Beludavimab / 7sob

A4DAB038_7sob_N_O | Source PDB: 7sob | Chains: N, O | Done
99.56
Yes
10 Å
Yes
Avg A4D Score
-0.5846
Max Score
1.8128
Min Score
-3.8516
Total Score
-133.3
Score CDR
-0.092
Score non-CDR
-0.7375

Calculation Parameters

Chain Sequence(s) VQLVQSGAEVKKPGASVKVSCKASGYPFTSYGISWVRQAPGQGLEWMGWISTYNGNTNYAQKFQGRVTMTTDTSTTTGYMELRRLRSDDTAVYYCARDYTRGAWFGESLIGGFDNWGQGTLVTVSSASVLTQSPGTLSLSPGERATLSCRASQTVSSTSLAWYQQKPGQAPRLLIYGASSRATGIPDRFSGSGSGTDFTLTISRLEPEDFAVYYCQQHDTSLTFGGGT input.pdb
Selected Chain(s) N (Heavy), O (Light)
Distance of Aggregation 10 Å
FoldX Energy Minimization Yes
pH Calculations Yes
Downloads Download all data (.tar.gz)

Aggrescan4D Profile

Aggregation-prone (score > 0)
Soluble (score < 0)
Buried (score = 0)

Per-Residue A4D Scores

Download CSV
Minimum Score -3.8516
Maximum Score 1.8128
Average Score -0.5846
Total Score -133.2975

Residues with A4D score > 0.0 are highlighted as aggregation-prone.

