Nirsevimab / 5udc

A4DAB181_5udc_E_G | Source PDB: 5udc | Chains: E, G | Done
100
Yes
10 Å
Yes
Avg A4D Score
-0.6718
Max Score
2.6636
Min Score
-3.6371
Total Score
-290.89
Score CDR
-0.1279
Score non-CDR
-0.7477

Calculation Parameters

Chain Sequence(s) QVQLVQSGAEVKKPGSSVMVSCQASGGLLEDYIINWVRQAPGQGPEWMGGIIPVLGTVHYGPKFQGRVTITADESTDTAYMELSSLRSEDTAMYYCATETALVVSETYLPHYFDNWGQGTLVTVSSASTKGPSVFPLAPTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSDIQMTQSPSSLSAAVGDRVTITCQASQDIVNYLNWYQQKPGKAPKLLIYVASNLETGVPSRFSGSGSGTDFSLTISSLQPEDVATYYCQQYDNLPLTFGGGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGE input.pdb
Selected Chain(s) E (Heavy), G (Light)
Distance of Aggregation 10 Å
FoldX Energy Minimization Yes
pH Calculations Yes
Downloads Download all data (.tar.gz)

Aggrescan4D Profile

Aggregation-prone (score > 0)
Soluble (score < 0)
Buried (score = 0)

Per-Residue A4D Scores

Download CSV
Minimum Score -3.6371
Maximum Score 2.6636
Average Score -0.6718
Total Score -290.895

Residues with A4D score > 0.0 are highlighted as aggregation-prone.

