Paridiprubart / 4r7n

A4DAB203_4r7n_G_H | Source PDB: 4r7n | Chains: G, H | Done
96
Yes
10 Å
Yes
Avg A4D Score
-0.6851
Max Score
1.7792
Min Score
-4.0916
Total Score
-293.9
Score CDR
-0.1559
Score non-CDR
-0.7471

Calculation Parameters

Chain Sequence(s) QVQLQESGPGLVKPSDTLSLTCAVSGYPIRFGYSWHWIRQPPGKGLEWMGYIHYSGYTDFNPSLKTRITISRDTSKNQFSLKLSSVTAVDTAVYYCARKDSGNYFPYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPEIVLTQSPDFQSVTPKEKVTITCRASQSISDHLHWYQQKPDQSPKLLIKYASHAISGVPSRFSGSGSGTDFTLTINSLEAEDAATYYCQQGYDFPLTFGGGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNR input.pdb
Selected Chain(s) G (Heavy), H (Light)
Distance of Aggregation 10 Å
FoldX Energy Minimization Yes
pH Calculations Yes
Downloads Download all data (.tar.gz)

Aggrescan4D Profile

Aggregation-prone (score > 0)
Soluble (score < 0)
Buried (score = 0)

Per-Residue A4D Scores

Download CSV
Minimum Score -4.0916
Maximum Score 1.7792
Average Score -0.6851
Total Score -293.8994

Residues with A4D score > 0.0 are highlighted as aggregation-prone.

