Tixagevimab / 7l7e

A4DAB270_7l7e_H_L | Source PDB: 7l7e | Chains: H, L | Done
99.14
Yes
10 Å
Yes
Avg A4D Score
-0.7264
Max Score
1.8042
Min Score
-3.4758
Total Score
-313.8
Score CDR
-0.3319
Score non-CDR
-0.7804

Calculation Parameters

Chain Sequence(s) EVQLVQSGPEVKKPGTSVKVSCKASGFTFMSSAVQWVRQARGQRLEWIGWIVIGSGNTNYAQKFQERVTITRDMSTSTAYMELSSLRSEDTAVYYCAAPYCSSISCNDGFDIWGQGTMVTVSSASTKGPSVFPLAPSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPEIVLTQSPGTLSLSPGERATLSCRASQSVSSSYLAWYQQKPGQAPRLLIYGASSRATGIPDRFSGSGSGTDFTLTISRLEPEDFAVYYCQHYGSSRGWTFGQGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRG input.pdb
Selected Chain(s) H (Heavy), L (Light)
Distance of Aggregation 10 Å
FoldX Energy Minimization Yes
pH Calculations Yes
Downloads Download all data (.tar.gz)

Aggrescan4D Profile

Aggregation-prone (score > 0)
Soluble (score < 0)
Buried (score = 0)

Per-Residue A4D Scores

Download CSV
Minimum Score -3.4758
Maximum Score 1.8042
Average Score -0.7264
Total Score -313.7953

Residues with A4D score > 0.0 are highlighted as aggregation-prone.

