYYYSMDVWGKGTTVTVSSASTKGPSVFPLAPSSKTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCLSVALGETARISCGRQALGSRAVQWYQHRPGQAPILLIYNNQDRPSGIPERFSGTPDINFGTRATLTISGVEAGDEADYYCHMWDSRSGFSWSFGGATRLTVLGQPKAAPSVTLFPPSSEELQANKATLVCLISDFYPGAVTVAWKADSSPVKAGVETTTPSKQSNNKYAASSYLSLTPEQWKSHRSYSCQVTHEGSTVEKTVAPTEC input.pdb
Selected Chain(s) H (Heavy), L (Light)
Distance of Aggregation 10 Å
FoldX Energy Minimization Yes
pH Calculations Yes
Downloads Download all data (.tar.gz)

Aggrescan4D Profile

Aggregation-prone (score > 0)
Soluble (score < 0)
Buried (score = 0)

Per-Residue A4D Scores

Download CSV
Minimum Score -3.1789
Maximum Score 2.8553
Average Score -0.605
Total Score -264.995

Residues with A4D score > 0.0 are highlighted as aggregation-prone.

Index Residue Chain A4D Score Classification
1 Q H -1.3687 Soluble
2 V H -0.6771 Soluble
3 Q H -1.5892 Soluble
4 L H 0.0000 Buried
5 Q H -1.3229 Soluble
6 E H 0.0000 Buried
7 S H -0.4975 Soluble
8 G H 0.0000 Buried
9 P H -0.3839 Soluble
11 G H 0.0000 Buried
12 L H -0.1980 Soluble
13 V H -1.1401 Soluble
14 K H -2.3154 Soluble
15 P H -1.7414 Soluble
16 S H -1.7807 Soluble
17 E H -2.5923 Soluble
18 T H -1.7612 Soluble
19 L H 0.0000 Buried
20 S H -0.7335 Soluble
21 V H 0.0000 Buried
22 T H -0.4710 Soluble
23 C H 0.0000 Buried
24 S H -1.0428 Soluble
25 V H 0.0000 Buried
26 S H -1.1552 Soluble
27 G H -1.2383 Soluble
28 D H -1.4410 Soluble
29 S H -1.1278 Soluble
30 M H 0.0000 Buried
35 N H -2.4243 Soluble
36 N H -1.6814 Soluble
37 Y H -0.4295 Soluble
38 Y H -0.7114 Soluble
39 W H 0.0000 Buried
40 T H 0.0000 Buried
41 W H 0.0000 Buried
42 I H 0.0000 Buried
43 R H 0.0000 Buried
44 Q H -1.0493 Soluble
45 S H -1.0947 Soluble
46 P H -1.0861 Soluble
47 G H -1.4886 Soluble
48 K H -2.3481 Soluble
49 G H -1.6804 Soluble
50 L H 0.0000 Buried
51 E H -1.4330 Soluble
52 W H 0.0000 Buried
53 I H 0.0000 Buried
54 G H 0.0000 Buried
55 Y H 0.2003 Aggregation-prone
56 I H 0.0000 Buried
57 S H -1.6920 Soluble
58 D H -2.3700 Soluble
59 R H -3.1650 Soluble
63 E H -3.1789 Soluble
64 S H -1.7654 Soluble
65 A H -0.7130 Soluble
66 T H -0.0055 Soluble
67 Y H 0.2086 Aggregation-prone
68 N H 0.0000 Buried
69 P H -0.6097 Soluble
70 S H -0.6547 Soluble
71 L H -0.7207 Soluble
72 N H -1.4905 Soluble
74 S H -0.9573 Soluble
75 R H -1.0626 Soluble
76 V H 0.0000 Buried
77 V H 0.1424 Aggregation-prone
78 I H 0.0000 Buried
79 S H -0.6867 Soluble
80 R H -1.3941 Soluble
81 D H -1.4833 Soluble
82 T H -1.3077 Soluble
83 S H -1.3690 Soluble
84 K H -2.2811 Soluble
85 N H -2.0138 Soluble
86 Q H -1.4224 Soluble
87 L H 0.0000 Buried
88 S H -0.4833 Soluble
89 L H 0.0000 Buried
90 K H -0.9124 Soluble
91 L H 0.0000 Buried
92 N H -1.5956 Soluble
93 S H -1.5733 Soluble
94 V H 0.0000 Buried
95 T H -0.9573 Soluble
96 P H -0.6252 Soluble
97 A H -0.2263 Soluble
98 D H -0.2896 Soluble
