Diridavumab / 4evn

A4DAB087_4evn_K_L | Source PDB: 4evn | Chains: K, L | Done
96.55
Yes
10 Å
Yes
Avg A4D Score
-0.6534
Max Score
3.1994
Min Score
-3.22
Total Score
-283.59
Score CDR
0.0068
Score non-CDR
-0.7453

Calculation Parameters

Chain Sequence(s) QVQLVESGAEVKKPGSSVKVSCKASGGPFRSYAISWVRQAPGQGPEWMGGIIPIFGTTKYAPKFQGRVTITADDFAGTVYMELSSLRSEDTAMYYCAKHMGYQVRETMDVWGKGTTVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPVLTQPPSVSAAPGQKVTISCSGSSSNIGNNYVSWYQQLPGTAPKLLIYDNNKRPSGIPDRFSGSKSGTSATLGITGLQTGDEADYYCGTWDSSLSAYVVFGGGTKLTVLGQPKANPTVTLFPPSSEELQANKATLVCLISDFYPGAVTVAWKADGSPVKAGVETTKPSKQSNNKYAASSYLSLTPEQWKSHRSYSCQVTHEGSTVEKTVAPTE input.pdb
Selected Chain(s) K (Heavy), L (Light)
Distance of Aggregation 10 Å
FoldX Energy Minimization Yes
pH Calculations Yes
Downloads Download all data (.tar.gz)

Aggrescan4D Profile

Aggregation-prone (score > 0)
Soluble (score < 0)
Buried (score = 0)

Per-Residue A4D Scores

Download CSV
Minimum Score -3.22
Maximum Score 3.1994
Average Score -0.6534
Total Score -283.5911

Residues with A4D score > 0.0 are highlighted as aggregation-prone.

