Anvatabart / 7t97

A4DAB021_7t97_H_L | Source PDB: 7t97 | Chains: H, L | Done
100
Yes
10 Å
Yes
Avg A4D Score
-0.6974
Max Score
2.1613
Min Score
-3.5883
Total Score
-300.56
Score CDR
-0.5216
Score non-CDR
-0.7189

Calculation Parameters

Chain Sequence(s) VQLVESGGGLVQPGGSLRLSCAASGFNIKDTYIHWVRQAPGKGLEWVARIYPTNGYTRYADSVKGRFTISADTSKNTAYLQMNSLRAEDTAVYYCSRWGGDGFYAMDYWGQGTLVTVSSACTKCPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKDIQMTQSPSSLSASVGDRVTITCRASQDVNTAVAWYQQKPGKAPKLLIYSASFLYSGVPSRFSGSRSGTDFTLTISSLQPEDFATYYCQQHYTTPPTFGQGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRG input.pdb
Selected Chain(s) H (Heavy), L (Light)
Distance of Aggregation 10 Å
FoldX Energy Minimization Yes
pH Calculations Yes
Downloads Download all data (.tar.gz)

Aggrescan4D Profile

Aggregation-prone (score > 0)
Soluble (score < 0)
Buried (score = 0)

Per-Residue A4D Scores

Download CSV
Minimum Score -3.5883
Maximum Score 2.1613
Average Score -0.6974
Total Score -300.5593

Residues with A4D score > 0.0 are highlighted as aggregation-prone.

