Ociperlimab / 8jen

A4DAB185_8jen_E_F | Source PDB: 8jen | Chains: E, F | Done
100
Yes
10 Å
Yes
Avg A4D Score
-0.7093
Max Score
1.2068
Min Score
-3.5972
Total Score
-305.69
Score CDR
-0.4409
Score non-CDR
-0.7413

Calculation Parameters

Chain Sequence(s) EVQLVESGGGLVQPGGSLRLSCAASGFTFSDYYMYWVRQAPGKGLEWVAYITKGGGSTYYPDSVKGRFTISRDNAKNTLYLQMNSLRAEDTAVYYCARQTNYDFTMDYWGQGTLVTVSSASTKGPSVFPLAPSSGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCEIVMTQSPATLSVSPGERATLSCKASQDVGTSVAWYQQKPGQAPRLLIYWASARHTGIPARFSGSGSGTEFTLTISSLQSEDFAVYYCQQYSSYPLTFGGGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC input.pdb
Selected Chain(s) E (Heavy), F (Light)
Distance of Aggregation 10 Å
FoldX Energy Minimization Yes
pH Calculations Yes
Downloads Download all data (.tar.gz)

Aggrescan4D Profile

Aggregation-prone (score > 0)
Soluble (score < 0)
Buried (score = 0)

Per-Residue A4D Scores

Download CSV
Minimum Score -3.5972
Maximum Score 1.2068
Average Score -0.7093
Total Score -305.6941

Residues with A4D score > 0.0 are highlighted as aggregation-prone.