Index Residue Chain A4D Score Classification
1 Q E -1.5956 Soluble
2 V E -1.1263 Soluble
3 Q E -1.5940 Soluble
4 L E 0.0000 Buried
5 V E 0.2663 Aggregation-prone
6 Q E 0.0000 Buried
7 S E -0.3037 Soluble
8 G E -0.9486 Soluble
9 A E -1.0984 Soluble
11 E E -1.6228 Soluble
12 V E -1.0632 Soluble
13 K E -1.7556 Soluble
14 K E -2.4222 Soluble
15 P E -1.9248 Soluble
16 G E -1.5852 Soluble
17 S E -1.2599 Soluble
18 S E -1.0053 Soluble
19 V E 0.0000 Buried
20 M E 0.1812 Aggregation-prone
21 V E 0.0000 Buried
22 S E 0.0884 Aggregation-prone
23 C E 0.0000 Buried
24 Q E -0.4791 Soluble
25 A E 0.0000 Buried
26 S E -0.8497 Soluble
27 G E -1.0055 Soluble
28 G E -0.7404 Soluble
29 L E -0.5089 Soluble
30 L E 0.0000 Buried
35 E E -1.4522 Soluble
36 D E -0.3579 Soluble
37 Y E -0.0450 Soluble
38 I E 0.0000 Buried
39 I E 0.0000 Buried
40 N E 0.0000 Buried
41 W E 0.0000 Buried
42 V E 0.0000 Buried
43 R E 0.0000 Buried
44 Q E -0.6239 Soluble
45 A E -1.0437 Soluble
46 P E -1.0856 Soluble
47 G E -1.2211 Soluble
48 Q E -1.7361 Soluble
49 G E -1.0665 Soluble
50 P E 0.0000 Buried
51 E E -0.5449 Soluble
52 W E 0.0000 Buried
53 M E 0.0000 Buried
54 G E 0.0000 Buried
55 G E 0.0000 Buried
56 I E 0.0000 Buried
57 I E 0.0000 Buried
58 P E -0.4649 Soluble
59 V E 0.5774 Aggregation-prone
62 L E 0.2465 Aggregation-prone
63 G E 0.0178 Aggregation-prone
64 T E 0.2527 Aggregation-prone
65 V E 0.7381 Aggregation-prone
66 H E 0.2643 Aggregation-prone
67 Y E -0.3427 Soluble
68 G E 0.0000 Buried
69 P E -1.6874 Soluble
70 K E -2.2208 Soluble
71 F E 0.0000 Buried
72 Q E -2.0308 Soluble
74 G E -1.4644 Soluble
75 R E -1.3603 Soluble
76 V E 0.0000 Buried
77 T E -0.4834 Soluble
78 I E 0.0000 Buried
79 T E -0.3836 Soluble
80 A E -1.1190 Soluble
81 D E -2.0113 Soluble
82 E E -2.6016 Soluble
83 S E -1.3919 Soluble
84 T E -1.1061 Soluble
85 D E -1.4601 Soluble
86 T E 0.0000 Buried
87 A E 0.0000 Buried
88 Y E -0.0212 Soluble
89 M E 0.0000 Buried
90 E E -0.7071 Soluble
91 L E 0.0000 Buried
92 S E -0.8819 Soluble
93 S E -1.1109 Soluble
94 L E 0.0000 Buried
95 R E -2.6615 Soluble
96 S E -2.1190 Soluble
97 E E -2.4194 Soluble
98 D E 0.0000 Buried
99 T E -0.9171 Soluble
100 A E 0.0000 Buried
101 M E -0.0003 Soluble
102 Y E 0.0000 Buried
103 Y E 0.0000 Buried
104 C E 0.0000 Buried
105 A E 0.0000 Buried
106 T E 0.0000 Buried
107 E E 0.0000 Buried
108 T E 0.2163 Aggregation-prone
109 A E 0.0000 Buried
110 L E 2.1820 Aggregation-prone
111 V E 2.6636 Aggregation-prone
111A V E 1.3974 Aggregation-prone
111B S E -0.0832 Soluble
111C E E -1.5376 Soluble
112C T E -0.6763 Soluble
112B Y E 0.0451 Aggregation-prone
112A L E 0.1996 Aggregation-prone
112 P E 0.0000 Buried
113 H E 0.1619 Aggregation-prone
114 Y E 0.2640 Aggregation-prone
115 F E 0.0000 Buried
116 D E -0.9490 Soluble
117 N E -1.1946 Soluble
118 W E 0.0000 Buried
119 G E 0.0000 Buried
120 Q E -1.4534 Soluble
121 G E -0.7460 Soluble
122 T E 0.0000 Buried
123 L E -0.3061 Soluble
124 V E 0.0000 Buried
125 T E 0.0000 Buried
126 V E 0.0000 Buried
127 S E -1.1514 Soluble
128 S E -1.0389 Soluble
129 A E -0.6258 Soluble
130 S E -0.7339 Soluble
131 T E -0.9890 Soluble
132 K E -1.2536 Soluble
133 G E -1.4345 Soluble
134 P E 0.0000 Buried
135 S E -0.2369 Soluble
136 V E 0.0000 Buried
137 F E -0.5342 Soluble
138 P E -1.1969 Soluble
139 L E 0.0000 Buried
140 A E 0.0000 Buried
141 P E -0.7895 Soluble
142 T E -0.2924 Soluble
143 A E -0.1659 Soluble
144 A E 0.0000 Buried
145 L E 0.0000 Buried
