Calculation Parameters
| Chain Sequence(s) |
QVQLVQSGAEVKKPGASVKVSCKASGYPFTSYGISWVRQAPGQGLEWMGWISTYNGNTNYAQKFQGRVTMTTDTSTTTGYMELRRLRSDDTAVYYCARDYTRGAWFGESLIGGFDNWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSEIVLTQSPGTLSLSPGERATLSCRASQTVSSTSLAWYQQKPGQAPRLLIYGASSRATGIPDRFSGSGSGTDFTLTISRLEPEDFAVYYCQQHDTSLTFGGGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGE
input.pdb
|
| Selected Chain(s) | A (Heavy), B (Light) |
| Distance of Aggregation | 10 Å |
| FoldX Energy Minimization | Yes |
| pH Calculations | Yes |
| Downloads | Download all data (.tar.gz) |
Aggrescan4D Profile
Per-Residue A4D Scores
Download CSVResidues with A4D score > 0.0 are highlighted as aggregation-prone.
| Index | Residue | Chain | A4D Score | Classification |
|---|---|---|---|---|
| 1 | Q | A | -1.3971 | Soluble |
| 2 | V | A | -1.0348 | Soluble |
| 3 | Q | A | -1.5193 | Soluble |
| 4 | L | A | 0.0000 | Buried |
| 5 | V | A | -0.0032 | Soluble |
| 6 | Q | A | 0.0000 | Buried |
| 7 | S | A | -0.5592 | Soluble |
| 8 | G | A | -0.4930 | Soluble |
| 9 | A | A | 0.0879 | Aggregation-prone |
| 11 | E | A | -0.1881 | Soluble |
| 12 | V | A | 0.2616 | Aggregation-prone |
| 13 | K | A | -1.2789 | Soluble |
| 14 | K | A | -2.4389 | Soluble |
| 15 | P | A | -2.4230 | Soluble |
| 16 | G | A | -2.1915 | Soluble |
| 17 | A | A | -1.8200 | Soluble |
| 18 | S | A | -2.0184 | Soluble |
| 19 | V | A | 0.0000 | Buried |
| 20 | K | A | -1.9182 | Soluble |
| 21 | V | A | 0.0000 | Buried |
| 22 | S | A | -0.5637 | Soluble |
| 23 | C | A | 0.0000 | Buried |
| 24 | K | A | -1.0321 | Soluble |
| 25 | A | A | 0.0000 | Buried |
| 26 | S | A | -0.8477 | Soluble |
| 27 | G | A | -0.8986 | Soluble |
| 28 | Y | A | -0.4391 | Soluble |
| 29 | P | A | -0.1995 | Soluble |
| 30 | F | A | 0.0000 | Buried |
| 35 | T | A | 0.3607 | Aggregation-prone |
| 36 | S | A | 0.5141 | Aggregation-prone |
| 37 | Y | A | 0.5893 | Aggregation-prone |
| 38 | G | A | 0.0000 | Buried |
| 39 | I | A | 0.0000 | Buried |
| 40 | S | A | 0.0000 | Buried |
| 41 | W | A | 0.0000 | Buried |
| 42 | V | A | 0.0000 | Buried |
| 43 | R | A | -0.3283 | Soluble |
| 44 | Q | A | -0.6016 | Soluble |
| 45 | A | A | -0.9817 | Soluble |
| 46 | P | A | -0.7804 | Soluble |
| 47 | G | A | -1.2207 | Soluble |
| 48 | Q | A | -1.7404 | Soluble |
| 49 | G | A | -1.1211 | Soluble |
| 50 | L | A | 0.0000 | Buried |
| 51 | E | A | -0.8494 | Soluble |
| 52 | W | A | -0.3085 | Soluble |
| 53 | M | A | 0.0000 | Buried |
| 54 | G | A | 0.0000 | Buried |
| 55 | W | A | 0.0000 | Buried |
| 56 | I | A | 0.0000 | Buried |
| 57 | S | A | 0.0000 | Buried |
| 58 | T | A | 0.0000 | Buried |
| 59 | Y | A | 0.9048 | Aggregation-prone |
| 62 | N | A | -0.6306 | Soluble |
| 63 | G | A | -1.1046 | Soluble |
| 64 | N | A | -1.7749 | Soluble |
| 65 | T | A | -1.4258 | Soluble |
| 66 | N | A | -1.7501 | Soluble |
| 67 | Y | A | -1.4858 | Soluble |