Index Residue Chain A4D Score Classification
1 E H -1.7857 Soluble
2 V H -0.5965 Soluble
3 Q H -0.9627 Soluble
4 L H 0.0000 Buried
5 V H 0.1013 Aggregation-prone
6 Q H 0.0000 Buried
7 S H -0.6321 Soluble
8 G H -0.7144 Soluble
9 P H -0.3681 Soluble
11 E H -0.4801 Soluble
12 V H 0.1578 Aggregation-prone
13 K H -1.1469 Soluble
14 K H -2.0772 Soluble
15 P H -1.6304 Soluble
16 G H -1.3628 Soluble
17 T H -1.1245 Soluble
18 S H -1.2702 Soluble
19 V H 0.0000 Buried
20 K H -1.9923 Soluble
21 V H 0.0000 Buried
22 S H -0.5686 Soluble
23 C H 0.0000 Buried
24 K H -0.7639 Soluble
25 A H 0.0000 Buried
26 S H -0.6591 Soluble
27 G H -0.7097 Soluble
28 F H -0.0629 Soluble
29 T H 0.3881 Aggregation-prone
30 F H 0.0000 Buried
35 M H 0.1914 Aggregation-prone
36 S H 0.2529 Aggregation-prone
37 S H 0.0000 Buried
38 A H 0.0463 Aggregation-prone
39 V H 0.0000 Buried
40 Q H 0.0000 Buried
41 W H 0.0000 Buried
42 V H 0.0000 Buried
43 R H 0.0000 Buried
44 Q H -1.1056 Soluble
45 A H -1.7989 Soluble
46 R H -2.5744 Soluble
47 G H -2.1973 Soluble
48 Q H -2.6437 Soluble
49 R H -2.1716 Soluble
50 L H 0.0000 Buried
51 E H -0.9473 Soluble
52 W H 0.0000 Buried
53 I H 0.0000 Buried
54 G H 0.0000 Buried
55 W H -0.2537 Soluble
56 I H 0.0000 Buried
57 V H -0.1892 Soluble
58 I H 0.0000 Buried
59 G H -0.4159 Soluble
62 S H -0.7161 Soluble
63 G H -0.8887 Soluble
64 N H -1.4044 Soluble
65 T H -0.8594 Soluble
66 N H -1.1784 Soluble
67 Y H -1.4669 Soluble
68 A H -2.2554 Soluble
69 Q H -3.1929 Soluble
70 K H -2.9451 Soluble
71 F H 0.0000 Buried
72 Q H -3.0404 Soluble
74 E H -2.9947 Soluble
75 R H -1.9444 Soluble
76 V H 0.0000 Buried
77 T H -0.9915 Soluble
78 I H 0.0000 Buried
79 T H -0.5335 Soluble
80 R H -0.8936 Soluble
81 D H -0.9508 Soluble
82 M H -0.1982 Soluble
83 S H -0.3121 Soluble
84 T H -0.5177 Soluble
85 S H -0.4718 Soluble
86 T H 0.0000 Buried
87 A H 0.0000 Buried
88 Y H -0.6488 Soluble
89 M H 0.0000 Buried
90 E H -1.5319 Soluble
91 L H 0.0000 Buried
92 S H -1.2449 Soluble
93 S H -1.1436 Soluble
94 L H 0.0000 Buried
95 R H -2.3743 Soluble
96 S H -2.0218 Soluble
97 E H -2.3084 Soluble
98 D H 0.0000 Buried
99 T H -0.8803 Soluble
100 A H 0.0000 Buried
101 V H -0.0106 Soluble
102 Y H 0.0000 Buried
103 Y H 0.0000 Buried
104 C H 0.0000 Buried
105 A H 0.0000 Buried
106 A H 0.0000 Buried
107 P H -0.4993 Soluble
108 Y H -0.1529 Soluble
109 C H 0.0000 Buried
110 S H 0.4315 Aggregation-prone
111 S H 0.7554 Aggregation-prone
111A I H 1.8042 Aggregation-prone
112B S H 0.4361 Aggregation-prone
112A C H -0.2815 Soluble
112 N H -1.6483 Soluble
113 D H -2.0295 Soluble
114 G H 0.0000 Buried
115 F H 0.0000 Buried
116 D H -0.7348 Soluble
117 I H -0.2281 Soluble
118 W H 0.0000 Buried
119 G H 0.0000 Buried
120 Q H -1.3293 Soluble
121 G H -0.6640 Soluble
122 T H 0.0000 Buried
123 M H 0.1183 Aggregation-prone
124 V H 0.0000 Buried
125 T H 0.0000 Buried
126 V H 0.0000 Buried
127 S H -1.0257 Soluble
128 S H -0.9587 Soluble
129 A H -0.5874 Soluble
130 S H -0.6151 Soluble
131 T H -0.5992 Soluble
132 K H -1.3086 Soluble
133 G H -1.4127 Soluble
134 P H 0.0000 Buried
135 S H -0.4222 Soluble
136 V H 0.0000 Buried
137 F H 0.0000 Buried
138 P H -1.2126 Soluble
139 L H 0.0000 Buried
140 A H -0.5266 Soluble
141 P H 0.0000 Buried
142 S H -0.4939 Soluble
143 G H -0.8002 Soluble
144 G H -0.8642 Soluble
145 T H -0.5769 Soluble
146 A H -0.2453 Soluble
147 A H 0.0000 Buried
148 L H 0.0000 Buried
149 G H 0.0000 Buried