146 G E 0.0000 Buried
147 C E 0.0000 Buried
148 L E 0.0000 Buried
149 V E 0.0000 Buried
150 K E 0.0000 Buried
151 D E -0.3930 Soluble
152 Y E 0.0000 Buried
153 F E 0.0000 Buried
154 P E 0.0000 Buried
155 E E -0.6550 Soluble
156 P E -0.7898 Soluble
157 V E -0.7649 Soluble
158 T E -0.7434 Soluble
159 V E -0.5597 Soluble
160 S E -0.5146 Soluble
161 W E 0.0000 Buried
162 N E -0.7804 Soluble
163 S E -0.6941 Soluble
164 G E -0.5434 Soluble
165 A E -0.2121 Soluble
166 L E -0.0131 Soluble
167 T E -0.1951 Soluble
168 S E -0.2062 Soluble
169 G E -0.2298 Soluble
170 V E 0.1365 Aggregation-prone
171 H E -0.1866 Soluble
172 T E 0.0133 Aggregation-prone
173 F E 0.0000 Buried
174 P E -0.3014 Soluble
175 A E 0.2791 Aggregation-prone
176 V E 0.5499 Aggregation-prone
177 L E 1.0753 Aggregation-prone
178 Q E 0.2393 Aggregation-prone
179 S E -0.1291 Soluble
180 S E -0.2247 Soluble
181 G E 0.0217 Aggregation-prone
182 L E 0.1968 Aggregation-prone
183 Y E 0.5217 Aggregation-prone
184 S E 0.0000 Buried
185 L E 0.0000 Buried
186 S E 0.0000 Buried
187 S E 0.0000 Buried
188 V E 0.0000 Buried
189 V E 0.0000 Buried
190 T E -0.1466 Soluble
191 V E 0.0000 Buried
192 P E -0.3967 Soluble
193 S E -0.4509 Soluble
194 S E -0.5101 Soluble
195 S E -0.5351 Soluble
196 L E -0.6351 Soluble
197 G E -0.9087 Soluble
198 T E -0.6826 Soluble
199 Q E -0.9904 Soluble
200 T E -1.0961 Soluble
201 Y E 0.0000 Buried
202 I E -1.4418 Soluble
203 C E 0.0000 Buried
204 N E -1.7038 Soluble
205 V E 0.0000 Buried
206 N E -2.5259 Soluble
207 H E 0.0000 Buried
208 K E -3.1962 Soluble
209 P E -2.0277 Soluble
210 S E -2.0991 Soluble
211 N E -2.7248 Soluble
212 T E -2.2234 Soluble
213 K E -2.9876 Soluble
214 V E -1.7907 Soluble
215 D E -2.6230 Soluble
216 K E -1.9896 Soluble
217 R E -2.6289 Soluble
218 V E 0.0000 Buried
219 E E -2.8626 Soluble
220 P E -2.0303 Soluble
221 K E -2.6963 Soluble
222 S E -1.5506 Soluble
1 D G -2.2769 Soluble
2 I G 0.0000 Buried
3 Q G -2.0223 Soluble
4 M G 0.0000 Buried
5 T G -1.0581 Soluble
6 Q G -0.9152 Soluble
7 S G -0.7345 Soluble
8 P G -0.6725 Soluble
9 S G -0.9193 Soluble
10 S G -1.0367 Soluble
11 L G -0.7267 Soluble
12 S G -1.0330 Soluble
13 A G -1.1549 Soluble
14 A G -1.0491 Soluble
15 V G -0.3325 Soluble
16 G G -0.9120 Soluble
17 D G -1.9448 Soluble
18 R G -2.4123 Soluble
19 V G 0.0000 Buried
20 T G -0.5438 Soluble
21 I G 0.0000 Buried
22 T G -0.7466 Soluble
23 C G 0.0000 Buried
24 Q G -2.0532 Soluble
25 A G -1.8815 Soluble
26 S G -1.9883 Soluble
27 Q G -2.4094 Soluble
28 D G -2.3089 Soluble
29 I G 0.0000 Buried
36 V G 0.3213 Aggregation-prone
37 N G -0.0015 Soluble
38 Y G 0.5312 Aggregation-prone
39 L G 0.0000 Buried
40 N G 0.0000 Buried
41 W G 0.0000 Buried
42 Y G 0.0000 Buried
43 Q G 0.0000 Buried
44 Q G 0.0000 Buried
45 K G -1.7619 Soluble
46 P G -1.4356 Soluble
47 G G -1.7714 Soluble
48 K G -2.4447 Soluble
49 A G -1.5977 Soluble
50 P G 0.0000 Buried
51 K G -1.4928 Soluble
52 L G 0.0000 Buried
53 L G 0.0000 Buried
54 I G 0.0000 Buried
55 Y G 0.4452 Aggregation-prone
56 V G 0.8288 Aggregation-prone
57 A G 0.0000 Buried
65 S G -0.3502 Soluble
66 N G -0.3796 Soluble
67 L G 0.0206 Aggregation-prone
68 E G -0.6026 Soluble
69 T G -0.4289 Soluble
70 G G -0.4897 Soluble
71 V G -0.3194 Soluble
72 P G -0.3558 Soluble
74 S G -0.4322 Soluble
75 R G -0.7439 Soluble
76 F G 0.0000 Buried
77 S G -0.3867 Soluble
78 G G -0.2965 Soluble
79 S G -0.8146 Soluble
80 G G -0.9314 Soluble
83 S G -0.7893 Soluble