Index Residue Chain A4D Score Classification
1 Q K -1.4507 Soluble
2 V K -0.9711 Soluble
3 Q K -1.3277 Soluble
4 L K 0.0000 Buried
5 V K 0.5083 Aggregation-prone
6 E K -0.1277 Soluble
7 S K -0.4871 Soluble
8 G K -0.5212 Soluble
9 A K -0.5122 Soluble
11 E K -0.8219 Soluble
12 V K -0.3989 Soluble
13 K K -1.4146 Soluble
14 K K -2.2469 Soluble
15 P K -2.2466 Soluble
16 G K -1.6308 Soluble
17 S K -1.2488 Soluble
18 S K -1.1765 Soluble
19 V K 0.0000 Buried
20 K K -2.0108 Soluble
21 V K 0.0000 Buried
22 S K -0.5522 Soluble
23 C K 0.0000 Buried
24 K K -0.9144 Soluble
25 A K 0.0000 Buried
26 S K -0.7712 Soluble
27 G K -0.9409 Soluble
28 G K -0.6067 Soluble
29 P K 0.3623 Aggregation-prone
30 F K 1.9084 Aggregation-prone
35 R K 0.0000 Buried
36 S K 0.9127 Aggregation-prone
37 Y K 0.9913 Aggregation-prone
38 A K 0.0000 Buried
39 I K 0.0000 Buried
40 S K 0.0000 Buried
41 W K 0.0000 Buried
42 V K 0.0000 Buried
43 R K -0.3697 Soluble
44 Q K -0.5871 Soluble
45 A K -0.9179 Soluble
46 P K -0.7604 Soluble
47 G K -1.0980 Soluble
48 Q K -1.3858 Soluble
49 G K -0.9439 Soluble
50 P K 0.0000 Buried
51 E K -0.6175 Soluble
52 W K 0.0000 Buried
53 M K 0.0000 Buried
54 G K 0.0000 Buried
55 G K 0.0000 Buried
56 I K 0.0000 Buried
57 I K 1.1400 Aggregation-prone
58 P K 0.0000 Buried
59 I K 3.1994 Aggregation-prone
62 F K 2.7879 Aggregation-prone
63 G K 1.1555 Aggregation-prone
64 T K 0.5734 Aggregation-prone
65 T K -0.1565 Soluble
66 K K -0.7820 Soluble
67 Y K -0.8818 Soluble
68 A K 0.0000 Buried
69 P K -1.2944 Soluble
70 K K -2.2526 Soluble
71 F K 0.0000 Buried
72 Q K -2.1817 Soluble
74 G K -1.5582 Soluble
75 R K -1.5116 Soluble
76 V K 0.0000 Buried
77 T K -0.8706 Soluble
78 I K 0.0000 Buried
79 T K -0.4494 Soluble
80 A K -0.3538 Soluble
81 D K -0.7826 Soluble
82 D K 0.4203 Aggregation-prone
83 F K 1.6432 Aggregation-prone
84 A K 0.4230 Aggregation-prone
85 G K 0.0000 Buried
86 T K -0.2860 Soluble
87 V K 0.0000 Buried
88 Y K -0.6356 Soluble
89 M K 0.0000 Buried
90 E K -1.3802 Soluble
91 L K 0.0000 Buried
92 S K -1.2038 Soluble
93 S K -1.2513 Soluble
94 L K 0.0000 Buried
95 R K -3.1012 Soluble
96 S K -2.3882 Soluble
97 E K -2.5531 Soluble
98 D K 0.0000 Buried
99 T K -1.0091 Soluble
100 A K 0.0000 Buried
101 M K -0.0799 Soluble
102 Y K 0.0000 Buried
103 Y K 0.0000 Buried
104 C K 0.0000 Buried
105 A K 0.0000 Buried
106 K K -0.0510 Soluble
107 H K 0.0000 Buried
108 M K 0.2310 Aggregation-prone
109 G K 0.2163 Aggregation-prone
110 Y K 1.0498 Aggregation-prone
111 Q K -0.4656 Soluble
112A V K 0.0000 Buried
112 R K -1.6627 Soluble
113 E K -1.2135 Soluble
114 T K -0.5825 Soluble
115 M K 0.0000 Buried
116 D K -0.3403 Soluble
117 V K -0.2095 Soluble
118 W K 0.0000 Buried
119 G K 0.0000 Buried
120 K K -1.5057 Soluble
121 G K -0.7596 Soluble
122 T K 0.0000 Buried
123 T K -0.1445 Soluble
124 V K 0.0000 Buried
125 T K -0.8634 Soluble
126 V K 0.0000 Buried
127 S K -1.2667 Soluble
128 S K -1.2505 Soluble
129 A K -0.7723 Soluble
130 S K -0.8406 Soluble
131 T K -0.9197 Soluble
132 K K -1.8895 Soluble
133 G K -1.8153 Soluble
134 P K -0.9710 Soluble
135 S K -0.4638 Soluble
136 V K 0.0000 Buried
137 F K -0.4849 Soluble
138 P K -0.9318 Soluble
139 L K 0.0000 Buried
140 A K -1.0483 Soluble
141 P K 0.0000 Buried
142 S K -1.0840 Soluble
143 S K -1.1780 Soluble
144 K K -1.8235 Soluble
145 S K -1.0653 Soluble
146 T K -1.0122 Soluble
147 S K -0.9054 Soluble
148 G K -0.9280 Soluble
149 G K -0.9049 Soluble