Index Residue Chain A4D Score Classification
2 V N 0.9146 Aggregation-prone
3 Q N -0.5984 Soluble
4 L N 0.0000 Buried
5 V N -0.5146 Soluble
6 Q N -0.5891 Soluble
7 S N -0.8594 Soluble
8 G N -0.7711 Soluble
9 A N -0.1115 Soluble
11 E N -0.4515 Soluble
12 V N 0.6845 Aggregation-prone
13 K N -1.0929 Soluble
14 K N -2.3684 Soluble
15 P N -2.6253 Soluble
16 G N -2.3677 Soluble
17 A N -1.9038 Soluble
18 S N -2.0497 Soluble
19 V N 0.0000 Buried
20 K N -2.0862 Soluble
21 V N 0.0000 Buried
22 S N -0.6895 Soluble
23 C N 0.0000 Buried
24 K N -1.1253 Soluble
25 A N 0.0000 Buried
26 S N -0.3233 Soluble
27 G N -0.0155 Soluble
28 Y N 0.0586 Aggregation-prone
29 P N -0.1120 Soluble
30 F N 0.0000 Buried
35 T N 0.2534 Aggregation-prone
36 S N 0.4044 Aggregation-prone
37 Y N 0.5481 Aggregation-prone
38 G N 0.0000 Buried
39 I N 0.0000 Buried
40 S N 0.0000 Buried
41 W N 0.0000 Buried
42 V N 0.0000 Buried
43 R N -0.3727 Soluble
44 Q N -0.6140 Soluble
45 A N -0.9389 Soluble
46 P N -0.8403 Soluble
47 G N -1.2107 Soluble
48 Q N -1.7228 Soluble
49 G N -0.9435 Soluble
50 L N 0.0000 Buried
51 E N -0.4627 Soluble
52 W N 0.0000 Buried
53 M N 0.0000 Buried
54 G N 0.0000 Buried
55 W N 0.0000 Buried
56 I N 0.0000 Buried
57 S N 0.0000 Buried
58 T N 0.0000 Buried
59 Y N 0.5693 Aggregation-prone
62 N N -0.6190 Soluble
63 G N -1.2000 Soluble
64 N N -1.5938 Soluble
65 T N -1.4706 Soluble
66 N N -1.7524 Soluble
67 Y N -1.2793 Soluble
68 A N -1.5193 Soluble
69 Q N -2.5766 Soluble
70 K N -2.6822 Soluble
71 F N 0.0000 Buried
72 Q N -2.4615 Soluble
74 G N -1.8403 Soluble
75 R N -1.9873 Soluble
76 V N 0.0000 Buried
77 T N -0.8778 Soluble
78 M N 0.0000 Buried
79 T N -0.4495 Soluble
80 T N -0.5888 Soluble
81 D N -1.0272 Soluble
82 T N -0.5110 Soluble
83 S N -0.5266 Soluble
84 T N -0.6227 Soluble
85 T N -0.6712 Soluble
86 T N 0.0000 Buried
87 G N 0.0000 Buried
88 Y N -0.5524 Soluble
89 M N 0.0000 Buried
90 E N -1.3828 Soluble
91 L N 0.0000 Buried
92 R N -2.4737 Soluble
93 R N -3.1250 Soluble
94 L N 0.0000 Buried
95 R N -3.3903 Soluble
96 S N -2.3439 Soluble
97 D N -2.4641 Soluble
98 D N 0.0000 Buried
99 T N -0.7557 Soluble
100 A N 0.0000 Buried
101 V N 0.2738 Aggregation-prone
102 Y N 0.0000 Buried
103 Y N 0.0000 Buried
104 C N 0.0000 Buried
105 A N 0.0000 Buried
106 R N 0.0178 Aggregation-prone
107 D N 0.0000 Buried
108 Y N 0.9465 Aggregation-prone
109 T N 0.0000 Buried
110 R N 0.0062 Aggregation-prone
111 G N 0.0000 Buried
111A A N 0.0000 Buried
111B W N 1.5212 Aggregation-prone
111C F N 1.5169 Aggregation-prone
112D G N -0.5828 Soluble
112C E N -1.3488 Soluble
112B S N -0.6467 Soluble
112A L N 0.4543 Aggregation-prone
112 I N 1.8128 Aggregation-prone
113 G N 0.0000 Buried
114 G N 0.0000 Buried
115 F N 0.0000 Buried
116 D N -0.2757 Soluble
117 N N -0.2453 Soluble
118 W N -0.2857 Soluble
119 G N 0.0000 Buried
120 Q N -1.4347 Soluble
121 G N -0.6273 Soluble
122 T N 0.0000 Buried
123 L N 0.3631 Aggregation-prone
124 V N 0.0000 Buried
125 T N -0.3257 Soluble
126 V N 0.0000 Buried
127 S N -1.0745 Soluble
128 S N -1.1103 Soluble
129 A N -0.3484 Soluble
130 S N -0.2850 Soluble
3 V O 1.3342 Aggregation-prone
4 L O 0.0000 Buried
5 T O -0.4183 Soluble
6 Q O -0.8121 Soluble
7 S O -0.7471 Soluble
8 P O -0.4996 Soluble
9 G O -0.6341 Soluble
10 T O -0.1750 Soluble
11 L O 0.3288 Aggregation-prone
12 S O 0.1394 Aggregation-prone
13 L O -0.4374 Soluble
14 S O -1.0981 Soluble
15 P O -1.8409 Soluble
16 G O -2.6398 Soluble
17 E O -3.4343 Soluble
18 R O -3.5756 Soluble
19 A O 0.0000 Buried
20 T O -0.5087 Soluble
21 L O 0.0000 Buried
22 S O -0.7446 Soluble
23 C O 0.0000 Buried
24 R O -1.5902 Soluble
25 A O -0.8204 Soluble
26 S O -0.5898 Soluble
27 Q O -1.2993 Soluble
28 T O -1.2214 Soluble
29 V O 0.0000 Buried
30 S O -0.6555 Soluble
36 S O -0.2834 Soluble
37 T O 0.2030 Aggregation-prone
38 S O 0.0000 Buried
39 L O 0.0000 Buried
40 A O 0.0000 Buried
41 W O 0.0000 Buried
42 Y O 0.0000 Buried
43 Q O -0.4738 Soluble
44 Q O -0.9205 Soluble
45 K O -1.6765 Soluble
46 P O -1.0661 Soluble
47 G O -1.5925 Soluble
48 Q O -2.2647 Soluble
49 A O -1.4550 Soluble
50 P O 0.0000 Buried
51 R O -1.3460 Soluble
52 L O 0.0000 Buried
53 L O 0.0000 Buried
54 I O 0.0000 Buried
55 Y O 0.3266 Aggregation-prone
56 G O 0.3490 Aggregation-prone
57 A O 0.0000 Buried
65 S O -0.6145 Soluble
66 S O -0.4650 Soluble
67 R O -1.3626 Soluble
68 A O -0.7267 Soluble
69 T O -0.5283 Soluble
70 G O -0.7342 Soluble
71 I O -0.8278 Soluble
72 P O -1.2531 Soluble
74 D O -2.3691 Soluble
75 R O -2.0463 Soluble
76 F O 0.0000 Buried
77 S O -0.9246 Soluble
78 G O -0.5158 Soluble
79 S O -0.6558 Soluble
80 G O -0.9350 Soluble
83 S O -0.8895 Soluble
84 G O -1.0118 Soluble
85 T O -1.4000 Soluble
86 D O -1.7187 Soluble
87 F O 0.0000 Buried
88 T O -0.6706 Soluble
89 L O 0.0000 Buried
90 T O -0.8019 Soluble
91 I O 0.0000 Buried
92 S O -2.5225 Soluble
93 R O -3.8516 Soluble
94 L O 0.0000 Buried
95 E O -2.3461 Soluble
96 P O -1.3464 Soluble
97 E O -1.8127 Soluble
98 D O 0.0000 Buried
99 F O 1.0048 Aggregation-prone
100 A O 0.4232 Aggregation-prone
101 V O 0.6756 Aggregation-prone
102 Y O 0.0000 Buried
103 Y O 0.0000 Buried
104 C O 0.0000 Buried
105 Q O 0.0000 Buried
106 Q O 0.0000 Buried
107 H O 0.0000 Buried
108 D O -1.0451 Soluble
114 T O -0.5554 Soluble
115 S O -0.5806 Soluble
116 L O 0.2910 Aggregation-prone
117 T O 0.4445 Aggregation-prone
118 F O 0.5437 Aggregation-prone
119 G O 0.0000 Buried
120 G O -0.6120 Soluble
121 G O -0.4741 Soluble
122 T O -0.1916 Soluble

