Beludavimab / 7l0n

A4DAB038_7l0n_C_D | Source PDB: 7l0n | Chains: C, D | Done
99.57
Yes
10 Å
Yes
Avg A4D Score
-0.7083
Max Score
2.3023
Min Score
-3.7026
Total Score
-309.51
Score CDR
-0.1679
Score non-CDR
-0.7845

Calculation Parameters

Chain Sequence(s) QVQLVQSGAEVKKPGASVKVSCKASGYPFTSYGISWVRQAPGQGLEWMGWISTYNGNTNYAQKFQGRVTMTTDTSTTTGYMELRRLRSDDTAVYYCARDYTRGAWFGESLIGGFDNWGQGTLVTVSSASTKGPSVFPLAPSSKGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKEIVLTQSPGTLSLSPGERATLSCRASQTVSSTSLAWYQQKPGQAPRLLIYGASSRATGIPDRFSGSGSGTDFTLTISRLEPEDFAVYYCQQHDTSLTFGGGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGE input.pdb
Selected Chain(s) C (Heavy), D (Light)
Distance of Aggregation 10 Å
FoldX Energy Minimization Yes
pH Calculations Yes
Downloads Download all data (.tar.gz)

Aggrescan4D Profile

Aggregation-prone (score > 0)
Soluble (score < 0)
Buried (score = 0)

Per-Residue A4D Scores

Download CSV
Minimum Score -3.7026
Maximum Score 2.3023
Average Score -0.7083
Total Score -309.5139

Residues with A4D score > 0.0 are highlighted as aggregation-prone.