150 C H 0.0000 Buried
151 L H 0.0000 Buried
152 V H 0.0000 Buried
153 K H 0.0000 Buried
154 D H -0.3079 Soluble
155 Y H 0.0000 Buried
156 F H 0.0000 Buried
157 P H 0.0000 Buried
158 E H -0.2740 Soluble
159 P H -0.6124 Soluble
160 V H -0.5968 Soluble
161 T H -0.5543 Soluble
162 V H -0.2014 Soluble
163 S H -0.4165 Soluble
164 W H 0.0000 Buried
165 N H -0.8902 Soluble
166 S H -0.7065 Soluble
167 G H -0.5680 Soluble
168 A H -0.2383 Soluble
169 L H 0.0342 Aggregation-prone
170 T H -0.1538 Soluble
171 S H -0.1704 Soluble
172 G H -0.2048 Soluble
173 V H 0.1665 Aggregation-prone
174 H H -0.3243 Soluble
175 T H 0.0539 Aggregation-prone
176 F H 0.0000 Buried
177 P H -0.5869 Soluble
178 A H 0.0000 Buried
179 V H 0.2447 Aggregation-prone
180 L H 0.7517 Aggregation-prone
181 Q H 0.0360 Aggregation-prone
182 S H -0.1789 Soluble
183 S H -0.2747 Soluble
184 G H -0.1025 Soluble
185 L H 0.0018 Aggregation-prone
186 Y H 0.0000 Buried
187 S H 0.0000 Buried
188 L H 0.0000 Buried
189 S H 0.0000 Buried
190 S H 0.0000 Buried
191 V H 0.0000 Buried
192 V H 0.0000 Buried
193 T H -0.1352 Soluble
194 V H 0.0000 Buried
195 P H -0.5602 Soluble
196 S H -0.6496 Soluble
197 S H -0.6982 Soluble
198 S H 0.0000 Buried
199 L H -0.9410 Soluble
200 G H -1.1288 Soluble
201 T H -0.8076 Soluble
202 Q H -1.4080 Soluble
203 T H -1.2927 Soluble
204 Y H 0.0000 Buried
205 I H -1.6509 Soluble
206 C H 0.0000 Buried
207 N H -1.7294 Soluble
208 V H 0.0000 Buried
209 N H -2.0127 Soluble
210 H H 0.0000 Buried
211 K H -2.8268 Soluble
212 P H -1.6667 Soluble
213 S H -1.8935 Soluble
214 N H -2.7590 Soluble
215 T H -2.1102 Soluble
216 K H -2.8376 Soluble
217 V H -1.8840 Soluble
218 D H -2.7937 Soluble
219 K H -2.2023 Soluble
220 K H -2.6977 Soluble
221 V H 0.0000 Buried
222 E H -2.4636 Soluble
223 P H -1.2185 Soluble
1 E L -1.8235 Soluble
2 I L -0.1130 Soluble
3 V L 0.7637 Aggregation-prone
4 L L 0.0000 Buried
5 T L -0.4681 Soluble
6 Q L 0.0000 Buried
7 S L -0.5882 Soluble
8 P L -0.4520 Soluble
9 G L -0.7618 Soluble
10 T L -0.4387 Soluble
11 L L -0.2640 Soluble
12 S L -0.5991 Soluble
13 L L -1.0491 Soluble
14 S L -1.6057 Soluble
15 P L -1.9845 Soluble
16 G L -2.4057 Soluble
17 E L -2.6804 Soluble
18 R L -2.9845 Soluble
19 A L 0.0000 Buried
20 T L -0.5904 Soluble
21 L L 0.0000 Buried
22 S L -0.7696 Soluble
23 C L 0.0000 Buried
24 R L -1.5986 Soluble
25 A L -0.8148 Soluble
26 S L -0.7990 Soluble
27 Q L -1.5375 Soluble
28 S L -1.1709 Soluble
29 V L -0.4690 Soluble
30 S L -0.1284 Soluble
36 S L -0.3448 Soluble
37 S L -0.0924 Soluble
38 Y L 0.4390 Aggregation-prone
39 L L 0.0000 Buried
40 A L 0.0000 Buried
41 W L 0.0000 Buried
42 Y L 0.0000 Buried
43 Q L -0.7038 Soluble
44 Q L 0.0000 Buried
45 K L -1.3957 Soluble
46 P L -1.5498 Soluble
47 G L -1.4435 Soluble
48 Q L -2.0657 Soluble
49 A L -1.3866 Soluble
50 P L 0.0000 Buried
51 R L -1.4428 Soluble
52 L L 0.0000 Buried
53 L L 0.0000 Buried
54 I L 0.0000 Buried
55 Y L -0.4330 Soluble
56 G L -0.3937 Soluble
57 A L 0.0000 Buried
65 S L -0.6404 Soluble
66 S L -0.8217 Soluble
67 R L -1.2703 Soluble
68 A L -1.0410 Soluble
69 T L -0.6036 Soluble
70 G L -0.7657 Soluble
71 I L -0.8051 Soluble
72 P L -1.1685 Soluble
74 D L -2.3072 Soluble
75 R L -1.9638 Soluble
76 F L 0.0000 Buried
77 S L -0.8681 Soluble
78 G L -0.4978 Soluble
79 S L -0.7858 Soluble
80 G L -1.2017 Soluble
83 S L -1.0402 Soluble
84 G L -1.2376 Soluble
85 T L -1.7529 Soluble
86 D L -2.4908 Soluble