Index Residue Chain A4D Score Classification
2 V H 1.0503 Aggregation-prone
3 Q H -0.1850 Soluble
4 L H 0.0000 Buried
5 V H 0.1036 Aggregation-prone
6 E H 0.0000 Buried
7 S H -0.5016 Soluble
8 G H -0.8026 Soluble
9 G H -0.2412 Soluble
11 G H -0.3220 Soluble
12 L H 0.1218 Aggregation-prone
13 V H 0.0000 Buried
14 Q H -1.5840 Soluble
15 P H -1.8083 Soluble
16 G H -1.4952 Soluble
17 G H -1.1448 Soluble
18 S H -1.3372 Soluble
19 L H -1.0642 Soluble
20 R H -2.2060 Soluble
21 L H 0.0000 Buried
22 S H -0.5681 Soluble
23 C H 0.0000 Buried
24 A H -0.3841 Soluble
25 A H 0.0000 Buried
26 S H -0.4569 Soluble
27 G H -0.1611 Soluble
28 F H -0.8391 Soluble
29 N H -2.3341 Soluble
30 I H 0.0000 Buried
35 K H -2.9348 Soluble
36 D H -3.0722 Soluble
37 T H 0.0000 Buried
38 Y H -0.4862 Soluble
39 I H 0.0000 Buried
40 H H 0.0000 Buried
41 W H 0.0000 Buried
42 V H 0.0000 Buried
43 R H 0.0000 Buried
44 Q H -0.8167 Soluble
45 A H -1.2040 Soluble
46 P H -0.9679 Soluble
47 G H -1.4645 Soluble
48 K H -2.3920 Soluble
49 G H -1.6306 Soluble
50 L H 0.0000 Buried
51 E H -1.0888 Soluble
52 W H 0.0000 Buried
53 V H 0.0000 Buried
54 A H 0.0000 Buried
55 R H -0.6563 Soluble
56 I H 0.0000 Buried
57 Y H -0.5878 Soluble
58 P H 0.0000 Buried
59 T H -1.2516 Soluble
62 N H -0.9610 Soluble
63 G H -0.3910 Soluble
64 Y H 0.4313 Aggregation-prone
65 T H -0.4935 Soluble
66 R H -1.9234 Soluble
67 Y H -1.7044 Soluble
68 A H 0.0000 Buried
69 D H -2.5676 Soluble
70 S H -1.7130 Soluble
71 V H 0.0000 Buried
72 K H -2.6515 Soluble
74 G H -1.6520 Soluble
75 R H -1.2846 Soluble
76 F H 0.0000 Buried
77 T H -1.1748 Soluble
78 I H 0.0000 Buried
79 S H -0.2735 Soluble
80 A H -0.8763 Soluble
81 D H -1.4431 Soluble
82 T H -1.6034 Soluble
83 S H -1.5858 Soluble
84 K H -2.2407 Soluble
85 N H -1.8296 Soluble
86 T H 0.0000 Buried
87 A H 0.0000 Buried
88 Y H 0.0000 Buried
89 L H 0.0000 Buried
90 Q H -1.5718 Soluble
91 M H 0.0000 Buried
92 N H -1.4717 Soluble
93 S H -1.2941 Soluble
94 L H 0.0000 Buried
95 R H -2.4402 Soluble
96 A H -1.7841 Soluble
97 E H -2.2718 Soluble
98 D H 0.0000 Buried
99 T H -0.7094 Soluble
100 A H 0.0000 Buried
101 V H 0.1447 Aggregation-prone
102 Y H 0.0000 Buried
103 Y H 0.0000 Buried
104 C H 0.0000 Buried
105 S H 0.0000 Buried
106 R H -0.1496 Soluble
107 W H 0.0000 Buried
108 G H -0.4515 Soluble
109 G H -1.2575 Soluble
110 D H -2.0836 Soluble
111 G H -1.0211 Soluble
112 F H -0.1051 Soluble
113 Y H 0.2997 Aggregation-prone
114 A H 0.0000 Buried
115 M H 0.0000 Buried
116 D H 0.0000 Buried
117 Y H 0.1564 Aggregation-prone
118 W H -0.3067 Soluble
119 G H 0.0000 Buried
120 Q H -1.5695 Soluble
121 G H -0.6872 Soluble
122 T H 0.0152 Aggregation-prone
123 L H 0.4760 Aggregation-prone
124 V H 0.0000 Buried
125 T H -0.4409 Soluble
126 V H 0.0000 Buried
127 S H -0.8655 Soluble
128 S H -0.5152 Soluble
129 A H -0.1034 Soluble
130 C H 0.2287 Aggregation-prone
131 T H -0.2368 Soluble
132 K H -1.0456 Soluble
133 C H -0.9173 Soluble
134 P H 0.0000 Buried
135 S H -0.2828 Soluble
136 V H 0.0000 Buried
137 F H 0.0000 Buried
138 P H -1.1067 Soluble
139 L H 0.0000 Buried
140 A H -1.3017 Soluble
141 P H 0.0000 Buried
142 S H -1.2256 Soluble
143 S H -0.9846 Soluble
144 K H -1.1611 Soluble
145 S H 0.0000 Buried
146 T H -0.7373 Soluble
147 S H -0.7176 Soluble
148 G H -0.8325 Soluble
149 G H -0.8851 Soluble
150 T H -0.5852 Soluble
151 A H 0.0000 Buried
152 A H 0.0000 Buried
153 L H 0.0000 Buried
154 G H 0.0000 Buried
