Beludavimab / 7yqx

A4DAB038_7yqx_H_F | Source PDB: 7yqx | Chains: H, F | Done
99.57
Yes
10 Å
Yes
Avg A4D Score
-0.7168
Max Score
1.6796
Min Score
-3.6231
Total Score
-165.58
Score CDR
-0.2603
Score non-CDR
-0.8561

Calculation Parameters

Chain Sequence(s) QVQLVQSGAEVKKPGASVKVSCKASGYPFTSYGISWVRQAPGQGLEWMGWISTYNGNTNYAQKFQGRVTMTTDTSTTTGYMELRRLRSDDTAVYYCARDYTRGAWFGESLIGGFDNWGQGTLVEIVLTQSPGTLSLSPGERATLSCRASQTVSSTSLAWYQQKPGQAPRLLIYGASSRATGIPDRFSGSGSGTDFTLTISRLEPEDFAVYYCQQHDTSLTFGGGTKVEIKR input.pdb
Selected Chain(s) H (Heavy), F (Light)
Distance of Aggregation 10 Å
FoldX Energy Minimization Yes
pH Calculations Yes
Downloads Download all data (.tar.gz)

Aggrescan4D Profile

Aggregation-prone (score > 0)
Soluble (score < 0)
Buried (score = 0)

Per-Residue A4D Scores

Download CSV
Minimum Score -3.6231
Maximum Score 1.6796
Average Score -0.7168
Total Score -165.5814

Residues with A4D score > 0.0 are highlighted as aggregation-prone.