Index Residue Chain A4D Score Classification
1 Q C -1.2067 Soluble
2 V C -0.4767 Soluble
3 Q C -0.8185 Soluble
4 L C 0.0000 Buried
5 V C 0.5062 Aggregation-prone
6 Q C 0.0000 Buried
7 S C -0.5539 Soluble
8 G C -0.3716 Soluble
9 A C -0.2619 Soluble
11 E C -1.0928 Soluble
12 V C -0.4798 Soluble
13 K C -1.6350 Soluble
14 K C -2.6032 Soluble
15 P C -2.7666 Soluble
16 G C -2.5155 Soluble
17 A C -2.0117 Soluble
18 S C -2.2086 Soluble
19 V C 0.0000 Buried
20 K C -2.3799 Soluble
21 V C 0.0000 Buried
22 S C -0.4944 Soluble
23 C C 0.0000 Buried
24 K C -0.4983 Soluble
25 A C 0.0000 Buried
26 S C -0.5271 Soluble
27 G C -0.7608 Soluble
28 Y C -0.3234 Soluble
29 P C -0.2890 Soluble
30 F C 0.0000 Buried
35 T C 0.1491 Aggregation-prone
36 S C 0.3711 Aggregation-prone
37 Y C 0.5363 Aggregation-prone
38 G C 0.0000 Buried
39 I C 0.0000 Buried
40 S C 0.0000 Buried
41 W C 0.0000 Buried
42 V C 0.0000 Buried
43 R C 0.0000 Buried
44 Q C -0.5126 Soluble
45 A C -0.9019 Soluble
46 P C -0.7158 Soluble
47 G C -1.2433 Soluble
48 Q C -1.7322 Soluble
49 G C -1.0748 Soluble
50 L C 0.0000 Buried
51 E C -0.6001 Soluble
52 W C 0.0000 Buried
53 M C 0.0000 Buried
54 G C 0.0000 Buried
55 W C 0.0000 Buried
56 I C 0.0000 Buried
57 S C 0.0000 Buried
58 T C 0.0000 Buried
59 Y C 0.3812 Aggregation-prone
62 N C -0.9399 Soluble
63 G C -1.2592 Soluble
64 N C -1.6096 Soluble
65 T C -1.4710 Soluble
66 N C -1.7778 Soluble
67 Y C -1.3329 Soluble
68 A C -1.6107 Soluble
69 Q C -2.7920 Soluble
70 K C -2.6902 Soluble
71 F C 0.0000 Buried
72 Q C -2.5179 Soluble
74 G C -1.7521 Soluble
75 R C -2.2433 Soluble
76 V C 0.0000 Buried
77 T C -1.1051 Soluble
78 M C 0.0000 Buried
79 T C -0.5841 Soluble
80 T C -0.5137 Soluble
81 D C -0.7889 Soluble
82 T C -0.5430 Soluble
83 S C -0.4908 Soluble
84 T C -0.5247 Soluble
85 T C -0.5767 Soluble
86 T C 0.0000 Buried
87 G C 0.0000 Buried
88 Y C -0.5536 Soluble
89 M C 0.0000 Buried
90 E C -1.8751 Soluble
91 L C 0.0000 Buried
92 R C -3.3240 Soluble
93 R C -3.4559 Soluble
94 L C 0.0000 Buried
95 R C -3.6174 Soluble
96 S C -2.3399 Soluble
97 D C -2.4912 Soluble
98 D C 0.0000 Buried
99 T C -0.8098 Soluble
100 A C 0.0000 Buried
101 V C 0.4429 Aggregation-prone
102 Y C 0.0000 Buried
103 Y C 0.0000 Buried
104 C C 0.0000 Buried
105 A C 0.0000 Buried
106 R C -0.1710 Soluble
107 D C 0.0000 Buried
108 Y C 1.0814 Aggregation-prone
109 T C 0.0000 Buried
110 R C -0.0222 Soluble
111 G C 0.5284 Aggregation-prone
111A A C 0.0000 Buried
111B W C 1.3772 Aggregation-prone
111C F C 1.4623 Aggregation-prone
112D G C -0.5881 Soluble
112C E C -1.3749 Soluble
112B S C -0.4968 Soluble
112A L C 0.9021 Aggregation-prone
112 I C 2.3023 Aggregation-prone
113 G C 0.0000 Buried
114 G C 0.0000 Buried
115 F C 0.0000 Buried
116 D C -0.6912 Soluble
117 N C -0.7946 Soluble
118 W C -0.5222 Soluble
119 G C 0.0000 Buried
120 Q C -1.2138 Soluble
121 G C -0.3703 Soluble
122 T C 0.0000 Buried
123 L C 0.5883 Aggregation-prone
124 V C 0.0000 Buried
125 T C 0.0000 Buried
126 V C 0.0000 Buried
127 S C -1.3623 Soluble
128 S C -1.1522 Soluble
129 A C -0.7776 Soluble
130 S C -0.8416 Soluble
131 T C -0.8348 Soluble
132 K C -1.4546 Soluble
133 G C -1.5272 Soluble
134 P C 0.0000 Buried
135 S C -0.5640 Soluble
136 V C 0.0000 Buried
137 F C 0.0000 Buried
138 P C -1.0593 Soluble
139 L C 0.0000 Buried
140 A C -1.2845 Soluble
141 P C 0.0000 Buried
142 S C -1.1237 Soluble
143 S C -1.4630 Soluble
144 K C -1.9204 Soluble
145 G C -0.9039 Soluble
146 T C -0.7206 Soluble
