Suvizumab / 3ntc

A4DAB250_3ntc_H_L | Source PDB: 3ntc | Chains: H, L | Done
100
Yes
10 Å
Yes
Avg A4D Score
-0.6918
Max Score
1.1507
Min Score
-3.4175
Total Score
-300.92
Score CDR
-0.2463
Score non-CDR
-0.7509

Calculation Parameters

Chain Sequence(s) QVQLVQSGAEVKKPGASVKVSCKASGYTFTNSWIGWFRQAPGQGLEWIGDIYPGGGYTNYNEIFKGKATMTADTSTNTAYMELSSLRSEDTAVYYCSRGIPGYAMDYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDIQMTQRPDSLSASVGDRVTMSCKSSQSLLNSGDQKNYLTWYQQKPGQPPKLLIYWASTGESGVPDRFSGSGSGTDFTFTISSLQPEDIATYYCQNDYSYPWTFGQGTKVEIKRTVAAPSVFIFPPSDQQLKSGTASVVCLNNNFYPKEAKVQWKVDNALQSGNSQESVTQQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGC input.pdb
Selected Chain(s) H (Heavy), L (Light)
Distance of Aggregation 10 Å
FoldX Energy Minimization Yes
pH Calculations Yes
Downloads Download all data (.tar.gz)

Aggrescan4D Profile

Aggregation-prone (score > 0)
Soluble (score < 0)
Buried (score = 0)

Per-Residue A4D Scores

Download CSV
Minimum Score -3.4175
Maximum Score 1.1507
Average Score -0.6918
Total Score -300.9191

Residues with A4D score > 0.0 are highlighted as aggregation-prone.

