Zemocimig / 8gv0

A4DAB305_8gv0_G_H | Source PDB: 8gv0 | Chains: G, H | Done
100
Yes
10 Å
Yes
Avg A4D Score
-0.8366
Max Score
1.5023
Min Score
-3.8076
Total Score
-363.1
Score CDR
-0.6871
Score non-CDR
-0.8758

Calculation Parameters

Chain Sequence(s) QVQLVESGGGLVQPGGSLRLSCAASGFTFSYYDIQWVRQAPGKGLEWVSSISPSGQSTYYRREVKGRFTISRDNSKNTLYLQMNSLRAEDTAVYYCARRTGREEWIFDYWGQGTLVTVSSASTKGPSVFPLAPCSRSTSESTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYTCNVDHKPSNTKVDKRVESEIVLTQSPATLSVSPGERATLSCRASRSVRRELAWYQQKPGQAPELLIYGASTRETGIPARFSGSGSGTDFTLTINSLEAEDAATYYCQQYRDPPGTFGGGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC input.pdb
Selected Chain(s) G (Heavy), H (Light)
Distance of Aggregation 10 Å
FoldX Energy Minimization Yes
pH Calculations Yes
Downloads Download all data (.tar.gz)

Aggrescan4D Profile

Aggregation-prone (score > 0)
Soluble (score < 0)
Buried (score = 0)

Per-Residue A4D Scores

Download CSV
Minimum Score -3.8076
Maximum Score 1.5023
Average Score -0.8366
Total Score -363.0999

Residues with A4D score > 0.0 are highlighted as aggregation-prone.