Index Residue Chain A4D Score Classification
1 Q H -1.1525 Soluble
2 V H -0.3944 Soluble
3 Q H -0.6779 Soluble
4 L H -0.2371 Soluble
5 V H 0.2852 Aggregation-prone
6 Q H 0.0000 Buried
7 S H -0.3918 Soluble
8 G H -0.1434 Soluble
9 A H 0.4641 Aggregation-prone
11 E H 0.1141 Aggregation-prone
12 V H 0.6020 Aggregation-prone
13 K H -1.9053 Soluble
14 K H -2.6265 Soluble
15 P H -2.8386 Soluble
16 G H -2.5940 Soluble
17 A H -2.2985 Soluble
18 S H -2.4653 Soluble
19 V H 0.0000 Buried
20 K H -1.9894 Soluble
21 V H 0.0000 Buried
22 S H -0.4695 Soluble
23 C H 0.0000 Buried
24 K H -0.4520 Soluble
25 A H 0.0000 Buried
26 S H -0.5260 Soluble
27 G H -0.7014 Soluble
28 Y H -0.2911 Soluble
29 P H -0.2850 Soluble
30 F H 0.0000 Buried
35 T H 0.1639 Aggregation-prone
36 S H 0.7404 Aggregation-prone
37 Y H 0.5321 Aggregation-prone
38 G H 0.0000 Buried
39 I H 0.0000 Buried
40 S H 0.0000 Buried
41 W H 0.0000 Buried
42 V H 0.0000 Buried
43 R H -0.4416 Soluble
44 Q H -0.7353 Soluble
45 A H -0.7062 Soluble
46 P H -0.9103 Soluble
47 G H -1.2326 Soluble
48 Q H -1.7608 Soluble
49 G H -1.1821 Soluble
50 L H 0.0000 Buried
51 E H -0.9914 Soluble
52 W H -0.2547 Soluble
53 M H 0.0000 Buried
54 G H 0.0000 Buried
55 W H 0.0000 Buried
56 I H 0.0000 Buried
57 S H 0.0000 Buried
58 T H 0.0000 Buried
59 Y H 0.4353 Aggregation-prone
62 N H -1.3018 Soluble
63 G H -1.6409 Soluble
64 N H -1.6029 Soluble
65 T H -1.2390 Soluble
66 N H -1.2750 Soluble
67 Y H -1.0129 Soluble
68 A H -1.4270 Soluble
69 Q H -2.3926 Soluble
70 K H -2.4556 Soluble
71 F H -1.4391 Soluble
72 Q H -2.2142 Soluble
74 G H -1.7368 Soluble
75 R H -1.7144 Soluble
76 V H 0.0000 Buried
77 T H -0.6841 Soluble
78 M H 0.0000 Buried
79 T H -0.3251 Soluble
80 T H -0.5453 Soluble
81 D H -0.6781 Soluble
82 T H -0.3876 Soluble
83 S H -0.4322 Soluble
84 T H -0.4441 Soluble
85 T H -0.5129 Soluble
86 T H 0.0000 Buried
87 G H 0.0000 Buried
88 Y H -0.4371 Soluble
89 M H 0.0000 Buried
90 E H -1.8545 Soluble
91 L H 0.0000 Buried
92 R H -2.9976 Soluble
93 R H -3.2018 Soluble
94 L H 0.0000 Buried
95 R H -3.6231 Soluble
96 S H -2.8913 Soluble
97 D H -2.6094 Soluble
98 D H -1.7896 Soluble
99 T H -0.7468 Soluble
100 A H 0.0143 Aggregation-prone
101 V H 0.0000 Buried
102 Y H 0.0000 Buried
103 Y H 0.0000 Buried
104 C H 0.0000 Buried
105 A H 0.0000 Buried
106 R H -0.1254 Soluble
107 D H 0.0000 Buried
108 Y H 0.6773 Aggregation-prone
109 T H 0.0000 Buried
110 R H -0.3815 Soluble
111 G H 0.4540 Aggregation-prone
111A A H 0.6451 Aggregation-prone
111B W H 1.6445 Aggregation-prone
111C F H 1.6104 Aggregation-prone
112D G H -0.4491 Soluble
112C E H -1.4290 Soluble
112B S H -0.9503 Soluble
112A L H 0.1006 Aggregation-prone
112 I H 0.9543 Aggregation-prone
113 G H 0.0000 Buried
114 G H 0.0000 Buried
115 F H 0.0000 Buried
116 D H -0.5399 Soluble
117 N H -0.5147 Soluble
118 W H -0.3082 Soluble
119 G H 0.0000 Buried
120 Q H -1.1077 Soluble
121 G H -0.3123 Soluble
122 T H 0.0000 Buried
123 L H 1.6796 Aggregation-prone
124 V H 0.7391 Aggregation-prone
1 E F -1.4634 Soluble
2 I F -0.1815 Soluble
3 V F 1.0179 Aggregation-prone
4 L F 0.2251 Aggregation-prone
5 T F -0.6321 Soluble
6 Q F -1.1133 Soluble
7 S F -0.9872 Soluble
8 P F -0.8412 Soluble
9 G F -0.9900 Soluble
10 T F -0.9318 Soluble
11 L F -0.9015 Soluble
12 S F -0.6050 Soluble
13 L F 0.0000 Buried
14 S F -1.3222 Soluble
15 P F -1.7833 Soluble
16 G F -2.1370 Soluble
17 E F -2.7710 Soluble
18 R F -2.9126 Soluble
19 A F 0.0000 Buried
20 T F -0.4967 Soluble
21 L F 0.0000 Buried
22 S F -1.0750 Soluble
23 C F -1.4596 Soluble
24 R F -2.4485 Soluble
25 A F 0.0000 Buried
26 S F -0.8817 Soluble
27 Q F -1.1944 Soluble
28 T F -1.2874 Soluble
29 V F -1.1258 Soluble
30 S F -0.6345 Soluble
36 S F -0.6003 Soluble
37 T F -0.1137 Soluble
38 S F 0.0000 Buried
39 L F 0.0000 Buried
40 A F 0.0000 Buried
41 W F 0.0000 Buried
42 Y F 0.0000 Buried
43 Q F 0.0000 Buried
44 Q F -0.9921 Soluble
45 K F -1.7099 Soluble
46 P F -1.6049 Soluble
47 G F -1.3949 Soluble
48 Q F -1.9991 Soluble
49 A F -1.2792 Soluble
50 P F 0.0000 Buried
51 R F -0.7993 Soluble
52 L F 0.0000 Buried
53 L F 0.0000 Buried
54 I F 0.0000 Buried
55 Y F 0.2334 Aggregation-prone
56 G F 0.0000 Buried
57 A F -0.4119 Soluble
65 S F -0.7141 Soluble
66 S F -0.9832 Soluble
67 R F -2.1927 Soluble
68 A F -1.0128 Soluble
69 T F -0.8499 Soluble
70 G F -1.2901 Soluble
71 I F 0.0000 Buried
72 P F -1.6666 Soluble
74 D F -2.7539 Soluble
75 R F -2.4020 Soluble
76 F F 0.0000 Buried
77 S F -0.8847 Soluble
78 G F -0.5258 Soluble
79 S F -0.7389 Soluble
80 G F -1.4369 Soluble
83 S F -1.2332 Soluble
84 G F -1.5084 Soluble
85 T F -1.8976 Soluble
86 D F -2.6887 Soluble
87 F F 0.0000 Buried
88 T F -1.0554 Soluble
89 L F 0.0000 Buried
90 T F -0.6489 Soluble
91 I F 0.0000 Buried
92 S F -2.5714 Soluble
93 R F -3.3632 Soluble
94 L F 0.0000 Buried
95 E F -2.5294 Soluble
96 P F -1.6686 Soluble
97 E F -2.2199 Soluble
98 D F 0.0000 Buried
99 F F -1.3294 Soluble
100 A F 0.0000 Buried
101 V F 0.0000 Buried
102 Y F 0.0000 Buried
103 Y F 0.0000 Buried
104 C F 0.0000 Buried
105 Q F 0.0000 Buried
106 Q F 0.0000 Buried
107 H F -0.7509 Soluble
108 D F -1.7476 Soluble
114 T F -0.9936 Soluble
115 S F -0.6804 Soluble
116 L F -0.2788 Soluble
117 T F -0.0270 Soluble
118 F F 0.0505 Aggregation-prone
119 G F 0.0000 Buried
120 G F -0.7044 Soluble
121 G F -1.1709 Soluble
122 T F 0.0000 Buried
123 K F -2.1666 Soluble
124 V F -1.3462 Soluble
125 E F -1.8928 Soluble
126 I F -0.5029 Soluble
127 K F -1.1907 Soluble
128 R F -1.8785 Soluble