84 G G -1.0426 Soluble
85 T G -1.8901 Soluble
86 D G -2.4095 Soluble
87 F G 0.0000 Buried
88 S G -0.7814 Soluble
89 L G 0.0000 Buried
90 T G -0.6116 Soluble
91 I G 0.0000 Buried
92 S G -1.3393 Soluble
93 S G -1.2045 Soluble
94 L G 0.0000 Buried
95 Q G -1.0794 Soluble
96 P G -1.8367 Soluble
97 E G -2.2756 Soluble
98 D G 0.0000 Buried
99 V G 0.0000 Buried
100 A G 0.0000 Buried
101 T G 0.0000 Buried
102 Y G 0.0000 Buried
103 Y G 0.0000 Buried
104 C G 0.0000 Buried
105 Q G 0.0000 Buried
106 Q G 0.0000 Buried
107 Y G 0.0977 Aggregation-prone
108 D G -0.7818 Soluble
109 N G -0.9141 Soluble
114 L G -0.3558 Soluble
115 P G -0.6939 Soluble
116 L G 0.0000 Buried
117 T G -0.6893 Soluble
118 F G -0.2400 Soluble
119 G G 0.0000 Buried
120 G G -1.1327 Soluble
121 G G -1.0232 Soluble
122 T G 0.0000 Buried
123 K G -1.9856 Soluble
124 V G 0.0000 Buried
125 E G -1.3554 Soluble
126 I G 0.0000 Buried
127 K G -1.6815 Soluble
128 R G -1.0758 Soluble
129 T G -0.1131 Soluble
130 V G 0.4899 Aggregation-prone
131 A G 0.2257 Aggregation-prone
132 A G -0.0812 Soluble
133 P G 0.0000 Buried
134 S G -0.0863 Soluble
135 V G 0.0000 Buried
136 F G 0.1494 Aggregation-prone
137 I G 0.1143 Aggregation-prone
138 F G 0.0000 Buried
139 P G -0.4942 Soluble
140 P G 0.0000 Buried
141 S G 0.0000 Buried
142 D G -2.8467 Soluble
143 E G -2.4149 Soluble
144 Q G 0.0000 Buried
145 L G -2.1423 Soluble
146 K G -2.6967 Soluble
147 S G -1.6946 Soluble
148 G G -1.3184 Soluble
149 T G -1.0318 Soluble
150 A G 0.0000 Buried
151 S G 0.0000 Buried
152 V G 0.0000 Buried
153 V G 0.0000 Buried
154 C G 0.0000 Buried
155 L G 0.0000 Buried
156 L G 0.0000 Buried
157 N G 0.0000 Buried
158 N G -0.7533 Soluble
159 F G 0.0000 Buried
160 Y G 0.0000 Buried
161 P G -1.5009 Soluble
162 R G -2.3617 Soluble
163 E G -2.9633 Soluble
164 A G -2.2093 Soluble
165 K G -2.4870 Soluble
166 V G -1.3223 Soluble
167 Q G -0.8921 Soluble
168 W G 0.0000 Buried
169 K G -0.4865 Soluble
170 V G 0.0000 Buried
171 D G -1.4194 Soluble
172 N G -1.2186 Soluble
173 A G -0.3013 Soluble
174 L G 0.4163 Aggregation-prone
175 Q G -0.2285 Soluble
176 S G -0.4531 Soluble
177 G G -0.9103 Soluble
178 N G -0.7737 Soluble
179 S G -1.0149 Soluble
180 Q G -1.1657 Soluble
181 E G -1.7045 Soluble
182 S G -0.6952 Soluble
183 V G -0.3089 Soluble
184 T G -0.9574 Soluble
185 E G -2.1529 Soluble
186 Q G 0.0000 Buried
187 D G -2.2664 Soluble
188 S G -2.4522 Soluble
189 K G -2.8667 Soluble
190 D G -2.3148 Soluble
191 S G 0.0000 Buried
192 T G 0.0000 Buried
193 Y G 0.0000 Buried
194 S G 0.0000 Buried
195 L G 0.0000 Buried
196 S G 0.0000 Buried
197 S G 0.0000 Buried
198 T G -0.4981 Soluble
199 L G 0.0000 Buried
200 T G -0.2117 Soluble
201 L G -0.6351 Soluble
202 S G -1.1844 Soluble
203 K G -2.3074 Soluble
204 A G -2.0108 Soluble
205 D G -2.9144 Soluble
206 Y G 0.0000 Buried
207 E G -3.5276 Soluble
208 K G -3.6371 Soluble
209 H G -2.8809 Soluble
210 K G -3.1604 Soluble
211 V G -1.4845 Soluble
212 Y G 0.0000 Buried
213 A G 0.0000 Buried
214 C G 0.0000 Buried
215 E G -1.0312 Soluble
216 V G 0.0000 Buried
217 T G -1.2553 Soluble
218 H G 0.0000 Buried
219 Q G -1.4940 Soluble
220 G G -0.4188 Soluble
221 L G -0.2453 Soluble
222 S G -0.4710 Soluble
223 S G -0.4224 Soluble
224 P G -0.4150 Soluble
225 V G -0.1015 Soluble
226 T G -0.6032 Soluble
227 K G -0.9780 Soluble
228 S G -0.8439 Soluble
229 F G -1.2902 Soluble
230 N G -2.5940 Soluble
231 R G -2.9439 Soluble
232 G G -2.4961 Soluble
233 E G -2.8027 Soluble