Index Residue Chain A4D Score Classification
1 Q G -1.5037 Soluble
2 V G 0.0000 Buried
3 Q G -1.8825 Soluble
4 L G 0.0000 Buried
5 Q G -2.0017 Soluble
6 E G -1.2648 Soluble
7 S G -1.1378 Soluble
8 G G -0.8526 Soluble
9 P G -0.6390 Soluble
11 G G -0.7482 Soluble
12 L G -0.4013 Soluble
13 V G 0.0000 Buried
14 K G -1.5142 Soluble
15 P G -1.2486 Soluble
16 S G -1.3650 Soluble
17 D G -2.0380 Soluble
18 T G -1.3462 Soluble
19 L G 0.0000 Buried
20 S G -0.7813 Soluble
21 L G 0.0000 Buried
22 T G -0.8533 Soluble
23 C G 0.0000 Buried
24 A G -1.3258 Soluble
25 V G 0.0000 Buried
26 S G -1.2641 Soluble
27 G G -0.9731 Soluble
28 Y G -0.1570 Soluble
29 P G -0.2245 Soluble
30 I G 0.0000 Buried
31 R G -0.8607 Soluble
35 F G 1.3100 Aggregation-prone
36 G G 0.8397 Aggregation-prone
37 Y G 0.6022 Aggregation-prone
38 S G 0.0000 Buried
39 W G 0.0000 Buried
40 H G 0.0000 Buried
41 W G 0.0000 Buried
42 I G 0.0000 Buried
43 R G 0.0000 Buried
44 Q G 0.0000 Buried
45 P G -0.5697 Soluble
46 P G -1.1644 Soluble
47 G G -1.4714 Soluble
48 K G -2.2412 Soluble
49 G G -1.3579 Soluble
50 L G 0.0000 Buried
51 E G -0.7385 Soluble
52 W G 0.0000 Buried
53 M G 0.0000 Buried
54 G G 0.0000 Buried
55 Y G 0.0000 Buried
56 I G 0.0000 Buried
57 H G 0.3788 Aggregation-prone
58 Y G 0.7242 Aggregation-prone
59 S G 0.3792 Aggregation-prone
63 G G 0.0675 Aggregation-prone
64 Y G 1.0489 Aggregation-prone
65 T G 0.3619 Aggregation-prone
66 D G -0.1651 Soluble
67 F G -0.2923 Soluble
68 N G 0.0000 Buried
69 P G -0.8836 Soluble
70 S G -0.6466 Soluble
71 L G 0.0000 Buried
72 K G -1.2888 Soluble
74 T G -0.8325 Soluble
75 R G -1.0216 Soluble
76 I G 0.0000 Buried
77 T G -0.7209 Soluble
78 I G 0.0000 Buried
79 S G -0.7207 Soluble
80 R G -1.5600 Soluble
81 D G -2.2481 Soluble
82 T G -1.8889 Soluble
83 S G -1.7935 Soluble
84 K G -2.3979 Soluble
85 N G -1.9474 Soluble
86 Q G -1.6847 Soluble
87 F G 0.0000 Buried
88 S G -0.7958 Soluble
89 L G 0.0000 Buried
90 K G -1.0770 Soluble
91 L G 0.0000 Buried
92 S G -1.0598 Soluble
93 S G -1.1071 Soluble
94 V G 0.0000 Buried
95 T G 0.0585 Aggregation-prone
96 A G 0.7265 Aggregation-prone
97 V G 1.7792 Aggregation-prone
98 D G 0.0000 Buried
99 T G 0.6336 Aggregation-prone
100 A G 0.0000 Buried
101 V G 0.0169 Aggregation-prone
102 Y G 0.0000 Buried
103 Y G 0.0000 Buried
104 C G 0.0000 Buried
105 A G 0.0000 Buried
106 R G 0.0000 Buried
107 K G -0.3029 Soluble
108 D G -0.2769 Soluble
109 S G -0.3979 Soluble
110 G G -0.1975 Soluble
113 N G -0.2978 Soluble
114 Y G -0.1203 Soluble
115 F G 0.0000 Buried
116 P G -0.1750 Soluble
117 Y G -0.3479 Soluble
118 W G -0.7193 Soluble
119 G G 0.0000 Buried
120 Q G -2.0809 Soluble
121 G G -1.2376 Soluble
122 T G -0.6639 Soluble
123 L G -0.0554 Soluble
124 V G 0.0000 Buried
125 T G 0.1000 Aggregation-prone
126 V G 0.0000 Buried
127 S G -0.4580 Soluble
128 S G -0.6017 Soluble
129 A G -0.5200 Soluble
130 S G -0.7464 Soluble
131 T G -1.1036 Soluble
132 K G -1.9261 Soluble
133 G G -1.5744 Soluble
134 P G 0.0000 Buried
135 S G -0.4264 Soluble
136 V G 0.0000 Buried
137 F G -0.8660 Soluble
138 P G -1.1387 Soluble
139 L G 0.0000 Buried
140 A G -0.5626 Soluble
141 P G 0.0000 Buried
142 S G -0.7439 Soluble
143 S G -1.1499 Soluble
144 K G -2.0866 Soluble
145 S G -1.4236 Soluble
146 T G -1.0671 Soluble
147 S G -1.1459 Soluble
148 G G -1.1378 Soluble
149 G G -0.9681 Soluble
150 T G -0.5275 Soluble
151 A G 0.0000 Buried
152 A G 0.0000 Buried
153 L G 0.0000 Buried
