Danvilostomig / 7su1

A4DAB080_7su1_H_L | Source PDB: 7su1 | Chains: H, L | Done
97.35
Yes
10 Å
Yes
Avg A4D Score
-0.7371
Max Score
1.9462
Min Score
-3.5928
Total Score
-314.75
Score CDR
-0.4127
Score non-CDR
-0.7763

Calculation Parameters

Chain Sequence(s) VQLVESGGGVVQPGRSLRLSCAASGFTFSHYTMHWVRQAPGKGLEWVTFISYDGHNKYYADSVKGRFTISRDNSKNTLYLQMNSLRAEDTAIYYCARHGWLGPFDYWGQGTLVTVSSASTKGPSVFPLAPSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKEIVLTQSPGTLSLSPGERATLSCRASQEVGESELAWYQQKPGQAPRLLIYGAFSRATGIPDRFSGSGSGTDFTLTISRLEPEDFAVYYCQQYGSSPWTFGQGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGE input.pdb
Selected Chain(s) H (Heavy), L (Light)
Distance of Aggregation 10 Å
FoldX Energy Minimization Yes
pH Calculations Yes
Downloads Download all data (.tar.gz)

Aggrescan4D Profile

Aggregation-prone (score > 0)
Soluble (score < 0)
Buried (score = 0)

Per-Residue A4D Scores

Download CSV
Minimum Score -3.5928
Maximum Score 1.9462
Average Score -0.7371
Total Score -314.7516

Residues with A4D score > 0.0 are highlighted as aggregation-prone.

