Nirsevimab / 5udd

A4DAB181_5udd_L_R | Source PDB: 5udd | Chains: L, R | Done
100
Yes
10 Å
Yes
Avg A4D Score
-0.6648
Max Score
2.5766
Min Score
-3.8792
Total Score
-287.21
Score CDR
-0.1694
Score non-CDR
-0.7341

Calculation Parameters

Chain Sequence(s) QVQLVQSGAEVKKPGSSVMVSCQASGGLLEDYIINWVRQAPGQGPEWMGGIIPVLGTVHYGPKFQGRVTITADESTDTAYMELSSLRSEDTAMYYCATETALVVSETYLPHYFDNWGQGTLVTVSSASTKGPSVFPLAPSSGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPDIQMTQSPSSLSAAVGDRVTITCQASQDIVNYLNWYQQKPGKAPKLLIYVASNLETGVPSRFSGSGSGTDFSLTISSLQPEDVATYYCQQYDNLPLTFGGGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNR input.pdb
Selected Chain(s) L (Heavy), R (Light)
Distance of Aggregation 10 Å
FoldX Energy Minimization Yes
pH Calculations Yes
Downloads Download all data (.tar.gz)

Aggrescan4D Profile

Aggregation-prone (score > 0)
Soluble (score < 0)
Buried (score = 0)

Per-Residue A4D Scores

Download CSV
Minimum Score -3.8792
Maximum Score 2.5766
Average Score -0.6648
Total Score -287.2083

Residues with A4D score > 0.0 are highlighted as aggregation-prone.

