Zinlirvimab / 9bew

A4DAB308_9bew_H_L | Source PDB: 9bew | Chains: H, L | Done
100
Yes
10 Å
Yes
Avg A4D Score
-0.579
Max Score
2.939
Min Score
-3.2318
Total Score
-137.23
Score CDR
-0.3274
Score non-CDR
-0.6682

Calculation Parameters

Chain Sequence(s) QVQLQESGPGLVKPSETLSVTCSVSGDSMNNYYWTWIRQSPGKGLEWIGYISDRESATYNPSLNSRVVISRDTSKNQLSLKLNSVTPADTAVYYCATARRGQRIYGVVSFGEFFYYYSMDVWGKGTTVTVSSALSVALGETARISCGRQALGSRAVQWYQHRPGQAPILLIYNNQDRPSGIPERFSGTPDINFGTRATLTISGVEAGDEADYYCHMWDSRSGFSWSFGGATRLTVLG input.pdb
Selected Chain(s) H (Heavy), L (Light)
Distance of Aggregation 10 Å
FoldX Energy Minimization Yes
pH Calculations Yes
Downloads Download all data (.tar.gz)

Aggrescan4D Profile

Aggregation-prone (score > 0)
Soluble (score < 0)
Buried (score = 0)

Per-Residue A4D Scores

Download CSV
Minimum Score -3.2318
Maximum Score 2.939
Average Score -0.579
Total Score -137.2333

Residues with A4D score > 0.0 are highlighted as aggregation-prone.