Index Residue Chain A4D Score Classification
1 Q G -1.2317 Soluble
2 V G 0.0000 Buried
3 Q G -0.9605 Soluble
4 L G 0.1386 Aggregation-prone
5 V G 1.0792 Aggregation-prone
6 E G 0.0000 Buried
7 S G -0.3923 Soluble
8 G G -0.6153 Soluble
9 G G -0.7525 Soluble
11 G G -0.0920 Soluble
12 L G 0.3354 Aggregation-prone
13 V G -0.2651 Soluble
14 Q G -1.3695 Soluble
15 P G -1.1770 Soluble
16 G G -1.2358 Soluble
17 G G -0.9221 Soluble
18 S G -1.2288 Soluble
19 L G -1.0662 Soluble
20 R G -2.0226 Soluble
21 L G 0.0000 Buried
22 S G -0.2608 Soluble
23 C G 0.0000 Buried
24 A G 0.0982 Aggregation-prone
25 A G -0.1088 Soluble
26 S G -0.4204 Soluble
27 G G -0.3714 Soluble
28 F G 1.3438 Aggregation-prone
29 T G 0.9764 Aggregation-prone
30 F G 0.0000 Buried
35 S G 0.3117 Aggregation-prone
36 Y G 1.2254 Aggregation-prone
37 Y G 0.6460 Aggregation-prone
38 D G 0.0000 Buried
39 I G 0.0000 Buried
40 Q G 0.0000 Buried
41 W G 0.0000 Buried
42 V G 0.0000 Buried
43 R G -0.4480 Soluble
44 Q G 0.0000 Buried
45 A G -1.1262 Soluble
46 P G -0.9876 Soluble
47 G G -1.4458 Soluble
48 K G -2.2183 Soluble
49 G G -1.3686 Soluble
50 L G 0.0000 Buried
51 E G -0.7768 Soluble
52 W G 0.0000 Buried
53 V G 0.0000 Buried
54 S G 0.0000 Buried
55 S G 0.0000 Buried
56 I G 0.0000 Buried
57 S G -0.2689 Soluble
58 P G -0.6821 Soluble
59 S G -0.6974 Soluble
62 G G -1.2202 Soluble
63 Q G -1.4859 Soluble
64 S G -0.6780 Soluble
65 T G -0.0577 Soluble
66 Y G 0.3979 Aggregation-prone
67 Y G -1.1815 Soluble
68 R G -2.4616 Soluble
69 R G -3.5273 Soluble
70 E G -3.8076 Soluble
71 V G 0.0000 Buried
72 K G -3.2950 Soluble
74 G G -2.4710 Soluble
75 R G -2.5353 Soluble
76 F G 0.0000 Buried
77 T G -0.9451 Soluble
78 I G 0.0000 Buried
79 S G -0.6685 Soluble
80 R G -1.2539 Soluble
81 D G -2.1446 Soluble
82 N G -2.0743 Soluble
83 S G -1.8195 Soluble
84 K G -2.5616 Soluble
85 N G -1.7395 Soluble
86 T G -1.0973 Soluble
87 L G 0.0000 Buried
88 Y G -0.5122 Soluble
89 L G 0.0000 Buried
90 Q G -1.4621 Soluble
91 M G 0.0000 Buried
92 N G -1.5845 Soluble
93 S G -1.2757 Soluble
94 L G 0.0000 Buried
95 R G -1.6650 Soluble
96 A G -1.3601 Soluble
97 E G -2.1368 Soluble
98 D G 0.0000 Buried
99 T G -0.5214 Soluble
100 A G 0.0000 Buried
101 V G -0.0086 Soluble
102 Y G 0.0000 Buried
103 Y G 0.0000 Buried
104 C G 0.0000 Buried
105 A G 0.0000 Buried
106 R G 0.0000 Buried
107 R G -0.7578 Soluble
108 T G -1.3259 Soluble
109 G G -1.6577 Soluble
110 R G -3.0071 Soluble
111 E G -3.4453 Soluble
112 E G -3.0247 Soluble
113 W G -1.1834 Soluble
114 I G 0.0000 Buried
115 F G 0.0000 Buried
116 D G -0.3068 Soluble
117 Y G 0.0688 Aggregation-prone
118 W G 0.0000 Buried
119 G G 0.0000 Buried
120 Q G -1.1343 Soluble
121 G G -0.6060 Soluble
122 T G 0.0000 Buried
123 L G 0.1458 Aggregation-prone
124 V G 0.0000 Buried
125 T G -0.1363 Soluble
126 V G 0.0000 Buried
127 S G -0.7873 Soluble
128 S G -0.7165 Soluble
129 A G -0.5098 Soluble
130 S G -0.6200 Soluble
131 T G -0.6640 Soluble
132 K G -1.3787 Soluble
133 G G -1.2156 Soluble
134 P G -0.4912 Soluble
135 S G -0.6587 Soluble
136 V G 0.0000 Buried
137 F G 0.0000 Buried
138 P G -1.2421 Soluble
139 L G 0.0000 Buried
140 A G -0.2060 Soluble
141 P G -0.0996 Soluble
142 C G -0.2802 Soluble
143 S G -0.9059 Soluble
144 R G -1.4702 Soluble
145 S G -1.2128 Soluble
146 T G -1.2925 Soluble
147 S G -1.3981 Soluble
148 E G -2.1374 Soluble
149 S G -1.2579 Soluble
150 T G -0.8754 Soluble
151 A G -0.5903 Soluble
152 A G 0.0000 Buried