147 A C 0.0000 Buried
148 A C 0.0000 Buried
149 L C 0.0000 Buried
150 G C 0.0000 Buried
151 C C 0.0000 Buried
152 L C 0.0000 Buried
153 V C 0.0000 Buried
154 K C 0.0000 Buried
155 D C -0.4619 Soluble
156 Y C 0.0000 Buried
157 F C 0.0000 Buried
158 P C 0.0000 Buried
159 E C -0.5341 Soluble
160 P C -0.8399 Soluble
161 V C -0.7714 Soluble
162 T C -0.6282 Soluble
163 V C -0.2642 Soluble
164 S C -0.2685 Soluble
165 W C 0.0000 Buried
166 N C -0.5731 Soluble
167 S C -0.5478 Soluble
168 G C -0.5357 Soluble
169 A C -0.1960 Soluble
170 L C 0.0819 Aggregation-prone
171 T C -0.1332 Soluble
172 S C -0.1795 Soluble
173 G C -0.2482 Soluble
174 V C 0.1465 Aggregation-prone
175 H C -0.3336 Soluble
176 T C -0.2005 Soluble
177 F C 0.0000 Buried
178 P C -0.2415 Soluble
179 A C 0.2518 Aggregation-prone
180 V C 0.6877 Aggregation-prone
181 L C 1.3433 Aggregation-prone
182 Q C 0.0000 Buried
183 S C -0.0059 Soluble
184 S C -0.1701 Soluble
185 G C 0.1022 Aggregation-prone
186 L C 0.0390 Aggregation-prone
187 Y C 0.0000 Buried
188 S C 0.0000 Buried
189 L C 0.0000 Buried
190 S C 0.0000 Buried
191 S C 0.0000 Buried
192 V C 0.0000 Buried
193 V C 0.0000 Buried
194 T C -0.1469 Soluble
195 V C 0.0000 Buried
196 P C -0.4652 Soluble
197 S C -0.7950 Soluble
198 S C -0.5830 Soluble
199 S C -0.5998 Soluble
200 L C -0.7374 Soluble
201 G C -0.9770 Soluble
202 T C -0.6859 Soluble
203 Q C -1.1832 Soluble
204 T C -1.1206 Soluble
205 Y C 0.0000 Buried
206 I C -0.9447 Soluble
207 C C 0.0000 Buried
208 N C -1.0556 Soluble
209 V C 0.0000 Buried
210 N C -1.9026 Soluble
211 H C 0.0000 Buried
212 K C -2.7607 Soluble
213 P C -1.5636 Soluble
214 S C -1.9498 Soluble
215 N C -2.6434 Soluble
216 T C -2.0400 Soluble
217 K C -2.3869 Soluble
218 V C -0.9190 Soluble
219 D C -1.4950 Soluble
220 K C -1.6675 Soluble
221 K C -2.2534 Soluble
222 V C 0.0000 Buried
223 E C -2.7900 Soluble
224 P C -1.9500 Soluble
225 K C -2.4570 Soluble
1 E D -1.8023 Soluble
2 I D 0.0000 Buried
3 V D 0.7863 Aggregation-prone
4 L D 0.0000 Buried
5 T D -0.5738 Soluble
6 Q D -0.6725 Soluble
7 S D -0.7789 Soluble
8 P D -0.6886 Soluble
9 G D -0.8569 Soluble
10 T D -0.4976 Soluble
11 L D -0.2439 Soluble
12 S D -0.5442 Soluble
13 L D -1.0007 Soluble
14 S D -1.5933 Soluble
15 P D -2.0924 Soluble
16 G D -2.3629 Soluble
17 E D -3.5921 Soluble
18 R D -3.5553 Soluble
19 A D 0.0000 Buried
20 T D -0.5089 Soluble
21 L D 0.0000 Buried
22 S D -0.9237 Soluble
23 C D 0.0000 Buried
24 R D -1.9697 Soluble
25 A D 0.0000 Buried
26 S D -1.0121 Soluble
27 Q D -1.5685 Soluble
28 T D -1.3636 Soluble
29 V D 0.0000 Buried
30 S D -0.5671 Soluble
36 S D -0.2858 Soluble
37 T D 0.3669 Aggregation-prone
38 S D 0.0000 Buried
39 L D 0.0000 Buried
40 A D 0.0000 Buried
41 W D 0.0000 Buried
42 Y D 0.0000 Buried
43 Q D 0.0000 Buried
44 Q D 0.0000 Buried
45 K D -1.5319 Soluble
46 P D -1.3415 Soluble
47 G D -1.3081 Soluble
48 Q D -2.0015 Soluble
49 A D -1.3183 Soluble
50 P D 0.0000 Buried
51 R D -1.1191 Soluble
52 L D 0.0000 Buried
53 L D 0.0000 Buried
54 I D 0.0000 Buried
55 Y D 0.3801 Aggregation-prone
56 G D 0.4046 Aggregation-prone
57 A D 0.0000 Buried
65 S D -0.6511 Soluble
66 S D -0.4658 Soluble
67 R D -1.4397 Soluble
68 A D -0.8097 Soluble
69 T D -0.5901 Soluble
70 G D -0.7754 Soluble
71 I D -0.8833 Soluble
72 P D -1.2205 Soluble
74 D D -2.3425 Soluble
75 R D -1.9626 Soluble
76 F D 0.0000 Buried
77 S D -0.9050 Soluble
78 G D -0.5451 Soluble
79 S D -0.7709 Soluble
80 G D -1.2105 Soluble
