Beludavimab / 6wpt

A4DAB038_6wpt_D_E | Source PDB: 6wpt | Chains: D, E | Done
99.57
Yes
10 Å
Yes
Avg A4D Score
-0.5827
Max Score
1.671
Min Score
-3.5545
Total Score
-128.78
Score CDR
-0.1149
Score non-CDR
-0.734

Calculation Parameters

Chain Sequence(s) VQLVQSGAEVKKPGASVKVSCKASGYPFTSYGISWVRQAPGQGLEWMGWISTYNGNTNYAQKFQGRVTMTTDTSTTTGYMELRRLRSDDTAVYYCARDYTRGAWFGESLIGGFDNWGQGTLVTIVLTQSTLSLSPGERATLSCRASQTVSSTSLAWYQQKPGQAPRLLIYGASSRATGIPDRFSGSGSGTDFTLTISRLEPEDFAVYYCQQHDTSLTFGGG input.pdb
Selected Chain(s) D (Heavy), E (Light)
Distance of Aggregation 10 Å
FoldX Energy Minimization Yes
pH Calculations Yes
Downloads Download all data (.tar.gz)

Aggrescan4D Profile

Aggregation-prone (score > 0)
Soluble (score < 0)
Buried (score = 0)

Per-Residue A4D Scores

Download CSV
Minimum Score -3.5545
Maximum Score 1.671
Average Score -0.5827
Total Score -128.7779

Residues with A4D score > 0.0 are highlighted as aggregation-prone.

Index Residue Chain A4D Score Classification
2 V D 0.8978 Aggregation-prone
3 Q D -0.5181 Soluble
4 L D 0.0000 Buried
5 V D 0.3105 Aggregation-prone
6 Q D -0.1118 Soluble
7 S D -0.6921 Soluble
8 G D -0.7411 Soluble
9 A D -0.2898 Soluble
11 E D -0.9289 Soluble
12 V D 0.4446 Aggregation-prone
13 K D -1.2715 Soluble
14 K D -2.2886 Soluble
15 P D -2.6109 Soluble
16 G D -2.1514 Soluble
17 A D -1.7246 Soluble
18 S D -2.0825 Soluble
19 V D 0.0000 Buried
20 K D -1.7592 Soluble
21 V D 0.0000 Buried
22 S D -0.4825 Soluble
23 C D 0.0000 Buried
24 K D -0.8416 Soluble
25 A D 0.0000 Buried
26 S D -0.2252 Soluble
27 G D -0.0351 Soluble
28 Y D 0.0553 Aggregation-prone
29 P D -0.3091 Soluble
30 F D 0.0000 Buried
35 T D 0.2306 Aggregation-prone
36 S D 0.4198 Aggregation-prone
37 Y D 0.5852 Aggregation-prone
38 G D 0.0000 Buried
39 I D 0.0000 Buried
40 S D 0.0000 Buried
41 W D 0.0000 Buried
42 V D 0.0000 Buried
43 R D -0.4735 Soluble
44 Q D -0.6718 Soluble
45 A D -0.9422 Soluble
46 P D -0.8730 Soluble
47 G D -1.2061 Soluble
48 Q D -1.8238 Soluble
49 G D -1.0896 Soluble
50 L D 0.0000 Buried
51 E D -0.8248 Soluble
52 W D 0.0000 Buried
53 M D 0.0000 Buried
54 G D 0.0000 Buried
55 W D 0.0000 Buried
56 I D 0.0000 Buried
57 S D 0.0000 Buried
58 T D 0.0000 Buried
59 Y D 0.3253 Aggregation-prone
62 N D -0.8932 Soluble
63 G D -1.4032 Soluble
64 N D -1.5057 Soluble
65 T D -1.2211 Soluble
66 N D -1.2906 Soluble
67 Y D -1.1684 Soluble
68 A D -1.5204 Soluble
69 Q D -2.5470 Soluble
70 K D -2.6290 Soluble
71 F D -2.0083 Soluble
72 Q D -2.4220 Soluble
74 G D -1.9359 Soluble
75 R D -2.1753 Soluble
76 V D 0.0000 Buried
77 T D -0.8153 Soluble
78 M D -0.3780 Soluble
79 T D -0.4177 Soluble
80 T D -0.5518 Soluble
81 D D -1.0696 Soluble
82 T D -0.5422 Soluble
83 S D -0.5535 Soluble
84 T D -0.5971 Soluble
85 T D -0.6780 Soluble
86 T D 0.0000 Buried
87 G D 0.0000 Buried
88 Y D -0.3875 Soluble
89 M D 0.0000 Buried
90 E D -1.4653 Soluble
91 L D 0.0000 Buried
92 R D -2.6804 Soluble
93 R D -3.2153 Soluble
94 L D 0.0000 Buried
95 R D -3.2873 Soluble
96 S D -2.2502 Soluble
97 D D -2.4491 Soluble
98 D D 0.0000 Buried
99 T D -0.6629 Soluble
100 A D 0.0000 Buried
101 V D 0.2948 Aggregation-prone
102 Y D 0.0000 Buried
103 Y D 0.0000 Buried
104 C D 0.0000 Buried
105 A D 0.0000 Buried
106 R D -0.1264 Soluble
107 D D 0.0000 Buried
108 Y D 1.0688 Aggregation-prone
109 T D 0.0000 Buried
110 R D -0.0092 Soluble
111 G D 0.4590 Aggregation-prone
111A A D 0.0000 Buried
111B W D 1.5220 Aggregation-prone
111C F D 1.6039 Aggregation-prone
112D G D -0.3204 Soluble
112C E D -1.3674 Soluble
112B S D -0.6846 Soluble
112A L D 0.4350 Aggregation-prone
112 I D 1.6531 Aggregation-prone
113 G D 0.0000 Buried
114 G D 0.0000 Buried
115 F D 0.0000 Buried
116 D D -0.8730 Soluble
117 N D -0.7343 Soluble
118 W D 0.0000 Buried
119 G D -0.9738 Soluble
120 Q D -1.3500 Soluble
121 G D -0.5509 Soluble
122 T D 0.0000 Buried
123 L D 0.4800 Aggregation-prone
124 V D 0.0000 Buried
125 T D -0.4533 Soluble
2 I E 1.2346 Aggregation-prone
3 V E 1.6710 Aggregation-prone
4 L E 0.0000 Buried
5 T E -0.6424 Soluble
6 Q E -0.8945 Soluble
7 S E -0.5011 Soluble
10 T E 0.4887 Aggregation-prone
11 L E 1.2139 Aggregation-prone
12 S E 0.4021 Aggregation-prone
13 L E -0.1907 Soluble
14 S E -0.9401 Soluble
15 P E -1.7529 Soluble
16 G E -2.3576 Soluble
17 E E -3.0609 Soluble
18 R E -3.4102 Soluble
19 A E 0.0000 Buried
20 T E -0.2738 Soluble
21 L E 0.1435 Aggregation-prone
22 S E -0.8163 Soluble
23 C E 0.0000 Buried
24 R E -2.0991 Soluble
25 A E -0.9563 Soluble
26 S E -0.5121 Soluble
27 Q E -1.1936 Soluble
28 T E -1.1452 Soluble
29 V E 0.0000 Buried
30 S E -0.6745 Soluble
36 S E -0.3100 Soluble
37 T E 0.2218 Aggregation-prone
38 S E 0.0000 Buried
39 L E 0.0000 Buried
40 A E 0.0000 Buried
41 W E 0.0000 Buried
42 Y E 0.0000 Buried
43 Q E 0.0000 Buried
44 Q E 0.0000 Buried
45 K E -1.2685 Soluble
46 P E -0.8961 Soluble
47 G E -1.5219 Soluble
48 Q E -2.1410 Soluble
49 A E -1.4746 Soluble
50 P E 0.0000 Buried
51 R E -1.3589 Soluble
52 L E 0.0000 Buried
53 L E 0.0000 Buried
54 I E 0.0000 Buried
55 Y E 0.1844 Aggregation-prone
56 G E 0.2803 Aggregation-prone
57 A E 0.0000 Buried
65 S E -0.5978 Soluble
66 S E -0.5016 Soluble
67 R E -1.4815 Soluble
68 A E -0.8140 Soluble
69 T E -0.5961 Soluble
70 G E -0.7790 Soluble
71 I E -1.0030 Soluble
72 P E -1.4582 Soluble
74 D E -2.4884 Soluble
75 R E -2.4753 Soluble
76 F E 0.0000 Buried
77 S E -1.0181 Soluble
78 G E -0.4771 Soluble
79 S E -0.7206 Soluble
80 G E -1.0233 Soluble
83 S E -0.9775 Soluble
84 G E -1.2304 Soluble
85 T E -1.8086 Soluble
86 D E -2.4295 Soluble
87 F E 0.0000 Buried
88 T E -0.7637 Soluble
89 L E 0.0000 Buried
90 T E -0.8367 Soluble
91 I E 0.0000 Buried
92 S E -2.5610 Soluble
93 R E -3.5545 Soluble
94 L E 0.0000 Buried
95 E E -1.9865 Soluble
96 P E -1.3506 Soluble
97 E E -1.8709 Soluble
98 D E 0.0000 Buried
99 F E 0.3890 Aggregation-prone
100 A E 0.1777 Aggregation-prone
101 V E 1.0985 Aggregation-prone
102 Y E 0.0000 Buried
103 Y E 0.0000 Buried
104 C E 0.0000 Buried
105 Q E 0.0000 Buried
106 Q E 0.0000 Buried
107 H E 0.0000 Buried
108 D E -1.1109 Soluble
114 T E -0.5139 Soluble
115 S E -0.5367 Soluble
116 L E 0.1286 Aggregation-prone
117 T E 0.3730 Aggregation-prone
118 F E 0.2637 Aggregation-prone
119 G E 0.0000 Buried
120 G E -0.7357 Soluble
121 G E -0.6076 Soluble