Index Residue Chain A4D Score Classification
1 Q L -1.6719 Soluble
2 V L 0.0000 Buried
3 Q L -1.4751 Soluble
4 L L 0.0000 Buried
5 V L 0.9062 Aggregation-prone
6 Q L 0.0000 Buried
7 S L -0.1968 Soluble
8 G L -1.0862 Soluble
9 A L -1.2649 Soluble
11 E L -1.8232 Soluble
12 V L -1.2257 Soluble
13 K L -2.0721 Soluble
14 K L -2.5978 Soluble
15 P L -2.1248 Soluble
16 G L -1.7157 Soluble
17 S L -1.3441 Soluble
18 S L -0.9885 Soluble
19 V L 0.0000 Buried
20 M L 0.2583 Aggregation-prone
21 V L 0.0000 Buried
22 S L 0.1990 Aggregation-prone
23 C L 0.0000 Buried
24 Q L -0.1123 Soluble
25 A L 0.0000 Buried
26 S L -0.7736 Soluble
27 G L -1.0082 Soluble
28 G L -0.7411 Soluble
29 L L -0.4728 Soluble
30 L L 0.0000 Buried
35 E L -0.8914 Soluble
36 D L -0.0012 Soluble
37 Y L 0.0640 Aggregation-prone
38 I L 0.0000 Buried
39 I L 0.0000 Buried
40 N L 0.0000 Buried
41 W L 0.0000 Buried
42 V L 0.0000 Buried
43 R L -0.3737 Soluble
44 Q L 0.0000 Buried
45 A L -0.9373 Soluble
46 P L -0.8243 Soluble
47 G L -1.1923 Soluble
48 Q L -1.7067 Soluble
49 G L -1.0834 Soluble
50 P L 0.0000 Buried
51 E L -0.5752 Soluble
52 W L 0.0000 Buried
53 M L 0.0000 Buried
54 G L 0.0000 Buried
55 G L 0.0000 Buried
56 I L 0.0000 Buried
57 I L 0.0000 Buried
58 P L -0.1744 Soluble
59 V L 0.5661 Aggregation-prone
62 L L 0.2845 Aggregation-prone
63 G L 0.0398 Aggregation-prone
64 T L 0.1523 Aggregation-prone
65 V L 0.5724 Aggregation-prone
66 H L 0.1475 Aggregation-prone
67 Y L -0.3956 Soluble
68 G L 0.0000 Buried
69 P L -1.5996 Soluble
70 K L -2.2002 Soluble
71 F L 0.0000 Buried
72 Q L -1.9990 Soluble
74 G L -1.4813 Soluble
75 R L -1.4116 Soluble
76 V L 0.0000 Buried
77 T L -0.4964 Soluble
78 I L 0.0000 Buried
79 T L -0.3196 Soluble
80 A L -0.9193 Soluble
81 D L -1.6708 Soluble
82 E L -2.1024 Soluble
83 S L -1.2077 Soluble
84 T L -1.0207 Soluble
85 D L -1.3489 Soluble
86 T L 0.0000 Buried
87 A L 0.0000 Buried
88 Y L 0.0101 Aggregation-prone
89 M L 0.0000 Buried
90 E L -0.5749 Soluble
91 L L 0.0000 Buried
92 S L -0.8869 Soluble
93 S L -1.2464 Soluble
94 L L 0.0000 Buried
95 R L -3.1114 Soluble
96 S L -2.2690 Soluble
97 E L -2.5065 Soluble
98 D L 0.0000 Buried
99 T L -0.9744 Soluble
100 A L 0.0000 Buried
101 M L 0.0243 Aggregation-prone
102 Y L 0.0000 Buried
103 Y L 0.0000 Buried
104 C L 0.0000 Buried
105 A L 0.0000 Buried
106 T L 0.0000 Buried
107 E L 0.0000 Buried
108 T L 0.3941 Aggregation-prone
109 A L 0.0000 Buried
110 L L 2.2895 Aggregation-prone
111 V L 2.5766 Aggregation-prone
111A V L 1.3957 Aggregation-prone
111B S L -0.1024 Soluble
111C E L -1.5467 Soluble
112C T L -0.7056 Soluble
112B Y L -0.2022 Soluble
112A L L -0.0718 Soluble
112 P L 0.0000 Buried
113 H L -0.0512 Soluble
114 Y L 0.2497 Aggregation-prone
115 F L 0.0000 Buried
116 D L -0.7085 Soluble
117 N L -1.0605 Soluble
118 W L -0.5796 Soluble
119 G L 0.0000 Buried
120 Q L -1.3381 Soluble
121 G L -0.7139 Soluble
122 T L 0.0000 Buried
123 L L -0.3014 Soluble
124 V L 0.0000 Buried
125 T L -1.0581 Soluble
126 V L 0.0000 Buried
127 S L -1.2586 Soluble
128 S L -0.9553 Soluble
129 A L -0.7151 Soluble
130 S L -1.0539 Soluble
131 T L -1.2869 Soluble
132 K L -1.9560 Soluble
133 G L -1.6640 Soluble
134 P L 0.0000 Buried
135 S L -0.4672 Soluble
136 V L 0.0000 Buried
137 F L 0.0000 Buried
138 P L -1.1817 Soluble
139 L L 0.0000 Buried
140 A L -0.5514 Soluble
141 P L 0.0000 Buried
142 S L -0.4423 Soluble
143 S L -0.3352 Soluble
144 G L -0.5982 Soluble
145 T L -0.4676 Soluble
