Eltrekibart / 6wzk

A4DAB101_6wzk_C_D | Source PDB: 6wzk | Chains: C, D | Done
100
Yes
10 Å
Yes
Avg A4D Score
-0.6959
Max Score
1.8224
Min Score
-3.6512
Total Score
-302.0
Score CDR
-0.3983
Score non-CDR
-0.7373

Calculation Parameters

Chain Sequence(s) QVQLVQSGAEVKKPGASVKVSCKASGYEFTSYWIHWVRQAPGQGLEWMGNISPNSGSANYNEKFKSRVTMTRDTSTSTVYMELSSLRSEDTAVYYCAREGPYSYYPSREYYGSDLWGQGTLVTVSSASTKGPSVFPLAPCSESTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTKTYTCNVDHKPSNTKVDKRVEIVLTQSPATLSLSPGERATLSCRASQSISNNLHWYQQKPGQAPRLLIYYTSRSVSGIPARFSGSGSGTDFTLTISSLEPEDFAVYYCGQNNEWPEVFGGGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC input.pdb
Selected Chain(s) C (Heavy), D (Light)
Distance of Aggregation 10 Å
FoldX Energy Minimization Yes
pH Calculations Yes
Downloads Download all data (.tar.gz)

Aggrescan4D Profile

Aggregation-prone (score > 0)
Soluble (score < 0)
Buried (score = 0)

Per-Residue A4D Scores

Download CSV
Minimum Score -3.6512
Maximum Score 1.8224
Average Score -0.6959
Total Score -302.003

Residues with A4D score > 0.0 are highlighted as aggregation-prone.