Index Residue Chain A4D Score Classification
1 Q H -1.3926 Soluble
2 V H -0.8712 Soluble
3 Q H -1.3585 Soluble
4 L H 0.0000 Buried
5 V H -0.3660 Soluble
6 Q H -0.5315 Soluble
7 S H -0.9093 Soluble
8 G H -1.1288 Soluble
9 A H 0.0000 Buried
11 E H -1.7152 Soluble
12 V H -1.0566 Soluble
13 K H -1.6454 Soluble
14 K H -2.3438 Soluble
15 P H -2.0065 Soluble
16 G H -1.4631 Soluble
17 A H -1.1753 Soluble
18 S H -1.2324 Soluble
19 V H 0.0000 Buried
20 K H -1.9996 Soluble
21 V H 0.0000 Buried
22 S H -0.7705 Soluble
23 C H 0.0000 Buried
24 K H -1.7958 Soluble
25 A H -1.1916 Soluble
26 S H -1.0840 Soluble
27 G H -0.8871 Soluble
28 Y H -0.5795 Soluble
29 T H -0.5272 Soluble
30 F H 0.0000 Buried
35 T H -0.9645 Soluble
36 N H -1.1093 Soluble
37 S H 0.0000 Buried
38 W H 0.4026 Aggregation-prone
39 I H 0.0000 Buried
40 G H 0.0000 Buried
41 W H 0.0000 Buried
42 F H 0.0000 Buried
43 R H -0.2402 Soluble
44 Q H -0.5172 Soluble
45 A H -0.8606 Soluble
46 P H -0.8484 Soluble
47 G H -1.3617 Soluble
48 Q H -1.7570 Soluble
49 G H -1.2108 Soluble
50 L H -0.4921 Soluble
52 W H 0.0000 Buried
53 I H 0.0000 Buried
54 G H 0.0000 Buried
55 D H 0.0000 Buried
56 I H 0.0000 Buried
57 Y H 0.2251 Aggregation-prone
58 P H 0.0000 Buried
59 G H -0.6575 Soluble
62 G H -0.4088 Soluble
63 G H 0.0259 Aggregation-prone
64 Y H 1.0012 Aggregation-prone
65 T H 0.4322 Aggregation-prone
66 N H -0.2423 Soluble
67 Y H -0.5510 Soluble
68 N H 0.0000 Buried
69 E H -1.4137 Soluble
70 I H 0.5965 Aggregation-prone
71 F H 0.0000 Buried
72 K H -1.9904 Soluble
74 G H -1.3032 Soluble
76 A H -0.9343 Soluble
77 T H -0.7673 Soluble
78 M H 0.0000 Buried
79 T H -0.0753 Soluble
80 A H -0.6267 Soluble
81 D H -1.2764 Soluble
82 T H -0.9130 Soluble
83 S H -0.6735 Soluble
84 T H -0.9556 Soluble
85 N H -1.3281 Soluble
86 T H 0.0000 Buried
87 A H 0.0000 Buried
88 Y H -0.6658 Soluble
89 M H 0.0000 Buried
90 E H -1.2392 Soluble
91 L H 0.0000 Buried
92 S H -0.9503 Soluble
93 S H -1.0457 Soluble
94 L H 0.0000 Buried
95 R H -2.5028 Soluble
96 S H -2.0882 Soluble
97 E H -2.3568 Soluble
98 D H 0.0000 Buried
99 T H -0.8874 Soluble
100 A H 0.0000 Buried
101 V H 0.1005 Aggregation-prone
102 Y H 0.0000 Buried
103 Y H 0.0000 Buried
104 C H 0.0000 Buried
105 S H 0.0000 Buried
106 R H 0.2493 Aggregation-prone
107 G H 0.0000 Buried
108 I H 0.9590 Aggregation-prone
109 P H 0.3081 Aggregation-prone
110 G H 0.2822 Aggregation-prone
113 Y H 1.1350 Aggregation-prone
114 A H 0.0000 Buried
115 M H 0.0000 Buried
116 D H -0.0130 Soluble
117 Y H -0.0999 Soluble
118 W H 0.0000 Buried
119 G H -0.4845 Soluble
121 G H -0.6258 Soluble
122 T H 0.0000 Buried
123 L H -0.3170 Soluble
124 V H 0.0000 Buried
125 T H -0.9680 Soluble
126 V H 0.0000 Buried
127 S H -1.1067 Soluble
128 S H -0.9388 Soluble
129 A H -0.5980 Soluble
130 S H -0.7434 Soluble
131 T H -1.1608 Soluble
132 K H -1.4505 Soluble
133 G H -1.4731 Soluble
134 P H -0.7592 Soluble
135 S H -0.4040 Soluble
136 V H 0.0000 Buried
137 F H 0.0000 Buried
138 P H -1.0199 Soluble
139 L H 0.0000 Buried
140 A H -1.3470 Soluble
141 P H 0.0000 Buried
142 S H -1.1275 Soluble
143 S H -0.7443 Soluble
144 K H -1.1979 Soluble
145 S H 0.0000 Buried
146 T H -0.7277 Soluble
147 S H -0.7176 Soluble
148 G H -0.8057 Soluble
149 G H -0.8804 Soluble
150 T H -0.5971 Soluble
151 A H 0.0000 Buried
152 A H 0.0000 Buried
153 L H 0.0000 Buried
154 G H 0.0000 Buried
155 C H 0.0000 Buried
156 L H 0.0000 Buried
157 V H 0.0000 Buried
158 K H 0.0000 Buried