155 C H 0.0000 Buried
156 L H 0.0000 Buried
157 V H 0.0000 Buried
158 K H -0.3907 Soluble
159 D H -0.5199 Soluble
160 Y H 0.0000 Buried
161 F H 0.0000 Buried
162 P H 0.0000 Buried
163 E H -0.4692 Soluble
164 P H -0.6148 Soluble
165 V H -0.5456 Soluble
166 T H -0.5405 Soluble
167 V H -0.3437 Soluble
168 S H -0.4292 Soluble
169 W H 0.0000 Buried
170 N H -0.8787 Soluble
171 S H -0.7548 Soluble
172 G H -0.6258 Soluble
173 A H -0.2969 Soluble
174 L H -0.0714 Soluble
175 T H -0.2128 Soluble
176 S H -0.2029 Soluble
177 G H -0.2348 Soluble
178 V H 0.1388 Aggregation-prone
179 H H -0.3038 Soluble
180 T H 0.0084 Aggregation-prone
181 F H 0.0000 Buried
182 P H -0.3632 Soluble
183 A H 0.2415 Aggregation-prone
184 V H 0.7259 Aggregation-prone
185 L H 1.4810 Aggregation-prone
186 Q H 0.4333 Aggregation-prone
187 S H -0.1502 Soluble
188 S H -0.1794 Soluble
189 G H 0.1109 Aggregation-prone
190 L H 0.2086 Aggregation-prone
191 Y H 0.4435 Aggregation-prone
192 S H 0.0000 Buried
193 L H 0.0000 Buried
194 S H 0.0000 Buried
195 S H 0.0000 Buried
196 V H 0.0000 Buried
197 V H 0.0000 Buried
198 T H -0.1442 Soluble
199 V H 0.0000 Buried
200 P H -0.6387 Soluble
201 S H -0.5997 Soluble
202 S H -0.6118 Soluble
203 S H 0.0000 Buried
204 L H -0.8695 Soluble
205 G H -1.0970 Soluble
206 T H -0.8433 Soluble
207 Q H -1.4846 Soluble
208 T H -1.2358 Soluble
209 Y H 0.0000 Buried
210 I H -1.2725 Soluble
211 C H 0.0000 Buried
212 N H -1.5441 Soluble
213 V H 0.0000 Buried
214 N H -1.7431 Soluble
215 H H 0.0000 Buried
216 K H -2.6417 Soluble
217 P H -1.4128 Soluble
218 S H -1.5564 Soluble
219 N H -2.3386 Soluble
220 T H -1.9294 Soluble
221 K H -2.6082 Soluble
222 V H -1.6279 Soluble
223 D H -2.5262 Soluble
224 K H -2.0864 Soluble
225 K H -2.3131 Soluble
226 V H 0.0000 Buried
227 E H -2.8184 Soluble
228 P H -2.0644 Soluble
229 K H -2.2503 Soluble
1 D L -2.2357 Soluble
2 I L 0.0000 Buried
3 Q L -2.2918 Soluble
4 M L 0.0000 Buried
5 T L -1.4275 Soluble
6 Q L 0.0000 Buried
7 S L -0.9910 Soluble
8 P L -0.7750 Soluble
9 S L -1.0620 Soluble
10 S L -1.0882 Soluble
11 L L -0.7780 Soluble
12 S L -0.8688 Soluble
13 A L -0.9742 Soluble
14 S L -0.9145 Soluble
15 V L -0.2137 Soluble
16 G L -0.7866 Soluble
17 D L -1.8234 Soluble
18 R L -2.3197 Soluble
19 V L 0.0000 Buried
20 T L -0.6329 Soluble
21 I L 0.0000 Buried
22 T L -0.7614 Soluble
23 C L 0.0000 Buried
24 R L -2.7637 Soluble
25 A L 0.0000 Buried
26 S L -2.1589 Soluble
27 Q L -2.5884 Soluble
28 D L -2.6444 Soluble
29 V L 0.0000 Buried
36 N L -1.5557 Soluble
37 T L -0.5434 Soluble
38 A L -0.0393 Soluble
39 V L 0.0000 Buried
40 A L 0.0000 Buried
41 W L 0.0000 Buried
42 Y L 0.0000 Buried
43 Q L 0.0000 Buried
44 Q L 0.0000 Buried
45 K L -1.7220 Soluble
46 P L -1.3482 Soluble
47 G L -1.5730 Soluble
48 K L -2.4972 Soluble
49 A L -1.5752 Soluble
50 P L 0.0000 Buried
51 K L -1.4026 Soluble
52 L L 0.0000 Buried
53 L L 0.0000 Buried
54 I L 0.0000 Buried
55 Y L 1.2936 Aggregation-prone
56 S L 0.5561 Aggregation-prone
57 A L 0.0000 Buried
65 S L 0.6569 Aggregation-prone
66 F L 2.1613 Aggregation-prone
67 L L 1.4451 Aggregation-prone
68 Y L 0.6415 Aggregation-prone
69 S L 0.0356 Aggregation-prone
70 G L -0.4839 Soluble
71 V L 0.0000 Buried
72 P L -0.3523 Soluble
74 S L -0.4050 Soluble
75 R L -0.7195 Soluble
76 F L 0.0000 Buried
77 S L 0.0747 Aggregation-prone
78 G L 0.0543 Aggregation-prone
79 S L -0.6792 Soluble
80 R L -1.7089 Soluble