Index Residue Chain A4D Score Classification
1 E E -2.1582 Soluble
2 V E -1.4148 Soluble
3 Q E -1.4170 Soluble
4 L E 0.0000 Buried
5 V E 0.6263 Aggregation-prone
6 E E 0.0000 Buried
7 S E -0.4711 Soluble
8 G E -1.0102 Soluble
9 G E -0.6026 Soluble
11 G E -0.1183 Soluble
12 L E -0.0345 Soluble
13 V E 0.0000 Buried
14 Q E -1.6921 Soluble
15 P E -1.8606 Soluble
16 G E -1.5462 Soluble
17 G E -1.1380 Soluble
18 S E -1.3414 Soluble
19 L E -1.2139 Soluble
20 R E -2.1680 Soluble
21 L E 0.0000 Buried
22 S E -0.4894 Soluble
23 C E 0.0000 Buried
24 A E -0.1317 Soluble
25 A E 0.0000 Buried
26 S E -0.8779 Soluble
27 G E -1.2950 Soluble
28 F E -0.8011 Soluble
29 T E -0.7013 Soluble
30 F E 0.0000 Buried
35 S E -1.4832 Soluble
36 D E -2.1657 Soluble
37 Y E -1.0977 Soluble
38 Y E -0.3468 Soluble
39 M E 0.0000 Buried
40 Y E 0.0000 Buried
41 W E 0.0000 Buried
42 V E 0.0000 Buried
43 R E 0.0000 Buried
44 Q E -0.7488 Soluble
45 A E -1.1383 Soluble
46 P E -0.9598 Soluble
47 G E -1.5009 Soluble
48 K E -2.2689 Soluble
49 G E -1.3852 Soluble
50 L E 0.0000 Buried
51 E E -0.8780 Soluble
52 W E 0.0000 Buried
53 V E 0.0000 Buried
54 A E 0.0000 Buried
55 Y E 0.0000 Buried
56 I E 0.0000 Buried
57 T E -0.6785 Soluble
58 K E -1.4417 Soluble
59 G E -1.3927 Soluble
62 G E -0.9573 Soluble
63 G E -0.8294 Soluble
64 S E -0.3777 Soluble
65 T E 0.1643 Aggregation-prone
66 Y E 0.4262 Aggregation-prone
67 Y E -0.4598 Soluble
68 P E 0.0000 Buried
69 D E -2.3707 Soluble
70 S E -1.5880 Soluble
71 V E 0.0000 Buried
72 K E -2.5121 Soluble
74 G E -1.7899 Soluble
75 R E -1.4309 Soluble
76 F E 0.0000 Buried
77 T E -0.8638 Soluble
78 I E 0.0000 Buried
79 S E -0.5374 Soluble
80 R E -1.0447 Soluble
81 D E -1.4603 Soluble
82 N E -1.7622 Soluble
83 A E -1.2566 Soluble
84 K E -2.1678 Soluble
85 N E -1.5810 Soluble
86 T E -0.8719 Soluble
87 L E 0.0000 Buried
88 Y E -0.6597 Soluble
89 L E 0.0000 Buried
90 Q E -1.5434 Soluble
91 M E 0.0000 Buried
92 N E -1.4392 Soluble
93 S E -1.3363 Soluble
94 L E 0.0000 Buried
95 R E -2.8745 Soluble
96 A E -2.0601 Soluble
97 E E -2.4181 Soluble
98 D E 0.0000 Buried
99 T E -0.8739 Soluble
100 A E 0.0000 Buried
101 V E 0.1522 Aggregation-prone
102 Y E 0.0000 Buried
103 Y E 0.0000 Buried
104 C E 0.0000 Buried
105 A E 0.0000 Buried
106 R E 0.0000 Buried
107 Q E 0.0000 Buried
108 T E 0.0000 Buried
109 N E -1.0600 Soluble
110 Y E 0.1890 Aggregation-prone
112 D E 0.3883 Aggregation-prone
113 F E 0.8911 Aggregation-prone
114 T E 0.0000 Buried
115 M E 0.0000 Buried
116 D E 0.0000 Buried
117 Y E -0.2029 Soluble
118 W E 0.0000 Buried
119 G E 0.0000 Buried
120 Q E -1.3773 Soluble
121 G E -0.5389 Soluble
122 T E 0.0000 Buried
123 L E 0.0906 Aggregation-prone
124 V E 0.0000 Buried
125 T E 0.0000 Buried
126 V E 0.0000 Buried
127 S E -1.0693 Soluble
128 S E -0.7220 Soluble
129 A E -0.4984 Soluble
130 S E -0.5914 Soluble
131 T E -0.5875 Soluble
132 K E -1.1220 Soluble
133 G E -1.3171 Soluble
134 P E -0.5519 Soluble
135 S E -0.4007 Soluble
136 V E 0.0000 Buried
137 F E -0.8038 Soluble
138 P E -1.3296 Soluble
139 L E 0.0000 Buried
140 A E -1.2313 Soluble
141 P E 0.0000 Buried
142 S E -0.6912 Soluble
143 S E -0.3439 Soluble
144 G E -0.6326 Soluble
145 T E -0.5138 Soluble
146 A E -0.2677 Soluble
147 A E 0.0000 Buried
148 L E 0.0000 Buried
149 G E 0.0000 Buried
150 C E 0.0000 Buried
151 L E 0.0000 Buried
152 V E 0.0000 Buried
153 K E 0.0000 Buried
154 D E -0.3559 Soluble
155 Y E 0.0000 Buried
