Glenzocimab / 7r58

A4DAB131_7r58_H_L | Source PDB: 7r58 | Chains: H, L | Done
100
Yes
10 Å
Yes
Avg A4D Score
-0.7061
Max Score
2.1166
Min Score
-3.6933
Total Score
-306.44
Score CDR
—
Score non-CDR
—

Calculation Parameters

Chain Sequence(s) QVQLVQSGAEVKKPGASVKVSCKASGYTFTSYNMHWVRQAPGQGLEWMGGIYPGNGDTSYNQKFQGRVTMTRDTSTSTVYMELSSLRSEDTAVYYCARGTVVGDWYFDVWGQGTLVTVSSASTKGPSVFPLAPSTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDIQMTQSPSSLSASVGDRVTITCRSSQSLENSNGNTYLNWYQQKPGKAPKLLIYRVSNRFSGVPSRFSGSGSGTDFTFTISSLQPEDIATYYCLQLTHVPWTFGQGTKVEITRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGE input.pdb
Selected Chain(s) H (Heavy), L (Light)
Distance of Aggregation 10 Å
FoldX Energy Minimization Yes
pH Calculations Yes
Downloads Download all data (.tar.gz)

Aggrescan4D Profile

Aggregation-prone (score > 0)
Soluble (score < 0)
Buried (score = 0)

Per-Residue A4D Scores

Download CSV
Minimum Score -3.6933
Maximum Score 2.1166
Average Score -0.7061
Total Score -306.4366

Residues with A4D score > 0.0 are highlighted as aggregation-prone.