3D Structure — colored by A4D score

Sequence - click residue to focus in viewer  |  colored by A4D score
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Color Legend (B-factor = A4D Score)
Score > 1.5 — highly aggregation-prone
Score 0.5–1.5 — aggregation-prone
Score ≈ 0 — buried
Score −1 to −0.5 — soluble
Score < −2.5 — highly soluble
pH Structure
Load structure at specific pH condition
A4D Score Threshold
Highlight residues > threshold in the sequence panel
CDR Regions
HCDR1
HCDR2
HCDR3
LCDR1
LCDR2
LCDR3
Display Options

pH-Dependent Aggregation Profiles

A4D scores calculated across 11 pH conditions (4.0–9.0, step 0.5). Click a row to view the structure at that pH. The input structure is globular — max score is recommended for pH analysis.

pH Avg A4D Score Max A4D Score Downloads
4.0 -0.488 5.3173 CSV PDB
4.5 -0.5251 5.2309 CSV PDB
5.0 -0.5682 5.1089 CSV PDB
5.5 -0.6105 4.995 CSV PDB
6.0 -0.645 4.9316 CSV PDB
6.5 -0.6671 4.8816 CSV PDB
7.0 -0.6768 4.8518 CSV PDB
7.5 -0.6778 4.8386 CSV PDB
8.0 -0.673 4.8338 CSV PDB
8.5 -0.6634 4.8321 CSV PDB
9.0 -0.6488 4.8312 CSV PDB
Average A4D Score vs pH
Max A4D Score vs pH