156 F E 0.0000 Buried
157 P E 0.0000 Buried
158 E E -0.5536 Soluble
159 P E -0.7369 Soluble
160 V E -0.6153 Soluble
161 T E -0.4729 Soluble
162 V E -0.0473 Soluble
163 S E -0.2610 Soluble
164 W E 0.0000 Buried
165 N E -0.8082 Soluble
166 S E -0.5609 Soluble
167 G E -0.5476 Soluble
168 A E -0.2509 Soluble
169 L E -0.0141 Soluble
170 T E -0.1712 Soluble
171 S E -0.1714 Soluble
172 G E -0.1253 Soluble
173 V E 0.2095 Aggregation-prone
174 H E -0.2474 Soluble
175 T E 0.0252 Aggregation-prone
176 F E 0.0000 Buried
177 P E -0.2970 Soluble
178 A E 0.1588 Aggregation-prone
179 V E 0.4120 Aggregation-prone
180 L E 1.0202 Aggregation-prone
181 Q E 0.1115 Aggregation-prone
182 S E -0.1011 Soluble
183 S E -0.1987 Soluble
184 G E 0.0513 Aggregation-prone
185 L E 0.1231 Aggregation-prone
186 Y E 0.3866 Aggregation-prone
187 S E 0.2503 Aggregation-prone
188 L E 0.0000 Buried
189 S E 0.0000 Buried
190 S E 0.0000 Buried
191 V E 0.0000 Buried
192 V E 0.0000 Buried
193 T E -0.1309 Soluble
194 V E 0.0000 Buried
195 P E -0.5053 Soluble
196 S E -0.6040 Soluble
197 S E -0.6416 Soluble
198 S E -0.6517 Soluble
199 L E -0.8244 Soluble
200 G E -0.9755 Soluble
201 T E -0.7837 Soluble
202 Q E -1.3325 Soluble
203 T E -1.1616 Soluble
204 Y E 0.0000 Buried
205 I E -1.1965 Soluble
206 C E 0.0000 Buried
207 N E -1.2563 Soluble
208 V E 0.0000 Buried
209 N E -1.7303 Soluble
210 H E 0.0000 Buried
211 K E -2.7917 Soluble
212 P E -1.6362 Soluble
213 S E -1.8718 Soluble
214 N E -2.5949 Soluble
215 T E -2.1207 Soluble
216 K E -2.5867 Soluble
217 V E -1.4662 Soluble
218 D E -2.0886 Soluble
219 K E -2.0665 Soluble
220 K E -2.5737 Soluble
221 V E 0.0000 Buried
222 E E -2.9144 Soluble
223 P E -1.9092 Soluble
224 K E -1.8613 Soluble
225 S E -0.8082 Soluble
226 C E 0.0277 Aggregation-prone
1 E F -1.4702 Soluble
2 I F 0.0000 Buried
3 V F 0.7506 Aggregation-prone
4 M F 0.0000 Buried
5 T F -0.2402 Soluble
6 Q F 0.0000 Buried
7 S F -0.5031 Soluble
8 P F -0.3138 Soluble
9 A F -0.2078 Soluble
10 T F -0.1070 Soluble
11 L F -0.0836 Soluble
12 S F -0.5768 Soluble
13 V F 0.0000 Buried
14 S F -1.7107 Soluble
15 P F -1.8010 Soluble
16 G F -2.0163 Soluble
17 E F -2.7665 Soluble
18 R F -2.8637 Soluble
19 A F 0.0000 Buried
20 T F -0.6486 Soluble
21 L F 0.0000 Buried
22 S F -0.8908 Soluble
23 C F 0.0000 Buried
24 K F -2.4012 Soluble
25 A F -1.5311 Soluble
26 S F -1.4176 Soluble
27 Q F -2.5449 Soluble
28 D F -2.9764 Soluble
29 V F 0.0000 Buried
36 G F -1.0967 Soluble
37 T F -0.3477 Soluble
38 S F 0.1179 Aggregation-prone
39 V F 0.0000 Buried
40 A F 0.0000 Buried
41 W F 0.0000 Buried
42 Y F 0.0000 Buried
43 Q F 0.0000 Buried
44 Q F 0.0000 Buried
45 K F -2.0171 Soluble
46 P F -1.5226 Soluble
47 G F -1.5731 Soluble
48 Q F -2.3706 Soluble
49 A F -1.6478 Soluble
50 P F 0.0000 Buried
51 R F -2.0021 Soluble
52 L F 0.0000 Buried
53 L F 0.0000 Buried
54 I F 0.0000 Buried
55 Y F 0.4879 Aggregation-prone
56 W F 1.0254 Aggregation-prone
57 A F 0.0000 Buried
65 S F -0.2565 Soluble
66 A F -0.2843 Soluble
67 R F -1.0208 Soluble
68 H F 0.0000 Buried
69 T F -0.5114 Soluble
70 G F -0.5722 Soluble
71 I F -0.5630 Soluble
72 P F -0.3742 Soluble
74 A F -0.3774 Soluble
75 R F -0.7093 Soluble
76 F F 0.0000 Buried
77 S F -0.5838 Soluble
78 G F -0.3785 Soluble
79 S F -0.5927 Soluble
80 G F -1.1110 Soluble
83 S F -1.1162 Soluble
84 G F -1.9194 Soluble
85 T F -2.4988 Soluble
86 E F -2.9974 Soluble
87 F F 0.0000 Buried