Index Residue Chain A4D Score Classification
1 Q H -1.7135 Soluble
2 V H -1.3917 Soluble
3 Q H -1.8673 Soluble
4 L H -1.3964 Soluble
5 Q H -2.0465 Soluble
6 E H -1.3397 Soluble
7 S H -0.9881 Soluble
8 G H -0.2989 Soluble
9 P H -0.0258 Soluble
11 G H 0.3098 Aggregation-prone
12 L H 1.1372 Aggregation-prone
13 V H 0.0000 Buried
14 K H -1.0943 Soluble
15 P H -1.2888 Soluble
16 S H -1.4711 Soluble
17 E H -1.9938 Soluble
18 T H -1.7437 Soluble
19 L H 0.0000 Buried
20 S H -1.0158 Soluble
21 V H 0.0000 Buried
22 T H -0.7689 Soluble
23 C H 0.0000 Buried
24 S H -1.2475 Soluble
25 V H 0.0000 Buried
26 S H -1.5867 Soluble
27 G H -1.7654 Soluble
28 D H -2.2669 Soluble
29 S H -1.5202 Soluble
30 M H -1.5885 Soluble
35 N H -2.0974 Soluble
36 N H -2.2721 Soluble
37 Y H -1.2175 Soluble
38 Y H -0.7308 Soluble
39 W H 0.0000 Buried
40 T H 0.0000 Buried
41 W H 0.0000 Buried
42 I H 0.0000 Buried
43 R H -0.7107 Soluble
44 Q H -1.1066 Soluble
45 S H -1.1179 Soluble
46 P H -1.0827 Soluble
47 G H -1.4832 Soluble
48 K H -2.3400 Soluble
49 G H -1.6757 Soluble
50 L H 0.0000 Buried
51 E H -1.6652 Soluble
52 W H 0.0000 Buried
53 I H 0.0000 Buried
54 G H 0.0000 Buried
55 Y H 0.2902 Aggregation-prone
56 I H 0.0000 Buried
57 S H -1.6639 Soluble
58 D H -2.4894 Soluble
59 R H -3.0624 Soluble
63 E H -3.2318 Soluble
64 S H -1.7675 Soluble
65 A H -0.7135 Soluble
66 T H -0.0794 Soluble
67 Y H -0.0936 Soluble
68 N H 0.0000 Buried
69 P H -0.8659 Soluble
70 S H -0.7745 Soluble
71 L H -0.9792 Soluble
72 N H -1.7889 Soluble
74 S H -1.2725 Soluble
75 R H -2.1181 Soluble
76 V H 0.0000 Buried
77 V H 0.0522 Aggregation-prone
78 I H 0.0000 Buried
79 S H -1.0866 Soluble
80 R H -2.0721 Soluble
81 D H -2.8529 Soluble
82 T H -2.0169 Soluble
83 S H -1.8224 Soluble
84 K H -2.7436 Soluble
85 N H -2.2689 Soluble
86 Q H -1.9307 Soluble
87 L H 0.0000 Buried
88 S H -0.7951 Soluble
89 L H 0.0000 Buried
90 K H -1.9302 Soluble
91 L H 0.0000 Buried
92 N H -2.3388 Soluble
93 S H -1.5197 Soluble
94 V H 0.0000 Buried
95 T H -0.6012 Soluble
96 P H -0.5154 Soluble
97 A H -0.1796 Soluble
98 D H -0.2586 Soluble
99 T H -0.1955 Soluble
100 A H 0.0000 Buried
101 V H -0.2238 Soluble
102 Y H 0.0000 Buried
103 Y H 0.0000 Buried
104 C H 0.0000 Buried
105 A H 0.0000 Buried
106 T H 0.0000 Buried
107 A H 0.0000 Buried
108 R H -1.8314 Soluble
109 R H -2.3617 Soluble
110 G H -1.2584 Soluble
111 Q H -0.5343 Soluble
111A R H 0.3054 Aggregation-prone
111B I H 2.1145 Aggregation-prone
111C Y H 1.8677 Aggregation-prone
111D G H 1.6968 Aggregation-prone
111E V H 2.5624 Aggregation-prone
111F V H 2.9390 Aggregation-prone
112G S H 1.6859 Aggregation-prone
112F F H 2.3306 Aggregation-prone
112E G H 1.3416 Aggregation-prone
112D E H 1.2548 Aggregation-prone
112C F H 1.6496 Aggregation-prone
112B F H 0.5028 Aggregation-prone
112A Y H 0.0488 Aggregation-prone
112 Y H 0.0000 Buried
113 Y H 0.0000 Buried
114 S H 0.0000 Buried
115 M H 0.0000 Buried
116 D H -0.8021 Soluble
117 V H -0.2330 Soluble
118 W H 0.0000 Buried
119 G H 0.0000 Buried
120 K H -2.3043 Soluble
121 G H -1.4143 Soluble
122 T H -0.7411 Soluble
123 T H -0.0095 Soluble
124 V H 0.0000 Buried
125 T H 0.1333 Aggregation-prone
126 V H 0.0169 Aggregation-prone
127 S H -0.1488 Soluble
128 S H -0.4469 Soluble
129 A H -0.1896 Soluble
11 L L 0.5784 Aggregation-prone
12 S L 0.5922 Aggregation-prone
13 V L 0.5310 Aggregation-prone
14 A L 0.6325 Aggregation-prone
15 L L 0.8547 Aggregation-prone
16 G L -0.5870 Soluble
17 E L -1.3141 Soluble
18 T L -1.0781 Soluble
19 A L 0.0000 Buried
20 R L -1.8917 Soluble
21 I L 0.0000 Buried
22 S L -1.2386 Soluble
23 C L -1.0805 Soluble
24 G L -1.5634 Soluble
25 R L -2.0119 Soluble
26 Q L -2.0044 Soluble
27 A L -1.0187 Soluble
28 L L -0.1766 Soluble
29 G L 0.0212 Aggregation-prone
36 S L 0.5972 Aggregation-prone
37 R L 0.0000 Buried
38 A L 0.0000 Buried
39 V L 0.0000 Buried
40 Q L 0.0000 Buried
41 W L 0.0000 Buried
42 Y L 0.0000 Buried
43 Q L 0.0000 Buried
44 H L 0.0000 Buried
45 R L -1.4225 Soluble
46 P L -1.1678 Soluble
47 G L -1.3995 Soluble
48 Q L -1.7233 Soluble
49 A L -1.0227 Soluble
50 P L 0.0000 Buried
51 I L 0.3332 Aggregation-prone
52 L L 0.0000 Buried
53 L L 0.0000 Buried
54 I L 0.0000 Buried
55 Y L -0.6788 Soluble
56 N L -1.0461 Soluble
57 N L 0.0000 Buried
65 Q L -1.7581 Soluble
66 D L -1.4635 Soluble
67 R L -1.5400 Soluble
68 P L -0.7896 Soluble
69 S L -0.7208 Soluble
70 G L -0.5367 Soluble
71 I L -0.6895 Soluble
72 P L -1.3563 Soluble
74 E L -2.2100 Soluble
75 R L -1.3963 Soluble
76 F L 0.0000 Buried
77 S L -1.0583 Soluble
78 G L -0.7840 Soluble
79 T L -0.6056 Soluble
80 P L -0.3737 Soluble
81 D L 0.2023 Aggregation-prone
81A I L 1.6781 Aggregation-prone
82 N L 0.4094 Aggregation-prone
83 F L 1.3406 Aggregation-prone
84 G L 0.0188 Aggregation-prone
85 T L -0.7810 Soluble
86 R L -2.1751 Soluble
87 A L -1.5809 Soluble
88 T L -1.0568 Soluble
89 L L 0.0000 Buried
90 T L -0.9334 Soluble
91 I L 0.0000 Buried
92 S L -1.4641 Soluble
93 G L -1.1594 Soluble
94 V L -0.9286 Soluble
95 E L -1.7958 Soluble
96 A L -0.8165 Soluble
97 G L -1.2257 Soluble
98 D L 0.0000 Buried
99 E L -1.8888 Soluble
100 A L 0.0000 Buried
101 D L 0.0000 Buried
102 Y L 0.0000 Buried
103 Y L 0.0000 Buried
104 C L 0.0000 Buried
105 H L 0.0000 Buried
106 M L 0.0000 Buried
107 W L 0.0000 Buried
108 D L 0.0000 Buried
109 S L -0.4938 Soluble
110 R L -1.7844 Soluble
112 S L -0.9261 Soluble
113 G L -0.5931 Soluble
114 F L 0.4463 Aggregation-prone
115 S L 0.2064 Aggregation-prone
116 W L -0.0882 Soluble
117 S L -0.5771 Soluble
118 F L 0.0000 Buried
119 G L -1.1047 Soluble
120 G L -1.3115 Soluble
121 A L -1.0272 Soluble
122 T L -0.6979 Soluble
123 R L -1.8161 Soluble
124 L L 0.0000 Buried
125 T L -0.0307 Soluble
126 V L 0.5380 Aggregation-prone
127 L L 1.4380 Aggregation-prone
128 G L 0.5212 Aggregation-prone