99 T H -0.1408 Soluble
100 A H 0.0000 Buried
101 V H 0.0202 Aggregation-prone
102 Y H 0.0000 Buried
103 Y H 0.0000 Buried
104 C H 0.0000 Buried
105 A H 0.0000 Buried
106 T H 0.0000 Buried
107 A H 0.0000 Buried
108 R H -1.0610 Soluble
109 R H -1.1290 Soluble
110 G H -0.7746 Soluble
111 Q H -0.3524 Soluble
111A R H 0.0993 Aggregation-prone
111B I H 1.6970 Aggregation-prone
111C Y H 1.7192 Aggregation-prone
111D G H 1.6478 Aggregation-prone
111E V H 2.5555 Aggregation-prone
111F V H 2.8553 Aggregation-prone
112G S H 1.7089 Aggregation-prone
112F F H 2.3182 Aggregation-prone
112E G H 1.3756 Aggregation-prone
112D E H 1.2348 Aggregation-prone
112C F H 1.4062 Aggregation-prone
112B F H 0.5934 Aggregation-prone
112A Y H 0.3318 Aggregation-prone
112 Y H 0.0000 Buried
113 Y H 0.0000 Buried
114 S H 0.0000 Buried
115 M H 0.0000 Buried
116 D H -0.9222 Soluble
117 V H -0.0842 Soluble
118 W H -0.4480 Soluble
119 G H 0.0000 Buried
120 K H -2.3024 Soluble
121 G H -1.2136 Soluble
122 T H -0.5447 Soluble
123 T H -0.0868 Soluble
124 V H 0.0000 Buried
125 T H -0.2550 Soluble
126 V H 0.0000 Buried
127 S H -0.7317 Soluble
128 S H -0.8866 Soluble
129 A H -0.5230 Soluble
130 S H -0.6635 Soluble
131 T H -0.7430 Soluble
132 K H -1.4227 Soluble
133 G H -1.5994 Soluble
134 P H -0.8659 Soluble
135 S H -0.3858 Soluble
136 V H 0.0000 Buried
137 F H 0.0000 Buried
138 P H 0.0000 Buried
139 L H 0.0000 Buried
140 A H -1.3646 Soluble
141 P H 0.0000 Buried
142 S H -1.1595 Soluble
143 S H -1.3275 Soluble
144 K H -1.9745 Soluble
145 T H -0.4327 Soluble
146 A H -0.4963 Soluble
147 A H -0.3602 Soluble
148 L H 0.0000 Buried
149 G H 0.0000 Buried
150 C H 0.0000 Buried
151 L H 0.0000 Buried
152 V H 0.0000 Buried
153 K H -0.4721 Soluble
154 D H -0.3502 Soluble
155 Y H 0.0000 Buried
156 F H -0.4670 Soluble
157 P H 0.0000 Buried
158 E H -0.6100 Soluble
159 P H -0.7955 Soluble
160 V H 0.0000 Buried
161 T H -0.8500 Soluble
162 V H -0.4627 Soluble
163 S H -0.3859 Soluble
164 W H 0.0000 Buried
165 N H -0.5594 Soluble
166 S H -0.6042 Soluble
167 G H -0.5029 Soluble
168 A H -0.2218 Soluble
169 L H 0.0085 Aggregation-prone
170 T H -0.1135 Soluble
171 S H -0.1955 Soluble
172 G H -0.2316 Soluble
173 V H 0.2767 Aggregation-prone
174 H H -0.1192 Soluble
175 T H -0.0588 Soluble
176 F H 0.0000 Buried
177 P H 0.0139 Aggregation-prone
178 A H 0.2276 Aggregation-prone
179 V H 0.0000 Buried
180 L H 1.3449 Aggregation-prone
181 Q H 0.3525 Aggregation-prone
182 S H -0.0722 Soluble
183 S H -0.1771 Soluble
184 G H 0.1031 Aggregation-prone
185 L H 0.2103 Aggregation-prone
186 Y H 0.5538 Aggregation-prone
187 S H 0.0000 Buried
188 L H 0.0000 Buried
189 S H 0.0000 Buried
190 S H 0.0000 Buried
191 V H 0.0000 Buried
192 V H 0.0000 Buried
193 T H -0.1866 Soluble
194 V H 0.0000 Buried
195 P H -0.3407 Soluble
196 S H -0.5370 Soluble