88 T F -0.8954 Soluble
89 L F 0.0000 Buried
90 T F -0.5949 Soluble
91 I F 0.0000 Buried
92 S F -1.4581 Soluble
93 S F -1.8482 Soluble
94 L F 0.0000 Buried
95 Q F -2.1938 Soluble
96 S F -1.7985 Soluble
97 E F -2.3114 Soluble
98 D F 0.0000 Buried
99 F F 0.0000 Buried
100 A F 0.0000 Buried
101 V F -0.2032 Soluble
102 Y F 0.0000 Buried
103 Y F 0.0000 Buried
104 C F 0.0000 Buried
105 Q F 0.0000 Buried
106 Q F 0.0000 Buried
107 Y F 0.0000 Buried
108 S F -0.3929 Soluble
109 S F -0.3991 Soluble
114 Y F 0.2075 Aggregation-prone
115 P F -0.4269 Soluble
116 L F 0.0000 Buried
117 T F 0.0076 Aggregation-prone
118 F F 0.1928 Aggregation-prone
119 G F 0.0000 Buried
120 G F -0.6656 Soluble
121 G F 0.0000 Buried
122 T F 0.0000 Buried
123 K F -0.4017 Soluble
124 V F 0.0000 Buried
125 E F 0.0000 Buried
126 I F -1.0469 Soluble
127 K F -1.4482 Soluble
128 R F -0.8870 Soluble
129 T F 0.1324 Aggregation-prone
130 V F 1.2068 Aggregation-prone
131 A F 0.3395 Aggregation-prone
132 A F 0.0158 Aggregation-prone
133 P F 0.0000 Buried
134 S F -0.1046 Soluble
135 V F 0.0000 Buried
136 F F 0.3263 Aggregation-prone
137 I F 0.2819 Aggregation-prone
138 F F 0.0000 Buried
139 P F -0.4669 Soluble
140 P F 0.0000 Buried
141 S F -1.8544 Soluble
142 D F -3.0398 Soluble
143 E F -3.2048 Soluble
144 Q F 0.0000 Buried
145 L F -2.2678 Soluble
146 K F -2.9419 Soluble
147 S F -1.8471 Soluble
148 G F -1.4629 Soluble
149 T F -1.1252 Soluble
150 A F 0.0000 Buried
151 S F 0.0000 Buried
152 V F 0.0000 Buried
153 V F 0.0000 Buried
154 C F 0.0000 Buried
155 L F 0.0000 Buried
156 L F 0.0000 Buried
157 N F 0.0000 Buried
158 N F -1.0036 Soluble
159 F F 0.0000 Buried
160 Y F 0.0000 Buried
161 P F -1.4167 Soluble
162 R F -2.7157 Soluble
163 E F -3.0296 Soluble
164 A F -2.2318 Soluble
165 K F -2.2821 Soluble
166 V F -1.2301 Soluble
167 Q F -0.7487 Soluble
168 W F 0.0000 Buried
169 K F -0.8290 Soluble
170 V F 0.0000 Buried
171 D F -2.1478 Soluble
172 N F -1.7339 Soluble
173 A F -0.4526 Soluble
174 L F 0.3950 Aggregation-prone
175 Q F -0.5414 Soluble
176 S F -0.6612 Soluble
177 G F -1.2036 Soluble
178 N F -1.4108 Soluble
179 S F -1.5232 Soluble
180 Q F -1.6627 Soluble
181 E F -1.6915 Soluble
182 S F -0.7133 Soluble
183 V F -0.5588 Soluble
184 T F -0.8883 Soluble
185 E F -1.6351 Soluble
186 Q F -1.6531 Soluble
187 D F -2.0067 Soluble
188 S F -1.8313 Soluble
189 K F -2.6147 Soluble
190 D F -2.4063 Soluble
191 S F -2.0011 Soluble
192 T F 0.0000 Buried
193 Y F 0.0000 Buried
194 S F 0.0000 Buried
195 L F 0.0000 Buried
196 S F 0.0000 Buried
197 S F 0.0000 Buried
198 T F -0.7910 Soluble
199 L F 0.0000 Buried
200 T F -0.6183 Soluble
201 L F -0.7697 Soluble
202 S F -1.0928 Soluble
203 K F -2.1801 Soluble
204 A F -1.8403 Soluble
205 D F -2.4822 Soluble
206 Y F 0.0000 Buried
207 E F -3.4882 Soluble
208 K F -3.5972 Soluble
209 H F -3.1524 Soluble
210 K F -3.2406 Soluble
211 V F -1.4195 Soluble
212 Y F 0.0000 Buried
213 A F 0.0000 Buried
214 C F 0.0000 Buried
215 E F -0.9652 Soluble
216 V F 0.0000 Buried
217 T F -1.1791 Soluble
218 H F 0.0000 Buried
219 Q F -1.4530 Soluble
220 G F -0.2829 Soluble
221 L F -0.1928 Soluble
222 S F -0.4503 Soluble
223 S F -0.4527 Soluble
224 P F -0.5888 Soluble
225 V F -0.0329 Soluble
226 T F -0.4754 Soluble
227 K F -0.6253 Soluble
228 S F -0.4359 Soluble
229 F F -0.7131 Soluble
230 N F -1.6743 Soluble
231 R F -2.2896 Soluble
232 G F -1.8209 Soluble
233 E F -1.9648 Soluble
234 C F -0.4780 Soluble