Index Residue Chain A4D Score Classification
1 Q C -1.2462 Soluble
2 V C -0.6316 Soluble
3 Q C -1.2694 Soluble
4 L C 0.0000 Buried
5 V C -0.1856 Soluble
6 Q C 0.0000 Buried
7 S C -0.6760 Soluble
8 G C -0.6449 Soluble
9 A C -0.3016 Soluble
11 E C -0.7118 Soluble
12 V C -0.2994 Soluble
13 K C -1.5168 Soluble
14 K C -2.4048 Soluble
15 P C -2.2599 Soluble
16 G C -1.6140 Soluble
17 A C -1.1824 Soluble
18 S C -1.3938 Soluble
19 V C 0.0000 Buried
20 K C -2.1318 Soluble
21 V C 0.0000 Buried
22 S C -0.6831 Soluble
23 C C 0.0000 Buried
24 K C -1.0049 Soluble
25 A C 0.0000 Buried
26 S C -0.9718 Soluble
27 G C -1.0268 Soluble
28 Y C -1.0088 Soluble
29 E C -1.6680 Soluble
30 F C -0.9817 Soluble
35 T C -0.8587 Soluble
36 S C -0.4687 Soluble
37 Y C -0.1552 Soluble
38 W C 0.2436 Aggregation-prone
39 I C 0.0000 Buried
40 H C 0.0000 Buried
41 W C 0.0000 Buried
42 V C 0.0000 Buried
43 R C 0.0000 Buried
44 Q C 0.0000 Buried
45 A C -0.8800 Soluble
46 P C -0.7622 Soluble
47 G C -1.2248 Soluble
48 Q C -1.7102 Soluble
49 G C -1.1198 Soluble
50 L C 0.0000 Buried
51 E C -0.5575 Soluble
52 W C 0.0000 Buried
53 M C 0.0000 Buried
54 G C 0.0000 Buried
55 N C 0.0000 Buried
56 I C 0.0000 Buried
57 S C -0.6465 Soluble
58 P C 0.0000 Buried
59 N C -1.4502 Soluble
62 S C -1.0202 Soluble
63 G C -0.9576 Soluble
64 S C -0.7611 Soluble
65 A C -0.4622 Soluble
66 N C -1.0143 Soluble
67 Y C -1.4046 Soluble
68 N C -1.9794 Soluble
69 E C -3.3526 Soluble
70 K C -3.0887 Soluble
71 F C 0.0000 Buried
72 K C -2.9427 Soluble
74 S C -1.7994 Soluble
75 R C -1.5948 Soluble
76 V C 0.0000 Buried
77 T C -0.9577 Soluble
78 M C 0.0000 Buried
79 T C -0.5221 Soluble
80 R C -1.1462 Soluble
81 D C -1.1111 Soluble
82 T C -0.8620 Soluble
83 S C -0.5399 Soluble
84 T C -0.6381 Soluble
85 S C -0.8738 Soluble
86 T C 0.0000 Buried
87 V C 0.0000 Buried
88 Y C -0.7626 Soluble
89 M C 0.0000 Buried
90 E C -1.6099 Soluble
91 L C 0.0000 Buried
92 S C -1.1563 Soluble
93 S C -1.2323 Soluble
94 L C 0.0000 Buried
95 R C -3.0987 Soluble
96 S C -2.3573 Soluble
97 E C -2.5138 Soluble
98 D C 0.0000 Buried
99 T C -0.9154 Soluble
100 A C 0.0000 Buried
101 V C 0.3977 Aggregation-prone
102 Y C 0.0000 Buried
103 Y C 0.0000 Buried
104 C C 0.0000 Buried
105 A C 0.0000 Buried
106 R C 0.0000 Buried
107 E C 0.0000 Buried
108 G C 0.0000 Buried
109 P C -0.0921 Soluble
110 Y C 0.7418 Aggregation-prone
111 S C 0.8975 Aggregation-prone
111A Y C 1.8224 Aggregation-prone
111B Y C 1.7772 Aggregation-prone
111C P C 0.1972 Aggregation-prone
112C S C -0.9327 Soluble
112B R C -2.2858 Soluble
112A E C -1.6454 Soluble
112 Y C -0.4952 Soluble
113 Y C 0.0513 Aggregation-prone
114 G C 0.0000 Buried
115 S C 0.0000 Buried
116 D C -0.9500 Soluble
117 L C -0.6337 Soluble
118 W C -0.7389 Soluble
119 G C 0.0000 Buried
120 Q C -1.4078 Soluble
121 G C -0.6011 Soluble
122 T C 0.0000 Buried
123 L C 0.0604 Aggregation-prone
124 V C 0.0000 Buried
125 T C 0.0000 Buried
126 V C 0.0000 Buried
127 S C -1.4232 Soluble
128 S C -1.1768 Soluble
129 A C -0.6505 Soluble
130 S C -0.6998 Soluble
131 T C -0.5279 Soluble
132 K C -1.2024 Soluble
133 G C -1.3603 Soluble
134 P C -0.6373 Soluble
135 S C -0.4733 Soluble
136 V C 0.0000 Buried
137 F C 0.0000 Buried
138 P C -0.7417 Soluble
139 L C 0.0000 Buried
140 A C 0.1954 Aggregation-prone
141 P C 0.0922 Aggregation-prone
142 C C -0.2655 Soluble
143 S C -0.2545 Soluble
144 E C -2.0159 Soluble
145 S C -1.2577 Soluble
146 T C -0.9416 Soluble