3D Structure — colored by A4D score

Sequence - click residue to focus in viewer  |  colored by A4D score
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Downloads
Color Legend (B-factor = A4D Score)
Score > 1.5 — highly aggregation-prone
Score 0.5–1.5 — aggregation-prone
Score ≈ 0 — buried
Score −1 to −0.5 — soluble
Score < −2.5 — highly soluble
pH Structure
Load structure at specific pH condition
A4D Score Threshold
Highlight residues > threshold in the sequence panel
CDR Regions
HCDR1
HCDR2
HCDR3
LCDR1
LCDR2
LCDR3
Display Options

pH-Dependent Aggregation Profiles

A4D scores calculated across 11 pH conditions (4.0–9.0, step 0.5). Click a row to view the structure at that pH. The input structure is globular — max score is recommended for pH analysis.

pH Avg A4D Score Max A4D Score Downloads
4.0 -0.49 5.3352 CSV PDB
4.5 -0.5232 5.2378 CSV PDB
5.0 -0.561 5.1406 CSV PDB
5.5 -0.5965 5.0722 CSV PDB
6.0 -0.6233 5.0092 CSV PDB
6.5 -0.6374 4.9622 CSV PDB
7.0 -0.6391 4.936 CSV PDB
7.5 -0.6322 4.925 CSV PDB
8.0 -0.62 4.9211 CSV PDB
8.5 -0.603 4.9197 CSV PDB
9.0 -0.5811 4.919 CSV PDB
Average A4D Score vs pH
Max A4D Score vs pH