Adintrevimab / 7u2e

A4DAB006_7u2e_H_L | Source PDB: 7u2e | Chains: H, L | Done
97.46
Yes
10 Å
Yes
Avg A4D Score
-0.6285
Max Score
1.3318
Min Score
-3.0373
Total Score
-272.75
Score CDR
-0.2666
Score non-CDR
-0.6832

Calculation Parameters

Chain Sequence(s) EVQLVESGGGLVKPGGSLRLSCAASGFTFSSYYMNWVRQAPGKGLEWVSSISSDGYNTYYPDSLKGRFTISRDSAKNSLYLQMNSLRADDTAVYYCARDFSGHTAVAGTGFEYWGQGTLVTVSSASTKGPSVFPLAPGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSQPVLTQPPSVSGAPGQRITISCTGSSSNIGAGYDVHWYQQLPGTAPKLLIYGSSSRPSGVPDRFSGSKSGTSASLAITGLQAEDEADYYCQSYDSSLSVLYVFGTGTKVTVLGQPKAAPSVTLFPPSSEELQANKATLVCLISDFYPGAVTVAWKADSSPVKAGVETTTPSKQSNNKYAASSYLSLTPEQWKSHRSYSCQVTHEGSTVEKTVAPT input.pdb
Selected Chain(s) H (Heavy), L (Light)
Distance of Aggregation 10 Å
FoldX Energy Minimization Yes
pH Calculations Yes
Downloads Download all data (.tar.gz)

Aggrescan4D Profile

Aggregation-prone (score > 0)
Soluble (score < 0)
Buried (score = 0)

Per-Residue A4D Scores

Download CSV
Minimum Score -3.0373
Maximum Score 1.3318
Average Score -0.6285
Total Score -272.7499

Residues with A4D score > 0.0 are highlighted as aggregation-prone.