| 68 | A | A | -1.6985 | Soluble |
| 69 | Q | A | -2.7885 | Soluble |
| 70 | K | A | -2.7095 | Soluble |
| 71 | F | A | 0.0000 | Buried |
| 72 | Q | A | -2.4991 | Soluble |
| 74 | G | A | -1.8782 | Soluble |
| 75 | R | A | -1.8663 | Soluble |
| 76 | V | A | 0.0000 | Buried |
| 77 | T | A | -0.7419 | Soluble |
| 78 | M | A | 0.0000 | Buried |
| 79 | T | A | -0.4144 | Soluble |
| 80 | T | A | -0.4774 | Soluble |
| 81 | D | A | -0.9246 | Soluble |
| 82 | T | A | -0.3418 | Soluble |
| 83 | S | A | -0.4809 | Soluble |
| 84 | T | A | -0.5852 | Soluble |
| 85 | T | A | -0.6873 | Soluble |
| 86 | T | A | 0.0000 | Buried |
| 87 | G | A | 0.0000 | Buried |
| 88 | Y | A | -0.5282 | Soluble |
| 89 | M | A | 0.0000 | Buried |
| 90 | E | A | -1.3345 | Soluble |
| 91 | L | A | 0.0000 | Buried |
| 92 | R | A | -2.4135 | Soluble |
| 93 | R | A | -3.0501 | Soluble |
| 94 | L | A | 0.0000 | Buried |
| 95 | R | A | -3.4795 | Soluble |
| 96 | S | A | -2.3768 | Soluble |
| 97 | D | A | -2.4858 | Soluble |
| 98 | D | A | 0.0000 | Buried |
| 99 | T | A | -0.8457 | Soluble |
| 100 | A | A | 0.0000 | Buried |
| 101 | V | A | 0.2881 | Aggregation-prone |
| 102 | Y | A | 0.0000 | Buried |
| 103 | Y | A | 0.0000 | Buried |
| 104 | C | A | 0.0000 | Buried |
| 105 | A | A | 0.0000 | Buried |
| 106 | R | A | -0.2866 | Soluble |
| 107 | D | A | 0.0000 | Buried |
| 108 | Y | A | 0.9650 | Aggregation-prone |
| 109 | T | A | 0.0000 | Buried |
| 110 | R | A | 0.1272 | Aggregation-prone |
| 111 | G | A | 0.0000 | Buried |
| 111A | A | A | 0.0000 | Buried |
| 111B | W | A | 1.4762 | Aggregation-prone |
| 111C | F | A | 1.7796 | Aggregation-prone |
| 112D | G | A | -0.0500 | Soluble |
| 112C | E | A | -0.4578 | Soluble |
| 112B | S | A | -0.2265 | Soluble |
| 112A | L | A | 0.7357 | Aggregation-prone |
| 112 | I | A | 2.0590 | Aggregation-prone |
| 113 | G | A | 0.0000 | Buried |
| 114 | G | A | 0.0000 | Buried |
| 115 | F | A | 0.0000 | Buried |
| 116 | D | A | -0.7660 | Soluble |
| 117 | N | A | -1.0750 | Soluble |
| 118 | W | A | -0.8847 | Soluble |
| 119 | G | A | 0.0000 | Buried |
| 120 | Q | A | -1.3215 | Soluble |
| 121 | G | A | -0.4655 | Soluble |
| 122 | T | A | 0.0000 | Buried |
| 123 | L | A | 0.5834 | Aggregation-prone |
| 124 | V | A | 0.0000 | Buried |
| 125 | T | A | -0.4475 | Soluble |
| 126 | V | A | 0.0000 | Buried |
| 127 | S | A | -1.2978 | Soluble |
| 128 | S | A | -1.1239 | Soluble |
| 129 | A | A | -0.7198 | Soluble |
| 130 | S | A | -0.6562 | Soluble |
| 131 | T | A | -0.6499 | Soluble |
| 132 | K | A | -1.1375 | Soluble |
| 133 | G | A | -1.3658 | Soluble |
| 134 | P | A | 0.0000 | Buried |
| 135 | S | A | -0.4288 | Soluble |
| 136 | V | A | 0.0000 | Buried |
| 137 | F | A | 0.0000 | Buried |
| 138 | P | A | -1.0784 | Soluble |
| 139 | L | A | 0.0000 | Buried |
| 140 | A | A | -1.1837 | Soluble |
| 141 | P | A | 0.0000 | Buried |