153 L G 0.3252 Aggregation-prone
154 G G 0.0000 Buried
155 C G 0.0000 Buried
156 L G 0.0000 Buried
157 V G 0.0000 Buried
158 K G 0.0000 Buried
159 D G -0.4573 Soluble
160 Y G 0.0000 Buried
161 F G 0.0000 Buried
162 P G 0.0000 Buried
163 E G -0.4535 Soluble
164 P G -0.6525 Soluble
165 V G 0.0000 Buried
166 T G -0.6898 Soluble
167 V G -0.3373 Soluble
168 S G -0.4521 Soluble
169 W G 0.0000 Buried
170 N G -1.0069 Soluble
171 S G -0.7550 Soluble
172 G G -0.6366 Soluble
173 A G -0.3018 Soluble
174 L G -0.1341 Soluble
175 T G -0.1839 Soluble
176 S G -0.1790 Soluble
177 G G -0.2373 Soluble
178 V G 0.1121 Aggregation-prone
179 H G -0.4530 Soluble
180 T G -0.0483 Soluble
181 F G 0.0000 Buried
182 P G -0.0657 Soluble
183 A G 0.3081 Aggregation-prone
184 V G 0.7525 Aggregation-prone
185 L G 1.5023 Aggregation-prone
186 Q G 0.3593 Aggregation-prone
187 S G -0.0091 Soluble
188 S G -0.1607 Soluble
189 G G 0.2238 Aggregation-prone
190 L G 0.2883 Aggregation-prone
191 Y G 0.5204 Aggregation-prone
192 S G 0.3139 Aggregation-prone
193 L G 0.0000 Buried
194 S G 0.0000 Buried
195 S G 0.0000 Buried
196 V G 0.0000 Buried
197 V G 0.0000 Buried
198 T G -0.0491 Soluble
199 V G 0.0539 Aggregation-prone
200 P G -0.4764 Soluble
201 S G -0.7914 Soluble
202 S G -0.5607 Soluble
203 S G -0.3888 Soluble
204 L G -0.3693 Soluble
205 G G -0.7500 Soluble
206 T G -0.7180 Soluble
207 Q G -1.3890 Soluble
208 T G -1.2189 Soluble
209 Y G -1.1765 Soluble
210 T G -1.9969 Soluble
211 C G 0.0000 Buried
212 N G -1.9437 Soluble
213 V G 0.0000 Buried
214 D G -1.9419 Soluble
215 H G 0.0000 Buried
216 K G -2.8573 Soluble
217 P G -1.5233 Soluble
218 S G -1.8526 Soluble
219 N G -2.5113 Soluble
220 T G -2.2540 Soluble
221 K G -2.6084 Soluble
222 V G -1.6097 Soluble
223 D G -2.7531 Soluble
224 K G -2.7672 Soluble
225 R G -3.2432 Soluble
226 V G -1.8973 Soluble
227 E G -2.4462 Soluble
228 S G -1.2193 Soluble
1 E H -1.6128 Soluble
2 I H -0.7959 Soluble
3 V H 0.6835 Aggregation-prone
4 L H 0.0000 Buried
5 T H -0.4948 Soluble
6 Q H 0.0000 Buried
7 S H -0.8803 Soluble
8 P H -0.4246 Soluble
9 A H -0.4652 Soluble
10 T H -0.7000 Soluble
11 L H -0.5269 Soluble
12 S H -0.8295 Soluble
13 V H -1.2078 Soluble
14 S H -1.7459 Soluble
15 P H -2.0390 Soluble
16 G H -2.1659 Soluble
17 E H -3.1121 Soluble
18 R H -3.2760 Soluble
19 A H 0.0000 Buried
20 T H -0.7974 Soluble
21 L H 0.0000 Buried
22 S H -1.0631 Soluble
23 C H 0.0000 Buried
24 R H -2.3969 Soluble
25 A H -1.4330 Soluble
26 S H -1.0829 Soluble
27 R H -2.6035 Soluble
28 S H -2.5976 Soluble
29 V H 0.0000 Buried
36 R H -3.5651 Soluble
37 R H -3.4636 Soluble
38 E H -2.5671 Soluble
39 L H 0.0000 Buried
40 A H 0.0000 Buried
41 W H 0.0000 Buried
42 Y H 0.0000 Buried
43 Q H -1.0096 Soluble
44 Q H -1.1928 Soluble
45 K H -1.6759 Soluble
46 P H -1.3211 Soluble
47 G H -1.3573 Soluble
48 Q H -1.9612 Soluble
49 A H -1.2225 Soluble
50 P H 0.0000 Buried
51 E H -1.1133 Soluble
52 L H 0.0000 Buried
53 L H 0.0000 Buried
54 I H 0.0000 Buried
55 Y H -0.4790 Soluble
56 G H 0.0000 Buried
57 A H 0.0000 Buried
65 S H -0.7753 Soluble
66 T H -0.5265 Soluble
67 R H 0.0000 Buried
68 E H -1.8747 Soluble
69 T H -1.1213 Soluble
70 G H -0.8155 Soluble
71 I H -0.8758 Soluble
72 P H -0.8911 Soluble
74 A H -1.0415 Soluble
75 R H -2.6802 Soluble
76 F H 0.0000 Buried
77 S H -1.0525 Soluble
78 G H -0.4135 Soluble
79 S H -0.8936 Soluble
80 G H -1.4010 Soluble
83 S H -1.9502 Soluble
84 G H -2.2328 Soluble
85 T H -2.4845 Soluble
