Paridiprubart / 4r7d

A4DAB203_4r7d_O_P | Source PDB: 4r7d | Chains: O, P | Done
100
Yes
10 Å
Yes
Avg A4D Score
-0.6655
Max Score
1.8016
Min Score
-3.6536
Total Score
-279.49
Score CDR
-0.1023
Score non-CDR
-0.733

Calculation Parameters

Chain Sequence(s) VQLQESGPGLVKPSDTLSLTCAVSGYSITGGYSWHWIRQPPGKGLEWMGYIHYSGYTDFNPSLKTRITISRDTSKNQFSLKLSSVTAVDTAVYYCARKDPSDAFPYWGQGTLVTVSSASTKGPSVFPLAPTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPIVLTQSPDFQSVTPKEKVTITCRASQSISDHLHWYQQKPDQSPKLLIKYASHAISGVPSRFSGSGSGTDFTLTINSLEAEDAATYYCQQGHSFPLTFGGGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRG input.pdb
Selected Chain(s) O (Heavy), P (Light)
Distance of Aggregation 10 Å
FoldX Energy Minimization Yes
pH Calculations Yes
Downloads Download all data (.tar.gz)

Aggrescan4D Profile

Aggregation-prone (score > 0)
Soluble (score < 0)
Buried (score = 0)

Per-Residue A4D Scores

Download CSV
Minimum Score -3.6536
Maximum Score 1.8016
Average Score -0.6655
Total Score -279.4943

Residues with A4D score > 0.0 are highlighted as aggregation-prone.