146 A L -0.2614 Soluble
147 A L 0.0000 Buried
148 L L 0.0000 Buried
149 G L 0.0000 Buried
150 C L 0.0000 Buried
151 L L 0.0000 Buried
152 V L 0.0000 Buried
153 K L -0.3580 Soluble
154 D L -0.6551 Soluble
155 Y L 0.0000 Buried
156 F L -0.5502 Soluble
157 P L 0.0000 Buried
158 E L -0.5502 Soluble
159 P L -0.7846 Soluble
160 V L 0.0000 Buried
161 T L -0.5390 Soluble
162 V L -0.2050 Soluble
163 S L -0.3901 Soluble
164 W L 0.0000 Buried
165 N L -0.6931 Soluble
166 S L -0.6403 Soluble
167 G L -0.4546 Soluble
168 A L -0.2077 Soluble
169 L L 0.0664 Aggregation-prone
170 T L -0.1203 Soluble
171 S L -0.3344 Soluble
172 G L -0.2003 Soluble
173 V L 0.2171 Aggregation-prone
174 H L 0.0000 Buried
175 T L -0.1241 Soluble
176 F L 0.0000 Buried
177 P L -0.3486 Soluble
178 A L 0.1901 Aggregation-prone
179 V L 0.5345 Aggregation-prone
180 L L 1.4151 Aggregation-prone
181 Q L 0.3305 Aggregation-prone
182 S L 0.0020 Aggregation-prone
183 S L -0.1942 Soluble
184 G L 0.1046 Aggregation-prone
185 L L 0.0401 Aggregation-prone
186 Y L 0.5740 Aggregation-prone
187 S L 0.0000 Buried
188 L L 0.0000 Buried
189 S L 0.0000 Buried
190 S L 0.0000 Buried
191 V L 0.0000 Buried
192 V L 0.0000 Buried
193 T L -0.0655 Soluble
194 V L 0.0000 Buried
195 P L -0.4627 Soluble
196 S L -0.5323 Soluble
197 S L -0.5513 Soluble
198 S L -0.5306 Soluble
199 L L -0.6917 Soluble
200 G L -0.9210 Soluble
201 T L -0.6074 Soluble
202 Q L -0.9438 Soluble
203 T L -0.9401 Soluble
204 Y L 0.0000 Buried
205 I L -1.2574 Soluble
206 C L 0.0000 Buried
207 N L -1.5542 Soluble
208 V L 0.0000 Buried
209 N L -1.7399 Soluble
210 H L 0.0000 Buried
211 K L -2.9881 Soluble
212 P L -2.1281 Soluble
213 S L -2.1743 Soluble
214 N L -2.5998 Soluble
215 T L -2.1437 Soluble
216 K L -2.7535 Soluble
217 V L -1.9195 Soluble
218 D L -2.6696 Soluble
219 K L -2.1365 Soluble
220 R L -2.5844 Soluble
221 V L 0.0000 Buried
222 E L -2.0943 Soluble
223 P L -1.0713 Soluble
1 D R -2.3759 Soluble
2 I R 0.0000 Buried
3 Q R -2.0254 Soluble
4 M R 0.0000 Buried
5 T R -0.9608 Soluble
6 Q R 0.0000 Buried
7 S R -0.6161 Soluble
8 P R -0.6006 Soluble
9 S R -0.8492 Soluble
10 S R -1.0844 Soluble
11 L R -0.8295 Soluble
12 S R -1.0517 Soluble
13 A R -1.2051 Soluble
14 A R -1.1336 Soluble
15 V R -0.3103 Soluble
16 G R -0.9311 Soluble
17 D R -2.0037 Soluble
18 R R -2.3795 Soluble
19 V R 0.0000 Buried
20 T R -0.6445 Soluble
21 I R 0.0000 Buried
22 T R -0.6363 Soluble
23 C R 0.0000 Buried
24 Q R -1.8479 Soluble
25 A R -1.7110 Soluble
26 S R -1.9801 Soluble
27 Q R -2.4902 Soluble
28 D R -2.3802 Soluble
29 I R 0.0000 Buried
36 V R 0.1764 Aggregation-prone
37 N R -0.1250 Soluble
38 Y R 0.2364 Aggregation-prone
39 L R 0.0000 Buried
40 N R 0.0000 Buried
41 W R 0.0000 Buried
42 Y R 0.0000 Buried
43 Q R -1.0368 Soluble
44 Q R -1.4209 Soluble
45 K R -1.9921 Soluble
46 P R -1.6100 Soluble
47 G R -1.8081 Soluble
48 K R -2.5242 Soluble
49 A R -1.6403 Soluble
50 P R 0.0000 Buried
51 K R -1.6194 Soluble
52 L R 0.0000 Buried
53 L R 0.0000 Buried
54 I R 0.0000 Buried
55 Y R 0.4243 Aggregation-prone
56 V R 0.6200 Aggregation-prone
57 A R 0.0000 Buried
65 S R -0.3773 Soluble
66 N R -0.3349 Soluble
67 L R 0.0902 Aggregation-prone
68 E R -0.4348 Soluble
69 T R -0.3497 Soluble
70 G R -0.4571 Soluble
71 V R -0.3085 Soluble
72 P R -0.3297 Soluble
74 S R -0.4306 Soluble
75 R R -0.7450 Soluble
76 F R 0.0000 Buried
77 S R -0.4223 Soluble
78 G R -0.3280 Soluble
79 S R -0.7958 Soluble
80 G R -0.8912 Soluble