Index Residue Chain A4D Score Classification
1 Q H -1.3728 Soluble
2 V H -0.6895 Soluble
3 Q H -1.0374 Soluble
4 L H 0.0000 Buried
5 V H 0.7224 Aggregation-prone
6 Q H 0.0000 Buried
7 S H -0.3968 Soluble
8 G H -0.6250 Soluble
9 A H -0.5531 Soluble
11 E H -0.9255 Soluble
12 V H -0.5878 Soluble
13 K H -1.5679 Soluble
14 K H -2.4695 Soluble
15 P H -2.2632 Soluble
16 G H -1.6531 Soluble
17 A H -1.2647 Soluble
18 S H -1.3991 Soluble
19 V H 0.0000 Buried
20 K H -1.9988 Soluble
21 V H 0.0000 Buried
22 S H -0.4965 Soluble
23 C H 0.0000 Buried
24 K H -0.8548 Soluble
25 A H 0.0000 Buried
26 S H -0.7043 Soluble
27 G H -0.8847 Soluble
28 Y H -0.2853 Soluble
29 T H -0.0400 Soluble
30 F H 0.0000 Buried
35 T H -0.1052 Soluble
36 S H 0.5239 Aggregation-prone
37 Y H 0.7000 Aggregation-prone
38 N H 0.2922 Aggregation-prone
39 M H 0.0000 Buried
40 H H 0.0000 Buried
41 W H 0.0000 Buried
42 V H 0.0000 Buried
43 R H 0.0000 Buried
44 Q H -0.5964 Soluble
45 A H -0.9857 Soluble
46 P H -0.8246 Soluble
47 G H -1.2170 Soluble
48 Q H -1.7949 Soluble
49 G H -1.2315 Soluble
50 L H 0.0000 Buried
51 E H -0.5901 Soluble
52 W H 0.0000 Buried
53 M H 0.0000 Buried
54 G H 0.0000 Buried
55 G H 0.0000 Buried
56 I H 0.0000 Buried
57 Y H -0.5836 Soluble
58 P H 0.0000 Buried
59 G H -1.0517 Soluble
62 N H -1.9482 Soluble
63 G H -1.7504 Soluble
64 D H -2.2553 Soluble
65 T H -1.0667 Soluble
66 S H -0.5480 Soluble
67 Y H -0.6981 Soluble
68 N H 0.0000 Buried
69 Q H -2.5351 Soluble
70 K H -2.7043 Soluble
71 F H 0.0000 Buried
72 Q H -2.4625 Soluble
74 G H -1.6380 Soluble
75 R H -1.5056 Soluble
76 V H 0.0000 Buried
77 T H -0.7805 Soluble
78 M H 0.0000 Buried
79 T H -0.7523 Soluble
80 R H -1.2561 Soluble
81 D H -1.1637 Soluble
82 T H -0.8699 Soluble
83 S H -0.5557 Soluble
84 T H -0.6899 Soluble
85 S H -0.7842 Soluble
86 T H 0.0000 Buried
87 V H 0.0000 Buried
88 Y H -0.6601 Soluble
89 M H 0.0000 Buried
90 E H -1.3827 Soluble
91 L H 0.0000 Buried
92 S H -1.1518 Soluble
93 S H -1.2408 Soluble
94 L H 0.0000 Buried
95 R H -3.0349 Soluble
96 S H -2.1746 Soluble
97 E H -2.3380 Soluble
98 D H 0.0000 Buried
99 T H -0.9517 Soluble
100 A H 0.0000 Buried
101 V H 0.1080 Aggregation-prone
102 Y H 0.0000 Buried
103 Y H 0.0000 Buried
104 C H 0.0000 Buried
105 A H 0.0000 Buried
106 R H 0.0000 Buried
107 G H 0.0000 Buried
108 T H 0.0000 Buried
109 V H 1.7422 Aggregation-prone
110 V H 2.1166 Aggregation-prone
111 G H 0.9595 Aggregation-prone
112 D H 0.3182 Aggregation-prone
113 W H 0.2394 Aggregation-prone
114 Y H 0.4167 Aggregation-prone
115 F H 0.0000 Buried
116 D H -0.3110 Soluble
117 V H -0.3012 Soluble
118 W H 0.0000 Buried
119 G H 0.0000 Buried
120 Q H -1.2723 Soluble
121 G H -0.6045 Soluble
122 T H 0.0000 Buried
123 L H -0.0312 Soluble
124 V H 0.0000 Buried
125 T H -0.8219 Soluble
126 V H 0.0000 Buried
127 S H -1.2313 Soluble
128 S H -0.9954 Soluble
129 A H -0.5825 Soluble
130 S H -0.6686 Soluble
131 T H -0.6356 Soluble
132 K H -1.3199 Soluble
133 G H -1.4434 Soluble
134 P H 0.0000 Buried
135 S H -0.4423 Soluble
136 V H 0.0000 Buried
137 F H 0.0000 Buried
138 P H -1.2142 Soluble
139 L H 0.0000 Buried
140 A H -1.2415 Soluble
141 P H 0.0000 Buried
142 S H -0.7023 Soluble
143 T H -0.2889 Soluble
144 A H -0.1908 Soluble
145 A H 0.0000 Buried
146 L H 0.0000 Buried
147 G H 0.0000 Buried
148 C H 0.0000 Buried
149 L H 0.0000 Buried
150 V H 0.0000 Buried
151 K H 0.0000 Buried
152 D H -0.5905 Soluble
153 Y H 0.0000 Buried