154 G G 0.0000 Buried
155 C G 0.0000 Buried
156 L G 0.0000 Buried
157 V G 0.0000 Buried
158 K G 0.0000 Buried
159 D G -0.4893 Soluble
160 Y G 0.0000 Buried
161 F G 0.0000 Buried
162 P G 0.0000 Buried
163 E G -0.2571 Soluble
164 P G -0.5176 Soluble
165 V G -0.5297 Soluble
166 T G -0.4663 Soluble
167 V G -0.3320 Soluble
168 S G -0.3263 Soluble
169 W G 0.0000 Buried
170 N G -0.6732 Soluble
171 S G -0.5842 Soluble
172 G G -0.3796 Soluble
173 A G -0.1824 Soluble
174 L G 0.0117 Aggregation-prone
175 T G -0.1583 Soluble
176 S G -0.1978 Soluble
177 G G -0.2355 Soluble
178 V G 0.1118 Aggregation-prone
179 H G -0.3551 Soluble
180 T G 0.0188 Aggregation-prone
181 F G 0.0000 Buried
182 P G -0.6355 Soluble
183 A G 0.2794 Aggregation-prone
184 V G 0.5498 Aggregation-prone
185 L G 1.3596 Aggregation-prone
186 Q G 0.2797 Aggregation-prone
187 S G -0.0457 Soluble
188 S G -0.2020 Soluble
189 G G 0.0644 Aggregation-prone
190 L G 0.1308 Aggregation-prone
191 Y G 0.6565 Aggregation-prone
192 S G 0.3399 Aggregation-prone
193 L G 0.0000 Buried
194 S G 0.0000 Buried
195 S G 0.0000 Buried
196 V G 0.0000 Buried
197 V G 0.0000 Buried
198 T G -0.1432 Soluble
199 V G 0.0000 Buried
200 P G -0.5581 Soluble
201 S G 0.0000 Buried
202 S G -0.7647 Soluble
203 S G -0.7024 Soluble
204 L G -0.8945 Soluble
205 G G -1.0324 Soluble
206 T G -0.7659 Soluble
207 Q G -1.1252 Soluble
208 T G -1.2079 Soluble
209 Y G 0.0000 Buried
210 I G -1.3310 Soluble
211 C G 0.0000 Buried
212 N G -1.4660 Soluble
213 V G 0.0000 Buried
214 N G -1.7071 Soluble
215 H G 0.0000 Buried
216 K G -2.6478 Soluble
217 P G -1.6602 Soluble
218 S G -1.9259 Soluble
219 N G -2.6120 Soluble
220 T G -2.0775 Soluble
221 K G -2.5934 Soluble
222 V G -1.5986 Soluble
223 D G -2.7104 Soluble
224 K G -2.3649 Soluble
225 R G -2.8438 Soluble
226 V G 0.0000 Buried
227 E G -2.4491 Soluble
228 P G -1.2308 Soluble
1 E H -1.4696 Soluble
2 I H -0.0750 Soluble
3 V H 0.8480 Aggregation-prone
4 L H 0.0000 Buried
5 T H -0.7869 Soluble
6 Q H 0.0000 Buried
7 S H -0.9697 Soluble
8 P H -0.7185 Soluble
9 D H -1.3675 Soluble
10 F H 0.3789 Aggregation-prone
11 Q H -0.2852 Soluble
12 S H -0.4987 Soluble
13 V H -1.3114 Soluble
14 T H -1.8013 Soluble
15 P H -2.2683 Soluble
16 K H -3.2462 Soluble
17 E H -3.5436 Soluble
18 K H -3.3016 Soluble
19 V H 0.0000 Buried
20 T H -0.6864 Soluble
21 I H 0.0000 Buried
22 T H -0.8643 Soluble
23 C H 0.0000 Buried
24 R H -2.2873 Soluble
25 A H 0.0000 Buried
26 S H -0.9112 Soluble
27 Q H -1.5257 Soluble
28 S H -1.4585 Soluble
29 I H 0.0000 Buried
36 S H -1.2156 Soluble
37 D H -1.5791 Soluble
38 H H -0.7796 Soluble
39 L H 0.0000 Buried
40 H H 0.0000 Buried
41 W H 0.0000 Buried
42 Y H 0.0000 Buried
43 Q H 0.0000 Buried
44 Q H -1.2079 Soluble
45 K H -1.6410 Soluble
46 P H -1.7646 Soluble
47 D H -2.6446 Soluble
48 Q H -2.2247 Soluble
49 S H -1.4259 Soluble
50 P H 0.0000 Buried
51 K H -1.3474 Soluble
52 L H 0.0000 Buried
53 L H 0.0000 Buried
54 I H 0.0000 Buried
55 K H -0.4865 Soluble
56 Y H -0.3032 Soluble
57 A H 0.0000 Buried
65 S H -0.8712 Soluble
66 H H -0.8845 Soluble
67 A H -0.3767 Soluble
68 I H -0.0787 Soluble
69 S H -0.3041 Soluble
70 G H -0.3964 Soluble
71 V H -0.2348 Soluble
72 P H -0.4249 Soluble
74 S H -0.6168 Soluble
75 R H -1.2271 Soluble
76 F H 0.0000 Buried
77 S H -0.7196 Soluble
78 G H -0.4586 Soluble
79 S H -0.8605 Soluble
80 G H -1.0529 Soluble
83 S H -1.2588 Soluble
84 G H -1.5811 Soluble
85 T H -1.7381 Soluble