197 S H -0.3982 Soluble
198 S H -0.3757 Soluble
199 L H -0.3325 Soluble
200 G H -0.8039 Soluble
201 T H -0.5533 Soluble
202 Q H -0.9980 Soluble
203 T H -0.7543 Soluble
204 Y H 0.0000 Buried
205 I H -0.7258 Soluble
206 C H 0.0000 Buried
207 N H -1.4170 Soluble
208 V H 0.0000 Buried
209 N H -2.5370 Soluble
210 H H 0.0000 Buried
211 K H -2.8778 Soluble
212 P H -1.6588 Soluble
213 S H -2.0020 Soluble
214 N H -2.5333 Soluble
215 T H -2.2877 Soluble
216 K H -2.9740 Soluble
217 V H -1.5676 Soluble
218 D H -2.0995 Soluble
219 K H -1.6318 Soluble
220 R H -1.4222 Soluble
221 V H 0.0000 Buried
222 E H -2.4445 Soluble
223 P H -1.7501 Soluble
224 K H -1.7797 Soluble
225 S H -0.7930 Soluble
226 C H 0.0662 Aggregation-prone
11 L L 0.8960 Aggregation-prone
12 S L 0.5013 Aggregation-prone
13 V L 0.0000 Buried
14 A L -0.2996 Soluble
15 L L -0.5407 Soluble
16 G L -1.3255 Soluble
17 E L -1.7272 Soluble
18 T L -1.3971 Soluble
19 A L 0.0000 Buried
20 R L -2.0427 Soluble
21 I L 0.0000 Buried
22 S L -1.1406 Soluble
23 C L 0.0000 Buried
24 G L -1.5741 Soluble
25 R L -1.9401 Soluble
26 Q L -1.9671 Soluble
27 A L -1.0608 Soluble
28 L L -0.2402 Soluble
29 G L -0.4486 Soluble
36 S L 0.1803 Aggregation-prone
37 R L 0.0000 Buried
38 A L 0.0000 Buried
39 V L 0.0000 Buried
40 Q L 0.0000 Buried
41 W L 0.0000 Buried
42 Y L 0.0000 Buried
43 Q L -0.1550 Soluble
44 H L 0.0000 Buried
45 R L -1.3144 Soluble
46 P L -1.1768 Soluble
47 G L -1.4465 Soluble
48 Q L -1.7292 Soluble
49 A L -0.8842 Soluble
50 P L 0.0000 Buried
51 I L 0.7947 Aggregation-prone
52 L L 0.0000 Buried
53 L L 0.0000 Buried
54 I L 0.0000 Buried
55 Y L -0.8285 Soluble
56 N L -1.0551 Soluble
57 N L 0.0000 Buried
65 Q L -1.5886 Soluble
66 D L -2.0870 Soluble
67 R L -1.6833 Soluble
68 P L -0.9783 Soluble
69 S L -0.7813 Soluble
70 G L -0.7506 Soluble
71 I L -0.5520 Soluble
72 P L -1.3102 Soluble
74 E L -2.2638 Soluble
75 R L -1.5821 Soluble
76 F L 0.0000 Buried
77 S L -1.3660 Soluble
78 G L -1.1994 Soluble
79 T L -0.7285 Soluble
80 P L -0.3983 Soluble
81 D L -0.0453 Soluble
81A I L 1.3457 Aggregation-prone
82 N L -0.0436 Soluble
83 F L 0.3990 Aggregation-prone
84 G L -0.3957 Soluble
85 T L -0.9153 Soluble
86 R L -2.2685 Soluble
87 A L 0.0000 Buried
88 T L 0.0000 Buried
89 L L 0.0000 Buried
90 T L -1.0476 Soluble
91 I L 0.0000 Buried
92 S L -1.5708 Soluble
93 G L -1.3018 Soluble
94 V L 0.0000 Buried
95 E L -2.0530 Soluble
96 A L -1.2125 Soluble
97 G L -1.3100 Soluble
98 D L 0.0000 Buried
99 E L -0.9204 Soluble
100 A L 0.0000 Buried
101 D L -1.0916 Soluble
102 Y L 0.0000 Buried
103 Y L 0.0000 Buried
104 C L 0.0000 Buried
105 H L 0.0000 Buried
106 M L 0.0000 Buried
107 W L 0.0000 Buried
108 D L 0.0000 Buried
109 S L -0.8733 Soluble
110 R L -1.8231 Soluble
112 S L -0.8627 Soluble
113 G L -0.3642 Soluble
114 F L 0.6739 Aggregation-prone