159 D H -0.5992 Soluble
160 Y H 0.0000 Buried
161 F H -0.4571 Soluble
162 P H 0.0000 Buried
163 E H -0.8548 Soluble
164 P H -0.8690 Soluble
165 V H 0.0000 Buried
166 T H -0.5837 Soluble
167 V H -0.4129 Soluble
168 S H -0.3980 Soluble
169 W H 0.0000 Buried
170 N H -0.8415 Soluble
171 S H -0.7105 Soluble
172 G H -0.5946 Soluble
173 A H -0.2259 Soluble
174 L H 0.0410 Aggregation-prone
175 T H -0.1271 Soluble
177 G H -0.3437 Soluble
178 V H 0.1073 Aggregation-prone
179 H H -0.2544 Soluble
180 T H -0.0819 Soluble
181 F H 0.0000 Buried
182 P H -0.2969 Soluble
183 A H 0.0521 Aggregation-prone
184 V H 0.3197 Aggregation-prone
185 L H 1.1507 Aggregation-prone
186 Q H 0.1876 Aggregation-prone
187 S H -0.0564 Soluble
188 S H -0.2278 Soluble
189 G H 0.0996 Aggregation-prone
190 L H 0.0681 Aggregation-prone
191 Y H 0.3521 Aggregation-prone
192 S H 0.0000 Buried
193 L H 0.0000 Buried
194 S H 0.0000 Buried
195 S H 0.0000 Buried
196 V H 0.0000 Buried
197 V H 0.0000 Buried
198 T H -0.2013 Soluble
199 V H 0.0000 Buried
200 P H -0.6156 Soluble
201 S H -0.5764 Soluble
202 S H -0.5934 Soluble
203 S H -0.5996 Soluble
204 L H -0.8683 Soluble
205 G H -1.0190 Soluble
206 T H -0.7529 Soluble
207 Q H -1.2970 Soluble
208 T H -1.2220 Soluble
209 Y H 0.0000 Buried
210 I H -1.2992 Soluble
211 C H 0.0000 Buried
212 N H -1.4501 Soluble
213 V H 0.0000 Buried
214 N H -1.8067 Soluble
215 H H 0.0000 Buried
216 K H -2.6884 Soluble
217 P H -1.8978 Soluble
218 S H -1.8965 Soluble
219 N H -2.6165 Soluble
220 T H -2.0531 Soluble
221 K H -2.6285 Soluble
222 V H -1.5915 Soluble
223 D H -2.4420 Soluble
224 K H -2.0998 Soluble
225 K H -2.5056 Soluble
226 V H 0.0000 Buried
227 E H -2.9138 Soluble
228 P H -1.9290 Soluble
229 K H -2.2025 Soluble
230 S H -0.9283 Soluble
231 C H 0.2304 Aggregation-prone
1 D L -2.1357 Soluble
2 I L 0.0000 Buried
3 Q L -2.2015 Soluble
4 M L 0.0000 Buried
5 T L -1.6902 Soluble
6 Q L -1.4143 Soluble
8 P L -1.4346 Soluble
9 D L -2.4424 Soluble
10 S L -1.6001 Soluble
11 L L -0.9924 Soluble
12 S L -1.0939 Soluble
13 A L -1.1895 Soluble
14 S L -1.1656 Soluble
15 V L -0.5063 Soluble
16 G L -0.9209 Soluble
17 D L -1.7498 Soluble
18 R L -2.3697 Soluble
19 V L 0.0000 Buried
20 T L -0.6417 Soluble
21 M L 0.0000 Buried
22 S L -1.1637 Soluble
23 C L 0.0000 Buried
24 K L -2.8206 Soluble
25 S L 0.0000 Buried
26 S L -2.0360 Soluble
27 Q L -2.0649 Soluble
28 S L -1.0233 Soluble
29 L L 0.0000 Buried
30 L L -0.4221 Soluble
31 N L -1.0553 Soluble
32 S L -1.2294 Soluble
33 G L -1.4795 Soluble
34 D L -1.9735 Soluble
35 Q L -2.0672 Soluble
36 K L -1.3567 Soluble
37 N L -0.5779 Soluble
38 Y L 0.1635 Aggregation-prone
39 L L 0.0000 Buried
40 T L 0.0000 Buried
41 W L 0.0000 Buried
42 Y L 0.0000 Buried
43 Q L 0.0000 Buried
44 Q L 0.0000 Buried
45 K L -1.5586 Soluble
46 P L -1.1956 Soluble
47 G L -1.3331 Soluble
48 Q L -1.7698 Soluble
49 P L -1.1882 Soluble
50 P L 0.0000 Buried
51 K L -1.7079 Soluble
52 L L 0.0000 Buried
53 L L 0.0000 Buried
54 I L 0.0000 Buried
55 Y L 0.0000 Buried
56 W L 0.0132 Aggregation-prone
57 A L 0.0000 Buried
65 S L -0.5501 Soluble
66 T L -0.4309 Soluble
67 G L -0.9700 Soluble
68 E L -0.8515 Soluble
69 S L -0.6055 Soluble
70 G L -0.8276 Soluble
71 V L -0.8922 Soluble
72 P L -1.1776 Soluble
74 D L -2.0934 Soluble
75 R L -1.5368 Soluble
76 F L 0.0000 Buried
77 S L -0.8273 Soluble
78 G L 0.0000 Buried
79 S L -0.7182 Soluble
80 G L -1.1877 Soluble
83 S L -1.1482 Soluble
84 G L -1.0955 Soluble
85 T L -1.7712 Soluble