83 S L -1.2553 Soluble
84 G L -1.6549 Soluble
85 T L -2.0731 Soluble
86 D L -1.8917 Soluble
87 F L 0.0000 Buried
88 T L -0.7888 Soluble
89 L L 0.0000 Buried
90 T L -0.6296 Soluble
91 I L 0.0000 Buried
92 S L -1.3570 Soluble
93 S L -1.1376 Soluble
94 L L 0.0000 Buried
95 Q L -0.9635 Soluble
96 P L -1.6842 Soluble
97 E L -2.0959 Soluble
98 D L 0.0000 Buried
99 F L 0.0000 Buried
100 A L 0.0000 Buried
101 T L -1.0655 Soluble
102 Y L 0.0000 Buried
103 Y L 0.0000 Buried
104 C L 0.0000 Buried
105 Q L 0.0000 Buried
106 Q L 0.0000 Buried
107 H L 0.4314 Aggregation-prone
108 Y L 0.6142 Aggregation-prone
109 T L 0.1886 Aggregation-prone
114 T L -0.4191 Soluble
115 P L -0.8302 Soluble
116 P L 0.0000 Buried
117 T L -0.6502 Soluble
118 F L -0.5266 Soluble
119 G L 0.0000 Buried
120 Q L -1.9466 Soluble
121 G L 0.0000 Buried
122 T L 0.0000 Buried
123 K L -2.1232 Soluble
124 V L 0.0000 Buried
125 E L -1.6485 Soluble
126 I L 0.0000 Buried
127 K L -1.2832 Soluble
128 R L -0.9057 Soluble
129 T L -0.1604 Soluble
130 V L 0.2373 Aggregation-prone
131 A L -0.0646 Soluble
132 A L -0.0986 Soluble
133 P L 0.0000 Buried
134 S L -0.1376 Soluble
135 V L 0.0000 Buried
136 F L 0.0000 Buried
137 I L 0.0000 Buried
138 F L 0.0000 Buried
139 P L -0.9147 Soluble
140 P L -0.8401 Soluble
141 S L -1.8282 Soluble
142 D L -3.0155 Soluble
143 E L -3.0013 Soluble
144 Q L 0.0000 Buried
145 L L -2.2918 Soluble
146 K L -2.9499 Soluble
147 S L -1.8923 Soluble
148 G L -1.5849 Soluble
149 T L -1.3899 Soluble
150 A L 0.0000 Buried
151 S L 0.0000 Buried
152 V L 0.0000 Buried
153 V L 0.0000 Buried
154 C L 0.0000 Buried
155 L L 0.0000 Buried
156 L L 0.0000 Buried
157 N L 0.0000 Buried
158 N L -0.7735 Soluble
159 F L 0.0000 Buried
160 Y L 0.0000 Buried
161 P L -1.6578 Soluble
162 R L -2.8008 Soluble
163 E L -3.1237 Soluble
164 A L -2.2820 Soluble
165 K L -2.3431 Soluble
166 V L -1.0018 Soluble
167 Q L -0.5260 Soluble
168 W L 0.0000 Buried
169 K L -0.5665 Soluble
170 V L 0.0000 Buried
171 D L -2.0100 Soluble
172 N L -1.3934 Soluble
173 A L -0.3397 Soluble
174 L L 0.5755 Aggregation-prone
175 Q L -0.6067 Soluble
177 G L -1.2996 Soluble
178 N L -1.7423 Soluble
179 S L -1.4906 Soluble
180 Q L -1.3361 Soluble
181 E L -1.8365 Soluble
182 S L -0.9909 Soluble
183 V L -0.8345 Soluble
184 T L -1.0517 Soluble
185 E L -1.9955 Soluble
186 Q L 0.0000 Buried
187 D L -2.0402 Soluble
188 S L -2.1960 Soluble
189 K L -2.5780 Soluble
190 D L -1.8440 Soluble
191 S L 0.0000 Buried
192 T L 0.0000 Buried
193 Y L 0.0000 Buried
194 S L 0.0000 Buried
195 L L 0.0000 Buried
196 S L 0.0000 Buried
197 S L 0.0000 Buried
198 T L -0.7603 Soluble
199 L L 0.0000 Buried
200 T L -0.7010 Soluble
201 L L -0.9306 Soluble
202 S L -1.1774 Soluble
203 K L -2.1907 Soluble
204 A L -1.9856 Soluble
205 D L -2.7960 Soluble
206 Y L 0.0000 Buried
207 E L -3.2995 Soluble
208 K L -3.5883 Soluble
209 H L -3.0485 Soluble
210 K L -3.0191 Soluble
211 V L -1.5717 Soluble
212 Y L 0.0000 Buried
213 A L 0.0000 Buried
214 C L 0.0000 Buried
215 E L -0.5908 Soluble
216 V L 0.0000 Buried
217 T L -1.1843 Soluble
218 H L 0.0000 Buried
219 Q L -1.7235 Soluble
220 G L -0.4322 Soluble
221 L L -0.2090 Soluble
222 S L -0.4312 Soluble
223 S L -0.4173 Soluble
224 P L -0.5375 Soluble
225 V L 0.0129 Aggregation-prone
226 T L -0.3491 Soluble
227 K L -0.6912 Soluble
228 S L -0.7406 Soluble
229 F L 0.0000 Buried
230 N L -2.0680 Soluble
231 R L -2.2209 Soluble
232 G L -1.3630 Soluble

