Zinlirvimab / 9bew

A4DAB308_9bew_J_K | Source PDB: 9bew | Chains: J, K | Done
100
Yes
10 Å
Yes
Avg A4D Score
-0.5437
Max Score
2.9341
Min Score
-3.2116
Total Score
-128.85
Score CDR
-0.2477
Score non-CDR
-0.6485

Calculation Parameters

Chain Sequence(s) QVQLQESGPGLVKPSETLSVTCSVSGDSMNNYYWTWIRQSPGKGLEWIGYISDRESATYNPSLNSRVVISRDTSKNQLSLKLNSVTPADTAVYYCATARRGQRIYGVVSFGEFFYYYSMDVWGKGTTVTVSSALSVALGETARISCGRQALGSRAVQWYQHRPGQAPILLIYNNQDRPSGIPERFSGTPDINFGTRATLTISGVEAGDEADYYCHMWDSRSGFSWSFGGATRLTVLG input.pdb
Selected Chain(s) J (Heavy), K (Light)
Distance of Aggregation 10 Å
FoldX Energy Minimization Yes
pH Calculations Yes
Downloads Download all data (.tar.gz)

Aggrescan4D Profile

Aggregation-prone (score > 0)
Soluble (score < 0)
Buried (score = 0)

Per-Residue A4D Scores

Download CSV
Minimum Score -3.2116
Maximum Score 2.9341
Average Score -0.5437
Total Score -128.8507

Residues with A4D score > 0.0 are highlighted as aggregation-prone.