Index Residue Chain A4D Score Classification
2 V H 0.5477 Aggregation-prone
3 Q H -0.4616 Soluble
4 L H 0.0000 Buried
5 V H 0.6346 Aggregation-prone
6 E H 0.0000 Buried
7 S H -0.3080 Soluble
8 G H -0.8308 Soluble
9 G H -0.3769 Soluble
11 G H -0.1226 Soluble
12 V H 0.2332 Aggregation-prone
13 V H 0.0000 Buried
14 Q H -2.0449 Soluble
15 P H -2.1982 Soluble
16 G H -2.2880 Soluble
17 R H -2.8621 Soluble
18 S H -2.0188 Soluble
19 L H -1.3224 Soluble
20 R H -1.7644 Soluble
21 L H 0.0000 Buried
22 S H -0.3814 Soluble
23 C H 0.0000 Buried
24 A H -0.3093 Soluble
25 A H 0.0000 Buried
26 S H -0.5402 Soluble
27 G H -0.2098 Soluble
28 F H -0.0895 Soluble
29 T H -0.4132 Soluble
30 F H 0.0000 Buried
35 S H -1.0419 Soluble
36 H H -0.7634 Soluble
37 Y H 0.0000 Buried
38 T H -0.0246 Soluble
39 M H 0.0000 Buried
40 H H 0.0000 Buried
41 W H 0.0000 Buried
42 V H 0.0000 Buried
43 R H 0.0000 Buried
44 Q H -0.7308 Soluble
45 A H -1.1288 Soluble
46 P H -0.8674 Soluble
47 G H -1.4676 Soluble
48 K H -2.4202 Soluble
49 G H -1.6682 Soluble
50 L H 0.0000 Buried
51 E H -1.3370 Soluble
52 W H 0.0000 Buried
53 V H 0.0000 Buried
54 T H 0.0000 Buried
55 F H 0.1300 Aggregation-prone
56 I H 0.0000 Buried
57 S H 0.0000 Buried
58 Y H -0.2613 Soluble
59 D H -1.7474 Soluble
62 G H -1.6089 Soluble
63 H H -2.0374 Soluble
64 N H -1.9556 Soluble
65 K H -1.0905 Soluble
66 Y H -0.2294 Soluble
67 Y H -0.6890 Soluble
68 A H 0.0000 Buried
69 D H -2.4625 Soluble
70 S H -1.7960 Soluble
71 V H 0.0000 Buried
72 K H -2.4978 Soluble
74 G H -1.6689 Soluble
75 R H 0.0000 Buried
76 F H 0.0000 Buried
77 T H -0.6881 Soluble
78 I H 0.0000 Buried
79 S H -0.5821 Soluble
80 R H -1.0627 Soluble
81 D H -1.7576 Soluble
82 N H -1.9839 Soluble
83 S H -1.6933 Soluble
84 K H -2.5571 Soluble
85 N H -2.0098 Soluble
86 T H -1.1997 Soluble
87 L H 0.0000 Buried
88 Y H -0.4367 Soluble
89 L H 0.0000 Buried
90 Q H -1.0204 Soluble
91 M H 0.0000 Buried
92 N H -1.8121 Soluble
93 S H -1.7998 Soluble
94 L H 0.0000 Buried
95 R H -2.6352 Soluble
96 A H -1.7507 Soluble
97 E H -2.2559 Soluble
98 D H 0.0000 Buried
99 T H -0.6565 Soluble
100 A H 0.0000 Buried
101 I H 0.4533 Aggregation-prone
102 Y H 0.0000 Buried
103 Y H 0.0000 Buried
104 C H 0.0000 Buried
105 A H 0.0000 Buried
106 R H 0.0000 Buried
107 H H 0.6153 Aggregation-prone
108 G H 0.0000 Buried
109 W H 1.7291 Aggregation-prone
110 L H 1.9462 Aggregation-prone
113 G H 0.8033 Aggregation-prone
114 P H 0.0000 Buried
115 F H 0.0000 Buried
116 D H 0.0038 Aggregation-prone
117 Y H -0.0405 Soluble
118 W H -0.2803 Soluble
119 G H 0.0000 Buried
120 Q H -1.4409 Soluble
121 G H 0.0000 Buried
122 T H 0.0998 Aggregation-prone
123 L H 0.4780 Aggregation-prone
124 V H 0.0000 Buried
125 T H 0.0000 Buried
126 V H 0.0000 Buried
127 S H -0.9174 Soluble
128 S H -0.8291 Soluble
129 A H -0.4920 Soluble
130 S H -0.5735 Soluble
131 T H -0.5872 Soluble
132 K H -1.2553 Soluble
133 G H -1.4120 Soluble
134 P H 0.0000 Buried
135 S H -0.2933 Soluble
136 V H 0.0000 Buried
137 F H -0.5905 Soluble
138 P H -1.0442 Soluble
139 L H 0.0000 Buried
140 A H -1.1068 Soluble
141 P H 0.0000 Buried
142 S H -1.0302 Soluble
143 G H -0.7701 Soluble
144 G H -0.8656 Soluble
145 T H -0.5935 Soluble
146 A H -0.3191 Soluble
147 A H 0.0000 Buried
148 L H 0.0000 Buried
149 G H 0.0000 Buried
150 C H 0.0000 Buried
151 L H 0.0000 Buried
152 V H 0.0000 Buried
153 K H 0.0000 Buried
154 D H -0.3811 Soluble
155 Y H 0.0000 Buried
156 F H 0.0000 Buried
157 P H 0.0000 Buried
158 E H -0.5086 Soluble
159 P H -0.7908 Soluble
160 V H -0.7632 Soluble
161 T H -0.6607 Soluble
162 V H -0.4025 Soluble
163 S H -0.4340 Soluble
164 W H 0.0000 Buried
165 N H -0.8581 Soluble
166 S H -0.6260 Soluble
167 G H -0.4261 Soluble
168 A H -0.1805 Soluble
169 L H 0.0001 Aggregation-prone
170 T H -0.1652 Soluble
171 S H -0.2032 Soluble
172 G H -0.2254 Soluble
173 V H 0.1528 Aggregation-prone
174 H H -0.3347 Soluble
175 T H -0.1776 Soluble
176 F H 0.0000 Buried
177 P H -0.4113 Soluble
178 A H 0.2042 Aggregation-prone
179 V H 0.5207 Aggregation-prone
180 L H 1.3571 Aggregation-prone
181 Q H 0.3099 Aggregation-prone
182 S H -0.0361 Soluble
183 S H -0.1559 Soluble
184 G H 0.0887 Aggregation-prone
185 L H 0.1514 Aggregation-prone
186 Y H 0.4214 Aggregation-prone
187 S H 0.0000 Buried
188 L H 0.0000 Buried
189 S H 0.0000 Buried
190 S H 0.0000 Buried
191 V H 0.0000 Buried
192 V H 0.0000 Buried
193 T H -0.1378 Soluble
194 V H 0.0000 Buried
195 P H -0.5307 Soluble
196 S H -0.6062 Soluble
197 S H -0.6071 Soluble
198 S H -0.5795 Soluble
199 L H -0.7744 Soluble
200 G H -0.9560 Soluble
201 T H -0.6933 Soluble
202 Q H -1.1667 Soluble
203 T H -1.1394 Soluble
204 Y H 0.0000 Buried
205 I H -1.5767 Soluble
206 C H 0.0000 Buried
207 N H -1.6363 Soluble
208 V H 0.0000 Buried
209 N H -1.9939 Soluble
210 H H 0.0000 Buried
211 K H -2.7196 Soluble
212 P H -1.5753 Soluble
213 S H -1.8258 Soluble
214 N H -2.5224 Soluble
215 T H -2.0407 Soluble
216 K H -2.6760 Soluble
217 V H -1.6080 Soluble
218 D H -2.6853 Soluble
219 K H -2.2315 Soluble
220 R H -2.8445 Soluble
221 V H 0.0000 Buried
222 E H -2.8654 Soluble