87 F L 0.0000 Buried
88 T L -0.7766 Soluble
89 L L 0.0000 Buried
90 T L -0.7591 Soluble
91 I L 0.0000 Buried
92 S L -2.3990 Soluble
93 R L -3.4758 Soluble
94 L L 0.0000 Buried
95 E L -2.3515 Soluble
96 P L -1.8032 Soluble
97 E L -2.2409 Soluble
98 D L 0.0000 Buried
99 F L -0.6192 Soluble
100 A L 0.0000 Buried
101 V L -0.3092 Soluble
102 Y L 0.0000 Buried
103 Y L 0.0000 Buried
104 C L 0.0000 Buried
105 Q L 0.0000 Buried
106 H L 0.0000 Buried
107 Y L 0.0000 Buried
108 G L 0.0000 Buried
109 S L -0.7984 Soluble
113 S L -1.3265 Soluble
114 R L -2.4371 Soluble
115 G L -1.6039 Soluble
116 W L 0.0000 Buried
117 T L -0.2392 Soluble
118 F L 0.0000 Buried
119 G L 0.0000 Buried
120 Q L -1.3978 Soluble
121 G L -0.9914 Soluble
122 T L 0.0000 Buried
123 K L -0.6356 Soluble
124 V L 0.0000 Buried
125 E L 0.0000 Buried
126 I L -0.7114 Soluble
127 K L -1.5772 Soluble
128 R L -1.0620 Soluble
129 T L 0.0610 Aggregation-prone
130 V L 1.1609 Aggregation-prone
131 A L 0.4567 Aggregation-prone
132 A L 0.1161 Aggregation-prone
133 P L 0.0000 Buried
134 S L -0.1094 Soluble
135 V L 0.0000 Buried
136 F L 0.1640 Aggregation-prone
137 I L 0.1437 Aggregation-prone
138 F L 0.0000 Buried
139 P L -0.5254 Soluble
140 P L 0.0000 Buried
141 S L -1.6360 Soluble
142 D L -3.0086 Soluble
143 E L -3.2211 Soluble
144 Q L 0.0000 Buried
145 L L -2.0146 Soluble
146 K L -2.7686 Soluble
147 S L -1.7229 Soluble
148 G L -1.2080 Soluble
149 T L -0.8881 Soluble
150 A L 0.0000 Buried
151 S L 0.0000 Buried
152 V L 0.0000 Buried
153 V L 0.0000 Buried
154 C L 0.0000 Buried
155 L L 0.0000 Buried
156 L L 0.0000 Buried
157 N L 0.0000 Buried
158 N L -0.6965 Soluble
159 F L 0.0000 Buried
160 Y L 0.0000 Buried
161 P L -1.6200 Soluble
162 R L -3.0842 Soluble
163 E L -3.2191 Soluble
164 A L -2.3028 Soluble
165 K L -2.4825 Soluble
166 V L -1.1368 Soluble
167 Q L -0.8145 Soluble
168 W L 0.0000 Buried
169 K L -0.7512 Soluble
170 V L 0.0000 Buried
171 D L -1.9027 Soluble
172 N L -1.4495 Soluble
173 A L -0.4949 Soluble
174 L L 0.2675 Aggregation-prone
175 Q L -0.5342 Soluble
176 S L -0.7210 Soluble
177 G L -1.1844 Soluble
178 N L -1.3596 Soluble
179 S L -1.4980 Soluble
180 Q L -1.6451 Soluble
181 E L -2.1765 Soluble
182 S L -0.8529 Soluble
183 V L -0.8496 Soluble
184 T L -1.1423 Soluble
185 E L -2.2649 Soluble
186 Q L -1.8774 Soluble
187 D L -1.8667 Soluble
188 S L -1.6441 Soluble
189 K L -2.1319 Soluble
190 D L -1.5326 Soluble
191 S L -1.6790 Soluble
192 T L 0.0000 Buried
193 Y L 0.0000 Buried
194 S L 0.0000 Buried
195 L L 0.0000 Buried
196 S L 0.0000 Buried
197 S L 0.0000 Buried
198 T L -0.7185 Soluble
199 L L 0.0000 Buried
200 T L -0.5802 Soluble
201 L L -0.4644 Soluble
202 S L -0.8434 Soluble
203 K L -1.6798 Soluble
204 A L -1.4715 Soluble
205 D L -1.9407 Soluble
206 Y L 0.0000 Buried
207 E L -3.0878 Soluble
208 K L -3.2647 Soluble
209 H L -3.0048 Soluble
210 K L -2.9504 Soluble
211 V L -1.3490 Soluble
212 Y L 0.0000 Buried
213 A L -0.6383 Soluble
214 C L 0.0000 Buried
215 E L -0.6980 Soluble
216 V L 0.0000 Buried
217 T L -1.1094 Soluble
218 H L 0.0000 Buried
219 Q L -1.5093 Soluble
220 G L -0.3818 Soluble
221 L L -0.1522 Soluble
222 S L -0.4435 Soluble
223 S L -0.4392 Soluble
224 P L -0.5568 Soluble
225 V L -0.0432 Soluble
226 T L -0.5033 Soluble
227 K L -0.8045 Soluble
228 S L -0.6250 Soluble
229 F L -0.7543 Soluble
230 N L -1.7125 Soluble
231 R L -2.0938 Soluble
232 G L -1.3028 Soluble

