Zinlirvimab / 6orn

A4DAB308_6orn_O_P | Source PDB: 6orn | Chains: O, P | Done
100
Yes
10 Å
Yes
Avg A4D Score
-0.6407
Max Score
2.6578
Min Score
-3.7382
Total Score
-151.85
Score CDR
-0.5981
Score non-CDR
-0.6558

Calculation Parameters

Chain Sequence(s) QVQLQESGPGLVKPSETLSVTCSVSGDSMNNYYWTWIRQSPGKGLEWIGYISDRESATYNPSLNSRVVISRDTSKNQLSLKLNSVTPADTAVYYCATARRGQRIYGVVSFGEFFYYYSMDVWGKGTTVTVSSALSVALGETARISCGRQALGSRAVQWYQHRPGQAPILLIYNNQDRPSGIPERFSGTPDINFGTRATLTISGVEAGDEADYYCHMWDSRSGFSWSFGGATRLTVLG input.pdb
Selected Chain(s) O (Heavy), P (Light)
Distance of Aggregation 10 Å
FoldX Energy Minimization Yes
pH Calculations Yes
Downloads Download all data (.tar.gz)

Aggrescan4D Profile

Aggregation-prone (score > 0)
Soluble (score < 0)
Buried (score = 0)

Per-Residue A4D Scores

Download CSV
Minimum Score -3.7382
Maximum Score 2.6578
Average Score -0.6407
Total Score -151.8524

Residues with A4D score > 0.0 are highlighted as aggregation-prone.

