Zinlirvimab / 6v8z

A4DAB308_6v8z_P_Q | Source PDB: 6v8z | Chains: P, Q | Done
100
Yes
10 Å
Yes
Avg A4D Score
-0.6587
Max Score
2.6813
Min Score
-3.128
Total Score
-288.49
Score CDR
-0.2716
Score non-CDR
-0.7225

Calculation Parameters

Chain Sequence(s) QVQLQESGPGLVKPSETLSVTCSVSGDSMNNYYWTWIRQSPGKGLEWIGYISDRESATYNPSLNSRVVISRDTSKNQLSLKLNSVTPADTAVYYCATARRGQRIYGVVSFGEFFYYYSMDVWGKGTTVTVSSASTKGPSVFPLAPSSKTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCLSVALGETARISCGRQALGSRAVQWYQHRPGQAPILLIYNNQDRPSGIPERFSGTPDINFGTRATLTISGVEAGDEADYYCHMWDSRSGFSWSFGGATRLTVLGQPKAAPSVTLFPPSSEELQANKATLVCLISDFYPGAVTVAWKADSSPVKAGVETTTPSKQSNNKYAASSYLSLTPEQWKSHRSYSCQVTHEGSTVEKTVAPTEC input.pdb
Selected Chain(s) P (Heavy), Q (Light)
Distance of Aggregation 10 Å
FoldX Energy Minimization Yes
pH Calculations Yes
Downloads Download all data (.tar.gz)

Aggrescan4D Profile

Aggregation-prone (score > 0)
Soluble (score < 0)
Buried (score = 0)

Per-Residue A4D Scores

Download CSV
Minimum Score -3.128
Maximum Score 2.6813
Average Score -0.6587
Total Score -288.4924

Residues with A4D score > 0.0 are highlighted as aggregation-prone.