| 142 | S | A | -1.1738 | Soluble |
| 143 | S | A | -0.9830 | Soluble |
| 144 | K | A | -1.2844 | Soluble |
| 145 | S | A | 0.0000 | Buried |
| 146 | T | A | -0.7757 | Soluble |
| 147 | S | A | -0.7203 | Soluble |
| 148 | G | A | -0.8398 | Soluble |
| 149 | G | A | -0.8842 | Soluble |
| 150 | T | A | -0.6146 | Soluble |
| 151 | A | A | 0.0000 | Buried |
| 152 | A | A | 0.0000 | Buried |
| 153 | L | A | 0.0000 | Buried |
| 154 | G | A | 0.0000 | Buried |
| 155 | C | A | 0.0000 | Buried |
| 156 | L | A | 0.0000 | Buried |
| 157 | V | A | 0.0000 | Buried |
| 158 | K | A | 0.0000 | Buried |
| 159 | D | A | -0.3344 | Soluble |
| 160 | Y | A | 0.0000 | Buried |
| 161 | F | A | 0.0000 | Buried |
| 162 | P | A | 0.0000 | Buried |
| 163 | E | A | -0.7981 | Soluble |
| 164 | P | A | -0.9476 | Soluble |
| 165 | V | A | -0.6331 | Soluble |
| 166 | T | A | -0.6912 | Soluble |
| 167 | V | A | -0.2557 | Soluble |
| 168 | S | A | -0.4608 | Soluble |
| 169 | W | A | 0.0000 | Buried |
| 170 | N | A | -0.7477 | Soluble |
| 171 | S | A | -0.6910 | Soluble |
| 172 | G | A | -0.5188 | Soluble |
| 173 | A | A | -0.2252 | Soluble |
| 174 | L | A | 0.0195 | Aggregation-prone |
| 175 | T | A | -0.1758 | Soluble |
| 176 | S | A | -0.2185 | Soluble |
| 177 | G | A | -0.2900 | Soluble |
| 178 | V | A | 0.1125 | Aggregation-prone |
| 179 | H | A | -0.2968 | Soluble |
| 180 | T | A | 0.0405 | Aggregation-prone |
| 181 | F | A | 0.0000 | Buried |
| 182 | P | A | -0.2704 | Soluble |
| 183 | A | A | 0.2553 | Aggregation-prone |
| 184 | V | A | 0.7942 | Aggregation-prone |
| 185 | L | A | 1.5834 | Aggregation-prone |
| 186 | Q | A | 0.5056 | Aggregation-prone |
| 187 | S | A | 0.0398 | Aggregation-prone |
| 188 | S | A | -0.1605 | Soluble |
| 189 | G | A | 0.1051 | Aggregation-prone |
| 190 | L | A | 0.1375 | Aggregation-prone |
| 191 | Y | A | 0.4990 | Aggregation-prone |
| 192 | S | A | 0.0000 | Buried |
| 193 | L | A | 0.0000 | Buried |
| 194 | S | A | 0.0000 | Buried |
| 195 | S | A | 0.0000 | Buried |
| 196 | V | A | 0.0000 | Buried |
| 197 | V | A | 0.0000 | Buried |
| 198 | T | A | -0.1521 | Soluble |
| 199 | V | A | 0.0000 | Buried |
| 200 | P | A | -0.6487 | Soluble |
| 201 | S | A | -0.6009 | Soluble |
| 202 | S | A | -0.6249 | Soluble |
| 203 | S | A | -0.7295 | Soluble |
| 204 | L | A | -0.8757 | Soluble |
| 205 | G | A | -1.0701 | Soluble |
| 206 | T | A | -0.8442 | Soluble |
| 207 | Q | A | -1.5253 | Soluble |
| 208 | T | A | -1.1714 | Soluble |
| 209 | Y | A | 0.0000 | Buried |
| 210 | I | A | -1.0259 | Soluble |
| 211 | C | A | 0.0000 | Buried |
| 212 | N | A | -1.5388 | Soluble |
| 213 | V | A | 0.0000 | Buried |
| 214 | N | A | -2.1975 | Soluble |
| 215 | H | A | 0.0000 | Buried |
| 216 | K | A | -2.8280 | Soluble |
| 217 | P | A | -1.6849 | Soluble |
| 218 | S | A | -1.8721 | Soluble |
| 219 | N | A | -2.6129 | Soluble |