3D Structure — colored by A4D score

Sequence - click residue to focus in viewer  |  colored by A4D score
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Downloads
Color Legend (B-factor = A4D Score)
Score > 1.5 — highly aggregation-prone
Score 0.5–1.5 — aggregation-prone
Score ≈ 0 — buried
Score −1 to −0.5 — soluble
Score < −2.5 — highly soluble
pH Structure
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A4D Score Threshold
Highlight residues > threshold in the sequence panel
CDR Regions
HCDR1
HCDR2
HCDR3
LCDR1
LCDR2
LCDR3
Display Options

pH-Dependent Aggregation Profiles

A4D scores calculated across 11 pH conditions (4.0–9.0, step 0.5). Click a row to view the structure at that pH. The input structure is globular — max score is recommended for pH analysis.

pH Avg A4D Score Max A4D Score Downloads
4.0 -0.6334 5.2853 CSV PDB
4.5 -0.6821 5.1921 CSV PDB
5.0 -0.7388 5.1214 CSV PDB
5.5 -0.7947 5.0674 CSV PDB
6.0 -0.841 5.0192 CSV PDB
6.5 -0.8701 4.9849 CSV PDB
7.0 -0.8802 4.9669 CSV PDB
7.5 -0.8761 4.9596 CSV PDB
8.0 -0.8625 4.957 CSV PDB
8.5 -0.8413 4.956 CSV PDB
9.0 -0.8139 4.9553 CSV PDB
Average A4D Score vs pH
Max A4D Score vs pH