3D Structure — colored by A4D score

Sequence - click residue to focus in viewer  |  colored by A4D score
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Color Legend (B-factor = A4D Score)
Score > 1.5 — highly aggregation-prone
Score 0.5–1.5 — aggregation-prone
Score ≈ 0 — buried
Score −1 to −0.5 — soluble
Score < −2.5 — highly soluble
pH Structure
Load structure at specific pH condition
A4D Score Threshold
Highlight residues > threshold in the sequence panel
CDR Regions
HCDR1
HCDR2
HCDR3
LCDR1
LCDR2
LCDR3
Display Options

pH-Dependent Aggregation Profiles

A4D scores calculated across 11 pH conditions (4.0–9.0, step 0.5). Click a row to view the structure at that pH. The input structure is globular — max score is recommended for pH analysis.

pH Avg A4D Score Max A4D Score Downloads
4.0 -0.7409 3.7419 CSV PDB
4.5 -0.7833 3.7419 CSV PDB
5.0 -0.8317 3.7419 CSV PDB
5.5 -0.8764 3.7419 CSV PDB
6.0 -0.9067 3.7419 CSV PDB
6.5 -0.914 3.7419 CSV PDB
7.0 -0.8988 3.7419 CSV PDB
7.5 -0.8691 3.7418 CSV PDB
8.0 -0.8315 3.7418 CSV PDB
8.5 -0.7876 3.7417 CSV PDB
9.0 -0.7365 3.7413 CSV PDB
Average A4D Score vs pH
Max A4D Score vs pH