| 220 | T | A | -2.1207 | Soluble |
| 221 | K | A | -2.8547 | Soluble |
| 222 | V | A | -1.8111 | Soluble |
| 223 | D | A | -2.5550 | Soluble |
| 224 | K | A | -2.0232 | Soluble |
| 225 | K | A | -1.9839 | Soluble |
| 226 | V | A | 0.0000 | Buried |
| 227 | E | A | -2.7839 | Soluble |
| 228 | P | A | -2.0437 | Soluble |
| 229 | K | A | -2.3790 | Soluble |
| 230 | S | A | -1.5091 | Soluble |
| 1 | E | B | -1.9315 | Soluble |
| 2 | I | B | 0.0000 | Buried |
| 3 | V | B | 0.3210 | Aggregation-prone |
| 4 | L | B | 0.0000 | Buried |
| 5 | T | B | -0.3681 | Soluble |
| 6 | Q | B | 0.0000 | Buried |
| 7 | S | B | -0.6225 | Soluble |
| 8 | P | B | -0.5161 | Soluble |
| 9 | G | B | -0.7333 | Soluble |
| 10 | T | B | -0.3723 | Soluble |
| 11 | L | B | -0.1846 | Soluble |
| 12 | S | B | -0.4802 | Soluble |
| 13 | L | B | -0.9801 | Soluble |
| 14 | S | B | -1.5761 | Soluble |
| 15 | P | B | -1.9625 | Soluble |
| 16 | G | B | -2.2900 | Soluble |
| 17 | E | B | -2.9868 | Soluble |
| 18 | R | B | -3.2892 | Soluble |
| 19 | A | B | 0.0000 | Buried |
| 20 | T | B | -0.6322 | Soluble |
| 21 | L | B | 0.0000 | Buried |
| 22 | S | B | -0.8489 | Soluble |
| 23 | C | B | 0.0000 | Buried |
| 24 | R | B | -1.9346 | Soluble |
| 25 | A | B | -1.1301 | Soluble |
| 26 | S | B | -1.1039 | Soluble |
| 27 | Q | B | -1.8200 | Soluble |
| 28 | T | B | -1.3162 | Soluble |
| 29 | V | B | 0.0000 | Buried |
| 30 | S | B | -0.6315 | Soluble |
| 36 | S | B | -0.2172 | Soluble |
| 37 | T | B | 0.3705 | Aggregation-prone |
| 38 | S | B | 0.0000 | Buried |
| 39 | L | B | 0.0000 | Buried |
| 40 | A | B | 0.0000 | Buried |
| 41 | W | B | 0.0000 | Buried |
| 42 | Y | B | 0.0000 | Buried |
| 43 | Q | B | 0.0000 | Buried |
| 44 | Q | B | 0.0000 | Buried |
| 45 | K | B | -1.4903 | Soluble |
| 46 | P | B | -1.2306 | Soluble |
| 47 | G | B | -1.4109 | Soluble |
| 48 | Q | B | -2.0162 | Soluble |
| 49 | A | B | -1.3894 | Soluble |
| 50 | P | B | 0.0000 | Buried |
| 51 | R | B | -1.5247 | Soluble |
| 52 | L | B | 0.0000 | Buried |
| 53 | L | B | 0.0000 | Buried |
| 54 | I | B | 0.0000 | Buried |
| 55 | Y | B | 0.4425 | Aggregation-prone |
| 56 | G | B | 0.4063 | Aggregation-prone |
| 57 | A | B | 0.0000 | Buried |
| 65 | S | B | -0.5973 | Soluble |
| 66 | S | B | -0.3682 | Soluble |
| 67 | R | B | -1.2719 | Soluble |
| 68 | A | B | -0.7763 | Soluble |
| 69 | T | B | -0.5896 | Soluble |
| 70 | G | B | -0.8586 | Soluble |
| 71 | I | B | 0.0000 | Buried |
| 72 | P | B | -1.2972 | Soluble |
| 74 | D | B | -2.3602 | Soluble |
| 75 | R | B | -1.9860 | Soluble |
| 76 | F | B | 0.0000 | Buried |
| 77 | S | B | -0.8930 | Soluble |
| 78 | G | B | 0.0000 | Buried |
| 79 | S | B | -0.7834 | Soluble |
| 80 | G | B | -1.2428 | Soluble |
| 83 | S | B | -1.0369 | Soluble |
| 84 | G | B | -1.2080 | Soluble |
| 85 | T | B | -1.8159 | Soluble |
| 86 | D | B | -2.5991 | Soluble |