Index Residue Chain A4D Score Classification
1 Q P -1.7129 Soluble
2 V P -1.4601 Soluble
3 Q P -1.9894 Soluble
4 L P 0.0000 Buried
5 Q P -1.5168 Soluble
6 E P 0.0000 Buried
7 S P -0.7900 Soluble
8 G P -0.4402 Soluble
9 P P -0.5096 Soluble
11 G P -0.5201 Soluble
12 L P -0.3914 Soluble
13 V P 0.0000 Buried
14 K P -1.9290 Soluble
15 P P -1.3837 Soluble
16 S P -1.4175 Soluble
17 E P -1.9524 Soluble
18 T P -1.4371 Soluble
19 L P 0.0000 Buried
20 S P -0.6778 Soluble
21 V P 0.0000 Buried
22 T P -0.4987 Soluble
23 C P 0.0000 Buried
24 S P -0.9716 Soluble
25 V P -1.2977 Soluble
26 S P -1.7666 Soluble
27 G P -1.9030 Soluble
28 D P -2.8614 Soluble
29 S P -1.8255 Soluble
30 M P 0.0000 Buried
35 N P -2.1231 Soluble
36 N P -1.9855 Soluble
37 Y P -1.1832 Soluble
38 Y P -1.0971 Soluble
39 W P 0.0000 Buried
40 T P 0.0000 Buried
41 W P 0.0000 Buried
42 I P 0.0000 Buried
43 R P -0.6823 Soluble
44 Q P -1.0398 Soluble
45 S P -0.9790 Soluble
46 P P -1.0811 Soluble
47 G P -1.4977 Soluble
48 K P -2.3328 Soluble
49 G P -1.6124 Soluble
50 L P 0.0000 Buried
51 E P -1.1873 Soluble
52 W P 0.0000 Buried
53 I P 0.0000 Buried
54 G P 0.0000 Buried
55 Y P 0.0000 Buried
56 I P 0.0000 Buried
57 S P 0.0000 Buried
58 D P -2.2705 Soluble
59 R P -2.9983 Soluble
63 E P -2.9029 Soluble
64 S P -1.6272 Soluble
65 A P -0.4494 Soluble
66 T P 0.2119 Aggregation-prone
67 Y P 0.6196 Aggregation-prone
68 N P 0.0000 Buried
69 P P -0.4038 Soluble
70 S P -0.4921 Soluble
71 L P -0.5374 Soluble
72 N P -1.4581 Soluble
74 S P -0.8233 Soluble
75 R P -0.9490 Soluble
76 V P 0.0000 Buried
77 V P 0.8413 Aggregation-prone
78 I P 0.3538 Aggregation-prone
79 S P -0.4928 Soluble
80 R P -1.2394 Soluble
81 D P -1.4767 Soluble
82 T P -1.5834 Soluble
83 S P -1.6095 Soluble
84 K P -2.4505 Soluble
85 N P -2.1153 Soluble
86 Q P -1.5253 Soluble
87 L P 0.0000 Buried
88 S P -0.3923 Soluble
89 L P 0.0000 Buried
90 K P -0.8554 Soluble
91 L P 0.0000 Buried
92 N P -1.4879 Soluble
93 S P -1.2312 Soluble
94 V P 0.0000 Buried
95 T P -0.7722 Soluble
96 P P -0.4893 Soluble
97 A P -0.1011 Soluble
98 D P 0.0000 Buried
99 T P -0.1512 Soluble
100 A P 0.0000 Buried
101 V P -0.0878 Soluble
102 Y P 0.0000 Buried
103 Y P 0.0000 Buried
104 C P 0.0000 Buried
105 A P 0.0000 Buried
106 T P 0.0000 Buried
107 A P 0.0000 Buried
108 R P -1.8494 Soluble
109 R P -2.0432 Soluble
110 G P -1.0850 Soluble
111 Q P -0.2750 Soluble
111A R P 0.2771 Aggregation-prone
111B I P 1.8483 Aggregation-prone
111C Y P 1.5970 Aggregation-prone
111D G P 1.6355 Aggregation-prone
111E V P 2.6640 Aggregation-prone
111F V P 2.6813 Aggregation-prone
112G S P 1.5008 Aggregation-prone
112F F P 2.3170 Aggregation-prone
112E G P 1.2043 Aggregation-prone
112D E P 1.1587 Aggregation-prone
112C F P 1.5181 Aggregation-prone
112B F P 0.9972 Aggregation-prone
112A Y P 0.8110 Aggregation-prone
112 Y P 0.0000 Buried
113 Y P -0.6924 Soluble
114 S P 0.0000 Buried
115 M P 0.0000 Buried
116 D P -0.4838 Soluble
117 V P -0.2255 Soluble
118 W P -0.4887 Soluble
119 G P -1.3498 Soluble
120 K P -2.2456 Soluble
121 G P -1.2018 Soluble
122 T P 0.0000 Buried
123 T P -0.1350 Soluble
124 V P 0.0000 Buried
125 T P -0.3239 Soluble
126 V P 0.0000 Buried
127 S P -0.7501 Soluble
128 S P -0.7863 Soluble
129 A P -0.5961 Soluble
130 S P -0.8055 Soluble
131 T P -1.0739 Soluble
132 K P -1.8056 Soluble
133 G P -1.5967 Soluble
134 P P -0.8406 Soluble
135 S P -0.4154 Soluble
136 V P 0.0000 Buried
137 F P -0.6404 Soluble
138 P P 0.0000 Buried
139 L P 0.0000 Buried
140 A P 0.0000 Buried
141 P P -0.7568 Soluble