3D Structure — colored by A4D score

Sequence - click residue to focus in viewer  |  colored by A4D score
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Color Legend (B-factor = A4D Score)
Score > 1.5 — highly aggregation-prone
Score 0.5–1.5 — aggregation-prone
Score ≈ 0 — buried
Score −1 to −0.5 — soluble
Score < −2.5 — highly soluble
pH Structure
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A4D Score Threshold
Highlight residues > threshold in the sequence panel
CDR Regions
HCDR1
HCDR2
HCDR3
LCDR1
LCDR2
LCDR3
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pH-Dependent Aggregation Profiles

A4D scores calculated across 11 pH conditions (4.0–9.0, step 0.5). Click a row to view the structure at that pH. The input structure is globular — max score is recommended for pH analysis.

pH Avg A4D Score Max A4D Score Downloads
4.0 -0.6558 2.8236 CSV PDB
4.5 -0.6994 2.8123 CSV PDB
5.0 -0.7516 2.8002 CSV PDB
5.5 -0.8022 2.7879 CSV PDB
6.0 -0.8391 2.7755 CSV PDB
6.5 -0.8522 2.7632 CSV PDB
7.0 -0.8402 2.7509 CSV PDB
7.5 -0.8113 2.7391 CSV PDB
8.0 -0.7731 2.7283 CSV PDB
8.5 -0.7288 2.7198 CSV PDB
9.0 -0.6783 2.7144 CSV PDB
Average A4D Score vs pH
Max A4D Score vs pH