Index Residue Chain A4D Score Classification
1 Q O -2.0898 Soluble
2 V O 0.0000 Buried
3 Q O -2.1955 Soluble
4 L O -1.2552 Soluble
5 Q O -1.5632 Soluble
6 E O 0.0000 Buried
7 S O -0.7161 Soluble
8 G O -0.5121 Soluble
9 P O -0.1214 Soluble
11 G O 0.4055 Aggregation-prone
12 L O 1.0349 Aggregation-prone
13 V O -0.2232 Soluble
14 K O -1.6575 Soluble
15 P O -1.2288 Soluble
16 S O -1.3871 Soluble
17 E O -1.7685 Soluble
18 T O -1.4191 Soluble
19 L O 0.0000 Buried
20 S O -0.7868 Soluble
21 V O 0.0000 Buried
22 T O -0.6724 Soluble
23 C O 0.0000 Buried
24 S O -1.1422 Soluble
25 V O 0.0000 Buried
26 S O -1.8987 Soluble
27 G O -2.1598 Soluble
28 D O -2.9073 Soluble
29 S O -2.0022 Soluble
30 M O -1.8376 Soluble
35 N O -2.3170 Soluble
36 N O -2.2882 Soluble
37 Y O -1.5415 Soluble
38 Y O -1.2338 Soluble
39 W O 0.0000 Buried
40 T O 0.0000 Buried
41 W O 0.0000 Buried
42 I O 0.0000 Buried
43 R O -0.5626 Soluble
44 Q O -0.9207 Soluble
45 S O -0.9549 Soluble
46 P O -1.0713 Soluble
47 G O -1.5037 Soluble
48 K O -2.2450 Soluble
49 G O -1.5001 Soluble
50 L O -0.8660 Soluble
51 E O -0.8928 Soluble
52 W O 0.0000 Buried
53 I O 0.0000 Buried
54 G O 0.0000 Buried
55 Y O 0.0395 Aggregation-prone
56 I O 0.0000 Buried
57 S O -2.5420 Soluble
58 D O -3.7382 Soluble
59 R O -3.6065 Soluble
63 E O -3.3795 Soluble
64 S O -1.6951 Soluble
65 A O -0.4446 Soluble
66 T O -0.0138 Soluble
67 Y O 0.0718 Aggregation-prone
68 N O -0.3528 Soluble
69 P O -0.6656 Soluble
70 S O -0.6260 Soluble
71 L O -0.8305 Soluble
72 N O -1.5980 Soluble
74 S O -1.0592 Soluble
75 R O -1.3517 Soluble
76 V O 0.0000 Buried
77 V O 0.4119 Aggregation-prone
78 I O 0.1538 Aggregation-prone
79 S O -0.5991 Soluble
80 R O -1.6229 Soluble
81 D O -1.8241 Soluble
82 T O -1.7808 Soluble
83 S O -1.6505 Soluble
84 K O -2.6317 Soluble
85 N O -2.6240 Soluble
86 Q O -1.7707 Soluble
87 L O 0.0000 Buried
88 S O -0.4909 Soluble
89 L O 0.0000 Buried
90 K O -0.8833 Soluble
91 L O -1.0533 Soluble
92 N O -1.8585 Soluble
93 S O -1.2715 Soluble
94 V O 0.0000 Buried
95 T O -0.7114 Soluble
96 P O -0.6100 Soluble
97 A O -0.1031 Soluble
98 D O 0.0000 Buried
99 T O -0.0025 Soluble
100 A O 0.0000 Buried
101 V O -0.2473 Soluble
102 Y O 0.0000 Buried
103 Y O 0.0000 Buried
104 C O 0.0000 Buried
105 A O 0.0000 Buried
106 T O 0.0000 Buried
107 A O 0.0000 Buried
108 R O -2.0794 Soluble
109 R O -2.2211 Soluble
110 G O -1.8190 Soluble
111 Q O -1.5912 Soluble
111A R O -1.3909 Soluble
111B I O 0.5936 Aggregation-prone
111C Y O 1.1703 Aggregation-prone
111D G O 1.0330 Aggregation-prone
111E V O 2.1285 Aggregation-prone
111F V O 2.6578 Aggregation-prone
112G S O 1.5994 Aggregation-prone
112F F O 2.1942 Aggregation-prone
112E G O 1.0551 Aggregation-prone
112D E O 0.8933 Aggregation-prone
112C F O 0.9773 Aggregation-prone
112B F O 0.2269 Aggregation-prone
112A Y O 0.1227 Aggregation-prone
112 Y O -0.4237 Soluble
113 Y O -0.8117 Soluble
114 S O -0.8325 Soluble
115 M O 0.0000 Buried
116 D O -0.6565 Soluble
117 V O -0.2096 Soluble
118 W O -0.2999 Soluble
119 G O 0.0000 Buried
120 K O -2.2859 Soluble
121 G O -1.2945 Soluble
122 T O -0.6457 Soluble
123 T O 0.0321 Aggregation-prone
124 V O 0.0000 Buried
125 T O 0.2024 Aggregation-prone
126 V O 0.0000 Buried
127 S O -0.4278 Soluble
128 S O -0.6817 Soluble
129 A O -0.3728 Soluble
11 L P 0.7684 Aggregation-prone
12 S P 0.7001 Aggregation-prone
13 V P 0.0000 Buried
14 A P 0.5845 Aggregation-prone
15 L P 0.7383 Aggregation-prone
16 G P -0.8301 Soluble
17 E P -1.4185 Soluble
18 T P -1.2223 Soluble
19 A P 0.0000 Buried
20 R P -1.7905 Soluble
21 I P 0.0000 Buried
22 S P -1.1304 Soluble
23 C P -0.9600 Soluble
24 G P -1.4489 Soluble
25 R P -1.7977 Soluble
26 Q P -1.8436 Soluble
27 A P -1.0422 Soluble
28 L P -0.3092 Soluble
29 G P -0.1581 Soluble
36 S P -0.1376 Soluble
37 R P 0.0000 Buried
38 A P 0.0000 Buried
39 V P 0.0000 Buried
40 Q P 0.0000 Buried
41 W P 0.0000 Buried
42 Y P 0.0000 Buried
43 Q P -0.3103 Soluble
44 H P 0.0000 Buried
45 R P -1.6038 Soluble
46 P P -1.4018 Soluble
47 G P -1.6052 Soluble
48 Q P -2.0424 Soluble
49 A P -1.1088 Soluble
50 P P 0.0000 Buried
51 I P 0.6326 Aggregation-prone
52 L P 0.0000 Buried
53 L P 0.0000 Buried
54 I P 0.0000 Buried
55 Y P -0.8248 Soluble
56 N P -1.5128 Soluble
57 N P 0.0000 Buried
65 Q P -2.3817 Soluble
66 D P -2.2855 Soluble
67 R P -1.7489 Soluble
68 P P -0.8512 Soluble
69 S P -0.6567 Soluble
70 G P -0.7182 Soluble
71 I P -0.6612 Soluble
72 P P -1.3253 Soluble
74 E P -2.3460 Soluble
75 R P -1.7839 Soluble
76 F P 0.0000 Buried
77 S P -1.2536 Soluble
78 G P -1.1703 Soluble
79 T P -0.9581 Soluble
80 P P -1.1409 Soluble
81 D P -1.2203 Soluble
81A I P 0.9896 Aggregation-prone
82 N P 0.1162 Aggregation-prone
83 F P 1.0939 Aggregation-prone
84 G P -0.1002 Soluble
85 T P -0.7654 Soluble
86 R P -2.1912 Soluble
87 A P -1.5958 Soluble
88 T P -1.0932 Soluble
89 L P 0.0000 Buried
90 T P -1.0388 Soluble
91 I P 0.0000 Buried
92 S P -1.6256 Soluble
93 G P -1.0861 Soluble
94 V P 0.0000 Buried
95 E P -1.2046 Soluble
96 A P -0.3672 Soluble
97 G P -0.8083 Soluble
98 D P 0.0000 Buried
99 E P -1.5526 Soluble
100 A P 0.0000 Buried
101 D P -1.5182 Soluble
102 Y P 0.0000 Buried
103 Y P 0.0000 Buried
104 C P 0.0000 Buried
105 H P 0.0000 Buried
106 M P 0.0000 Buried
107 W P 0.0000 Buried
108 D P 0.0000 Buried
109 S P -0.7469 Soluble
110 R P -1.8417 Soluble
112 S P -0.9716 Soluble
113 G P -0.3417 Soluble
114 F P 0.9994 Aggregation-prone
115 S P 0.4924 Aggregation-prone
116 W P 0.1727 Aggregation-prone
117 S P -0.2268 Soluble
118 F P 0.0000 Buried
119 G P -0.7292 Soluble
120 G P -1.2340 Soluble
121 A P -1.0982 Soluble
122 T P -0.8592 Soluble
123 R P -1.7720 Soluble
124 L P 0.0000 Buried
125 T P 0.0310 Aggregation-prone
126 V P 0.6590 Aggregation-prone
127 L P 1.4915 Aggregation-prone
128 G P 0.5684 Aggregation-prone