154 F H 0.0000 Buried
155 P H 0.0000 Buried
156 E H -0.3501 Soluble
157 P H -0.6088 Soluble
158 V H -0.5634 Soluble
159 T H -0.5667 Soluble
160 V H -0.2047 Soluble
161 S H -0.4220 Soluble
162 W H 0.0000 Buried
163 N H -0.7231 Soluble
164 S H -0.6600 Soluble
165 G H -0.5642 Soluble
166 A H -0.2339 Soluble
167 L H 0.0234 Aggregation-prone
168 T H -0.1715 Soluble
169 S H -0.1846 Soluble
170 G H -0.2396 Soluble
171 V H 0.1384 Aggregation-prone
172 H H -0.3362 Soluble
173 T H -0.0152 Soluble
174 F H 0.0000 Buried
175 P H -0.3252 Soluble
176 A H 0.2397 Aggregation-prone
177 V H 0.5025 Aggregation-prone
178 L H 1.1216 Aggregation-prone
179 Q H 0.2327 Aggregation-prone
180 S H -0.0904 Soluble
181 S H -0.2698 Soluble
182 G H -0.0306 Soluble
183 L H 0.0318 Aggregation-prone
184 Y H 0.4119 Aggregation-prone
185 S H 0.0000 Buried
186 L H 0.0000 Buried
187 S H 0.0000 Buried
188 S H 0.0000 Buried
189 V H 0.0000 Buried
190 V H 0.0000 Buried
191 T H -0.1572 Soluble
192 V H 0.0000 Buried
193 P H -0.5182 Soluble
194 S H -0.5044 Soluble
195 S H -0.5817 Soluble
196 S H -0.6459 Soluble
197 L H -0.7938 Soluble
198 G H -0.9497 Soluble
199 T H -0.6901 Soluble
200 Q H -1.1471 Soluble
201 T H -1.0465 Soluble
202 Y H 0.0000 Buried
203 I H -1.1553 Soluble
204 C H 0.0000 Buried
205 N H -1.5090 Soluble
206 V H 0.0000 Buried
207 N H -2.1118 Soluble
208 H H 0.0000 Buried
209 K H -2.6522 Soluble
210 P H -1.5712 Soluble
211 S H -1.8132 Soluble
212 N H -2.5315 Soluble
213 T H -2.0987 Soluble
214 K H -2.7761 Soluble
215 V H -1.7648 Soluble
216 D H -2.5149 Soluble
217 K H -2.0852 Soluble
218 K H -2.3713 Soluble
219 V H 0.0000 Buried
220 E H -2.8860 Soluble
221 P H -1.8880 Soluble
222 K H -2.2270 Soluble
223 S H -0.9923 Soluble
224 C H -0.1141 Soluble
1 D L -2.0198 Soluble
2 I L -1.5164 Soluble
3 Q L -2.0945 Soluble
4 M L 0.0000 Buried
5 T L -1.1538 Soluble
6 Q L 0.0000 Buried
7 S L -0.6962 Soluble
8 P L -0.5808 Soluble
9 S L -0.8296 Soluble
10 S L -0.8522 Soluble
11 L L -0.4688 Soluble
12 S L -0.5219 Soluble
13 A L -0.5960 Soluble
14 S L -0.3509 Soluble
15 V L 0.3082 Aggregation-prone
16 G L -0.7393 Soluble
17 D L -1.6674 Soluble
18 R L -2.2810 Soluble
19 V L 0.0000 Buried
20 T L -0.6267 Soluble
21 I L 0.0000 Buried
22 T L -0.6805 Soluble
23 C L 0.0000 Buried
24 R L -2.0789 Soluble
25 S L 0.0000 Buried
26 S L -1.8297 Soluble
27 Q L -2.2457 Soluble
28 S L -1.6333 Soluble
29 L L 0.0000 Buried
30 E L -2.6134 Soluble
31 N L -2.0312 Soluble
32 S L -1.6195 Soluble
34 N L -2.1896 Soluble
35 G L -2.0968 Soluble
36 N L -2.0405 Soluble
37 T L -1.4064 Soluble
38 Y L -0.3831 Soluble
39 L L 0.0000 Buried
40 N L 0.0000 Buried
41 W L 0.0000 Buried
42 Y L 0.0000 Buried
43 Q L 0.0000 Buried
44 Q L -1.3898 Soluble
45 K L -1.8803 Soluble
46 P L -1.5880 Soluble
47 G L -1.8196 Soluble
48 K L -2.5706 Soluble
49 A L -1.6393 Soluble
50 P L 0.0000 Buried
51 K L -1.6578 Soluble
52 L L 0.0000 Buried
53 L L 0.0000 Buried
54 I L 0.0000 Buried
55 Y L -0.6312 Soluble
56 R L -1.1264 Soluble
57 V L -0.7445 Soluble
65 S L -1.0561 Soluble
66 N L -1.4815 Soluble
67 R L -1.6484 Soluble
68 F L -0.7841 Soluble
69 S L -0.5909 Soluble
70 G L -0.6428 Soluble
71 V L -0.7175 Soluble
72 P L -0.5415 Soluble
74 S L -0.6986 Soluble
75 R L -0.9230 Soluble
76 F L 0.0000 Buried
77 S L -0.6941 Soluble
78 G L 0.0000 Buried
79 S L -0.7587 Soluble
80 G L -0.9123 Soluble
83 S L -1.2308 Soluble
84 G L -1.5281 Soluble
85 T L -1.7297 Soluble