150 T K -0.6470 Soluble
151 A K 0.0000 Buried
152 A K 0.0000 Buried
153 L K 0.0000 Buried
154 G K 0.0000 Buried
155 C K 0.0000 Buried
156 L K 0.0000 Buried
157 V K 0.0000 Buried
158 K K -0.5802 Soluble
159 D K -1.1115 Soluble
160 Y K 0.0000 Buried
161 F K 0.0000 Buried
162 P K 0.0000 Buried
163 E K -1.0830 Soluble
164 P K -0.9858 Soluble
165 V K -0.7189 Soluble
166 T K -0.5837 Soluble
167 V K -0.3393 Soluble
168 S K -0.3698 Soluble
169 W K 0.0000 Buried
170 N K -0.8847 Soluble
171 S K -0.7104 Soluble
172 G K -0.4963 Soluble
173 A K -0.2003 Soluble
174 L K 0.0647 Aggregation-prone
175 T K -0.1264 Soluble
176 S K -0.2475 Soluble
177 G K -0.3067 Soluble
178 V K 0.1397 Aggregation-prone
179 H K -0.1957 Soluble
180 T K -0.0511 Soluble
181 F K 0.0000 Buried
182 P K -0.2618 Soluble
183 A K -0.0310 Soluble
184 V K 0.0000 Buried
185 L K 0.9666 Aggregation-prone
186 Q K 0.0523 Aggregation-prone
187 S K -0.2290 Soluble
188 S K -0.3396 Soluble
189 G K -0.1533 Soluble
190 L K 0.0000 Buried
191 Y K -0.0882 Soluble
192 S K 0.0000 Buried
193 L K 0.0000 Buried
194 S K 0.0000 Buried
195 S K 0.0000 Buried
196 V K 0.0000 Buried
197 V K 0.0000 Buried
198 T K -0.2022 Soluble
199 V K 0.0000 Buried
200 P K -0.6630 Soluble
201 S K -0.6851 Soluble
202 S K -0.6545 Soluble
203 S K -0.6276 Soluble
204 L K -0.8768 Soluble
205 G K -1.1143 Soluble
206 T K -0.7448 Soluble
207 Q K -1.3279 Soluble
208 T K -1.2042 Soluble
209 Y K 0.0000 Buried
210 I K -1.5034 Soluble
211 C K 0.0000 Buried
212 N K -1.6011 Soluble
213 V K 0.0000 Buried
214 N K -1.7479 Soluble
215 H K 0.0000 Buried
216 K K -2.7749 Soluble
217 P K -1.7529 Soluble
218 S K -1.9701 Soluble
219 N K -2.6272 Soluble
220 T K -2.0892 Soluble
221 K K -2.6090 Soluble
222 V K -1.5169 Soluble
223 D K -2.7014 Soluble
224 K K -2.2996 Soluble
225 R K -2.8402 Soluble
226 V K 0.0000 Buried
227 E K -2.5943 Soluble
228 P K -1.2597 Soluble
3 V L 1.6161 Aggregation-prone
4 L L 0.0000 Buried
5 T L 0.0598 Aggregation-prone
6 Q L 0.0000 Buried
7 P L -0.5494 Soluble
8 P L -0.8054 Soluble
9 S L -0.8159 Soluble
11 V L -0.3365 Soluble
12 S L -0.3203 Soluble
13 A L -0.5145 Soluble
14 A L -0.8770 Soluble
15 P L -1.4974 Soluble
16 G L -1.9396 Soluble
17 Q L -2.5133 Soluble
18 K L -2.5997 Soluble
19 V L 0.0000 Buried
20 T L -0.4697 Soluble
21 I L 0.0000 Buried
22 S L -0.2913 Soluble
23 C L 0.0000 Buried
24 S L -0.1535 Soluble
25 G L -0.0641 Soluble
26 S L -0.4096 Soluble
27 S L -0.9360 Soluble
28 S L -0.5799 Soluble
29 N L 0.0000 Buried
30 I L 0.0000 Buried
35 G L -1.0868 Soluble
36 N L -1.3735 Soluble
37 N L -0.7213 Soluble
38 Y L 0.0952 Aggregation-prone
39 V L 0.0000 Buried
40 S L 0.0000 Buried
41 W L 0.0000 Buried
42 Y L 0.0000 Buried
43 Q L 0.0000 Buried
44 Q L 0.0000 Buried
45 L L -0.1723 Soluble
46 P L -0.5031 Soluble
47 G L -0.7568 Soluble
48 T L -0.7926 Soluble
49 A L -0.8952 Soluble
50 P L 0.0000 Buried
51 K L -0.7528 Soluble
52 L L 0.0000 Buried
53 L L 0.0000 Buried
54 I L 0.0000 Buried
55 Y L -1.1803 Soluble
56 D L -1.5384 Soluble
57 N L -1.4964 Soluble
65 N L -2.5283 Soluble
66 K L -2.8206 Soluble
67 R L -2.2422 Soluble
68 P L -1.0948 Soluble
69 S L -0.9177 Soluble
70 G L -0.8177 Soluble
71 I L -0.8561 Soluble
72 P L -1.2817 Soluble
74 D L -2.2021 Soluble
75 R L -1.5660 Soluble
76 F L 0.0000 Buried
77 S L -1.4709 Soluble
78 G L -1.4490 Soluble
79 S L -1.3450 Soluble
80 K L -1.0647 Soluble
83 S L -0.8007 Soluble
84 G L -1.0128 Soluble
85 T L -0.8920 Soluble