86 D H -2.4538 Soluble
87 F H 0.0000 Buried
88 T H -0.7599 Soluble
89 L H 0.0000 Buried
90 T H -1.4678 Soluble
91 I H 0.0000 Buried
92 N H -2.9743 Soluble
93 S H -2.6497 Soluble
94 L H 0.0000 Buried
95 E H -2.9955 Soluble
96 A H -2.7977 Soluble
97 E H -2.9015 Soluble
98 D H -1.6521 Soluble
99 A H 0.0000 Buried
100 A H 0.0000 Buried
101 T H -0.9935 Soluble
102 Y H 0.0000 Buried
103 Y H 0.0000 Buried
104 C H 0.0000 Buried
105 Q H 0.0000 Buried
106 Q H 0.0000 Buried
107 Y H -1.6808 Soluble
108 R H -3.1889 Soluble
109 D H -1.8106 Soluble
114 P H -1.0350 Soluble
115 P H -0.6572 Soluble
116 G H 0.0000 Buried
117 T H -0.4204 Soluble
118 F H 0.0000 Buried
119 G H 0.0000 Buried
120 G H -0.8415 Soluble
121 G H -0.9746 Soluble
122 T H 0.0000 Buried
123 K H -1.6811 Soluble
124 V H 0.0000 Buried
125 E H -1.4703 Soluble
126 I H 0.0000 Buried
127 K H -1.7978 Soluble
128 R H -1.6135 Soluble
129 T H -0.4275 Soluble
130 V H 0.3971 Aggregation-prone
131 A H -0.0456 Soluble
132 A H -0.1995 Soluble
133 P H 0.0000 Buried
134 S H -0.0746 Soluble
135 V H 0.0000 Buried
136 F H 0.2043 Aggregation-prone
137 I H 0.1682 Aggregation-prone
138 F H 0.0000 Buried
139 P H -0.2553 Soluble
140 P H -0.7213 Soluble
141 S H 0.0000 Buried
142 D H -2.7795 Soluble
143 E H -2.7995 Soluble
144 Q H 0.0000 Buried
145 L H -2.2852 Soluble
146 K H -2.8028 Soluble
147 S H -1.7968 Soluble
148 G H -1.4892 Soluble
149 T H -1.0831 Soluble
150 A H 0.0000 Buried
151 S H 0.0000 Buried
152 V H 0.0000 Buried
153 V H 0.0000 Buried
154 C H 0.0000 Buried
155 L H 0.0000 Buried
156 L H 0.0000 Buried
157 N H 0.0000 Buried
158 N H -1.0926 Soluble
159 F H 0.0000 Buried
160 Y H 0.0000 Buried
161 P H -1.3688 Soluble
162 R H -2.0229 Soluble
163 E H -2.6685 Soluble
164 A H -2.1521 Soluble
165 K H -2.3044 Soluble
166 V H -1.4261 Soluble
167 Q H -0.8126 Soluble
168 W H 0.0000 Buried
169 K H -0.8451 Soluble
170 V H 0.0000 Buried
171 D H -1.5281 Soluble
172 N H -1.4138 Soluble
173 A H -0.4055 Soluble
174 L H 0.3211 Aggregation-prone
175 Q H -0.3388 Soluble
176 S H -0.3737 Soluble
177 G H -0.6836 Soluble
178 N H -0.7155 Soluble
179 S H -1.0773 Soluble
180 Q H -1.4091 Soluble
181 E H -1.7017 Soluble
182 S H 0.0000 Buried
183 V H -0.2924 Soluble
184 T H -0.9874 Soluble
185 E H -2.0612 Soluble
186 Q H -2.2053 Soluble
187 D H -2.6250 Soluble
188 S H -2.8206 Soluble
189 K H -3.3106 Soluble
190 D H -3.6188 Soluble
191 S H 0.0000 Buried
192 T H -1.9345 Soluble
193 Y H 0.0000 Buried
194 S H 0.0000 Buried
195 L H 0.0000 Buried
196 S H 0.0000 Buried
197 S H 0.0000 Buried
198 T H -0.6664 Soluble
199 L H 0.0000 Buried
200 T H -0.4027 Soluble
201 L H -0.5559 Soluble
202 S H -1.1893 Soluble
203 K H -2.2062 Soluble
204 A H -1.8153 Soluble
205 D H -2.1091 Soluble
206 Y H -2.2899 Soluble
207 E H -3.4534 Soluble
208 K H -3.3094 Soluble
209 H H -2.5486 Soluble
210 K H -2.5635 Soluble
211 V H -1.2688 Soluble
212 Y H 0.0000 Buried
213 A H -0.8236 Soluble
214 C H 0.0000 Buried
215 E H -0.9772 Soluble
216 V H 0.0000 Buried
217 T H -1.3371 Soluble
218 H H -1.5072 Soluble
219 Q H -1.5045 Soluble
220 G H -0.4803 Soluble
221 L H -0.3358 Soluble
222 S H -0.5245 Soluble
223 S H -0.4453 Soluble
224 P H -0.6304 Soluble
225 V H 0.0398 Aggregation-prone
226 T H -0.4065 Soluble
227 K H -0.6539 Soluble
228 S H -0.6033 Soluble
229 F H 0.0000 Buried
230 N H -1.6075 Soluble
231 R H -2.3426 Soluble
232 G H -2.0543 Soluble
233 E H -2.1193 Soluble
234 C H -0.5389 Soluble

