Ravagalimab / 6pe9

A4DAB219_6pe9_K_M | Source PDB: 6pe9 | Chains: K, M | Done
98.25
Yes
10 Å
Yes
Avg A4D Score
-0.6513
Max Score
1.1061
Min Score
-2.9395
Total Score
-149.15
Score CDR
-0.3616
Score non-CDR
-0.7302

Calculation Parameters

Chain Sequence(s) EVQLVESGGGLVKPGGSLRLSCAASGFTFSDYGMNWVRQAPGKGLEWVSYISSGRSNIYYADTVKGRFTISRDNAKNSLYLQMNSLRAEDTAVYYCARSWGYFDVWGQGTTVTVSSDIVMTQSPDSLAVSLGERATINCKSSQSLLNLGNQKNYLTWFQQKPGQPPKLLIYWASTRESGVPDRFSGSGSGTDFTLTISSLQAEDVAVYYCQNDYTYPLTFGQGTKLEIK input.pdb
Selected Chain(s) K (Heavy), M (Light)
Distance of Aggregation 10 Å
FoldX Energy Minimization Yes
pH Calculations Yes
Downloads Download all data (.tar.gz)

Aggrescan4D Profile

Aggregation-prone (score > 0)
Soluble (score < 0)
Buried (score = 0)

Per-Residue A4D Scores

Download CSV
Minimum Score -2.9395
Maximum Score 1.1061
Average Score -0.6513
Total Score -149.1457

Residues with A4D score > 0.0 are highlighted as aggregation-prone.