| 87 | F | B | 0.0000 | Buried |
| 88 | T | B | -0.8322 | Soluble |
| 89 | L | B | 0.0000 | Buried |
| 90 | T | B | -0.7954 | Soluble |
| 91 | I | B | 0.0000 | Buried |
| 92 | S | B | -2.4276 | Soluble |
| 93 | R | B | -3.5163 | Soluble |
| 94 | L | B | 0.0000 | Buried |
| 95 | E | B | -2.3690 | Soluble |
| 96 | P | B | -1.6675 | Soluble |
| 97 | E | B | -2.1470 | Soluble |
| 98 | D | B | 0.0000 | Buried |
| 99 | F | B | -0.6432 | Soluble |
| 100 | A | B | 0.0000 | Buried |
| 101 | V | B | -0.2393 | Soluble |
| 102 | Y | B | 0.0000 | Buried |
| 103 | Y | B | 0.0000 | Buried |
| 104 | C | B | 0.0000 | Buried |
| 105 | Q | B | 0.0000 | Buried |
| 106 | Q | B | 0.0000 | Buried |
| 107 | H | B | 0.0000 | Buried |
| 108 | D | B | -1.3081 | Soluble |
| 114 | T | B | -1.1413 | Soluble |
| 115 | S | B | -1.0543 | Soluble |
| 116 | L | B | 0.0000 | Buried |
| 117 | T | B | -0.2688 | Soluble |
| 118 | F | B | 0.0000 | Buried |
| 119 | G | B | 0.0000 | Buried |
| 120 | G | B | -0.7558 | Soluble |
| 121 | G | B | -0.6867 | Soluble |
| 122 | T | B | 0.0000 | Buried |
| 123 | K | B | -0.5474 | Soluble |
| 124 | V | B | 0.0000 | Buried |
| 125 | E | B | 0.0000 | Buried |
| 126 | I | B | -0.7365 | Soluble |
| 127 | K | B | -1.4688 | Soluble |
| 128 | R | B | -1.1668 | Soluble |
| 129 | T | B | -0.2398 | Soluble |
| 130 | V | B | 0.2014 | Aggregation-prone |
| 131 | A | B | -0.0460 | Soluble |
| 132 | A | B | -0.1653 | Soluble |
| 133 | P | B | 0.0000 | Buried |
| 134 | S | B | -0.2022 | Soluble |
| 135 | V | B | 0.0000 | Buried |
| 136 | F | B | 0.0000 | Buried |
| 137 | I | B | 0.0000 | Buried |
| 138 | F | B | 0.0000 | Buried |
| 139 | P | B | -0.6194 | Soluble |
| 140 | P | B | 0.0000 | Buried |
| 141 | S | B | -1.7848 | Soluble |
| 142 | D | B | -2.8530 | Soluble |
| 143 | E | B | -3.1541 | Soluble |
| 144 | Q | B | 0.0000 | Buried |
| 145 | L | B | -2.2070 | Soluble |
| 146 | K | B | -2.9160 | Soluble |
| 147 | S | B | -1.8176 | Soluble |
| 148 | G | B | -1.4586 | Soluble |
| 149 | T | B | -1.2627 | Soluble |
| 150 | A | B | 0.0000 | Buried |
| 151 | S | B | 0.0000 | Buried |
| 152 | V | B | 0.0000 | Buried |
| 153 | V | B | 0.0000 | Buried |
| 154 | C | B | 0.0000 | Buried |
| 155 | L | B | 0.0000 | Buried |
| 156 | L | B | 0.0000 | Buried |
| 157 | N | B | 0.0000 | Buried |
| 158 | N | B | -0.7543 | Soluble |
| 159 | F | B | 0.0000 | Buried |
| 160 | Y | B | 0.0000 | Buried |
| 161 | P | B | -1.3254 | Soluble |
| 162 | R | B | -1.9307 | Soluble |
| 163 | E | B | -2.6263 | Soluble |
| 164 | A | B | -1.9206 | Soluble |
| 165 | K | B | -2.0099 | Soluble |
| 166 | V | B | -0.9370 | Soluble |
| 167 | Q | B | -0.5015 | Soluble |
| 168 | W | B | 0.0000 | Buried |
| 169 | K | B | -0.6617 | Soluble |
| 170 | V | B | 0.0000 | Buried |
| 171 | D | B | -1.9931 | Soluble |
| 172 | N | B | -1.4355 | Soluble |
| 173 | A | B | -0.3939 | Soluble |