147 A C -0.5019 Soluble
148 A C 0.0000 Buried
149 L C 0.0000 Buried
150 G C 0.0000 Buried
151 C C 0.0000 Buried
152 L C 0.0000 Buried
153 V C 0.0000 Buried
154 K C 0.0000 Buried
155 D C -0.4672 Soluble
156 Y C 0.0000 Buried
157 F C 0.0000 Buried
158 P C 0.0000 Buried
159 E C -0.4759 Soluble
160 P C -0.8124 Soluble
161 V C -0.7857 Soluble
162 T C -0.6606 Soluble
163 V C -0.4692 Soluble
164 S C -0.5381 Soluble
165 W C 0.0000 Buried
166 N C -0.9938 Soluble
167 S C -0.7780 Soluble
168 G C -0.6012 Soluble
169 A C -0.2717 Soluble
170 L C -0.1191 Soluble
171 T C -0.2154 Soluble
172 S C -0.2176 Soluble
173 G C -0.3153 Soluble
174 V C 0.1193 Aggregation-prone
175 H C -0.3435 Soluble
176 T C -0.1713 Soluble
177 F C 0.0000 Buried
178 P C -0.3104 Soluble
179 A C 0.1389 Aggregation-prone
180 V C 0.5200 Aggregation-prone
181 L C 1.0663 Aggregation-prone
182 Q C 0.1159 Aggregation-prone
183 S C -0.2017 Soluble
184 S C -0.2297 Soluble
185 G C 0.0070 Aggregation-prone
186 L C 0.0353 Aggregation-prone
187 Y C 0.0000 Buried
188 S C 0.0000 Buried
189 L C 0.0000 Buried
190 S C 0.0000 Buried
191 S C 0.0000 Buried
192 V C 0.0000 Buried
193 V C 0.0000 Buried
194 T C -0.1382 Soluble
195 V C 0.0000 Buried
196 P C -0.5733 Soluble
197 S C -0.6642 Soluble
198 S C -0.6479 Soluble
199 S C -0.5235 Soluble
200 L C -0.0452 Soluble
201 G C -0.6081 Soluble
202 T C -0.8059 Soluble
203 K C -1.4180 Soluble
204 T C -1.0377 Soluble
205 Y C 0.0000 Buried
206 T C -1.5399 Soluble
207 C C 0.0000 Buried
208 N C -1.7379 Soluble
209 V C 0.0000 Buried
210 D C -2.1562 Soluble
211 H C 0.0000 Buried
212 K C -2.7921 Soluble
213 P C -1.6101 Soluble
214 S C -1.8332 Soluble
215 N C -2.5903 Soluble
216 T C -2.1233 Soluble
217 K C -2.7792 Soluble
218 V C -1.7775 Soluble
219 D C -2.7190 Soluble
220 K C -2.1212 Soluble
221 R C -2.2118 Soluble
222 V C -0.5763 Soluble
1 E D -1.6020 Soluble
2 I D 0.0000 Buried
3 V D 0.7718 Aggregation-prone
4 L D 0.0000 Buried
5 T D -0.6317 Soluble
6 Q D -0.6751 Soluble
7 S D -0.6595 Soluble
8 P D -0.2663 Soluble
9 A D -0.2414 Soluble
10 T D -0.1537 Soluble
11 L D -0.1124 Soluble
12 S D -0.5888 Soluble
13 L D -1.0813 Soluble
14 S D -1.4673 Soluble
15 P D -1.7284 Soluble
16 G D -1.7959 Soluble
17 E D -2.4076 Soluble
18 R D -2.6940 Soluble
19 A D 0.0000 Buried
20 T D -0.6479 Soluble
21 L D 0.0000 Buried
22 S D -0.8863 Soluble
23 C D 0.0000 Buried
24 R D -2.3966 Soluble
25 A D 0.0000 Buried
26 S D -0.9999 Soluble
27 Q D -1.7232 Soluble
28 S D -1.3459 Soluble
29 I D 0.0000 Buried
36 S D -1.0251 Soluble
37 N D -0.9672 Soluble
38 N D 0.0000 Buried
39 L D 0.0000 Buried
40 H D 0.0000 Buried
41 W D 0.0000 Buried
42 Y D 0.0000 Buried
43 Q D 0.0000 Buried
44 Q D -0.9516 Soluble
45 K D -1.3439 Soluble
46 P D -1.3654 Soluble
47 G D -1.4445 Soluble
48 Q D -2.0747 Soluble
49 A D -1.3257 Soluble
50 P D 0.0000 Buried
51 R D -1.5725 Soluble
52 L D 0.0000 Buried
53 L D 0.0000 Buried
54 I D 0.0000 Buried
55 Y D -0.2453 Soluble
56 Y D -0.3316 Soluble
57 T D 0.0000 Buried
65 S D -0.8333 Soluble
66 R D -0.9941 Soluble
67 S D -0.6558 Soluble
68 V D -0.3454 Soluble
69 S D -0.4464 Soluble
70 G D -0.4375 Soluble
71 I D -0.2385 Soluble
72 P D -0.2232 Soluble
74 A D -0.2041 Soluble
75 R D -0.7256 Soluble
76 F D 0.0000 Buried
77 S D -0.5611 Soluble
78 G D -0.5493 Soluble
79 S D -0.7822 Soluble
80 G D -1.0795 Soluble
83 S D -1.0740 Soluble
84 G D -1.2460 Soluble
85 T D -1.8006 Soluble
86 D D -2.2746 Soluble