86 D H -2.2281 Soluble
87 F H 0.0000 Buried
88 T H -0.7705 Soluble
89 L H 0.0000 Buried
90 T H -0.8708 Soluble
91 I H 0.0000 Buried
92 N H -2.8154 Soluble
93 S H -2.8188 Soluble
94 L H 0.0000 Buried
95 E H -2.3468 Soluble
96 A H -2.4203 Soluble
97 E H -2.5775 Soluble
98 D H 0.0000 Buried
99 A H 0.0000 Buried
100 A H -1.0802 Soluble
101 T H -0.6629 Soluble
102 Y H 0.0000 Buried
103 Y H 0.0000 Buried
104 C H 0.0000 Buried
105 Q H 0.0000 Buried
106 Q H 0.0000 Buried
107 G H 0.0000 Buried
108 Y H 0.1589 Aggregation-prone
109 D H -0.5450 Soluble
114 F H 0.0160 Aggregation-prone
115 P H -0.2953 Soluble
116 L H 0.0000 Buried
117 T H 0.0000 Buried
118 F H 0.2658 Aggregation-prone
119 G H 0.0000 Buried
120 G H -1.0615 Soluble
121 G H 0.0000 Buried
122 T H 0.0000 Buried
123 K H -1.1744 Soluble
124 V H 0.0000 Buried
125 E H -0.9614 Soluble
126 I H 0.0000 Buried
127 K H -1.3221 Soluble
128 R H -0.8329 Soluble
129 T H 0.2537 Aggregation-prone
130 V H 1.0196 Aggregation-prone
131 A H 0.5026 Aggregation-prone
132 A H 0.0812 Aggregation-prone
133 P H 0.0000 Buried
134 S H -0.0416 Soluble
135 V H 0.0838 Aggregation-prone
136 F H 0.2006 Aggregation-prone
137 I H 0.1537 Aggregation-prone
138 F H 0.0000 Buried
139 P H -0.6907 Soluble
140 P H -0.6653 Soluble
141 S H -1.6330 Soluble
142 D H -2.9786 Soluble
143 E H -3.0546 Soluble
144 Q H 0.0000 Buried
145 L H -2.1594 Soluble
146 K H -2.8253 Soluble
147 S H -1.7797 Soluble
148 G H -1.4048 Soluble
149 T H -0.8911 Soluble
150 A H 0.0000 Buried
151 S H 0.0000 Buried
152 V H 0.0000 Buried
153 V H 0.0000 Buried
154 C H 0.0000 Buried
155 L H 0.0000 Buried
156 L H 0.0000 Buried
157 N H -0.2427 Soluble
158 N H -0.7892 Soluble
159 F H 0.0000 Buried
160 Y H 0.0000 Buried
161 P H -1.6042 Soluble
162 R H -3.0292 Soluble
163 E H -3.2561 Soluble
164 A H -2.3656 Soluble
165 K H -2.4025 Soluble
166 V H -1.0258 Soluble
167 Q H -0.5303 Soluble
168 W H 0.0000 Buried
169 K H -0.4130 Soluble
170 V H 0.0000 Buried
171 D H -1.5841 Soluble
172 N H -1.3141 Soluble
173 A H -0.1153 Soluble
174 L H 0.8322 Aggregation-prone
175 Q H -0.0885 Soluble
176 S H -0.5041 Soluble
177 G H -0.9508 Soluble
178 N H -0.8414 Soluble
179 S H -1.2402 Soluble
180 Q H -1.7406 Soluble
181 E H -1.9964 Soluble
182 S H -0.8405 Soluble
183 V H -0.7372 Soluble
184 T H -1.1012 Soluble
185 E H -2.4116 Soluble
186 Q H 0.0000 Buried
187 D H -2.1277 Soluble
188 S H -2.4153 Soluble
189 K H -2.8019 Soluble
190 D H -2.0818 Soluble
191 S H 0.0000 Buried
192 T H 0.0000 Buried
193 Y H 0.0000 Buried
194 S H 0.0000 Buried
195 L H 0.0000 Buried
196 S H 0.0000 Buried
197 S H 0.0000 Buried
198 T H -0.8029 Soluble
199 L H 0.0000 Buried
200 T H -0.3054 Soluble
201 L H -0.7298 Soluble
202 S H -1.2074 Soluble
203 K H -2.2598 Soluble
204 A H -1.9717 Soluble
205 D H -3.1402 Soluble
206 Y H 0.0000 Buried
207 E H -4.0916 Soluble
208 K H -3.8283 Soluble
209 H H -3.3766 Soluble
210 K H -3.4724 Soluble
211 V H -1.6251 Soluble
212 Y H 0.0000 Buried
213 A H 0.0000 Buried
214 C H 0.0000 Buried
215 E H -0.8699 Soluble
216 V H 0.0000 Buried
217 T H -1.1868 Soluble
218 H H 0.0000 Buried
219 Q H -1.6697 Soluble
220 G H -0.2741 Soluble
221 L H -0.2070 Soluble
222 S H -0.4844 Soluble
223 S H -0.4361 Soluble
224 P H -0.5885 Soluble
225 V H 0.0246 Aggregation-prone
226 T H -0.4391 Soluble
227 K H -0.6633 Soluble
228 S H -0.5925 Soluble
229 F H -1.0860 Soluble
230 N H -2.4790 Soluble
231 R H -3.1330 Soluble