115 S L 0.3110 Aggregation-prone
116 W L -0.0210 Soluble
117 S L -0.5338 Soluble
118 F L 0.0000 Buried
119 G L -1.0248 Soluble
120 G L -1.3543 Soluble
121 A L -1.1759 Soluble
122 T L -0.9040 Soluble
123 R L -1.6954 Soluble
124 L L 0.0000 Buried
125 T L -0.0811 Soluble
126 V L 0.0000 Buried
127 L L 0.4147 Aggregation-prone
128 G L -0.1903 Soluble
129 Q L 0.0000 Buried
130 P L -1.1405 Soluble
131 K L -2.1641 Soluble
132 A L -1.0524 Soluble
133 A L -0.5272 Soluble
134 P L -0.4494 Soluble
135 S L -0.3255 Soluble
136 V L 0.0000 Buried
137 T L -0.3446 Soluble
138 L L 0.0000 Buried
139 F L 0.0000 Buried
140 P L -0.0955 Soluble
141 P L 0.0000 Buried
142 S L 0.0000 Buried
143 S L -1.6768 Soluble
144 E L -2.4598 Soluble
145 E L 0.0000 Buried
146 L L -2.2164 Soluble
147 Q L -2.4001 Soluble
148 A L -1.9442 Soluble
149 N L -2.6307 Soluble
150 K L -2.4747 Soluble
151 A L 0.0000 Buried
152 T L 0.0000 Buried
153 L L 0.0000 Buried
154 V L 0.0000 Buried
155 C L 0.0000 Buried
156 L L 0.0000 Buried
157 I L 0.0000 Buried
158 S L -0.5158 Soluble
159 D L -1.2356 Soluble
160 F L 0.0000 Buried
161 Y L -1.1626 Soluble
162 P L -0.8524 Soluble
163 G L -0.5186 Soluble
164 A L -0.3508 Soluble
165 V L -0.2050 Soluble
166 T L -0.1786 Soluble
167 V L 0.1727 Aggregation-prone
168 A L -0.2587 Soluble
169 W L 0.0000 Buried
170 K L -0.8087 Soluble
171 A L 0.0000 Buried
172 D L -1.2722 Soluble
173 S L -0.6265 Soluble
174 S L -0.7074 Soluble
175 P L -0.7712 Soluble
176 V L -0.6180 Soluble
177 K L -1.5093 Soluble
178 A L -0.6405 Soluble
179 G L -0.3797 Soluble
180 V L -0.0269 Soluble
181 E L -0.0397 Soluble
182 T L 0.1565 Aggregation-prone
183 T L 0.0000 Buried
184 T L 0.0095 Aggregation-prone
185 P L -0.2504 Soluble
186 S L -0.4560 Soluble
187 K L -0.9527 Soluble
188 Q L -1.1287 Soluble
189 S L -1.0509 Soluble
190 N L -1.3321 Soluble
191 N L -1.1504 Soluble
192 K L -1.3218 Soluble
193 Y L -0.6315 Soluble
194 A L 0.0000 Buried
195 A L 0.0000 Buried
196 S L 0.0000 Buried
197 S L 0.0000 Buried
198 Y L 0.0000 Buried
199 L L 0.0000 Buried
200 S L -0.2208 Soluble
201 L L -0.6282 Soluble
202 T L -1.5899 Soluble
203 P L -2.3677 Soluble
204 E L -3.0581 Soluble
205 Q L -2.1144 Soluble
206 W L 0.0000 Buried
207 K L -3.0307 Soluble
208 S L -2.3978 Soluble
209 H L -2.3920 Soluble
210 R L -2.5279 Soluble
211 S L -1.6635 Soluble
212 Y L 0.0000 Buried
213 S L 0.0000 Buried
214 C L 0.0000 Buried
215 Q L -0.7570 Soluble
216 V L 0.0000 Buried
217 T L -0.6466 Soluble
218 H L 0.0000 Buried
219 E L -2.2904 Soluble
220 G L -1.4516 Soluble
221 S L -0.9414 Soluble
222 T L -0.6139 Soluble
223 V L -0.3336 Soluble
224 E L -1.1231 Soluble
225 K L -1.0452 Soluble
226 T L -0.6294 Soluble
227 V L -0.4738 Soluble
228 A L -1.1912 Soluble
229 P L -1.3801 Soluble
230 T L -1.2986 Soluble
231 E L -1.3849 Soluble
232 C L -0.7781 Soluble