Index Residue Chain A4D Score Classification
2 V O 0.8906 Aggregation-prone
3 Q O -0.8340 Soluble
4 L O 0.0000 Buried
5 Q O -1.9158 Soluble
6 E O -1.1603 Soluble
7 S O -0.7894 Soluble
8 G O -0.5958 Soluble
9 P O -0.3186 Soluble
11 G O -0.3206 Soluble
12 L O -0.1849 Soluble
13 V O -1.0542 Soluble
14 K O -2.2353 Soluble
15 P O -1.5657 Soluble
16 S O -1.6262 Soluble
17 D O -2.4835 Soluble
18 T O -1.7174 Soluble
19 L O 0.0000 Buried
20 S O -1.0691 Soluble
21 L O 0.0000 Buried
22 T O -0.9547 Soluble
23 C O 0.0000 Buried
24 A O -1.2884 Soluble
25 V O 0.0000 Buried
26 S O -0.6562 Soluble
27 G O -0.0708 Soluble
28 Y O 0.2578 Aggregation-prone
29 S O -0.2109 Soluble
30 I O 0.0000 Buried
31 T O -0.3288 Soluble
35 G O -0.2133 Soluble
36 G O 0.0000 Buried
37 Y O 0.4083 Aggregation-prone
38 S O 0.0000 Buried
39 W O 0.0000 Buried
40 H O 0.0000 Buried
41 W O 0.0000 Buried
42 I O 0.0000 Buried
43 R O 0.0000 Buried
44 Q O 0.0000 Buried
45 P O -0.5099 Soluble
46 P O -0.9857 Soluble
47 G O -1.4749 Soluble
48 K O -2.2569 Soluble
49 G O -1.4393 Soluble
50 L O 0.0000 Buried
51 E O -0.8203 Soluble
52 W O 0.0000 Buried
53 M O 0.0000 Buried
54 G O 0.0000 Buried
55 Y O 0.0000 Buried
56 I O 0.0000 Buried
57 H O 0.3550 Aggregation-prone
58 Y O 0.6362 Aggregation-prone
59 S O 0.3200 Aggregation-prone
63 G O 0.3925 Aggregation-prone
64 Y O 0.8992 Aggregation-prone
65 T O 0.0319 Aggregation-prone
66 D O -0.6811 Soluble
67 F O -0.4050 Soluble
68 N O -0.4646 Soluble
69 P O -1.0187 Soluble
70 S O -0.9879 Soluble
71 L O 0.0000 Buried
72 K O -1.9696 Soluble
74 T O -1.2753 Soluble
75 R O -1.2747 Soluble
76 I O 0.0000 Buried
77 T O -0.7628 Soluble
78 I O 0.0000 Buried
79 S O -0.8336 Soluble
80 R O -1.6444 Soluble
81 D O -2.3450 Soluble
82 T O -1.5965 Soluble
83 S O -1.6813 Soluble
84 K O -2.4701 Soluble
85 N O -1.7697 Soluble
86 Q O -1.8273 Soluble
87 F O 0.0000 Buried
88 S O -0.9424 Soluble
89 L O 0.0000 Buried
90 K O -1.6138 Soluble
91 L O 0.0000 Buried
92 S O -1.4425 Soluble
93 S O -1.1839 Soluble
94 V O 0.0000 Buried
95 T O -0.0587 Soluble
96 A O 0.7404 Aggregation-prone
97 V O 1.8016 Aggregation-prone
98 D O 0.0000 Buried
99 T O 0.7226 Aggregation-prone
100 A O 0.0000 Buried
101 V O 0.0365 Aggregation-prone
102 Y O 0.0000 Buried
103 Y O 0.0000 Buried
104 C O 0.0000 Buried
105 A O 0.0000 Buried
106 R O 0.0000 Buried
107 K O -0.2190 Soluble
108 D O -0.3586 Soluble
109 P O -0.4397 Soluble
110 S O 0.0000 Buried
113 D O -0.6687 Soluble
114 A O 0.0000 Buried
115 F O 0.0000 Buried
116 P O -0.0507 Soluble
117 Y O 0.2830 Aggregation-prone
118 W O -0.5549 Soluble
119 G O 0.0000 Buried
120 Q O -2.0725 Soluble
121 G O 0.0000 Buried
122 T O -0.3702 Soluble
123 L O 0.1632 Aggregation-prone
124 V O 0.0000 Buried
125 T O 0.1358 Aggregation-prone
126 V O -0.2687 Soluble
127 S O -0.5577 Soluble
128 S O -0.7406 Soluble
129 A O -0.4995 Soluble
130 S O -0.6653 Soluble
131 T O -0.9117 Soluble
132 K O -1.3484 Soluble
133 G O -1.5940 Soluble
134 P O -0.7279 Soluble
135 S O -0.3284 Soluble
136 V O -0.4730 Soluble
137 F O 0.0000 Buried
138 P O -1.1877 Soluble
139 L O 0.0000 Buried
140 A O -0.8672 Soluble
141 P O -0.5594 Soluble
142 T O -0.2970 Soluble
143 A O -0.2005 Soluble
144 A O 0.0000 Buried
145 L O 0.0000 Buried
146 G O 0.0000 Buried
147 C O 0.0000 Buried
148 L O 0.0000 Buried
149 V O 0.0000 Buried
150 K O 0.0000 Buried
151 D O -1.0526 Soluble
152 Y O 0.0000 Buried
153 F O 0.0000 Buried
154 P O 0.0000 Buried
155 E O -0.3078 Soluble
156 P O -0.5822 Soluble
157 V O -0.3884 Soluble
158 T O -0.4680 Soluble
159 V O -0.0710 Soluble
160 S O -0.3868 Soluble
161 W O 0.0000 Buried
162 N O -0.8288 Soluble
163 S O -0.6935 Soluble
164 G O -0.5314 Soluble
165 A O -0.2535 Soluble
166 L O -0.0158 Soluble
167 T O -0.1582 Soluble
168 S O -0.1526 Soluble
169 G O -0.1638 Soluble
170 V O 0.2359 Aggregation-prone
171 H O -0.2994 Soluble
172 T O 0.0215 Aggregation-prone
173 F O 0.0000 Buried
174 P O -0.3206 Soluble
175 A O 0.2997 Aggregation-prone
176 V O 0.7043 Aggregation-prone
177 L O 1.5283 Aggregation-prone
178 Q O 0.3967 Aggregation-prone
179 S O -0.0073 Soluble
180 S O -0.2258 Soluble
181 G O 0.0741 Aggregation-prone
182 L O -0.0109 Soluble
183 Y O 0.3926 Aggregation-prone
184 S O 0.0000 Buried
185 L O 0.0000 Buried
186 S O 0.0000 Buried
187 S O 0.0000 Buried
188 V O 0.0000 Buried
189 V O 0.0000 Buried
190 T O -0.1469 Soluble
191 V O 0.0000 Buried
192 P O -0.4196 Soluble
193 S O -0.5006 Soluble
194 S O -0.5837 Soluble
195 S O -0.6732 Soluble
196 L O -0.9159 Soluble
197 G O -1.0769 Soluble
198 T O -0.8175 Soluble
199 Q O -1.4325 Soluble
200 T O -1.2399 Soluble
201 Y O 0.0000 Buried
202 I O -1.3216 Soluble
203 C O 0.0000 Buried
204 N O -1.4548 Soluble
205 V O 0.0000 Buried
206 N O -1.7582 Soluble
207 H O 0.0000 Buried
208 K O -2.6051 Soluble
209 P O -1.8784 Soluble
210 S O -1.8588 Soluble
211 N O -2.3670 Soluble
212 T O -1.9987 Soluble
213 K O -2.5528 Soluble
214 V O -1.4018 Soluble
215 D O -2.5407 Soluble
216 K O -2.1865 Soluble
217 R O -2.8730 Soluble
218 V O 0.0000 Buried