3D Structure — colored by A4D score

Sequence - click residue to focus in viewer  |  colored by A4D score
Load structure to view sequence…
Downloads
Color Legend (B-factor = A4D Score)
Score > 1.5 — highly aggregation-prone
Score 0.5–1.5 — aggregation-prone
Score ≈ 0 — buried
Score −1 to −0.5 — soluble
Score < −2.5 — highly soluble
pH Structure
Load structure at specific pH condition
A4D Score Threshold
Highlight residues > threshold in the sequence panel
CDR Regions
HCDR1
HCDR2
HCDR3
LCDR1
LCDR2
LCDR3
Display Options

pH-Dependent Aggregation Profiles

A4D scores calculated across 11 pH conditions (4.0–9.0, step 0.5). Click a row to view the structure at that pH. The input structure is globular — max score is recommended for pH analysis.

pH Avg A4D Score Max A4D Score Downloads
4.0 -0.716 3.052 CSV PDB
4.5 -0.7608 2.8655 CSV PDB
5.0 -0.8139 2.6556 CSV PDB
5.5 -0.864 2.605 CSV PDB
6.0 -0.8985 2.6137 CSV PDB
6.5 -0.9087 2.6195 CSV PDB
7.0 -0.896 2.6221 CSV PDB
7.5 -0.8682 2.623 CSV PDB
8.0 -0.8319 2.6231 CSV PDB
8.5 -0.7891 2.6227 CSV PDB
9.0 -0.7392 2.621 CSV PDB
Average A4D Score vs pH
Max A4D Score vs pH