86 D L -1.9930 Soluble
87 F L 0.0000 Buried
88 T L -0.6348 Soluble
89 F L 0.0000 Buried
90 T L -0.5818 Soluble
91 I L 0.0000 Buried
92 S L -1.3444 Soluble
93 S L -1.1701 Soluble
94 L L 0.0000 Buried
95 Q L -0.8871 Soluble
96 P L -1.3150 Soluble
97 E L -1.6946 Soluble
98 D L 0.0000 Buried
99 I L 0.0000 Buried
100 A L 0.0000 Buried
101 T L -0.9606 Soluble
102 Y L 0.0000 Buried
103 Y L 0.0000 Buried
104 C L 0.0000 Buried
105 L L 0.0000 Buried
106 Q L 0.0000 Buried
107 L L 0.0000 Buried
108 T L -0.0867 Soluble
109 H L -0.0212 Soluble
114 V L 1.1929 Aggregation-prone
115 P L 0.1643 Aggregation-prone
116 W L 0.3195 Aggregation-prone
117 T L -0.3216 Soluble
118 F L -0.3145 Soluble
119 G L 0.0000 Buried
120 Q L -1.5013 Soluble
121 G L 0.0000 Buried
122 T L 0.0000 Buried
123 K L -1.6423 Soluble
124 V L 0.0000 Buried
125 E L -1.0937 Soluble
126 I L 0.0000 Buried
127 T L -0.1142 Soluble
128 R L -0.3586 Soluble
129 T L 0.0950 Aggregation-prone
130 V L 0.4128 Aggregation-prone
131 A L -0.0833 Soluble
132 A L -0.1463 Soluble
133 P L 0.0000 Buried
134 S L -0.1726 Soluble
135 V L 0.0000 Buried
136 F L -0.0491 Soluble
137 I L 0.0000 Buried
138 F L 0.0000 Buried
139 P L -0.5987 Soluble
140 P L -0.7904 Soluble
141 S L -1.6375 Soluble
142 D L -2.6614 Soluble
143 E L -2.3962 Soluble
144 Q L 0.0000 Buried
145 L L -2.0531 Soluble
146 K L -2.6386 Soluble
147 S L -1.5999 Soluble
148 G L -1.2907 Soluble
149 T L -0.9769 Soluble
150 A L 0.0000 Buried
151 S L 0.0000 Buried
152 V L 0.0000 Buried
153 V L 0.0000 Buried
154 C L 0.0000 Buried
155 L L 0.0000 Buried
156 L L 0.0000 Buried
157 N L 0.0000 Buried
158 N L -0.9886 Soluble
159 F L 0.0000 Buried
160 Y L -0.9702 Soluble
161 P L -1.5481 Soluble
162 R L -3.0432 Soluble
163 E L -3.2240 Soluble
164 A L -2.3449 Soluble
165 K L -2.3991 Soluble
166 V L -1.0290 Soluble
167 Q L -0.3939 Soluble
168 W L 0.0000 Buried
169 K L -0.4944 Soluble
170 V L 0.0000 Buried
171 D L -1.9729 Soluble
172 N L -1.5217 Soluble
173 A L -0.2319 Soluble
174 L L 0.8414 Aggregation-prone
175 Q L 0.0103 Aggregation-prone
176 S L -0.3455 Soluble
177 G L -0.8690 Soluble
178 N L -0.7789 Soluble
179 S L -1.0880 Soluble
180 Q L -1.3696 Soluble
181 E L -1.9413 Soluble
182 S L -0.8354 Soluble
183 V L -0.8321 Soluble
184 T L -1.1464 Soluble
185 E L -2.2406 Soluble
186 Q L 0.0000 Buried
187 D L -2.1628 Soluble
188 S L -2.2507 Soluble
189 K L -2.5904 Soluble
190 D L -1.9461 Soluble
191 S L 0.0000 Buried
192 T L 0.0000 Buried
193 Y L 0.0000 Buried
194 S L 0.0000 Buried
195 L L 0.0000 Buried
196 S L 0.0000 Buried
197 S L 0.0000 Buried
198 T L -0.6380 Soluble
199 L L 0.0000 Buried
200 T L -0.4489 Soluble
201 L L -0.7309 Soluble
202 S L -1.1515 Soluble
203 K L -2.1783 Soluble
204 A L -2.0119 Soluble
205 D L -2.7716 Soluble
206 Y L 0.0000 Buried
207 E L -3.5225 Soluble
208 K L -3.6933 Soluble
209 H L -3.0777 Soluble
210 K L -3.2809 Soluble
211 V L -1.4083 Soluble
212 Y L 0.0000 Buried
213 A L 0.0000 Buried
214 C L 0.0000 Buried
215 E L -0.7871 Soluble
216 V L 0.0000 Buried
217 T L -1.1925 Soluble
218 H L 0.0000 Buried
219 Q L -1.7557 Soluble
220 G L -0.4524 Soluble
221 L L -0.2548 Soluble
222 S L -0.4858 Soluble
223 S L -0.4017 Soluble
224 P L -0.5017 Soluble
225 V L 0.0799 Aggregation-prone
226 T L -0.4445 Soluble
227 K L -0.7314 Soluble
228 S L -0.6113 Soluble
229 F L -0.9864 Soluble
230 N L -1.9449 Soluble
231 R L -2.6187 Soluble
232 G L -2.2173 Soluble
233 E L -2.3875 Soluble