3D Structure — colored by A4D score

Sequence - click residue to focus in viewer  |  colored by A4D score
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Color Legend (B-factor = A4D Score)
Score > 1.5 — highly aggregation-prone
Score 0.5–1.5 — aggregation-prone
Score ≈ 0 — buried
Score −1 to −0.5 — soluble
Score < −2.5 — highly soluble
pH Structure
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A4D Score Threshold
Highlight residues > threshold in the sequence panel
CDR Regions
HCDR1
HCDR2
HCDR3
LCDR1
LCDR2
LCDR3
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pH-Dependent Aggregation Profiles

A4D scores calculated across 11 pH conditions (4.0–9.0, step 0.5). Click a row to view the structure at that pH. The input structure is globular — max score is recommended for pH analysis.

pH Avg A4D Score Max A4D Score Downloads
4.0 -0.6268 2.7104 CSV PDB
4.5 -0.6789 2.6409 CSV PDB
5.0 -0.7404 2.5443 CSV PDB
5.5 -0.8007 2.442 CSV PDB
6.0 -0.8481 2.4149 CSV PDB
6.5 -0.8725 2.3876 CSV PDB
7.0 -0.8719 2.3602 CSV PDB
7.5 -0.8541 2.3328 CSV PDB
8.0 -0.8265 2.306 CSV PDB
8.5 -0.7914 2.2806 CSV PDB
9.0 -0.7488 2.2586 CSV PDB
Average A4D Score vs pH
Max A4D Score vs pH