| 174 | L | B | 0.5037 | Aggregation-prone |
| 175 | Q | B | -0.3870 | Soluble |
| 176 | S | B | -0.7086 | Soluble |
| 177 | G | B | -1.2131 | Soluble |
| 178 | N | B | -1.4935 | Soluble |
| 179 | S | B | -1.3620 | Soluble |
| 180 | Q | B | -1.2363 | Soluble |
| 181 | E | B | -1.7458 | Soluble |
| 182 | S | B | -0.8153 | Soluble |
| 183 | V | B | -0.3703 | Soluble |
| 184 | T | B | -0.9448 | Soluble |
| 185 | E | B | -2.1157 | Soluble |
| 186 | Q | B | -1.7718 | Soluble |
| 187 | D | B | -2.0054 | Soluble |
| 188 | S | B | -1.7702 | Soluble |
| 189 | K | B | -2.3013 | Soluble |
| 190 | D | B | -1.7931 | Soluble |
| 191 | S | B | -1.7746 | Soluble |
| 192 | T | B | 0.0000 | Buried |
| 193 | Y | B | 0.0000 | Buried |
| 194 | S | B | 0.0000 | Buried |
| 195 | L | B | 0.0000 | Buried |
| 196 | S | B | 0.0000 | Buried |
| 197 | S | B | 0.0000 | Buried |
| 198 | T | B | -0.7143 | Soluble |
| 199 | L | B | 0.0000 | Buried |
| 200 | T | B | -0.5078 | Soluble |
| 201 | L | B | -0.8290 | Soluble |
| 202 | S | B | -1.1347 | Soluble |
| 203 | K | B | -2.1959 | Soluble |
| 204 | A | B | -1.9886 | Soluble |
| 205 | D | B | -2.6682 | Soluble |
| 206 | Y | B | 0.0000 | Buried |
| 207 | E | B | -3.7833 | Soluble |
| 208 | K | B | -3.7547 | Soluble |
| 209 | H | B | -3.0682 | Soluble |
| 210 | K | B | -3.2093 | Soluble |
| 211 | V | B | -1.4549 | Soluble |
| 212 | Y | B | 0.0000 | Buried |
| 213 | A | B | 0.0000 | Buried |
| 214 | C | B | 0.0000 | Buried |
| 215 | E | B | -0.7287 | Soluble |
| 216 | V | B | 0.0000 | Buried |
| 217 | T | B | -1.0620 | Soluble |
| 218 | H | B | 0.0000 | Buried |
| 219 | Q | B | -1.6119 | Soluble |
| 220 | G | B | -0.5003 | Soluble |
| 221 | L | B | -0.2875 | Soluble |
| 222 | S | B | -0.4688 | Soluble |
| 223 | S | B | -0.3991 | Soluble |
| 224 | P | B | -0.4597 | Soluble |
| 225 | V | B | 0.0477 | Aggregation-prone |
| 226 | T | B | -0.3921 | Soluble |
| 227 | K | B | -0.8509 | Soluble |
| 228 | S | B | -0.7195 | Soluble |
| 229 | F | B | 0.0000 | Buried |
| 230 | N | B | -1.9885 | Soluble |
| 231 | R | B | -2.6279 | Soluble |
| 232 | G | B | -2.2059 | Soluble |
| 233 | E | B | -2.5668 | Soluble |
3D Structure — colored by A4D score
pH-Dependent Aggregation Profiles
A4D scores calculated across 11 pH conditions (4.0–9.0, step 0.5). Click a row to view the structure at that pH. The input structure is globular — max score is recommended for pH analysis.
| pH | Avg A4D Score | Max A4D Score | Downloads |
|---|---|---|---|
| 4.0 | -0.6946 | 5.2004 | CSV PDB |
| 4.5 | -0.7369 | 5.1481 | CSV PDB |
| 5.0 | -0.7865 | 5.0759 | CSV PDB |
| 5.5 | -0.8338 | 4.9959 | CSV PDB |
| 6.0 | -0.8677 | 4.9205 | CSV PDB |
| 6.5 | -0.8802 | 4.8621 | CSV PDB |
| 7.0 | -0.8707 | 4.8282 | CSV PDB |
| 7.5 | -0.8456 | 4.8135 | CSV PDB |
| 8.0 | -0.8113 | 4.8081 | CSV PDB |
| 8.5 | -0.7703 | 4.8063 | CSV PDB |
| 9.0 | -0.7232 | 4.8054 | CSV PDB |