Index Residue Chain A4D Score Classification
1 E H -2.0791 Soluble
2 V H -1.1419 Soluble
3 Q H -1.3817 Soluble
4 L H 0.0000 Buried
5 V H 0.2204 Aggregation-prone
6 E H 0.0000 Buried
7 S H -0.6326 Soluble
8 G H -0.9912 Soluble
9 G H -0.6316 Soluble
11 G H 0.0000 Buried
12 L H -0.1625 Soluble
13 V H 0.0000 Buried
14 K H -2.1767 Soluble
15 P H -2.0294 Soluble
16 G H -1.6355 Soluble
17 G H -1.3485 Soluble
18 S H -1.3380 Soluble
19 L H -1.1679 Soluble
20 R H -1.9887 Soluble
21 L H 0.0000 Buried
22 S H -0.4811 Soluble
23 C H 0.0000 Buried
24 A H -0.3917 Soluble
25 A H 0.0000 Buried
26 S H -1.0294 Soluble
27 G H -1.1590 Soluble
28 F H -0.4776 Soluble
29 T H -0.1891 Soluble
30 F H 0.0000 Buried
35 S H -0.8814 Soluble
36 S H -0.5134 Soluble
37 Y H -0.1367 Soluble
38 Y H -0.0303 Soluble
39 M H 0.0000 Buried
40 N H 0.0000 Buried
41 W H 0.0000 Buried
42 V H 0.0000 Buried
43 R H -0.5189 Soluble
44 Q H 0.0000 Buried
45 A H -1.1929 Soluble
46 P H -0.9710 Soluble
47 G H -1.4558 Soluble
48 K H -2.2099 Soluble
49 G H -1.4023 Soluble
50 L H 0.0000 Buried
51 E H -0.7295 Soluble
52 W H 0.0000 Buried
53 V H 0.0000 Buried
54 S H 0.0000 Buried
55 S H 0.0000 Buried
56 I H 0.0000 Buried
57 S H 0.0000 Buried
58 S H -0.9012 Soluble
59 D H -1.7688 Soluble
62 G H -0.8145 Soluble
63 Y H 0.1401 Aggregation-prone
64 N H -0.7412 Soluble
65 T H -0.0926 Soluble
66 Y H 0.2836 Aggregation-prone
67 Y H -0.1403 Soluble
68 P H -0.9001 Soluble
69 D H -2.2599 Soluble
70 S H -1.6812 Soluble
71 L H 0.0000 Buried
72 K H -2.6142 Soluble
74 G H -1.7854 Soluble
75 R H -1.3718 Soluble
76 F H 0.0000 Buried
77 T H -0.4397 Soluble
78 I H 0.0000 Buried
79 S H -0.2503 Soluble
80 R H -0.9331 Soluble
81 D H -1.4728 Soluble
82 S H -1.5378 Soluble
83 A H -1.1852 Soluble
84 K H -2.1681 Soluble
85 N H -1.6597 Soluble
86 S H 0.0000 Buried
87 L H 0.0000 Buried
88 Y H -0.4807 Soluble
89 L H 0.0000 Buried
90 Q H -1.0590 Soluble
91 M H 0.0000 Buried
92 N H -1.3100 Soluble
93 S H -1.2711 Soluble
94 L H 0.0000 Buried
95 R H -2.4706 Soluble
96 A H -1.7976 Soluble
97 D H -2.1878 Soluble
98 D H 0.0000 Buried
99 T H -0.7231 Soluble
100 A H 0.0000 Buried
101 V H 0.1824 Aggregation-prone
102 Y H 0.0000 Buried
103 Y H 0.0000 Buried
104 C H 0.0000 Buried
105 A H 0.0000 Buried
106 R H 0.0000 Buried
107 D H 0.0000 Buried
108 F H 0.0000 Buried
109 S H -0.5891 Soluble
110 G H -0.9178 Soluble
111 H H -1.2478 Soluble
111A T H -0.6887 Soluble
111B A H -0.3082 Soluble
112B V H 0.0000 Buried
112A A H -0.3402 Soluble
112 G H -0.0241 Soluble
113 T H 0.0075 Aggregation-prone
114 G H 0.0000 Buried
115 F H 0.0000 Buried
116 E H -0.2629 Soluble
117 Y H 0.0170 Aggregation-prone
118 W H -0.2808 Soluble
119 G H 0.0000 Buried
120 Q H -1.0519 Soluble
121 G H 0.0000 Buried
122 T H -0.1119 Soluble
123 L H -0.0275 Soluble
124 V H 0.0000 Buried
125 T H -0.5293 Soluble
126 V H 0.0000 Buried
127 S H -1.1319 Soluble
128 S H -0.9974 Soluble
129 A H -0.5313 Soluble
130 S H -0.6377 Soluble
131 T H -0.5109 Soluble
132 K H -1.1293 Soluble
133 G H -1.3589 Soluble
134 P H -0.5961 Soluble
135 S H -0.2377 Soluble
136 V H 0.0000 Buried
137 F H 0.0000 Buried
138 P H -1.0600 Soluble
139 L H 0.0000 Buried
140 A H -1.2760 Soluble
141 P H -0.8648 Soluble
142 G H -0.6403 Soluble
143 T H -0.4963 Soluble
144 A H -0.2950 Soluble
145 A H -0.0627 Soluble
146 L H 0.0000 Buried
147 G H 0.0000 Buried
148 C H 0.0000 Buried
149 L H 0.0000 Buried
150 V H 0.0000 Buried