3D Structure — colored by A4D score

Sequence - click residue to focus in viewer  |  colored by A4D score
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Color Legend (B-factor = A4D Score)
Score > 1.5 — highly aggregation-prone
Score 0.5–1.5 — aggregation-prone
Score ≈ 0 — buried
Score −1 to −0.5 — soluble
Score < −2.5 — highly soluble
pH Structure
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A4D Score Threshold
Highlight residues > threshold in the sequence panel
CDR Regions
HCDR1
HCDR2
HCDR3
LCDR1
LCDR2
LCDR3
Display Options

pH-Dependent Aggregation Profiles

A4D scores calculated across 11 pH conditions (4.0–9.0, step 0.5). Click a row to view the structure at that pH. The input structure is globular — max score is recommended for pH analysis.

pH Avg A4D Score Max A4D Score Downloads
4.0 -0.7985 1.9332 CSV PDB
4.5 -0.8409 1.925 CSV PDB
5.0 -0.8897 1.9165 CSV PDB
5.5 -0.935 1.9079 CSV PDB
6.0 -0.9658 1.8993 CSV PDB
6.5 -0.9737 1.8907 CSV PDB
7.0 -0.9587 1.8823 CSV PDB
7.5 -0.9286 1.8743 CSV PDB
8.0 -0.89 1.8674 CSV PDB
8.5 -0.8446 1.8626 CSV PDB
9.0 -0.7928 1.8601 CSV PDB
Average A4D Score vs pH
Max A4D Score vs pH