219 E O -2.6257 Soluble
220 P O -1.4217 Soluble
2 I P 1.3743 Aggregation-prone
3 V P 1.5062 Aggregation-prone
4 L P 0.0000 Buried
5 T P -0.8025 Soluble
6 Q P 0.0000 Buried
7 S P -1.0383 Soluble
8 P P -0.9204 Soluble
9 D P -1.7037 Soluble
10 F P -0.3419 Soluble
11 Q P -0.6700 Soluble
12 S P -0.5658 Soluble
13 V P 0.0000 Buried
14 T P -1.9159 Soluble
15 P P -2.3391 Soluble
16 K P -3.3652 Soluble
17 E P -3.6536 Soluble
18 K P -3.3873 Soluble
19 V P 0.0000 Buried
20 T P -0.7477 Soluble
21 I P 0.0000 Buried
22 T P -0.9099 Soluble
23 C P 0.0000 Buried
24 R P -2.0631 Soluble
25 A P 0.0000 Buried
26 S P -0.4641 Soluble
27 Q P -0.9052 Soluble
28 S P -1.2959 Soluble
29 I P 0.0000 Buried
36 S P -1.4816 Soluble
37 D P -2.1123 Soluble
38 H P -1.3303 Soluble
39 L P 0.0000 Buried
40 H P 0.0000 Buried
41 W P 0.0000 Buried
42 Y P 0.0000 Buried
43 Q P 0.0000 Buried
44 Q P -1.3637 Soluble
45 K P -1.8667 Soluble
46 P P -1.8460 Soluble
47 D P -2.5436 Soluble
48 Q P -2.5060 Soluble
49 S P -1.6303 Soluble
50 P P 0.0000 Buried
51 K P -1.7111 Soluble
52 L P 0.0000 Buried
53 L P 0.0000 Buried
54 I P 0.0000 Buried
55 K P -0.6339 Soluble
56 Y P -0.7538 Soluble
57 A P 0.0000 Buried
65 S P -1.0614 Soluble
66 H P -1.0084 Soluble
67 A P -0.4181 Soluble
68 I P -0.1096 Soluble
69 S P -0.2662 Soluble
70 G P -0.3734 Soluble
71 V P -0.0456 Soluble
72 P P -0.2981 Soluble
74 S P -0.6587 Soluble
75 R P -1.2711 Soluble
76 F P 0.0000 Buried
77 S P -0.7893 Soluble
78 G P -0.5623 Soluble
79 S P -0.7085 Soluble
80 G P -1.0086 Soluble
83 S P -1.4082 Soluble
84 G P -1.3897 Soluble
85 T P -1.5548 Soluble
86 D P -1.6393 Soluble
87 F P 0.0000 Buried
88 T P -0.6643 Soluble
89 L P 0.0000 Buried
90 T P -0.9274 Soluble
91 I P 0.0000 Buried
92 N P -2.9327 Soluble
93 S P -2.9056 Soluble
94 L P 0.0000 Buried
95 E P -2.6872 Soluble
96 A P -2.5497 Soluble
97 E P -2.5798 Soluble
98 D P 0.0000 Buried
99 A P 0.0000 Buried
100 A P 0.0000 Buried
101 T P -0.6467 Soluble
102 Y P 0.0000 Buried
103 Y P 0.0000 Buried
104 C P 0.0000 Buried
105 Q P 0.0000 Buried
106 Q P 0.0000 Buried
107 G P 0.0000 Buried
108 H P -0.5653 Soluble
109 S P 0.6525 Aggregation-prone
114 F P 1.7287 Aggregation-prone
115 P P 0.9293 Aggregation-prone
116 L P 0.0000 Buried
117 T P 0.5700 Aggregation-prone
118 F P 0.0000 Buried
119 G P 0.0000 Buried
120 G P -1.1138 Soluble
121 G P 0.0000 Buried
122 T P 0.0000 Buried
123 K P -1.0867 Soluble
124 V P 0.0000 Buried
125 E P -1.0591 Soluble
126 I P 0.0000 Buried
127 K P -1.3888 Soluble
128 R P -0.7336 Soluble
129 T P 0.2969 Aggregation-prone
130 V P 1.0040 Aggregation-prone
131 A P 0.4445 Aggregation-prone
132 A P 0.0017 Aggregation-prone
133 P P 0.0000 Buried
134 S P -0.1715 Soluble
135 V P 0.0000 Buried
136 F P 0.0645 Aggregation-prone
137 I P 0.0489 Aggregation-prone
138 F P 0.0000 Buried
139 P P -0.7479 Soluble
140 P P -0.8620 Soluble
141 S P -1.6849 Soluble
142 D P -3.0123 Soluble
143 E P -3.0442 Soluble
144 Q P 0.0000 Buried
145 L P -1.9900 Soluble
146 K P -2.8079 Soluble
147 S P -1.7156 Soluble
148 G P -1.1780 Soluble
149 T P -0.7433 Soluble
150 A P 0.0000 Buried
151 S P 0.0000 Buried
152 V P 0.0000 Buried
153 V P 0.0000 Buried
154 C P 0.0000 Buried
155 L P 0.0000 Buried
156 L P 0.0000 Buried
157 N P 0.0000 Buried
158 N P -0.9498 Soluble
159 F P 0.0000 Buried
160 Y P 0.0000 Buried
161 P P -1.6320 Soluble
162 R P -3.1838 Soluble
163 E P -3.2665 Soluble
164 A P -2.3544 Soluble
165 K P -2.3407 Soluble
166 V P -1.0047 Soluble
167 Q P -0.4461 Soluble
168 W P 0.0000 Buried
169 K P -0.5167 Soluble
170 V P 0.0000 Buried
171 D P -2.1265 Soluble
172 N P -1.5268 Soluble
173 A P -0.3078 Soluble
174 L P 0.7386 Aggregation-prone
175 Q P -0.1433 Soluble
176 S P -0.4286 Soluble
177 G P -0.8591 Soluble
178 N P -0.7738 Soluble
179 S P -0.9118 Soluble
180 Q P -0.9383 Soluble
181 E P -1.4693 Soluble
182 S P 0.0000 Buried
183 V P -0.7980 Soluble
184 T P -1.2141 Soluble
185 E P -2.3076 Soluble
186 Q P -2.1796 Soluble
187 D P -2.3333 Soluble
188 S P -2.5413 Soluble
189 K P -2.8912 Soluble
190 D P -2.2297 Soluble
191 S P 0.0000 Buried
192 T P 0.0000 Buried
193 Y P 0.0000 Buried
194 S P 0.0000 Buried
195 L P 0.0000 Buried
196 S P 0.0000 Buried
197 S P 0.0000 Buried
198 T P -0.4785 Soluble
199 L P 0.0000 Buried
200 T P -0.2256 Soluble
201 L P -0.5619 Soluble
202 S P -1.0554 Soluble
203 K P -1.8249 Soluble
204 A P -1.7599 Soluble
205 D P -2.3610 Soluble
206 Y P 0.0000 Buried
207 E P -3.6512 Soluble
208 K P -3.6406 Soluble
209 H P -3.2627 Soluble
210 K P -3.4458 Soluble
211 V P -1.7996 Soluble
212 Y P 0.0000 Buried
213 A P 0.0000 Buried
214 C P 0.0000 Buried
215 E P -0.5867 Soluble
216 V P 0.0000 Buried
217 T P -1.1693 Soluble
218 H P 0.0000 Buried
219 Q P -1.6424 Soluble
220 G P -0.3286 Soluble
221 L P -0.3510 Soluble
222 S P -0.4416 Soluble
223 S P -0.4084 Soluble
224 P P -0.5181 Soluble
225 V P -0.0040 Soluble
226 T P -0.4360 Soluble
227 K P -0.6568 Soluble
228 S P -0.7150 Soluble
229 F P -1.0609 Soluble
230 N P -2.3514 Soluble
231 R P -2.5647 Soluble
232 G P -1.5058 Soluble