223 P H -2.0603 Soluble
224 K H -2.4803 Soluble
1 E L -1.4428 Soluble
2 I L -0.5645 Soluble
3 V L 0.8249 Aggregation-prone
4 L L 0.0000 Buried
5 T L -0.5469 Soluble
6 Q L 0.0000 Buried
7 S L -0.7040 Soluble
8 P L -0.4228 Soluble
9 G L -0.7624 Soluble
10 T L -0.2519 Soluble
11 L L -0.1257 Soluble
12 S L -0.4782 Soluble
13 L L -1.0062 Soluble
14 S L -1.5868 Soluble
15 P L -1.9999 Soluble
16 G L -2.2697 Soluble
17 E L -3.0506 Soluble
18 R L -3.3630 Soluble
19 A L 0.0000 Buried
20 T L -0.5490 Soluble
21 L L 0.0000 Buried
22 S L -0.7556 Soluble
23 C L 0.0000 Buried
24 R L -1.8883 Soluble
25 A L -1.2638 Soluble
26 S L -1.1569 Soluble
27 Q L -2.3416 Soluble
28 E L -2.9942 Soluble
29 V L 0.0000 Buried
30 G L -1.8882 Soluble
36 E L -2.1202 Soluble
37 S L -0.9091 Soluble
38 E L -1.1929 Soluble
39 L L 0.0000 Buried
40 A L 0.0000 Buried
41 W L 0.0000 Buried
42 Y L 0.0000 Buried
43 Q L 0.0000 Buried
44 Q L -1.3595 Soluble
45 K L -1.9835 Soluble
46 P L -1.5577 Soluble
47 G L -1.5660 Soluble
48 Q L -2.3497 Soluble
49 A L -1.6709 Soluble
50 P L 0.0000 Buried
51 R L -2.1524 Soluble
52 L L 0.0000 Buried
53 L L 0.0000 Buried
54 I L 0.0000 Buried
55 Y L 0.1547 Aggregation-prone
56 G L 0.0167 Aggregation-prone
57 A L 0.0605 Aggregation-prone
65 F L 1.4999 Aggregation-prone
66 S L 0.7520 Aggregation-prone
67 R L -0.3706 Soluble
68 A L -0.5872 Soluble
69 T L -0.3921 Soluble
70 G L -0.6770 Soluble
71 I L -0.7921 Soluble
72 P L -1.1558 Soluble
74 D L -2.2555 Soluble
75 R L -1.9915 Soluble
76 F L 0.0000 Buried
77 S L -0.4164 Soluble
78 G L -0.2565 Soluble
79 S L -0.6265 Soluble
80 G L -1.2871 Soluble
83 S L -1.6665 Soluble
84 G L -2.1056 Soluble
85 T L -2.2199 Soluble
86 D L -2.2563 Soluble
87 F L 0.0000 Buried
88 T L -0.6906 Soluble
89 L L 0.0000 Buried
90 T L -0.8777 Soluble
91 I L 0.0000 Buried
92 S L -2.4338 Soluble
93 R L -3.5928 Soluble
94 L L 0.0000 Buried
95 E L -2.6717 Soluble
96 P L -1.8592 Soluble
97 E L -2.3933 Soluble
98 D L 0.0000 Buried
99 F L 0.0000 Buried
100 A L 0.0000 Buried
101 V L -0.2464 Soluble
102 Y L 0.0000 Buried
103 Y L 0.0000 Buried
104 C L 0.0000 Buried
105 Q L 0.0000 Buried
106 Q L 0.0000 Buried
107 Y L -0.1832 Soluble
108 G L -0.6526 Soluble
109 S L -0.7389 Soluble
114 S L -0.5546 Soluble
115 P L -0.6271 Soluble
116 W L 0.0000 Buried
117 T L -0.1740 Soluble
118 F L -0.0003 Soluble
119 G L 0.0000 Buried
120 Q L -1.4931 Soluble
121 G L -1.0000 Soluble
122 T L 0.0000 Buried
123 K L -0.3663 Soluble
124 V L 0.0000 Buried
125 E L 0.0000 Buried
126 I L -0.7134 Soluble
127 K L -1.3459 Soluble
128 R L -1.0432 Soluble
129 T L -0.1057 Soluble
130 V L 0.3689 Aggregation-prone
131 A L 0.1403 Aggregation-prone
132 A L -0.1160 Soluble
133 P L 0.0000 Buried
134 S L -0.1871 Soluble
135 V L 0.0000 Buried
136 F L 0.0674 Aggregation-prone
137 I L 0.0851 Aggregation-prone
138 F L 0.0000 Buried
139 P L -0.7466 Soluble
140 P L -0.6963 Soluble
141 S L -1.3904 Soluble
142 D L -2.6256 Soluble
143 E L -2.3340 Soluble
144 Q L 0.0000 Buried
145 L L -1.9911 Soluble
146 K L -2.6504 Soluble
147 S L -1.6492 Soluble
148 G L -1.2252 Soluble
149 T L -1.0139 Soluble
150 A L 0.0000 Buried
151 S L 0.0000 Buried
152 V L 0.0000 Buried
153 V L 0.0000 Buried
154 C L 0.0000 Buried
155 L L 0.0000 Buried
156 L L 0.0000 Buried
157 N L 0.0000 Buried
158 N L -0.8173 Soluble
159 F L 0.0000 Buried
160 Y L 0.0000 Buried
161 P L -1.4559 Soluble
162 R L -2.4132 Soluble
163 E L -2.8691 Soluble
164 A L -2.0126 Soluble
165 K L -2.0389 Soluble
166 V L -0.9936 Soluble
167 Q L -0.6508 Soluble
168 W L 0.0000 Buried
169 K L -0.7047 Soluble
170 V L 0.0000 Buried
171 D L -1.6068 Soluble
172 N L -1.4542 Soluble
173 A L -0.4105 Soluble
174 L L 0.2480 Aggregation-prone
175 Q L -0.3511 Soluble
176 S L -0.5202 Soluble
177 G L -0.9537 Soluble
178 N L -0.8819 Soluble
179 S L -1.3934 Soluble
180 Q L -1.8569 Soluble
181 E L -2.2193 Soluble
182 S L -0.9930 Soluble
183 V L -0.8232 Soluble
184 T L 0.0000 Buried
185 E L -2.1923 Soluble
186 Q L -1.7938 Soluble
187 D L -1.9187 Soluble
188 S L -1.7368 Soluble
189 K L -2.3131 Soluble
190 D L -1.8509 Soluble
191 S L -1.7452 Soluble
192 T L 0.0000 Buried
193 Y L 0.0000 Buried
194 S L 0.0000 Buried
195 L L 0.0000 Buried
196 S L 0.0000 Buried
197 S L 0.0000 Buried
198 T L -0.8489 Soluble
199 L L 0.0000 Buried
200 T L -0.5322 Soluble
201 L L -0.7154 Soluble
202 S L -1.1352 Soluble
203 K L -2.1682 Soluble
204 A L -1.9524 Soluble
205 D L -2.7412 Soluble
206 Y L 0.0000 Buried
207 E L -3.2185 Soluble
208 K L -3.5006 Soluble
209 H L -2.8925 Soluble
210 K L -2.9896 Soluble
211 V L -1.4208 Soluble
212 Y L 0.0000 Buried
213 A L 0.0000 Buried
214 C L 0.0000 Buried
215 E L -0.7353 Soluble
216 V L 0.0000 Buried
217 T L -1.0697 Soluble
218 H L 0.0000 Buried
219 Q L -1.6656 Soluble
220 G L -0.4641 Soluble
221 L L -0.2393 Soluble
222 S L -0.4442 Soluble
223 S L -0.3992 Soluble
224 P L -0.4779 Soluble
225 V L -0.0250 Soluble
226 T L -0.5123 Soluble
227 K L -0.7636 Soluble
228 S L -0.6634 Soluble
229 F L -1.1767 Soluble
230 N L -2.2342 Soluble
231 R L -2.5991 Soluble
232 G L -2.2383 Soluble
233 E L -2.6811 Soluble