3D Structure — colored by A4D score

Sequence - click residue to focus in viewer  |  colored by A4D score
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Color Legend (B-factor = A4D Score)
Score > 1.5 — highly aggregation-prone
Score 0.5–1.5 — aggregation-prone
Score ≈ 0 — buried
Score −1 to −0.5 — soluble
Score < −2.5 — highly soluble
pH Structure
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A4D Score Threshold
Highlight residues > threshold in the sequence panel
CDR Regions
HCDR1
HCDR2
HCDR3
LCDR1
LCDR2
LCDR3
Display Options

pH-Dependent Aggregation Profiles

A4D scores calculated across 11 pH conditions (4.0–9.0, step 0.5). Click a row to view the structure at that pH. The input structure is globular — max score is recommended for pH analysis.

pH Avg A4D Score Max A4D Score Downloads
4.0 -0.4744 4.5418 CSV PDB
4.5 -0.5103 4.5145 CSV PDB
5.0 -0.5548 4.472 CSV PDB
5.5 -0.6001 4.4208 CSV PDB
6.0 -0.6378 4.3693 CSV PDB
6.5 -0.6613 4.3255 CSV PDB
7.0 -0.6698 4.2966 CSV PDB
7.5 -0.6678 4.2826 CSV PDB
8.0 -0.6601 4.2772 CSV PDB
8.5 -0.6484 4.2753 CSV PDB
9.0 -0.6329 4.2747 CSV PDB
Average A4D Score vs pH
Max A4D Score vs pH