142 S P -0.7606 Soluble
143 S P -1.1868 Soluble
144 K P -1.8544 Soluble
145 T P -0.7974 Soluble
146 A P 0.0000 Buried
147 A P -0.4191 Soluble
148 L P 0.0000 Buried
149 G P 0.0000 Buried
150 C P 0.0000 Buried
151 L P 0.0000 Buried
152 V P 0.0000 Buried
153 K P 0.0000 Buried
154 D P -0.8818 Soluble
155 Y P 0.0000 Buried
156 F P -0.5860 Soluble
157 P P 0.0000 Buried
158 E P -0.4421 Soluble
159 P P -0.4911 Soluble
160 V P -0.5501 Soluble
161 T P -0.7194 Soluble
162 V P 0.0000 Buried
163 S P -0.3442 Soluble
164 W P 0.0000 Buried
165 N P -0.8574 Soluble
166 S P -0.6604 Soluble
167 G P -0.3507 Soluble
168 A P -0.1626 Soluble
169 L P -0.0085 Soluble
170 T P -0.0999 Soluble
171 S P -0.2152 Soluble
172 G P -0.2244 Soluble
173 V P 0.1688 Aggregation-prone
174 H P -0.1516 Soluble
175 T P 0.0302 Aggregation-prone
176 F P -0.1061 Soluble
177 P P 0.0835 Aggregation-prone
178 A P 0.1789 Aggregation-prone
179 V P 0.0000 Buried
180 L P 0.8229 Aggregation-prone
181 Q P 0.0485 Aggregation-prone
182 S P -0.2505 Soluble
183 S P -0.4049 Soluble
184 G P -0.3320 Soluble
185 L P -0.1900 Soluble
186 Y P 0.2043 Aggregation-prone
187 S P 0.0000 Buried
188 L P 0.0000 Buried
189 S P 0.0000 Buried
190 S P 0.0000 Buried
191 V P 0.2041 Aggregation-prone
192 V P 0.0000 Buried
193 T P -0.3599 Soluble
194 V P 0.0000 Buried
195 P P -0.7820 Soluble
196 S P -0.9112 Soluble
197 S P -0.4855 Soluble
198 S P -0.7135 Soluble
199 L P 0.0000 Buried
200 G P -1.0772 Soluble
201 T P -0.9649 Soluble
202 Q P -1.3857 Soluble
203 T P -1.1611 Soluble
204 Y P 0.0000 Buried
205 I P -1.5800 Soluble
206 C P 0.0000 Buried
207 N P -1.7082 Soluble
208 V P 0.0000 Buried
209 N P -2.6350 Soluble
210 H P 0.0000 Buried
211 K P -2.8305 Soluble
212 P P -1.7978 Soluble
213 S P -2.0363 Soluble
214 N P -2.7170 Soluble
215 T P -2.3333 Soluble
216 K P -3.0196 Soluble
217 V P -1.9792 Soluble
218 D P -2.9502 Soluble
219 K P -2.3669 Soluble
220 R P -2.6915 Soluble
221 V P 0.0000 Buried
222 E P -1.8018 Soluble
223 P P -1.2448 Soluble
224 K P -0.9683 Soluble
225 S P -0.7886 Soluble
226 C P -0.8594 Soluble
11 L Q 0.2209 Aggregation-prone
12 S Q 0.3446 Aggregation-prone
13 V Q 0.0735 Aggregation-prone
14 A Q 0.0518 Aggregation-prone
15 L Q -0.3607 Soluble
16 G Q -1.3731 Soluble
17 E Q -1.8720 Soluble
18 T Q -1.4637 Soluble
19 A Q 0.0000 Buried
20 R Q -1.9327 Soluble
21 I Q 0.0000 Buried
22 S Q -1.0772 Soluble
23 C Q -1.1810 Soluble
24 G Q -1.4631 Soluble
25 R Q -1.6923 Soluble
26 Q Q -1.7538 Soluble
27 A Q -1.3122 Soluble
28 L Q -0.4176 Soluble
29 G Q -0.3364 Soluble
36 S Q 0.1996 Aggregation-prone
37 R Q -0.1072 Soluble
38 A Q 0.0000 Buried
39 V Q 0.0000 Buried
40 Q Q 0.0000 Buried
41 W Q 0.0000 Buried
42 Y Q 0.0000 Buried
43 Q Q 0.0000 Buried
44 H Q 0.0000 Buried
45 R Q -1.2519 Soluble
46 P Q -1.2801 Soluble
47 G Q -1.4724 Soluble
48 Q Q -1.8362 Soluble
49 A Q -0.9536 Soluble
50 P Q 0.0000 Buried
51 I Q 0.3772 Aggregation-prone
52 L Q 0.0000 Buried
53 L Q 0.0000 Buried
54 I Q 0.0000 Buried
55 Y Q -0.8679 Soluble
56 N Q -1.0760 Soluble
57 N Q -1.2424 Soluble
65 Q Q -1.9251 Soluble
66 D Q -1.7399 Soluble
67 R Q -2.0078 Soluble
68 P Q -1.2663 Soluble
69 S Q -0.9164 Soluble
70 G Q -0.7701 Soluble
71 I Q -0.7914 Soluble
72 P Q -1.3575 Soluble
74 E Q -2.3785 Soluble
75 R Q -1.7511 Soluble
76 F Q 0.0000 Buried
77 S Q -1.1739 Soluble
78 G Q -0.9605 Soluble
79 T Q -1.2873 Soluble
80 P Q -1.5980 Soluble
81 D Q -2.0772 Soluble
81A I Q -0.9426 Soluble
82 N Q -0.8455 Soluble
83 F Q 0.9296 Aggregation-prone
84 G Q -0.1982 Soluble