3D Structure — colored by A4D score

Sequence - click residue to focus in viewer  |  colored by A4D score
Load structure to view sequence…
Downloads
Color Legend (B-factor = A4D Score)
Score > 1.5 — highly aggregation-prone
Score 0.5–1.5 — aggregation-prone
Score ≈ 0 — buried
Score −1 to −0.5 — soluble
Score < −2.5 — highly soluble
pH Structure
Load structure at specific pH condition
A4D Score Threshold
Highlight residues > threshold in the sequence panel
CDR Regions
HCDR1
HCDR2
HCDR3
LCDR1
LCDR2
LCDR3
Display Options

pH-Dependent Aggregation Profiles

A4D scores calculated across 11 pH conditions (4.0–9.0, step 0.5). Click a row to view the structure at that pH. The input structure is globular — max score is recommended for pH analysis.

pH Avg A4D Score Max A4D Score Downloads
4.0 -0.7941 1.9915 CSV PDB
4.5 -0.836 1.9509 CSV PDB
5.0 -0.8863 1.8931 CSV PDB
5.5 -0.9351 1.828 CSV PDB
6.0 -0.9715 1.7656 CSV PDB
6.5 -0.9868 1.7527 CSV PDB
7.0 -0.9792 1.7527 CSV PDB
7.5 -0.9555 1.7527 CSV PDB
8.0 -0.9228 1.7527 CSV PDB
8.5 -0.8841 1.8178 CSV PDB
9.0 -0.8399 1.8944 CSV PDB
Average A4D Score vs pH
Max A4D Score vs pH