Gatralimab / 6obd

A4DAB126_6obd_H_L | Source PDB: 6obd | Chains: H, L | Done
100
Yes
10 Å
Yes
Avg A4D Score
-0.7326
Max Score
1.1722
Min Score
-3.6574
Total Score
-312.83
Score CDR
—
Score non-CDR
—

Calculation Parameters

Chain Sequence(s) EVQLVESGGGLVQPGGSLRLSCAASGFPFSNYWMNWVRQAPGKGLEWVGQIRLKSNNYATHYAESVKGRFTISRDDSKNSLYLQMNSLKTEDTAVYYCTPIDYWGQGTTVTVSSASTKGPSVFPLAPSSSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPDIVMTQTPLSLSVTPGQPASISCKSSQSLLYSNGKTYLNWVLQKPGQSPQRLIYLVSKLDSGVPDRFSGSGSGTDFTLKISRVEAEDVGVYYCVQGSHFHTFGQGTKLEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRG input.pdb
Selected Chain(s) H (Heavy), L (Light)
Distance of Aggregation 10 Å
FoldX Energy Minimization Yes
pH Calculations Yes
Downloads Download all data (.tar.gz)

Aggrescan4D Profile

Aggregation-prone (score > 0)
Soluble (score < 0)
Buried (score = 0)

Per-Residue A4D Scores

Download CSV
Minimum Score -3.6574
Maximum Score 1.1722
Average Score -0.7326
Total Score -312.8301

Residues with A4D score > 0.0 are highlighted as aggregation-prone.