86 D L -2.5185 Soluble
87 F L 0.0000 Buried
88 T L -0.8795 Soluble
89 F L 0.0000 Buried
90 T L -0.6229 Soluble
91 I L 0.0000 Buried
92 S L -1.5695 Soluble
93 S L -1.4132 Soluble
94 L L 0.0000 Buried
95 Q L -1.3041 Soluble
96 P L -1.8499 Soluble
97 E L -2.1915 Soluble
98 D L 0.0000 Buried
99 I L 0.0000 Buried
100 A L 0.0000 Buried
101 T L 0.0000 Buried
102 Y L 0.0000 Buried
103 Y L 0.0000 Buried
104 C L 0.0000 Buried
105 Q L 0.0000 Buried
106 N L 0.0000 Buried
107 D L 0.4084 Aggregation-prone
108 Y L 0.6369 Aggregation-prone
109 S L 0.3394 Aggregation-prone
114 Y L 0.3922 Aggregation-prone
115 P L 0.0222 Aggregation-prone
116 W L 0.0000 Buried
117 T L -0.5120 Soluble
118 F L 0.0000 Buried
119 G L 0.0000 Buried
120 Q L -1.9989 Soluble
121 G L 0.0000 Buried
122 T L 0.0000 Buried
123 K L -1.9154 Soluble
124 V L 0.0000 Buried
125 E L -1.5766 Soluble
126 I L 0.0000 Buried
127 K L -1.8503 Soluble
128 R L -1.0683 Soluble
129 T L 0.1059 Aggregation-prone
130 V L 1.0177 Aggregation-prone
131 A L 0.3805 Aggregation-prone
132 A L 0.1113 Aggregation-prone
133 P L 0.0000 Buried
134 S L -0.2277 Soluble
135 V L 0.0000 Buried
136 F L 0.0000 Buried
137 I L 0.0000 Buried
138 F L 0.0000 Buried
139 P L -0.6604 Soluble
140 P L -0.7495 Soluble
141 S L -1.5959 Soluble
142 D L -2.6307 Soluble
143 Q L -2.3356 Soluble
144 Q L 0.0000 Buried
145 L L -2.0755 Soluble
146 K L -2.6401 Soluble
147 S L -1.6595 Soluble
148 G L -1.2369 Soluble
149 T L -1.2083 Soluble
150 A L 0.0000 Buried
151 S L 0.0000 Buried
152 V L 0.0000 Buried
153 V L 0.0000 Buried
154 C L 0.0000 Buried
155 L L 0.0000 Buried
156 N L 0.0000 Buried
157 N L 0.0000 Buried
158 N L -0.7797 Soluble
159 F L 0.0000 Buried
160 Y L 0.0000 Buried
161 P L -1.3040 Soluble
162 K L -2.1621 Soluble
163 E L -2.8569 Soluble
164 A L -2.1127 Soluble
165 K L -2.3905 Soluble
166 V L -1.4132 Soluble
167 Q L -0.7794 Soluble
168 W L 0.0000 Buried
169 K L -0.7439 Soluble
170 V L 0.0000 Buried
171 D L -1.8521 Soluble
172 N L -1.5491 Soluble
173 A L -0.3891 Soluble
174 L L 0.4658 Aggregation-prone
175 Q L -0.4535 Soluble
176 S L -0.7502 Soluble
177 G L -1.3737 Soluble
178 N L -1.7418 Soluble
179 S L -1.7433 Soluble
180 Q L -1.8297 Soluble
181 E L -1.8806 Soluble
182 S L -0.9845 Soluble
183 V L -0.7263 Soluble
184 T L 0.0000 Buried
185 Q L -1.5931 Soluble
186 Q L 0.0000 Buried
187 D L -1.7635 Soluble
188 S L -2.1339 Soluble
189 K L -2.5953 Soluble
190 D L -1.8474 Soluble
191 S L 0.0000 Buried
192 T L 0.0000 Buried
193 Y L 0.0000 Buried
194 S L 0.0000 Buried
195 L L 0.0000 Buried
196 S L 0.0000 Buried
197 S L 0.0000 Buried
198 T L -0.9068 Soluble
199 L L 0.0000 Buried
200 T L -0.7566 Soluble
201 L L -0.9070 Soluble
202 S L -1.1045 Soluble
203 K L -2.1299 Soluble
204 A L -1.9036 Soluble
205 D L -2.5662 Soluble
206 Y L 0.0000 Buried
207 E L -3.2299 Soluble
208 K L -3.4175 Soluble
209 H L -2.5976 Soluble
210 K L -2.2014 Soluble
211 V L -1.0771 Soluble
212 Y L 0.0000 Buried
213 A L 0.0000 Buried
214 C L 0.0000 Buried
215 E L -0.7966 Soluble
216 V L 0.0000 Buried
217 T L -1.2173 Soluble
218 H L 0.0000 Buried
219 Q L -1.5455 Soluble
220 G L -0.2098 Soluble
221 L L -0.1031 Soluble
222 S L -0.4282 Soluble
223 S L -0.4248 Soluble
224 P L -0.4190 Soluble
225 V L -0.0426 Soluble
226 T L -0.5035 Soluble
227 K L -0.8550 Soluble
228 S L -0.7234 Soluble
229 F L 0.0000 Buried
230 N L -1.0170 Soluble
231 R L -1.3821 Soluble
232 G L -0.6213 Soluble
233 C L 0.2654 Aggregation-prone