85 T Q -1.0280 Soluble
86 R Q -2.1101 Soluble
87 A Q 0.0000 Buried
88 T Q -1.0494 Soluble
89 L Q 0.0000 Buried
90 T Q -0.8848 Soluble
91 I Q 0.0000 Buried
92 S Q -1.6023 Soluble
93 G Q -1.4305 Soluble
94 V Q 0.0000 Buried
95 E Q -1.9893 Soluble
96 A Q -1.0880 Soluble
97 G Q -1.0687 Soluble
98 D Q 0.0000 Buried
99 E Q -1.0435 Soluble
100 A Q 0.0000 Buried
101 D Q -1.1122 Soluble
102 Y Q 0.0000 Buried
103 Y Q 0.0000 Buried
104 C Q 0.0000 Buried
105 H Q 0.0000 Buried
106 M Q 0.0000 Buried
107 W Q 0.0000 Buried
108 D Q 0.0000 Buried
109 S Q -0.6821 Soluble
110 R Q -1.8045 Soluble
112 S Q -0.7886 Soluble
113 G Q -0.0031 Soluble
114 F Q 1.5554 Aggregation-prone
115 S Q 0.7676 Aggregation-prone
116 W Q 0.2174 Aggregation-prone
117 S Q -0.2103 Soluble
118 F Q -0.4855 Soluble
119 G Q -0.9410 Soluble
120 G Q -1.2189 Soluble
121 A Q -0.8064 Soluble
122 T Q -0.8015 Soluble
123 R Q -1.6837 Soluble
124 L Q 0.0000 Buried
125 T Q 0.0642 Aggregation-prone
126 V Q 0.0000 Buried
127 L Q 1.1130 Aggregation-prone
128 G Q 0.0731 Aggregation-prone
129 Q Q -0.6305 Soluble
130 P Q -1.3119 Soluble
131 K Q -2.1050 Soluble
132 A Q -1.4037 Soluble
133 A Q -0.7770 Soluble
134 P Q -0.5530 Soluble
135 S Q -0.3213 Soluble
136 V Q 0.0000 Buried
137 T Q -0.2087 Soluble
138 L Q -0.0452 Soluble
139 F Q 0.0000 Buried
140 P Q 0.0000 Buried
141 P Q 0.0000 Buried
142 S Q 0.0000 Buried
143 S Q -1.1300 Soluble
144 E Q -1.7788 Soluble
145 E Q 0.0000 Buried
146 L Q -1.2037 Soluble
147 Q Q -1.8276 Soluble
148 A Q -1.4201 Soluble
149 N Q -2.2228 Soluble
150 K Q -1.7998 Soluble
151 A Q 0.0000 Buried
152 T Q 0.0000 Buried
153 L Q 0.0000 Buried
154 V Q 0.0000 Buried
155 C Q 0.0000 Buried
156 L Q 0.0000 Buried
157 I Q 0.0000 Buried
158 S Q -0.6356 Soluble
159 D Q -1.5260 Soluble
160 F Q 0.0000 Buried
161 Y Q -1.1510 Soluble
162 P Q -0.8932 Soluble
163 G Q 0.0000 Buried
164 A Q -0.1930 Soluble
165 V Q -0.1457 Soluble
166 T Q -0.1240 Soluble
167 V Q 0.3323 Aggregation-prone
168 A Q -0.3970 Soluble
169 W Q 0.0000 Buried
170 K Q -1.0420 Soluble
171 A Q 0.0000 Buried
172 D Q -1.3909 Soluble
173 S Q -0.7256 Soluble
174 S Q -0.6040 Soluble
175 P Q -0.7776 Soluble
176 V Q -0.5204 Soluble
177 K Q -1.5051 Soluble
178 A Q -0.6856 Soluble
179 G Q -0.5052 Soluble
180 V Q -0.2889 Soluble
181 E Q -0.2113 Soluble
182 T Q 0.1220 Aggregation-prone
183 T Q 0.0580 Aggregation-prone
184 T Q -0.1758 Soluble
185 P Q -0.4146 Soluble
186 S Q -0.7528 Soluble
187 K Q -1.6376 Soluble
188 Q Q -1.4496 Soluble
189 S Q -1.2011 Soluble
190 N Q -1.5453 Soluble
191 N Q -1.3960 Soluble
192 K Q -1.7284 Soluble
193 Y Q -1.0152 Soluble
194 A Q 0.0000 Buried
195 A Q -0.1999 Soluble
196 S Q 0.0000 Buried
197 S Q 0.0000 Buried
198 Y Q 0.0000 Buried
199 L Q 0.0000 Buried
200 S Q -0.3537 Soluble
201 L Q 0.0000 Buried
202 T Q -1.6604 Soluble
203 P Q -2.1547 Soluble
204 E Q -2.9796 Soluble
205 Q Q -2.1657 Soluble
206 W Q 0.0000 Buried
207 K Q -3.1280 Soluble
208 S Q -2.2791 Soluble
209 H Q -2.4643 Soluble
210 R Q -2.6941 Soluble
211 S Q -1.8674 Soluble
212 Y Q 0.0000 Buried
213 S Q 0.0000 Buried
214 C Q 0.0000 Buried
215 Q Q -0.8186 Soluble
216 V Q 0.0000 Buried
217 T Q -0.8095 Soluble
218 H Q -1.1587 Soluble
219 E Q -2.2031 Soluble
220 G Q -1.5146 Soluble
221 S Q -1.1641 Soluble
222 T Q -0.9335 Soluble
223 V Q -0.7903 Soluble
224 E Q -2.0430 Soluble
225 K Q -1.5003 Soluble
226 T Q -1.1717 Soluble
227 V Q 0.0000 Buried
228 A Q -1.4694 Soluble
229 P Q -1.3189 Soluble
230 T Q -1.2193 Soluble
231 E Q -1.8456 Soluble
232 C Q -0.8522 Soluble