Index Residue Chain A4D Score Classification
1 E H -2.0751 Soluble
2 V H -1.2008 Soluble
3 Q H -1.1334 Soluble
4 L H 0.0000 Buried
5 V H 1.1722 Aggregation-prone
6 E H 0.0000 Buried
7 S H -0.3929 Soluble
8 G H -0.9643 Soluble
9 G H -0.6265 Soluble
11 G H -0.2767 Soluble
12 L H 0.0680 Aggregation-prone
13 V H 0.0000 Buried
14 Q H -1.6048 Soluble
15 P H -1.7874 Soluble
16 G H -1.4791 Soluble
17 G H -1.1128 Soluble
18 S H -1.3295 Soluble
19 L H -1.2107 Soluble
20 R H -2.2448 Soluble
21 L H 0.0000 Buried
22 S H -0.3811 Soluble
23 C H 0.0000 Buried
24 A H -0.1477 Soluble
25 A H 0.0000 Buried
26 S H -1.0918 Soluble
27 G H -1.2894 Soluble
28 F H -0.7163 Soluble
29 P H -0.7366 Soluble
30 F H 0.0000 Buried
35 S H -1.5629 Soluble
36 N H -1.4899 Soluble
37 Y H -0.3334 Soluble
38 W H 0.2501 Aggregation-prone
39 M H 0.0000 Buried
40 N H 0.0000 Buried
41 W H 0.0000 Buried
42 V H 0.0000 Buried
43 R H 0.0000 Buried
44 Q H -0.8738 Soluble
45 A H -1.2705 Soluble
46 P H -1.1856 Soluble
47 G H -1.4625 Soluble
48 K H -2.3356 Soluble
49 G H -1.5446 Soluble
50 L H 0.0000 Buried
51 E H -1.0793 Soluble
52 W H 0.0000 Buried
53 V H 0.0000 Buried
54 G H 0.0000 Buried
55 Q H 0.0000 Buried
56 I H 0.0000 Buried
57 R H -0.8852 Soluble
58 L H -1.4605 Soluble
59 K H -2.6094 Soluble
60 S H -1.8107 Soluble
61 N H -1.7448 Soluble
62 N H -2.0440 Soluble
63 Y H -1.0582 Soluble
64 A H -0.7722 Soluble
65 T H -0.2932 Soluble
66 H H -0.6321 Soluble
67 Y H -1.0026 Soluble
68 A H -1.6524 Soluble
69 E H -2.7458 Soluble
70 S H -1.6262 Soluble
71 V H 0.0000 Buried
72 K H -2.6316 Soluble
74 G H -1.7379 Soluble
75 R H -1.3590 Soluble
76 F H 0.0000 Buried
77 T H -0.9816 Soluble
78 I H 0.0000 Buried
79 S H -0.3549 Soluble
80 R H 0.0000 Buried
81 D H -1.8807 Soluble
82 D H -1.9932 Soluble
83 S H -1.6086 Soluble
84 K H -2.4108 Soluble
85 N H -1.8505 Soluble
86 S H 0.0000 Buried
87 L H 0.0000 Buried
88 Y H -0.5548 Soluble
89 L H 0.0000 Buried
90 Q H -1.6350 Soluble
91 M H 0.0000 Buried
92 N H -1.4318 Soluble
93 S H -1.2445 Soluble
94 L H 0.0000 Buried
95 K H -2.5842 Soluble
96 T H -1.9924 Soluble
97 E H -2.3956 Soluble
98 D H 0.0000 Buried
99 T H -0.9105 Soluble
100 A H 0.0000 Buried
101 V H 0.0289 Aggregation-prone
102 Y H 0.0000 Buried
103 Y H 0.0000 Buried
104 C H 0.0000 Buried
105 T H 0.0000 Buried
106 P H 0.0000 Buried
107 I H 0.0000 Buried
116 D H -0.4105 Soluble
117 Y H -0.1580 Soluble
118 W H -0.2935 Soluble
119 G H -0.4864 Soluble
120 Q H -1.1504 Soluble
121 G H 0.0000 Buried
122 T H -0.1596 Soluble
123 T H -0.2674 Soluble
124 V H 0.0000 Buried
125 T H -0.5626 Soluble
126 V H 0.0000 Buried
127 S H -0.9966 Soluble
128 S H -0.6603 Soluble
129 A H -0.4170 Soluble
130 S H -0.4476 Soluble
131 T H -0.8026 Soluble
132 K H -1.2571 Soluble
133 G H -1.4215 Soluble
134 P H 0.0000 Buried
135 S H -0.2341 Soluble
136 V H 0.0000 Buried
137 F H 0.0000 Buried
138 P H -1.1735 Soluble
139 L H 0.0000 Buried
140 A H -0.8808 Soluble
141 P H 0.0000 Buried
142 S H -0.5894 Soluble
143 S H -0.4723 Soluble
144 S H -0.6837 Soluble
145 G H -0.9188 Soluble
146 G H -0.9315 Soluble
147 T H -0.7009 Soluble
148 A H -0.3957 Soluble
149 A H 0.0000 Buried
150 L H 0.0000 Buried
151 G H 0.0000 Buried
152 C H 0.0000 Buried
153 L H 0.0000 Buried
154 V H 0.0000 Buried
155 K H 0.0000 Buried
156 D H -0.3557 Soluble
157 Y H 0.0000 Buried
158 F H 0.0000 Buried
159 P H 0.0000 Buried
160 E H -0.6734 Soluble
161 P H -0.8615 Soluble
162 V H -0.7122 Soluble
163 T H -0.5738 Soluble
164 V H -0.3523 Soluble
165 S H -0.3760 Soluble
166 W H 0.0000 Buried
167 N H -0.8223 Soluble
168 S H -0.6731 Soluble
169 G H -0.5769 Soluble
170 A H -0.2545 Soluble
171 L H -0.0344 Soluble
172 T H -0.2005 Soluble
173 S H -0.2243 Soluble
174 G H -0.3492 Soluble
175 V H 0.1434 Aggregation-prone
176 H H -0.3240 Soluble
177 T H -0.0060 Soluble
178 F H 0.0000 Buried
179 P H -0.3043 Soluble
180 A H 0.1871 Aggregation-prone
181 V H 0.4935 Aggregation-prone
182 L H 0.9106 Aggregation-prone
183 Q H 0.1805 Aggregation-prone
184 S H -0.1030 Soluble
185 S H -0.2236 Soluble
186 G H -0.0485 Soluble
187 L H 0.1160 Aggregation-prone
188 Y H 0.3601 Aggregation-prone
189 S H 0.0000 Buried
190 L H 0.0000 Buried
191 S H 0.0000 Buried
192 S H 0.0000 Buried
193 V H 0.0000 Buried
194 V H 0.0000 Buried
195 T H -0.1490 Soluble
196 V H 0.0000 Buried
197 P H -0.5458 Soluble
198 S H -0.6904 Soluble
199 S H -0.5495 Soluble
200 S H 0.0000 Buried
201 L H -0.4863 Soluble
202 G H -0.5489 Soluble
203 T H -0.5284 Soluble
204 Q H -0.9073 Soluble
205 T H -0.9014 Soluble
206 Y H 0.0000 Buried
207 I H -1.1191 Soluble
208 C H 0.0000 Buried
209 N H -1.4415 Soluble
210 V H 0.0000 Buried
211 N H -1.8646 Soluble
212 H H 0.0000 Buried
213 K H -2.7748 Soluble
214 P H -1.6633 Soluble
215 S H -1.9115 Soluble
216 N H -2.5677 Soluble
217 T H -2.0923 Soluble
218 K H -2.6613 Soluble
219 V H -1.7083 Soluble
220 D H -2.5041 Soluble
221 K H -2.1605 Soluble
222 K H -2.4654 Soluble
223 V H 0.0000 Buried
224 E H -2.3503 Soluble
225 P H -1.1461 Soluble
1 D L -1.7281 Soluble
2 I L -0.0675 Soluble
3 V L 0.9870 Aggregation-prone