3D Structure — colored by A4D score

Sequence - click residue to focus in viewer  |  colored by A4D score
Load structure to view sequence…
Downloads
Color Legend (B-factor = A4D Score)
Score > 1.5 — highly aggregation-prone
Score 0.5–1.5 — aggregation-prone
Score ≈ 0 — buried
Score −1 to −0.5 — soluble
Score < −2.5 — highly soluble
pH Structure
Load structure at specific pH condition
A4D Score Threshold
Highlight residues > threshold in the sequence panel
CDR Regions
HCDR1
HCDR2
HCDR3
LCDR1
LCDR2
LCDR3
Display Options

pH-Dependent Aggregation Profiles

A4D scores calculated across 11 pH conditions (4.0–9.0, step 0.5). Click a row to view the structure at that pH. The input structure is globular — max score is recommended for pH analysis.

pH Avg A4D Score Max A4D Score Downloads
4.0 -0.5307 4.4839 CSV PDB
4.5 -0.5696 4.4511 CSV PDB
5.0 -0.6173 4.403 CSV PDB
5.5 -0.6662 4.3474 CSV PDB
6.0 -0.708 4.2931 CSV PDB
6.5 -0.7365 4.2488 CSV PDB
7.0 -0.7504 4.2213 CSV PDB
7.5 -0.7538 4.2087 CSV PDB
8.0 -0.7506 4.204 CSV PDB
8.5 -0.7421 4.2024 CSV PDB
9.0 -0.7284 4.2019 CSV PDB
Average A4D Score vs pH
Max A4D Score vs pH