3D Structure — colored by A4D score

Sequence - click residue to focus in viewer  |  colored by A4D score
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Color Legend (B-factor = A4D Score)
Score > 1.5 — highly aggregation-prone
Score 0.5–1.5 — aggregation-prone
Score ≈ 0 — buried
Score −1 to −0.5 — soluble
Score < −2.5 — highly soluble
pH Structure
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A4D Score Threshold
Highlight residues > threshold in the sequence panel
CDR Regions
HCDR1
HCDR2
HCDR3
LCDR1
LCDR2
LCDR3
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pH-Dependent Aggregation Profiles

A4D scores calculated across 11 pH conditions (4.0–9.0, step 0.5). Click a row to view the structure at that pH. The input structure is globular — max score is recommended for pH analysis.

pH Avg A4D Score Max A4D Score Downloads
4.0 -0.7295 3.9329 CSV PDB
4.5 -0.7768 3.9256 CSV PDB
5.0 -0.8327 3.9251 CSV PDB
5.5 -0.8869 3.9371 CSV PDB
6.0 -0.9283 3.9608 CSV PDB
6.5 -0.9477 3.9836 CSV PDB
7.0 -0.9439 3.994 CSV PDB
7.5 -0.9235 3.9934 CSV PDB
8.0 -0.8934 3.9888 CSV PDB
8.5 -0.8561 3.9851 CSV PDB
9.0 -0.8123 3.9833 CSV PDB
Average A4D Score vs pH
Max A4D Score vs pH