87 F D 0.0000 Buried
88 T D -0.7983 Soluble
89 L D 0.0000 Buried
90 T D -0.6375 Soluble
91 I D 0.0000 Buried
92 S D -1.3869 Soluble
93 S D -1.7689 Soluble
94 L D 0.0000 Buried
95 E D -2.2146 Soluble
96 P D -1.8075 Soluble
97 E D -2.2713 Soluble
98 D D 0.0000 Buried
99 F D -0.6044 Soluble
100 A D -0.5731 Soluble
101 V D 0.0380 Aggregation-prone
102 Y D 0.0000 Buried
103 Y D 0.0000 Buried
104 C D 0.0000 Buried
105 G D 0.0000 Buried
106 Q D 0.0000 Buried
107 N D 0.0000 Buried
108 N D 0.0000 Buried
109 E D -1.0722 Soluble
114 W D -0.2669 Soluble
115 P D -0.8628 Soluble
116 E D 0.0000 Buried
117 V D 0.0880 Aggregation-prone
118 F D 0.0000 Buried
119 G D 0.0000 Buried
120 G D -0.5878 Soluble
121 G D -0.5822 Soluble
122 T D 0.0000 Buried
123 K D -0.3824 Soluble
124 V D 0.0000 Buried
125 E D 0.0000 Buried
126 I D -0.9030 Soluble
127 K D -1.7215 Soluble
128 R D -1.2316 Soluble
129 T D -0.2436 Soluble
130 V D 0.2137 Aggregation-prone
131 A D -0.0904 Soluble
132 A D -0.1353 Soluble
133 P D 0.0000 Buried
134 S D -0.0987 Soluble
135 V D 0.0734 Aggregation-prone
136 F D 0.1901 Aggregation-prone
137 I D 0.1244 Aggregation-prone
138 F D 0.0000 Buried
139 P D -0.3005 Soluble
140 P D 0.0000 Buried
141 S D -1.5863 Soluble
142 D D -3.0811 Soluble
143 E D -3.2630 Soluble
144 Q D 0.0000 Buried
145 L D -2.2725 Soluble
146 K D -2.9080 Soluble
147 S D -1.8134 Soluble
148 G D -1.3530 Soluble
149 T D -1.0023 Soluble
150 A D 0.0000 Buried
151 S D 0.0000 Buried
152 V D 0.0000 Buried
153 V D 0.0000 Buried
154 C D 0.0000 Buried
155 L D 0.0000 Buried
156 L D 0.0000 Buried
157 N D 0.0000 Buried
158 N D -0.8996 Soluble
159 F D 0.0000 Buried
160 Y D 0.0000 Buried
161 P D -1.7992 Soluble
162 R D -2.9858 Soluble
163 E D -3.1229 Soluble
164 A D -2.1342 Soluble
165 K D -2.0055 Soluble
166 V D -0.7750 Soluble
167 Q D -0.3488 Soluble
168 W D 0.0000 Buried
169 K D -0.4486 Soluble
170 V D 0.0000 Buried
171 D D -1.8282 Soluble
172 N D -1.4432 Soluble
173 A D -0.1893 Soluble
174 L D 0.7733 Aggregation-prone
175 Q D -0.2175 Soluble
176 S D -0.6659 Soluble
177 G D -1.2646 Soluble
178 N D -1.6179 Soluble
179 S D -1.2979 Soluble
180 Q D -1.1362 Soluble
181 E D -1.1530 Soluble
182 S D -0.4601 Soluble
183 V D -0.6840 Soluble
184 T D 0.0000 Buried
185 E D -2.2707 Soluble
186 Q D -1.8587 Soluble
187 D D -1.9149 Soluble
188 S D -1.8919 Soluble
189 K D -2.2258 Soluble
190 D D -1.6438 Soluble
191 S D 0.0000 Buried
192 T D 0.0000 Buried
193 Y D 0.0000 Buried
194 S D 0.0000 Buried
195 L D 0.0000 Buried
196 S D 0.0000 Buried
197 S D 0.0000 Buried
198 T D -0.5492 Soluble
199 L D 0.0000 Buried
200 T D -0.6380 Soluble
201 L D -0.8021 Soluble
202 S D -1.0419 Soluble
203 K D -1.9742 Soluble
204 A D -1.8719 Soluble
205 D D -2.7100 Soluble
206 Y D 0.0000 Buried
207 E D -3.4393 Soluble
208 K D -3.6512 Soluble
209 H D -3.0964 Soluble
210 K D -3.2872 Soluble
211 V D -1.4078 Soluble
212 Y D 0.0000 Buried
213 A D -0.7532 Soluble
214 C D 0.0000 Buried
215 E D -0.5953 Soluble
216 V D 0.0000 Buried
217 T D -1.0667 Soluble
218 H D 0.0000 Buried
219 Q D -1.6851 Soluble
220 G D -0.4202 Soluble
221 L D -0.1974 Soluble
222 S D -0.4246 Soluble
223 S D -0.4185 Soluble
224 P D -0.5221 Soluble
225 V D -0.0036 Soluble
226 T D -0.4102 Soluble
227 K D -0.5998 Soluble
228 S D -0.5869 Soluble
229 F D 0.0000 Buried
230 N D -1.8604 Soluble
231 R D -2.4650 Soluble
232 G D -1.9406 Soluble
233 E D -2.2192 Soluble
234 C D -0.5445 Soluble