4 M L 0.0000 Buried
5 T L -0.1728 Soluble
6 Q L 0.0000 Buried
7 T L 0.0587 Aggregation-prone
8 P L 0.3455 Aggregation-prone
9 L L 1.0477 Aggregation-prone
10 S L 0.2851 Aggregation-prone
11 L L 0.0667 Aggregation-prone
12 S L -0.5710 Soluble
13 V L -1.0878 Soluble
14 T L -1.5741 Soluble
15 P L -1.7549 Soluble
16 G L -1.7906 Soluble
17 Q L -2.3419 Soluble
18 P L -2.0925 Soluble
19 A L 0.0000 Buried
20 S L -0.9004 Soluble
21 I L 0.0000 Buried
22 S L -0.7350 Soluble
23 C L 0.0000 Buried
24 K L -1.5731 Soluble
25 S L 0.0000 Buried
26 S L -0.6185 Soluble
27 Q L -1.0734 Soluble
28 S L -0.3911 Soluble
29 L L 0.0000 Buried
30 L L 1.0216 Aggregation-prone
31 Y L 0.5714 Aggregation-prone
32 S L -0.4223 Soluble
34 N L -1.4663 Soluble
35 G L -1.0385 Soluble
36 K L -1.2674 Soluble
37 T L 0.0659 Aggregation-prone
38 Y L 0.4957 Aggregation-prone
39 L L 0.0000 Buried
40 N L 0.0000 Buried
41 W L 0.0000 Buried
42 V L 0.0000 Buried
43 L L 0.0000 Buried
44 Q L -1.0895 Soluble
45 K L -1.5967 Soluble
46 P L -1.4876 Soluble
47 G L -1.5077 Soluble
48 Q L -2.0621 Soluble
49 S L -1.5134 Soluble
50 P L 0.0000 Buried
51 Q L -1.3142 Soluble
52 R L -0.6223 Soluble
53 L L 0.0000 Buried
54 I L 0.0000 Buried
55 Y L -0.1245 Soluble
56 L L -0.1506 Soluble
57 V L -0.3584 Soluble
65 S L -0.8181 Soluble
66 K L -1.4545 Soluble
67 L L -0.8346 Soluble
68 D L -0.7657 Soluble
69 S L -0.6052 Soluble
70 G L -0.7020 Soluble
71 V L -0.5967 Soluble
72 P L -1.0848 Soluble
74 D L -2.1248 Soluble
75 R L -2.1145 Soluble
76 F L 0.0000 Buried
77 S L -1.5015 Soluble
78 G L -0.9501 Soluble
79 S L -1.1070 Soluble
80 G L -1.0947 Soluble
83 S L -0.6762 Soluble
84 G L -0.4365 Soluble
85 T L -1.2663 Soluble
86 D L -2.1205 Soluble
87 F L 0.0000 Buried
88 T L -1.1412 Soluble
89 L L 0.0000 Buried
90 K L -2.1965 Soluble
91 I L 0.0000 Buried
92 S L -2.3483 Soluble
93 R L -3.2017 Soluble
94 V L 0.0000 Buried
95 E L -2.2280 Soluble
96 A L -1.7943 Soluble
97 E L -2.1497 Soluble
98 D L 0.0000 Buried
99 V L -1.0109 Soluble
100 G L 0.0000 Buried
101 V L -0.1798 Soluble
102 Y L 0.0000 Buried
103 Y L 0.0000 Buried
104 C L 0.0000 Buried
105 V L 0.0000 Buried
106 Q L 0.0000 Buried
107 G L 0.1672 Aggregation-prone
108 S L 0.0000 Buried
114 H L -0.2722 Soluble
115 F L 0.1076 Aggregation-prone
116 H L -0.1066 Soluble
117 T L -0.1303 Soluble
118 F L 0.0000 Buried
119 G L 0.0000 Buried
120 Q L -0.9822 Soluble
121 G L 0.0000 Buried
122 T L 0.0000 Buried
123 K L -0.4832 Soluble
124 L L 0.0000 Buried
125 E L -0.9350 Soluble
126 I L 0.0000 Buried
127 K L -1.5646 Soluble
128 R L -1.1375 Soluble
129 T L -0.0881 Soluble
130 V L 0.4777 Aggregation-prone
131 A L 0.0601 Aggregation-prone
132 A L -0.0564 Soluble
133 P L 0.0000 Buried
134 S L -0.1375 Soluble
135 V L 0.0593 Aggregation-prone
136 F L 0.1387 Aggregation-prone
137 I L 0.1064 Aggregation-prone
138 F L 0.0000 Buried
139 P L -0.6370 Soluble
140 P L -0.8597 Soluble
141 S L -1.6619 Soluble
142 D L -2.9971 Soluble
143 E L -3.0654 Soluble
144 Q L 0.0000 Buried
145 L L -2.2116 Soluble
146 K L -2.8567 Soluble
147 S L -1.7972 Soluble
148 G L -1.2847 Soluble
149 T L -1.0840 Soluble
150 A L 0.0000 Buried
151 S L 0.0000 Buried
152 V L 0.0000 Buried
153 V L 0.0000 Buried
154 C L 0.0000 Buried
155 L L 0.0000 Buried
156 L L 0.0000 Buried
157 N L -0.3357 Soluble
158 N L -0.8118 Soluble
159 F L 0.0000 Buried
160 Y L 0.0000 Buried
161 P L -1.5035 Soluble
162 R L -2.6297 Soluble
163 E L -3.0407 Soluble
164 A L -2.3504 Soluble
165 K L -2.4429 Soluble
166 V L 0.0000 Buried
167 Q L -0.8740 Soluble
168 W L 0.0000 Buried
169 K L -0.5312 Soluble
170 V L 0.0000 Buried
171 D L -1.5180 Soluble
172 N L -1.4096 Soluble
173 A L -0.1991 Soluble
174 L L 0.7121 Aggregation-prone
175 Q L -0.3624 Soluble
176 S L -0.6841 Soluble
177 G L -1.3044 Soluble
178 N L -1.5930 Soluble
179 S L -1.4597 Soluble
180 Q L -1.4302 Soluble
181 E L -1.4678 Soluble
182 S L -0.6283 Soluble
183 V L -0.7231 Soluble
184 T L -1.1195 Soluble
185 E L -2.2049 Soluble
186 Q L -1.8597 Soluble
187 D L -1.9663 Soluble
188 S L -2.0002 Soluble
189 K L -2.2598 Soluble
190 D L -1.7880 Soluble
191 S L -1.7589 Soluble
192 T L 0.0000 Buried
193 Y L 0.0000 Buried
194 S L 0.0000 Buried
195 L L 0.0000 Buried
196 S L 0.0000 Buried
197 S L 0.0000 Buried
198 T L -0.7060 Soluble
199 L L 0.0000 Buried
200 T L -0.7017 Soluble
201 L L -0.8932 Soluble
202 S L -1.4021 Soluble
203 K L -2.2658 Soluble
204 A L -2.1298 Soluble
205 D L -3.1028 Soluble
206 Y L 0.0000 Buried
207 E L -3.5183 Soluble
208 K L -3.6574 Soluble
209 H L -3.0332 Soluble
210 K L -3.1997 Soluble
211 V L -1.8617 Soluble
212 Y L 0.0000 Buried
213 A L 0.0000 Buried
214 C L 0.0000 Buried
215 E L -0.8066 Soluble
216 V L 0.0000 Buried
217 T L -1.3132 Soluble
218 H L 0.0000 Buried
219 Q L -1.4573 Soluble
220 G L -0.3537 Soluble
221 L L -0.2084 Soluble
222 S L -0.4335 Soluble
223 S L -0.4613 Soluble
224 P L -0.6805 Soluble
225 V L -0.0712 Soluble
226 T L -0.4681 Soluble
227 K L -0.5376 Soluble
228 S L -0.6565 Soluble
229 F L -0.9543 Soluble
230 N L -2.1543 Soluble
231 R L -2.4355 Soluble
232 G L -1.3533 Soluble