151 K H 0.0000 Buried
152 D H -0.3035 Soluble
153 Y H 0.0000 Buried
154 F H -0.1403 Soluble
155 P H 0.0000 Buried
156 E H -0.4665 Soluble
157 P H -0.6783 Soluble
158 V H -0.7786 Soluble
159 T H -0.6909 Soluble
160 V H -0.4232 Soluble
161 S H -0.4135 Soluble
162 W H 0.0000 Buried
163 N H -0.7465 Soluble
164 S H -0.6136 Soluble
165 G H -0.3991 Soluble
166 A H -0.1845 Soluble
167 L H 0.0027 Aggregation-prone
168 T H -0.1780 Soluble
169 S H -0.2807 Soluble
170 G H -0.3256 Soluble
171 V H 0.0210 Aggregation-prone
172 H H -0.3287 Soluble
173 T H -0.1614 Soluble
174 F H 0.0000 Buried
175 P H -0.1652 Soluble
176 A H 0.1849 Aggregation-prone
177 V H 0.0000 Buried
178 L H 0.8117 Aggregation-prone
179 Q H 0.0515 Aggregation-prone
180 S H -0.2339 Soluble
181 S H -0.2284 Soluble
182 G H 0.0035 Aggregation-prone
183 L H 0.1353 Aggregation-prone
184 Y H 0.3841 Aggregation-prone
185 S H 0.0000 Buried
186 L H 0.0000 Buried
187 S H 0.0000 Buried
188 S H 0.0000 Buried
189 V H 0.1109 Aggregation-prone
190 V H 0.0000 Buried
191 T H -0.2330 Soluble
192 V H 0.0000 Buried
193 P H -0.5436 Soluble
194 S H -0.6199 Soluble
195 S H -0.6814 Soluble
196 S H -0.6867 Soluble
197 L H -0.9130 Soluble
198 G H -1.0358 Soluble
199 T H -0.8269 Soluble
200 Q H -1.3681 Soluble
201 T H -1.2734 Soluble
202 Y H 0.0000 Buried
203 I H -1.3547 Soluble
204 C H 0.0000 Buried
205 N H 0.0000 Buried
206 V H 0.0000 Buried
207 N H -2.2613 Soluble
208 H H 0.0000 Buried
209 K H -2.8787 Soluble
210 P H -1.5437 Soluble
211 S H -1.8279 Soluble
212 N H -2.6583 Soluble
213 T H -2.1920 Soluble
214 K H -2.7514 Soluble
215 V H -1.6470 Soluble
216 D H -2.5239 Soluble
217 K H -1.9686 Soluble
218 K H -2.5772 Soluble
219 V H 0.0000 Buried
220 E H -2.9442 Soluble
221 P H -1.9822 Soluble
222 K H -2.3981 Soluble
223 S H -1.2817 Soluble
1 Q L -0.8564 Soluble
2 P L -0.1186 Soluble
3 V L 1.1837 Aggregation-prone
4 L L 0.0000 Buried
5 T L 0.1733 Aggregation-prone
6 Q L 0.0000 Buried
7 P L -0.5072 Soluble
8 P L -0.7719 Soluble
9 S L -0.9194 Soluble
11 V L -0.4078 Soluble
12 S L -0.1104 Soluble
13 G L -0.5676 Soluble
14 A L -0.5820 Soluble
15 P L -1.1268 Soluble
16 G L -1.7407 Soluble
17 Q L -2.5103 Soluble
18 R L -2.6561 Soluble
19 I L 0.0000 Buried
20 T L -0.5380 Soluble
21 I L 0.0000 Buried
22 S L -0.3356 Soluble
23 C L 0.0000 Buried
24 T L -0.1461 Soluble
25 G L -0.2769 Soluble
26 S L -0.4717 Soluble
27 S L -0.7374 Soluble
28 S L -0.5563 Soluble
29 N L 0.0000 Buried
30 I L 0.0000 Buried
31 G L -0.9120 Soluble
35 A L -0.5256 Soluble
36 G L -0.6825 Soluble
37 Y L -0.3356 Soluble
38 D L -0.7211 Soluble
39 V L 0.0000 Buried
40 H L 0.0000 Buried
41 W L 0.0000 Buried
42 Y L 0.0000 Buried
43 Q L 0.0000 Buried
44 Q L -0.7306 Soluble
45 L L -0.5220 Soluble
46 P L -0.5207 Soluble
47 G L -0.6042 Soluble
48 T L -0.6873 Soluble
49 A L -0.7239 Soluble
50 P L 0.0000 Buried
51 K L -1.1925 Soluble
52 L L -0.5573 Soluble
53 L L 0.0000 Buried
54 I L 0.0000 Buried
55 Y L -0.2042 Soluble
56 G L -0.4497 Soluble
57 S L 0.0000 Buried
65 S L -0.7141 Soluble
66 S L -0.6328 Soluble
67 R L -1.3633 Soluble
68 P L -0.6719 Soluble
69 S L -0.6547 Soluble
70 G L -0.8692 Soluble
71 V L -0.8954 Soluble
72 P L -1.3687 Soluble
74 D L -2.1962 Soluble
75 R L -1.5534 Soluble
76 F L 0.0000 Buried
77 S L -0.9307 Soluble
78 G L -0.5548 Soluble
79 S L -0.7658 Soluble
80 K L -1.0593 Soluble
83 S L -0.8848 Soluble
84 G L -0.9508 Soluble
85 T L -0.7891 Soluble