86 S L -0.6507 Soluble
87 A L 0.0000 Buried
88 T L -0.5462 Soluble
89 L L 0.0000 Buried
90 G L 0.0000 Buried
91 I L 0.0000 Buried
92 T L -1.9625 Soluble
93 G L -1.9047 Soluble
94 L L 0.0000 Buried
95 Q L -1.7650 Soluble
96 T L -1.1713 Soluble
97 G L -0.9525 Soluble
98 D L 0.0000 Buried
99 E L -0.8497 Soluble
100 A L 0.0000 Buried
101 D L -0.9748 Soluble
102 Y L 0.0000 Buried
103 Y L 0.0000 Buried
104 C L 0.0000 Buried
105 G L 0.0000 Buried
106 T L 0.0000 Buried
107 W L 0.0000 Buried
108 D L 0.0000 Buried
109 S L -0.3716 Soluble
110 S L 0.5279 Aggregation-prone
112 L L 1.4236 Aggregation-prone
113 S L 0.4528 Aggregation-prone
114 A L 0.2072 Aggregation-prone
115 Y L -0.0117 Soluble
116 V L 0.0000 Buried
117 V L 0.0000 Buried
118 F L 0.0000 Buried
119 G L 0.0000 Buried
120 G L -0.5725 Soluble
121 G L -0.9924 Soluble
122 T L 0.0000 Buried
123 K L -1.5580 Soluble
124 L L 0.0000 Buried
125 T L -0.4558 Soluble
126 V L 0.0000 Buried
127 L L -0.1201 Soluble
128 G L -0.6361 Soluble
129 Q L -1.1865 Soluble
130 P L -1.4496 Soluble
131 K L -2.5459 Soluble
132 A L -1.9969 Soluble
133 N L -2.1352 Soluble
134 P L 0.0000 Buried
135 T L -0.4878 Soluble
136 V L 0.0000 Buried
137 T L -0.5732 Soluble
138 L L 0.0000 Buried
139 F L 0.0000 Buried
140 P L -0.3068 Soluble
141 P L -0.5350 Soluble
142 S L -0.8010 Soluble
143 S L -1.3508 Soluble
144 E L -2.0467 Soluble
145 E L 0.0000 Buried
146 L L -2.0465 Soluble
147 Q L -2.3174 Soluble
148 A L -1.9352 Soluble
149 N L -2.8111 Soluble
150 K L -2.9003 Soluble
151 A L 0.0000 Buried
152 T L 0.0000 Buried
153 L L 0.0000 Buried
154 V L 0.0000 Buried
155 C L 0.0000 Buried
156 L L 0.0000 Buried
157 I L 0.0000 Buried
158 S L -0.6744 Soluble
159 D L -1.4613 Soluble
160 F L 0.0000 Buried
161 Y L 0.0000 Buried
162 P L -1.1327 Soluble
163 G L -1.0481 Soluble
164 A L -0.4323 Soluble
165 V L -0.2931 Soluble
166 T L -0.0368 Soluble
167 V L 0.1868 Aggregation-prone
168 A L -0.3665 Soluble
169 W L 0.0000 Buried
170 K L -0.9865 Soluble
171 A L -1.3131 Soluble
172 D L -1.6466 Soluble
173 G L -1.2007 Soluble
174 S L -0.7549 Soluble
175 P L -0.9155 Soluble
176 V L -0.8239 Soluble
177 K L -1.6420 Soluble
178 A L -0.8495 Soluble
179 G L -0.6980 Soluble
180 V L -0.4529 Soluble
181 E L -0.6390 Soluble
182 T L -0.4563 Soluble
183 T L -0.8471 Soluble
184 K L -1.7463 Soluble
185 P L -1.1015 Soluble
186 S L -1.2105 Soluble
187 K L -1.7390 Soluble
188 Q L -1.6479 Soluble
189 S L -1.5782 Soluble
190 N L -2.3503 Soluble
191 N L -2.5551 Soluble
192 K L -2.1744 Soluble
193 Y L -1.1676 Soluble
194 A L 0.0000 Buried
195 A L 0.0000 Buried
196 S L 0.0000 Buried
197 S L 0.0000 Buried
198 Y L 0.0000 Buried
199 L L 0.0000 Buried
200 S L -0.7203 Soluble
201 L L 0.0000 Buried
202 T L -2.0068 Soluble
203 P L -2.6045 Soluble
204 E L -3.2200 Soluble
205 Q L -2.4634 Soluble
206 W L 0.0000 Buried
207 K L -3.0743 Soluble
208 S L -2.5031 Soluble
209 H L -2.4324 Soluble
210 R L -2.8627 Soluble
211 S L 0.0000 Buried
212 Y L 0.0000 Buried
213 S L 0.0000 Buried
214 C L 0.0000 Buried
215 Q L -0.8410 Soluble
216 V L 0.0000 Buried
217 T L -0.7755 Soluble
218 H L 0.0000 Buried
219 E L -2.4969 Soluble
220 G L -1.3844 Soluble
221 S L -1.0639 Soluble
222 T L -0.8747 Soluble
223 V L -0.7623 Soluble
224 E L -1.5492 Soluble
225 K L -1.4389 Soluble
226 T L -0.9801 Soluble
227 V L 0.0000 Buried
228 A L -1.5481 Soluble
229 P L -1.6706 Soluble
230 T L -1.2202 Soluble
231 E L -2.1387 Soluble