83 S D -1.1361 Soluble
84 G D -1.2131 Soluble
85 T D -1.8068 Soluble
86 D D -2.4808 Soluble
87 F D 0.0000 Buried
88 T D -0.8488 Soluble
89 L D 0.0000 Buried
90 T D -0.8042 Soluble
91 I D 0.0000 Buried
92 S D -2.5418 Soluble
93 R D -3.7026 Soluble
94 L D 0.0000 Buried
95 E D -2.4046 Soluble
96 P D -1.5817 Soluble
97 E D -2.0855 Soluble
98 D D 0.0000 Buried
99 F D -0.6626 Soluble
100 A D 0.0000 Buried
101 V D -0.3242 Soluble
102 Y D 0.0000 Buried
103 Y D 0.0000 Buried
104 C D 0.0000 Buried
105 Q D 0.0000 Buried
106 Q D 0.0000 Buried
107 H D 0.0000 Buried
108 D D -1.4174 Soluble
114 T D -1.1543 Soluble
115 S D -1.0434 Soluble
116 L D 0.0000 Buried
117 T D -0.0867 Soluble
118 F D 0.2646 Aggregation-prone
119 G D 0.0000 Buried
120 G D -0.7409 Soluble
121 G D -0.7675 Soluble
122 T D 0.0000 Buried
123 K D -0.7586 Soluble
124 V D 0.0000 Buried
125 E D 0.0000 Buried
126 I D -0.7309 Soluble
127 K D -1.4446 Soluble
128 R D -0.9491 Soluble
129 T D 0.1075 Aggregation-prone
130 V D 1.1592 Aggregation-prone
131 A D 0.2329 Aggregation-prone
132 A D 0.0176 Aggregation-prone
133 P D 0.0000 Buried
134 S D -0.0705 Soluble
135 V D 0.0000 Buried
136 F D -0.1097 Soluble
137 I D 0.0000 Buried
138 F D 0.0000 Buried
139 P D -0.6011 Soluble
140 P D -0.8635 Soluble
141 S D -1.6167 Soluble
142 D D -2.9936 Soluble
143 E D -2.8825 Soluble
144 Q D 0.0000 Buried
145 L D 0.0000 Buried
146 K D -2.9709 Soluble
147 S D -1.9069 Soluble
148 G D -1.5644 Soluble
149 T D -1.3023 Soluble
150 A D 0.0000 Buried
151 S D 0.0000 Buried
152 V D 0.0000 Buried
153 V D 0.0000 Buried
154 C D 0.0000 Buried
155 L D 0.0000 Buried
156 L D 0.0000 Buried
157 N D 0.0000 Buried
158 N D -0.9262 Soluble
159 F D 0.0000 Buried
160 Y D 0.0000 Buried
161 P D -1.4341 Soluble
162 R D -2.5335 Soluble
163 E D -3.0050 Soluble
164 A D -2.2578 Soluble
165 K D -2.3883 Soluble
166 V D -1.0485 Soluble
167 Q D -0.6158 Soluble
168 W D 0.0000 Buried
169 K D -0.8190 Soluble
170 V D 0.0000 Buried
171 D D -2.0560 Soluble
172 N D -1.4963 Soluble
173 A D -0.5302 Soluble
174 L D 0.3029 Aggregation-prone
175 Q D -0.3948 Soluble
176 S D -0.5254 Soluble
177 G D -0.8229 Soluble
178 N D -0.7010 Soluble
179 S D -0.8982 Soluble
180 Q D -0.8826 Soluble
181 E D -1.2682 Soluble
182 S D -0.5203 Soluble
183 V D -0.6837 Soluble
184 T D -1.0972 Soluble
185 E D -2.0769 Soluble
186 Q D -1.7831 Soluble
187 D D -1.8657 Soluble
188 S D -1.7352 Soluble
189 K D -2.3433 Soluble
190 D D -1.9911 Soluble
191 S D -1.8377 Soluble
192 T D 0.0000 Buried
193 Y D 0.0000 Buried
194 S D 0.0000 Buried
195 L D 0.0000 Buried
196 S D 0.0000 Buried
197 S D 0.0000 Buried
198 T D -0.5054 Soluble
199 L D 0.0000 Buried
200 T D -0.3642 Soluble
201 L D -0.6326 Soluble
202 S D -1.0802 Soluble
203 K D -2.1022 Soluble
204 A D -1.7973 Soluble
205 D D -2.4514 Soluble
206 Y D 0.0000 Buried
207 E D -3.1787 Soluble
208 K D -3.4824 Soluble
209 H D -2.9254 Soluble
210 K D -3.0596 Soluble
211 V D -1.4117 Soluble
212 Y D 0.0000 Buried
213 A D -0.8765 Soluble
214 C D 0.0000 Buried
215 E D -0.7903 Soluble
216 V D 0.0000 Buried
217 T D -1.1481 Soluble
218 H D 0.0000 Buried
219 Q D -1.5995 Soluble
220 G D -0.2988 Soluble
221 L D -0.2309 Soluble
222 S D -0.4729 Soluble
223 S D -0.4327 Soluble
224 P D -0.5213 Soluble
225 V D 0.0184 Aggregation-prone
226 T D -0.4542 Soluble
227 K D -0.6993 Soluble
228 S D -0.5710 Soluble
229 F D -1.0234 Soluble
230 N D -1.9215 Soluble
231 R D -2.5538 Soluble
232 G D -2.1041 Soluble
233 E D -2.7051 Soluble