86 S L -0.7175 Soluble
87 A L 0.0000 Buried
88 S L -0.4751 Soluble
89 L L 0.0000 Buried
90 A L -0.6191 Soluble
91 I L 0.0000 Buried
92 T L -1.8397 Soluble
93 G L -1.5986 Soluble
94 L L 0.0000 Buried
95 Q L -1.5494 Soluble
96 A L -1.4183 Soluble
97 E L -2.2346 Soluble
98 D L 0.0000 Buried
99 E L 0.0000 Buried
100 A L 0.0000 Buried
101 D L -0.9797 Soluble
102 Y L 0.0000 Buried
103 Y L 0.0000 Buried
104 C L 0.0000 Buried
105 Q L 0.0000 Buried
106 S L 0.0000 Buried
107 Y L 0.0593 Aggregation-prone
108 D L 0.0000 Buried
109 S L 0.2098 Aggregation-prone
110 S L 0.4860 Aggregation-prone
112 L L 1.3318 Aggregation-prone
113 S L 0.0368 Aggregation-prone
114 V L 0.2370 Aggregation-prone
115 L L 0.0000 Buried
116 Y L 0.0000 Buried
117 V L 0.0000 Buried
118 F L 0.0000 Buried
119 G L 0.0000 Buried
120 T L -0.0984 Soluble
121 G L -0.9017 Soluble
122 T L 0.0000 Buried
123 K L -1.7016 Soluble
124 V L 0.0000 Buried
125 T L -0.4584 Soluble
126 V L 0.0000 Buried
127 L L 0.6904 Aggregation-prone
128 G L -0.3801 Soluble
129 Q L -0.9417 Soluble
130 P L -1.2489 Soluble
131 K L -2.3103 Soluble
132 A L -1.2904 Soluble
133 A L -0.7065 Soluble
134 P L 0.0000 Buried
135 S L -0.3968 Soluble
136 V L 0.0000 Buried
137 T L -0.3384 Soluble
138 L L -0.2640 Soluble
139 F L 0.0000 Buried
140 P L -0.1046 Soluble
141 P L -0.4990 Soluble
142 S L -1.0859 Soluble
143 S L -1.4747 Soluble
144 E L -2.2323 Soluble
145 E L 0.0000 Buried
146 L L -1.8528 Soluble
147 Q L -2.2362 Soluble
148 A L -1.8684 Soluble
149 N L -2.5931 Soluble
150 K L -2.6190 Soluble
151 A L 0.0000 Buried
152 T L 0.0000 Buried
153 L L 0.0000 Buried
154 V L 0.0000 Buried
155 C L 0.0000 Buried
156 L L 0.0000 Buried
157 I L 0.0000 Buried
158 S L -0.4911 Soluble
159 D L -1.0932 Soluble
160 F L 0.0000 Buried
161 Y L -1.0792 Soluble
162 P L -0.9367 Soluble
163 G L -0.4581 Soluble
164 A L -0.2273 Soluble
165 V L -0.1186 Soluble
166 T L -0.0314 Soluble
167 V L 0.1967 Aggregation-prone
168 A L -0.3996 Soluble
169 W L 0.0000 Buried
170 K L -1.1626 Soluble
171 A L -1.3120 Soluble
172 D L -1.6047 Soluble
173 S L -0.8424 Soluble
174 S L -0.8786 Soluble
175 P L -0.9729 Soluble
176 V L -0.9772 Soluble
177 K L -1.7552 Soluble
178 A L -0.8613 Soluble
179 G L -0.7189 Soluble
180 V L -0.5272 Soluble
181 E L -0.5074 Soluble
182 T L -0.1025 Soluble
183 T L -0.0487 Soluble
184 T L -0.1502 Soluble
185 P L -0.2582 Soluble
186 S L -0.4302 Soluble
187 K L -0.8931 Soluble
188 Q L -1.1654 Soluble
189 S L -1.3817 Soluble
190 N L -1.9386 Soluble
191 N L 0.0000 Buried
192 K L -1.4306 Soluble
193 Y L -0.6621 Soluble
194 A L 0.0000 Buried
195 A L 0.0000 Buried
196 S L 0.0000 Buried
197 S L 0.0000 Buried
198 Y L 0.0000 Buried
199 L L 0.0000 Buried
200 S L -0.4089 Soluble
201 L L -0.8476 Soluble
202 T L -1.6575 Soluble
203 P L -2.2744 Soluble
204 E L -2.9892 Soluble
205 Q L -2.2517 Soluble
206 W L 0.0000 Buried
207 K L -3.0373 Soluble
208 S L -2.2908 Soluble
209 H L -2.3747 Soluble
210 R L -2.5919 Soluble
211 S L -1.5745 Soluble
212 Y L 0.0000 Buried
213 S L 0.0000 Buried
214 C L 0.0000 Buried
215 Q L -0.8493 Soluble
216 V L 0.0000 Buried
217 T L -0.6117 Soluble
218 H L 0.0000 Buried
219 E L -2.2948 Soluble
220 G L -1.4519 Soluble
221 S L -0.9402 Soluble
222 T L -0.6199 Soluble
223 V L -0.4348 Soluble
224 E L -1.4505 Soluble
225 K L -1.4123 Soluble
226 T L -0.8656 Soluble
227 V L -0.3245 Soluble
228 A L -0.8221 Soluble
229 P L -0.9633 Soluble
230 T L -0.5457 Soluble