83 S R -0.7630 Soluble
84 G R -1.1259 Soluble
85 T R -1.7911 Soluble
86 D R -2.2146 Soluble
87 F R 0.0000 Buried
88 S R -0.7176 Soluble
89 L R 0.0000 Buried
90 T R -0.6173 Soluble
91 I R 0.0000 Buried
92 S R -1.2906 Soluble
93 S R -1.1550 Soluble
94 L R 0.0000 Buried
95 Q R -1.0518 Soluble
96 P R -1.7431 Soluble
97 E R -2.2471 Soluble
98 D R 0.0000 Buried
99 V R 0.0000 Buried
100 A R 0.0000 Buried
101 T R 0.0000 Buried
102 Y R 0.0000 Buried
103 Y R 0.0000 Buried
104 C R 0.0000 Buried
105 Q R 0.0000 Buried
106 Q R 0.0000 Buried
107 Y R 0.0000 Buried
108 D R -1.2730 Soluble
109 N R -1.6288 Soluble
114 L R -0.7734 Soluble
115 P R -0.9260 Soluble
116 L R 0.0000 Buried
117 T R -0.8823 Soluble
118 F R 0.0000 Buried
119 G R 0.0000 Buried
120 G R -1.1251 Soluble
121 G R -1.0410 Soluble
122 T R 0.0000 Buried
123 K R -2.1365 Soluble
124 V R 0.0000 Buried
125 E R -1.8582 Soluble
126 I R 0.0000 Buried
127 K R -1.7729 Soluble
128 R R -1.1306 Soluble
129 T R -0.1446 Soluble
130 V R 0.6309 Aggregation-prone
131 A R 0.2398 Aggregation-prone
132 A R -0.0179 Soluble
133 P R -0.0750 Soluble
134 S R -0.0710 Soluble
135 V R 0.0000 Buried
136 F R 0.1324 Aggregation-prone
137 I R 0.0999 Aggregation-prone
138 F R 0.0000 Buried
139 P R -0.7457 Soluble
140 P R 0.0000 Buried
141 S R -1.7017 Soluble
142 D R -3.0229 Soluble
143 E R -3.1175 Soluble
144 Q R 0.0000 Buried
145 L R -2.2936 Soluble
146 K R -2.8007 Soluble
147 S R -1.7344 Soluble
148 G R -1.1536 Soluble
149 T R -0.7460 Soluble
150 A R 0.0000 Buried
151 S R 0.0000 Buried
152 V R 0.0000 Buried
153 V R 0.0000 Buried
154 C R 0.0000 Buried
155 L R 0.0000 Buried
156 L R 0.0000 Buried
157 N R -0.2912 Soluble
158 N R -0.5647 Soluble
159 F R 0.0000 Buried
160 Y R 0.0000 Buried
161 P R -1.8161 Soluble
162 R R -2.9047 Soluble
163 E R -3.2447 Soluble
164 A R -2.3367 Soluble
165 K R -2.1812 Soluble
166 V R 0.0000 Buried
167 Q R -0.8082 Soluble
168 W R 0.0000 Buried
169 K R -0.5866 Soluble
170 V R 0.0000 Buried
171 D R -2.0686 Soluble
172 N R -1.5843 Soluble
173 A R -0.4080 Soluble
174 L R 0.5872 Aggregation-prone
175 Q R -0.1999 Soluble
176 S R -0.4783 Soluble
177 G R -1.0732 Soluble
178 N R -0.9776 Soluble
179 S R -1.3368 Soluble
180 Q R -1.5997 Soluble
181 E R -2.0236 Soluble
182 S R -1.0087 Soluble
183 V R -0.6876 Soluble
184 T R -0.8864 Soluble
185 E R -2.3505 Soluble
186 Q R 0.0000 Buried
187 D R -2.1059 Soluble
188 S R -2.3351 Soluble
189 K R -2.6238 Soluble
190 D R -1.8743 Soluble
191 S R 0.0000 Buried
192 T R 0.0000 Buried
193 Y R 0.0000 Buried
194 S R 0.0000 Buried
195 L R 0.0000 Buried
196 S R 0.0000 Buried
197 S R 0.0000 Buried
198 T R -0.7360 Soluble
199 L R 0.0000 Buried
200 T R -0.2460 Soluble
201 L R -0.3851 Soluble
202 S R -1.1560 Soluble
203 K R -1.9296 Soluble
204 A R -1.9174 Soluble
205 D R -2.8078 Soluble
206 Y R 0.0000 Buried
207 E R -3.8792 Soluble
208 K R -3.6620 Soluble
209 H R -3.3017 Soluble
210 K R -3.4605 Soluble
211 V R -1.9047 Soluble
212 Y R 0.0000 Buried
213 A R -0.7564 Soluble
214 C R 0.0000 Buried
215 E R -0.6313 Soluble
216 V R 0.0000 Buried
217 T R -1.0439 Soluble
218 H R 0.0000 Buried
219 Q R -1.3349 Soluble
220 G R -0.3854 Soluble
221 L R -0.2107 Soluble
222 S R -0.4583 Soluble
223 S R -0.3859 Soluble
224 P R -0.2756 Soluble
225 V R 0.1747 Aggregation-prone
226 T R -0.3509 Soluble
227 K R -0.6778 Soluble
228 S R -0.9770 Soluble
229 F R -1.2595 Soluble
230 N R -2.4393 Soluble
231 R R -3.1345 Soluble