3D Structure — colored by A4D score

Sequence - click residue to focus in viewer  |  colored by A4D score
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Color Legend (B-factor = A4D Score)
Score > 1.5 — highly aggregation-prone
Score 0.5–1.5 — aggregation-prone
Score ≈ 0 — buried
Score −1 to −0.5 — soluble
Score < −2.5 — highly soluble
pH Structure
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A4D Score Threshold
Highlight residues > threshold in the sequence panel
CDR Regions
HCDR1
HCDR2
HCDR3
LCDR1
LCDR2
LCDR3
Display Options

pH-Dependent Aggregation Profiles

A4D scores calculated across 11 pH conditions (4.0–9.0, step 0.5). Click a row to view the structure at that pH. The input structure is globular — max score is recommended for pH analysis.

pH Avg A4D Score Max A4D Score Downloads
4.0 -0.7382 2.4625 CSV PDB
4.5 -0.783 2.4625 CSV PDB
5.0 -0.8374 2.4625 CSV PDB
5.5 -0.8903 2.4625 CSV PDB
6.0 -0.9295 2.4625 CSV PDB
6.5 -0.9445 2.4624 CSV PDB
7.0 -0.9335 2.4623 CSV PDB
7.5 -0.9048 2.4618 CSV PDB
8.0 -0.8667 2.4603 CSV PDB
8.5 -0.8228 2.4554 CSV PDB
9.0 -0.7741 2.4403 CSV PDB
Average A4D Score vs pH
Max A4D Score vs pH