3D Structure — colored by A4D score

Sequence - click residue to focus in viewer  |  colored by A4D score
Load structure to view sequence…
Downloads
Color Legend (B-factor = A4D Score)
Score > 1.5 — highly aggregation-prone
Score 0.5–1.5 — aggregation-prone
Score ≈ 0 — buried
Score −1 to −0.5 — soluble
Score < −2.5 — highly soluble
pH Structure
Load structure at specific pH condition
A4D Score Threshold
Highlight residues > threshold in the sequence panel
CDR Regions
HCDR1
HCDR2
HCDR3
LCDR1
LCDR2
LCDR3
Display Options

pH-Dependent Aggregation Profiles

A4D scores calculated across 11 pH conditions (4.0–9.0, step 0.5). Click a row to view the structure at that pH. The input structure is globular — max score is recommended for pH analysis.

pH Avg A4D Score Max A4D Score Downloads
4.0 -0.5993 2.1133 CSV PDB
4.5 -0.6328 2.0977 CSV PDB
5.0 -0.6696 2.0779 CSV PDB
5.5 -0.7014 2.0573 CSV PDB
6.0 -0.7192 2.0389 CSV PDB
6.5 -0.7165 2.0258 CSV PDB
7.0 -0.6952 2.019 CSV PDB
7.5 -0.6623 2.0163 CSV PDB
8.0 -0.6231 2.0153 CSV PDB
8.5 -0.5785 2.015 CSV PDB
9.0 -0.5287 2.0149 CSV PDB
Average A4D Score vs pH
Max A4D Score vs pH