3D Structure — colored by A4D score

Sequence - click residue to focus in viewer  |  colored by A4D score
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Color Legend (B-factor = A4D Score)
Score > 1.5 — highly aggregation-prone
Score 0.5–1.5 — aggregation-prone
Score ≈ 0 — buried
Score −1 to −0.5 — soluble
Score < −2.5 — highly soluble
pH Structure
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A4D Score Threshold
Highlight residues > threshold in the sequence panel
CDR Regions
HCDR1
HCDR2
HCDR3
LCDR1
LCDR2
LCDR3
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pH-Dependent Aggregation Profiles

A4D scores calculated across 11 pH conditions (4.0–9.0, step 0.5). Click a row to view the structure at that pH. The input structure is globular — max score is recommended for pH analysis.

pH Avg A4D Score Max A4D Score Downloads
4.0 -0.6458 2.6996 CSV PDB
4.5 -0.6947 2.6468 CSV PDB
5.0 -0.7534 2.5772 CSV PDB
5.5 -0.8111 2.5001 CSV PDB
6.0 -0.8563 2.4223 CSV PDB
6.5 -0.8795 2.3493 CSV PDB
7.0 -0.879 2.2847 CSV PDB
7.5 -0.8622 2.2429 CSV PDB
8.0 -0.8366 2.2213 CSV PDB
8.5 -0.8046 2.2011 CSV PDB
9.0 -0.7659 2.1844 CSV PDB
Average A4D Score vs pH
Max A4D Score vs pH