3D Structure — colored by A4D score

Sequence - click residue to focus in viewer  |  colored by A4D score
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Color Legend (B-factor = A4D Score)
Score > 1.5 — highly aggregation-prone
Score 0.5–1.5 — aggregation-prone
Score ≈ 0 — buried
Score −1 to −0.5 — soluble
Score < −2.5 — highly soluble
pH Structure
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A4D Score Threshold
Highlight residues > threshold in the sequence panel
CDR Regions
HCDR1
HCDR2
HCDR3
LCDR1
LCDR2
LCDR3
Display Options

pH-Dependent Aggregation Profiles

A4D scores calculated across 11 pH conditions (4.0–9.0, step 0.5). Click a row to view the structure at that pH. The input structure is globular — max score is recommended for pH analysis.

pH Avg A4D Score Max A4D Score Downloads
4.0 -0.5714 4.4901 CSV PDB
4.5 -0.6062 4.457 CSV PDB
5.0 -0.6486 4.4119 CSV PDB
5.5 -0.6891 4.3625 CSV PDB
6.0 -0.7174 4.3163 CSV PDB
6.5 -0.7263 4.2811 CSV PDB
7.0 -0.7152 4.2611 CSV PDB
7.5 -0.6901 4.2525 CSV PDB
8.0 -0.6576 4.2494 CSV PDB
8.5 -0.6204 4.2484 CSV PDB
9.0 -0.5792 4.2481 CSV PDB
Average A4D Score vs pH
Max A4D Score vs pH