3D Structure — colored by A4D score

Sequence - click residue to focus in viewer  |  colored by A4D score
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Color Legend (B-factor = A4D Score)
Score > 1.5 — highly aggregation-prone
Score 0.5–1.5 — aggregation-prone
Score ≈ 0 — buried
Score −1 to −0.5 — soluble
Score < −2.5 — highly soluble
pH Structure
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A4D Score Threshold
Highlight residues > threshold in the sequence panel
CDR Regions
HCDR1
HCDR2
HCDR3
LCDR1
LCDR2
LCDR3
Display Options

pH-Dependent Aggregation Profiles

A4D scores calculated across 11 pH conditions (4.0–9.0, step 0.5). Click a row to view the structure at that pH. The input structure is globular — max score is recommended for pH analysis.

pH Avg A4D Score Max A4D Score Downloads
4.0 -0.6823 2.3976 CSV PDB
4.5 -0.7248 2.3909 CSV PDB
5.0 -0.7733 2.3828 CSV PDB
5.5 -0.818 2.374 CSV PDB
6.0 -0.8477 2.3651 CSV PDB
6.5 -0.8532 2.3561 CSV PDB
7.0 -0.8341 2.3471 CSV PDB
7.5 -0.7987 2.3381 CSV PDB
8.0 -0.7543 2.3292 CSV PDB
8.5 -0.7029 2.3206 CSV PDB
9.0 -0.6442 2.312 CSV PDB
Average A4D Score vs pH
Max A4D Score vs pH