Index Residue Chain A4D Score Classification
1 Q J -1.7024 Soluble
2 V J -1.3738 Soluble
3 Q J -1.8537 Soluble
4 L J -1.3766 Soluble
5 Q J -2.0331 Soluble
6 E J -1.3193 Soluble
7 S J -0.9726 Soluble
8 G J -0.2872 Soluble
9 P J -0.0250 Soluble
11 G J 0.3126 Aggregation-prone
12 L J 1.1386 Aggregation-prone
13 V J 0.0000 Buried
14 K J -1.0940 Soluble
15 P J -1.2887 Soluble
16 S J -1.4712 Soluble
17 E J -1.9939 Soluble
18 T J -1.7438 Soluble
19 L J 0.0000 Buried
20 S J -1.0161 Soluble
21 V J 0.0000 Buried
22 T J -0.7686 Soluble
23 C J 0.0000 Buried
24 S J -1.2491 Soluble
25 V J 0.0000 Buried
26 S J -1.5884 Soluble
27 G J -1.7655 Soluble
28 D J -2.2666 Soluble
29 S J -1.5216 Soluble
30 M J -1.6154 Soluble
35 N J -2.1154 Soluble
36 N J -2.2934 Soluble
37 Y J -1.2787 Soluble
38 Y J 0.0000 Buried
39 W J 0.0000 Buried
40 T J 0.0000 Buried
41 W J 0.0000 Buried
42 I J 0.0000 Buried
43 R J -0.5497 Soluble
44 Q J -0.9676 Soluble
45 S J -0.9927 Soluble
46 P J -1.0659 Soluble
47 G J -1.4741 Soluble
48 K J -2.2592 Soluble
49 G J -1.5584 Soluble
50 L J 0.0000 Buried
51 E J -1.1449 Soluble
52 W J 0.0000 Buried
53 I J -0.0049 Soluble
54 G J 0.0000 Buried
55 Y J 0.2977 Aggregation-prone
56 I J 0.0000 Buried
57 S J -1.6937 Soluble
58 D J -2.4797 Soluble
59 R J -3.0365 Soluble
63 E J -3.2116 Soluble
64 S J -1.7561 Soluble
65 A J -0.7064 Soluble
66 T J -0.0529 Soluble
67 Y J -0.0224 Soluble
68 N J 0.0000 Buried
69 P J -0.8234 Soluble
70 S J -0.7304 Soluble
71 L J -0.9124 Soluble
72 N J -1.7659 Soluble
74 S J -1.2119 Soluble
75 R J -2.0531 Soluble
76 V J 0.0000 Buried
77 V J 0.0658 Aggregation-prone
78 I J 0.0000 Buried
79 S J -1.0780 Soluble
80 R J -2.0483 Soluble
81 D J -2.8254 Soluble
82 T J -2.0049 Soluble
83 S J -1.8138 Soluble
84 K J -2.7356 Soluble
85 N J -2.2614 Soluble
86 Q J -1.9223 Soluble
87 L J 0.0000 Buried
88 S J -0.7909 Soluble
89 L J 0.0000 Buried
90 K J -1.9214 Soluble
91 L J 0.0000 Buried
92 N J -2.3248 Soluble
93 S J -1.5098 Soluble
94 V J 0.0000 Buried
95 T J -0.5649 Soluble
96 P J -0.4647 Soluble
97 A J -0.0888 Soluble
98 D J 0.0000 Buried
99 T J -0.0998 Soluble
100 A J 0.0000 Buried
101 V J -0.1962 Soluble
102 Y J 0.0000 Buried
103 Y J 0.0000 Buried
104 C J 0.0000 Buried
105 A J 0.0000 Buried
106 T J 0.0000 Buried
107 A J 0.0000 Buried
108 R J -1.6822 Soluble
109 R J -2.2515 Soluble
110 G J -1.0969 Soluble
111 Q J -0.3903 Soluble
111A R J 0.3991 Aggregation-prone
111B I J 2.1917 Aggregation-prone
111C Y J 1.8122 Aggregation-prone
111D G J 1.6655 Aggregation-prone
111E V J 2.5473 Aggregation-prone
111F V J 2.9341 Aggregation-prone
112G S J 1.6765 Aggregation-prone
112F F J 2.3168 Aggregation-prone
112E G J 1.3245 Aggregation-prone
112D E J 1.2138 Aggregation-prone
112C F J 1.6914 Aggregation-prone
112B F J 0.6637 Aggregation-prone
112A Y J 0.4388 Aggregation-prone
112 Y J -0.1216 Soluble
113 Y J 0.0000 Buried
114 S J 0.0000 Buried
115 M J 0.0000 Buried
116 D J -0.4970 Soluble
117 V J -0.0041 Soluble
118 W J 0.0000 Buried
119 G J 0.0000 Buried
120 K J -2.2720 Soluble
121 G J 0.0000 Buried
122 T J -0.7024 Soluble
123 T J 0.0226 Aggregation-prone
124 V J 0.0000 Buried
125 T J 0.1719 Aggregation-prone
126 V J 0.0553 Aggregation-prone
127 S J -0.1482 Soluble
128 S J -0.4467 Soluble
129 A J -0.1895 Soluble
11 L K 0.5709 Aggregation-prone
12 S K 0.6194 Aggregation-prone
13 V K 0.5624 Aggregation-prone
14 A K 0.6846 Aggregation-prone
15 L K 0.8849 Aggregation-prone
16 G K -0.5856 Soluble
17 E K -1.3126 Soluble
18 T K -1.0764 Soluble
19 A K 0.0000 Buried
20 R K -1.8817 Soluble
21 I K 0.0000 Buried
22 S K -1.2134 Soluble
23 C K -1.0998 Soluble
24 G K -1.6904 Soluble
25 R K -2.2689 Soluble
26 Q K -2.0245 Soluble
27 A K 0.0000 Buried
28 L K 0.3452 Aggregation-prone
29 G K 0.2884 Aggregation-prone
36 S K 0.7134 Aggregation-prone
37 R K 0.0000 Buried
38 A K 0.0000 Buried
39 V K 0.0000 Buried
40 Q K 0.0000 Buried
41 W K 0.0000 Buried
42 Y K 0.0000 Buried
43 Q K 0.0000 Buried
44 H K 0.0000 Buried
45 R K -1.4297 Soluble
46 P K -1.1774 Soluble
47 G K -1.4018 Soluble
48 Q K -1.7332 Soluble
49 A K -0.9993 Soluble
50 P K 0.0000 Buried
51 I K 0.4241 Aggregation-prone
52 L K 0.0000 Buried
53 L K 0.0000 Buried
54 I K 0.0000 Buried
55 Y K -0.7311 Soluble
56 N K -1.0564 Soluble
57 N K 0.0000 Buried
65 Q K -1.8402 Soluble
66 D K -1.6465 Soluble
67 R K -1.8856 Soluble
68 P K -0.9174 Soluble
69 S K -0.7666 Soluble
70 G K -0.5763 Soluble
71 I K -0.7525 Soluble
72 P K -1.3671 Soluble
74 E K -2.2367 Soluble
75 R K -1.3872 Soluble
76 F K 0.0000 Buried
77 S K -1.1364 Soluble
78 G K -0.8332 Soluble
79 T K -0.5967 Soluble
80 P K -0.3542 Soluble
81 D K 0.2632 Aggregation-prone
81A I K 1.7051 Aggregation-prone
82 N K 0.4232 Aggregation-prone
83 F K 1.4206 Aggregation-prone
84 G K 0.0962 Aggregation-prone
85 T K -0.7673 Soluble
86 R K -2.1909 Soluble
87 A K -1.5914 Soluble
88 T K -1.0271 Soluble
89 L K 0.0000 Buried
90 T K -0.9333 Soluble
91 I K 0.0000 Buried
92 S K -1.4650 Soluble
93 G K -1.1539 Soluble
94 V K -0.9278 Soluble
95 E K -1.7966 Soluble
96 A K -0.7999 Soluble
97 G K -1.2299 Soluble
98 D K 0.0000 Buried
99 E K -1.8964 Soluble
100 A K 0.0000 Buried
101 D K 0.0000 Buried
102 Y K 0.0000 Buried
103 Y K 0.0000 Buried
104 C K 0.0000 Buried
105 H K 0.0000 Buried
106 M K 0.0000 Buried
107 W K 0.0000 Buried
108 D K 0.0000 Buried
109 S K -0.3413 Soluble
110 R K -1.6283 Soluble
112 S K -0.7921 Soluble
113 G K -0.5399 Soluble
114 F K 0.5390 Aggregation-prone
115 S K 0.2450 Aggregation-prone
116 W K 0.0386 Aggregation-prone
117 S K -0.4202 Soluble
118 F K 0.0000 Buried
119 G K -1.0968 Soluble
120 G K -1.3426 Soluble
121 A K -1.0167 Soluble
122 T K -0.6834 Soluble
123 R K -1.8194 Soluble
124 L K 0.0000 Buried
125 T K -0.0033 Soluble
126 V K 0.6013 Aggregation-prone
127 L K 1.5779 Aggregation-prone
128 G K 0.5896 Aggregation-prone