3D Structure — colored by A4D score

Sequence - click residue to focus in viewer  |  colored by A4D score
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Color Legend (B-factor = A4D Score)
Score > 1.5 — highly aggregation-prone
Score 0.5–1.5 — aggregation-prone
Score ≈ 0 — buried
Score −1 to −0.5 — soluble
Score < −2.5 — highly soluble
pH Structure
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A4D Score Threshold
Highlight residues > threshold in the sequence panel
CDR Regions
HCDR1
HCDR2
HCDR3
LCDR1
LCDR2
LCDR3
Display Options

pH-Dependent Aggregation Profiles

A4D scores calculated across 11 pH conditions (4.0–9.0, step 0.5). Click a row to view the structure at that pH. The input structure is globular — max score is recommended for pH analysis.

pH Avg A4D Score Max A4D Score Downloads
4.0 -0.7557 1.7271 CSV PDB
4.5 -0.7987 1.6815 CSV PDB
5.0 -0.8481 1.6111 CSV PDB
5.5 -0.8939 1.5542 CSV PDB
6.0 -0.9239 1.5046 CSV PDB
6.5 -0.9275 1.4653 CSV PDB
7.0 -0.9046 1.441 CSV PDB
7.5 -0.864 1.4474 CSV PDB
8.0 -0.8136 1.5337 CSV PDB
8.5 -0.7559 1.6213 CSV PDB
9.0 -0.6919 1.7065 CSV PDB
Average A4D Score vs pH
Max A4D Score vs pH