3D Structure — colored by A4D score

Sequence - click residue to focus in viewer  |  colored by A4D score
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Color Legend (B-factor = A4D Score)
Score > 1.5 — highly aggregation-prone
Score 0.5–1.5 — aggregation-prone
Score ≈ 0 — buried
Score −1 to −0.5 — soluble
Score < −2.5 — highly soluble
pH Structure
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A4D Score Threshold
Highlight residues > threshold in the sequence panel
CDR Regions
HCDR1
HCDR2
HCDR3
LCDR1
LCDR2
LCDR3
Display Options

pH-Dependent Aggregation Profiles

A4D scores calculated across 11 pH conditions (4.0–9.0, step 0.5). Click a row to view the structure at that pH. The input structure is globular — max score is recommended for pH analysis.

pH Avg A4D Score Max A4D Score Downloads
4.0 -0.7111 5.1331 CSV PDB
4.5 -0.7529 5.036 CSV PDB
5.0 -0.8018 4.9104 CSV PDB
5.5 -0.8479 4.7773 CSV PDB
6.0 -0.8799 4.6571 CSV PDB
6.5 -0.889 4.5944 CSV PDB
7.0 -0.875 4.5716 CSV PDB
7.5 -0.8453 4.5622 CSV PDB
8.0 -0.8064 4.5589 CSV PDB
8.5 -0.7607 4.5578 CSV PDB
9.0 -0.709 4.5571 CSV PDB
Average A4D Score vs pH
Max A4D Score vs pH