3D Structure — colored by A4D score

Sequence - click residue to focus in viewer  |  colored by A4D score
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Color Legend (B-factor = A4D Score)
Score > 1.5 — highly aggregation-prone
Score 0.5–1.5 — aggregation-prone
Score ≈ 0 — buried
Score −1 to −0.5 — soluble
Score < −2.5 — highly soluble
pH Structure
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A4D Score Threshold
Highlight residues > threshold in the sequence panel
CDR Regions
HCDR1
HCDR2
HCDR3
LCDR1
LCDR2
LCDR3
Display Options

pH-Dependent Aggregation Profiles

A4D scores calculated across 11 pH conditions (4.0–9.0, step 0.5). Click a row to view the structure at that pH. The input structure is globular — max score is recommended for pH analysis.

pH Avg A4D Score Max A4D Score Downloads
4.0 -0.9047 3.7187 CSV PDB
4.5 -0.9581 3.7187 CSV PDB
5.0 -1.0231 3.7187 CSV PDB
5.5 -1.0873 3.7187 CSV PDB
6.0 -1.1367 3.7187 CSV PDB
6.5 -1.1608 3.7187 CSV PDB
7.0 -1.1585 3.7187 CSV PDB
7.5 -1.138 3.7186 CSV PDB
8.0 -1.1079 3.7186 CSV PDB
8.5 -1.0715 3.7183 CSV PDB
9.0 -1.0297 3.7176 CSV PDB
Average A4D Score vs pH
Max A4D Score vs pH