Index Residue Chain A4D Score Classification
1 E K -2.1009 Soluble
2 V K -1.1988 Soluble
3 Q K -1.2720 Soluble
4 L K 0.0000 Buried
5 V K 1.1061 Aggregation-prone
6 E K 0.0000 Buried
7 S K -0.4794 Soluble
8 G K -1.0956 Soluble
9 G K -0.4810 Soluble
11 G K 0.2930 Aggregation-prone
12 L K 1.0118 Aggregation-prone
13 V K -0.3393 Soluble
14 K K -1.9021 Soluble
15 P K -2.0553 Soluble
16 G K -1.7441 Soluble
17 G K -1.4254 Soluble
18 S K -1.2655 Soluble
19 L K -1.0977 Soluble
20 R K -2.0757 Soluble
21 L K 0.0000 Buried
22 S K -0.3374 Soluble
23 C K 0.0000 Buried
24 A K -0.1125 Soluble
25 A K 0.0000 Buried
26 S K -0.8200 Soluble
27 G K -1.3479 Soluble
28 F K -0.7302 Soluble
29 T K -0.6886 Soluble
30 F K 0.0000 Buried
35 S K -1.3412 Soluble
36 D K -1.6320 Soluble
37 Y K -0.4416 Soluble
38 G K 0.0000 Buried
39 M K 0.0000 Buried
40 N K 0.0000 Buried
41 W K 0.0000 Buried
42 V K 0.0000 Buried
43 R K 0.0000 Buried
44 Q K -0.9121 Soluble
45 A K -1.2258 Soluble
46 P K -1.0127 Soluble
47 G K -1.4632 Soluble
48 K K -2.3555 Soluble
49 G K -1.5716 Soluble
50 L K 0.0000 Buried
51 E K -1.0812 Soluble
52 W K 0.0000 Buried
53 V K 0.0000 Buried
54 S K 0.0000 Buried
55 Y K 0.6801 Aggregation-prone
56 I K 0.0000 Buried
57 S K -0.7269 Soluble
58 S K -1.1638 Soluble
59 G K -1.7883 Soluble
62 R K -2.1656 Soluble
63 S K -1.2412 Soluble
64 N K -0.5295 Soluble
65 I K 0.7633 Aggregation-prone
66 Y K 0.9218 Aggregation-prone
67 Y K -0.0734 Soluble
68 A K 0.0000 Buried
69 D K -2.3455 Soluble
70 T K -1.4587 Soluble
71 V K 0.0000 Buried
72 K K -2.4426 Soluble
74 G K -1.6571 Soluble
75 R K 0.0000 Buried
76 F K 0.0000 Buried
77 T K -0.5739 Soluble
78 I K 0.0000 Buried
79 S K -0.2732 Soluble
80 R K -1.0096 Soluble
81 D K -1.5026 Soluble
82 N K -1.6657 Soluble
83 A K -1.4125 Soluble
84 K K -2.1814 Soluble
85 N K -1.5285 Soluble
86 S K -0.8219 Soluble
87 L K 0.0000 Buried
88 Y K -0.3684 Soluble
89 L K 0.0000 Buried
90 Q K -1.1151 Soluble
91 M K 0.0000 Buried
92 N K -1.6031 Soluble
93 S K -1.4203 Soluble
94 L K 0.0000 Buried
95 R K -2.7211 Soluble
96 A K -1.9957 Soluble
97 E K -2.3520 Soluble
98 D K 0.0000 Buried
99 T K -0.6730 Soluble
100 A K 0.0000 Buried
101 V K -0.0279 Soluble
102 Y K 0.0000 Buried
103 Y K 0.0000 Buried
104 C K 0.0000 Buried
105 A K 0.0000 Buried
106 R K 0.0000 Buried
107 S K 0.2736 Aggregation-prone
108 W K 0.7639 Aggregation-prone
109 G K 0.3044 Aggregation-prone
114 Y K 0.3712 Aggregation-prone
115 F K 0.0000 Buried
116 D K -0.3787 Soluble
117 V K -0.3591 Soluble
118 W K 0.0000 Buried
119 G K 0.0000 Buried
120 Q K -1.1975 Soluble
121 G K -0.5443 Soluble
122 T K 0.0000 Buried
123 T K -0.0086 Soluble
124 V K 0.0000 Buried
125 T K -0.1153 Soluble
126 V K 0.0000 Buried
127 S K -0.8189 Soluble
128 S K -0.6317 Soluble
1 D M -1.3909 Soluble
2 I M 0.0000 Buried
3 V M 0.7103 Aggregation-prone
4 M M 0.0000 Buried
5 T M -0.9360 Soluble
6 Q M 0.0000 Buried
7 S M -1.4722 Soluble
8 P M -1.5301 Soluble
9 D M -2.5144 Soluble
10 S M -1.7904 Soluble
11 L M -0.8417 Soluble
12 A M -0.7879 Soluble
13 V M 0.0000 Buried
14 S M -1.3317 Soluble
15 L M -0.5909 Soluble
16 G M -1.4166 Soluble
17 E M -2.9395 Soluble
18 R M -2.8228 Soluble
19 A M 0.0000 Buried
20 T M -0.6323 Soluble
21 I M 0.0000 Buried
22 N M -1.7252 Soluble
23 C M 0.0000 Buried
24 K M -2.3119 Soluble
25 S M 0.0000 Buried
26 S M -0.9758 Soluble
27 Q M -1.5600 Soluble
28 S M -0.8254 Soluble
29 L M 0.0000 Buried
30 L M -0.1672 Soluble
31 N M -0.3833 Soluble
32 L M 0.4556 Aggregation-prone
33 G M -0.7156 Soluble
34 N M -1.6113 Soluble
35 Q M -1.6008 Soluble
36 K M -1.0145 Soluble
37 N M -0.3039 Soluble
38 Y M 0.1837 Aggregation-prone
39 L M 0.0000 Buried
40 T M 0.0000 Buried
41 W M 0.0000 Buried
42 F M 0.0000 Buried
43 Q M 0.0000 Buried
44 Q M 0.0000 Buried
45 K M -1.1054 Soluble
46 P M -0.7662 Soluble
47 G M -1.1952 Soluble
48 Q M -1.6126 Soluble
49 P M -1.2537 Soluble
50 P M 0.0000 Buried
51 K M -1.4868 Soluble
52 L M 0.0000 Buried
53 L M 0.0000 Buried
54 I M 0.0000 Buried
55 Y M 0.1293 Aggregation-prone
56 W M 0.4759 Aggregation-prone
57 A M 0.0000 Buried
65 S M -0.3909 Soluble
66 T M -0.3043 Soluble
67 R M -1.0654 Soluble
68 E M -0.9725 Soluble
69 S M -0.8574 Soluble
70 G M -0.8834 Soluble
71 V M -1.0307 Soluble
72 P M -1.3048 Soluble
74 D M -2.2358 Soluble
75 R M -1.6356 Soluble
76 F M 0.0000 Buried
77 S M -0.8517 Soluble
78 G M -0.3911 Soluble
79 S M -0.6446 Soluble
80 G M -0.9375 Soluble
83 S M -0.8953 Soluble
84 G M -1.0219 Soluble
85 T M -1.5786 Soluble
86 D M -2.2864 Soluble
87 F M 0.0000 Buried
88 T M -1.0630 Soluble
89 L M 0.0000 Buried
90 T M -0.7063 Soluble
91 I M 0.0000 Buried
92 S M -1.8459 Soluble
93 S M -1.5720 Soluble
94 L M 0.0000 Buried
95 Q M -0.9892 Soluble
96 A M -1.0127 Soluble
97 E M -1.7732 Soluble
98 D M 0.0000 Buried
99 V M -0.6183 Soluble
100 A M 0.0000 Buried
101 V M -0.8684 Soluble
102 Y M 0.0000 Buried
103 Y M 0.0000 Buried
104 C M 0.0000 Buried
105 Q M 0.0000 Buried
106 N M 0.0000 Buried
107 D M 0.3702 Aggregation-prone
108 Y M 0.4801 Aggregation-prone
109 T M 0.3247 Aggregation-prone
114 Y M 0.6523 Aggregation-prone
115 P M -0.1999 Soluble
116 L M 0.1842 Aggregation-prone
117 T M -0.0129 Soluble
118 F M 0.0000 Buried
119 G M 0.0000 Buried
120 Q M -1.5755 Soluble
121 G M -1.5209 Soluble
122 T M 0.0000 Buried
123 K M -2.2452 Soluble
124 L M 0.0000 Buried
125 E M -1.6474 Soluble
126 I M -0.8582 Soluble
127 K M -1.6932 Soluble