3D Structure — colored by A4D score

Sequence - click residue to focus in viewer  |  colored by A4D score
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Color Legend (B-factor = A4D Score)
Score > 1.5 — highly aggregation-prone
Score 0.5–1.5 — aggregation-prone
Score ≈ 0 — buried
Score −1 to −0.5 — soluble
Score < −2.5 — highly soluble
pH Structure
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A4D Score Threshold
Highlight residues > threshold in the sequence panel
CDR Regions
HCDR1
HCDR2
HCDR3
LCDR1
LCDR2
LCDR3
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pH-Dependent Aggregation Profiles

A4D scores calculated across 11 pH conditions (4.0–9.0, step 0.5). Click a row to view the structure at that pH. The input structure is globular — max score is recommended for pH analysis.

pH Avg A4D Score Max A4D Score Downloads
4.0 -0.6654 4.3965 CSV PDB
4.5 -0.711 4.3776 CSV PDB
5.0 -0.7635 4.3555 CSV PDB
5.5 -0.8111 4.3372 CSV PDB
6.0 -0.8416 4.3256 CSV PDB
6.5 -0.8483 4.3151 CSV PDB
7.0 -0.8338 4.2977 CSV PDB
7.5 -0.8061 4.2728 CSV PDB
8.0 -0.7707 4.2441 CSV PDB
8.5 -0.7286 4.2154 CSV PDB
9.0 -0.6792 4.1904 CSV PDB
Average A4D Score vs pH
Max A4D Score vs pH