3D Structure — colored by A4D score

Sequence - click residue to focus in viewer  |  colored by A4D score
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Color Legend (B-factor = A4D Score)
Score > 1.5 — highly aggregation-prone
Score 0.5–1.5 — aggregation-prone
Score ≈ 0 — buried
Score −1 to −0.5 — soluble
Score < −2.5 — highly soluble
pH Structure
Load structure at specific pH condition
A4D Score Threshold
Highlight residues > threshold in the sequence panel
CDR Regions
HCDR1
HCDR2
HCDR3
LCDR1
LCDR2
LCDR3
Display Options

pH-Dependent Aggregation Profiles

A4D scores calculated across 11 pH conditions (4.0–9.0, step 0.5). Click a row to view the structure at that pH. The input structure is globular — max score is recommended for pH analysis.

pH Avg A4D Score Max A4D Score Downloads
4.0 -0.5752 4.4666 CSV PDB
4.5 -0.6081 4.4411 CSV PDB
5.0 -0.6485 4.4031 CSV PDB
5.5 -0.6873 4.3586 CSV PDB
6.0 -0.7144 4.3147 CSV PDB
6.5 -0.7219 4.2785 CSV PDB
7.0 -0.7083 4.2556 CSV PDB
7.5 -0.68 4.2449 CSV PDB
8.0 -0.6441 4.2409 CSV PDB
8.5 -0.6038 4.2395 CSV PDB
9.0 -0.5604 4.2391 CSV PDB
Average A4D Score vs pH
Max A4D Score vs pH