3D Structure — colored by A4D score

Sequence - click residue to focus in viewer  |  colored by A4D score
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Downloads
Color Legend (B-factor = A4D Score)
Score > 1.5 — highly aggregation-prone
Score 0.5–1.5 — aggregation-prone
Score ≈ 0 — buried
Score −1 to −0.5 — soluble
Score < −2.5 — highly soluble
pH Structure
Load structure at specific pH condition
A4D Score Threshold
Highlight residues > threshold in the sequence panel
CDR Regions
HCDR1
HCDR2
HCDR3
LCDR1
LCDR2
LCDR3
Display Options

pH-Dependent Aggregation Profiles

A4D scores calculated across 11 pH conditions (4.0–9.0, step 0.5). Click a row to view the structure at that pH. The input structure is globular — max score is recommended for pH analysis.

pH Avg A4D Score Max A4D Score Downloads
4.0 -0.546 3.5494 CSV PDB
4.5 -0.5936 3.4823 CSV PDB
5.0 -0.6478 3.4051 CSV PDB
5.5 -0.6987 3.3239 CSV PDB
6.0 -0.7361 3.2414 CSV PDB
6.5 -0.7545 3.1586 CSV PDB
7.0 -0.7555 3.076 CSV PDB
7.5 -0.7453 2.9947 CSV PDB
8.0 -0.7283 2.917 CSV PDB
8.5 -0.7052 2.8486 CSV PDB
9.0 -0.6741 2.7977 CSV PDB
Average A4D Score vs pH
Max A4D Score vs pH