3D Structure — colored by A4D score

Sequence - click residue to focus in viewer  |  colored by A4D score
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Color Legend (B-factor = A4D Score)
Score > 1.5 — highly aggregation-prone
Score 0.5–1.5 — aggregation-prone
Score ≈ 0 — buried
Score −1 to −0.5 — soluble
Score < −2.5 — highly soluble
pH Structure
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A4D Score Threshold
Highlight residues > threshold in the sequence panel
CDR Regions
HCDR1
HCDR2
HCDR3
LCDR1
LCDR2
LCDR3
Display Options

pH-Dependent Aggregation Profiles

A4D scores calculated across 11 pH conditions (4.0–9.0, step 0.5). Click a row to view the structure at that pH. The input structure is globular — max score is recommended for pH analysis.

pH Avg A4D Score Max A4D Score Downloads
4.0 -0.4657 4.5158 CSV PDB
4.5 -0.4998 4.48 CSV PDB
5.0 -0.5421 4.4309 CSV PDB
5.5 -0.5848 4.377 CSV PDB
6.0 -0.6201 4.3265 CSV PDB
6.5 -0.6417 4.2877 CSV PDB
7.0 -0.6484 4.2655 CSV PDB
7.5 -0.6446 4.256 CSV PDB
8.0 -0.6352 4.2526 CSV PDB
8.5 -0.6219 4.2514 CSV PDB
9.0 -0.605 4.2511 CSV PDB
Average A4D Score vs pH
Max A4D Score vs pH