3D Structure — colored by A4D score

Sequence - click residue to focus in viewer  |  colored by A4D score
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Color Legend (B-factor = A4D Score)
Score > 1.5 — highly aggregation-prone
Score 0.5–1.5 — aggregation-prone
Score ≈ 0 — buried
Score −1 to −0.5 — soluble
Score < −2.5 — highly soluble
pH Structure
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A4D Score Threshold
Highlight residues > threshold in the sequence panel
CDR Regions
HCDR1
HCDR2
HCDR3
LCDR1
LCDR2
LCDR3
Display Options

pH-Dependent Aggregation Profiles

A4D scores calculated across 11 pH conditions (4.0–9.0, step 0.5). Click a row to view the structure at that pH. The input structure is globular — max score is recommended for pH analysis.

pH Avg A4D Score Max A4D Score Downloads
4.0 -0.5995 6.2807 CSV PDB
4.5 -0.6305 6.2004 CSV PDB
5.0 -0.6662 6.1109 CSV PDB
5.5 -0.6976 6.018 CSV PDB
6.0 -0.7142 5.9241 CSV PDB
6.5 -0.7073 5.8299 CSV PDB
7.0 -0.677 5.7362 CSV PDB
7.5 -0.6319 5.7206 CSV PDB
8.0 -0.5797 5.7206 CSV PDB
8.5 -0.5231 5.7206 CSV PDB
9.0 -0.4628 5.7206 CSV PDB
Average A4D Score vs pH
Max A4D Score vs pH